[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sagittal-imbalance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sagittal-imbalance":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,75,97,128],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100603701","spontaneous-correction-of-sagittal-imbalance-after-isolated-lumbar-decompression-100603701",false,"NCT07139938","Spontaneous Correction of Sagittal Imbalance After Isolated Lumbar Decompression","Multicenter Study of Spontaneous Correction of Sagittal Imbalance After Isolated Decompression Surgery Without Corrective Fusion Procedure for Lumbar Spinal Stenosis","Inclusion Criteria:\n\n* 1\\. Age 45 and over;\n* 2\\. Radicular leg pain and\u002For neurogenic claudication with\u002Fwithout back pain, caused by single- or multi-level degenerative lumbar stenosis with\u002Fwithout spodylolisthesis, confirmed by MRI;\n* 3\\. Planned isolated decompression of the spinal canal without implantation of any devices;\n* 4\\. Symptoms persisting for at least 3 months prior to surgery;\n* 5\\. Given written Informed Consent;\n* 6\\. Able and agree to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements.\n\nNon-Inclusion Criteria:\n\n* 1\\. Prior any lumbar surgery;\n* 2\\. Scoliosis of any non-degenerative etiology (due to vertebral fractures, idiopathic, etc.);\n* 3\\. Degenerative scoliosis \\> 20 degrees;\n* 4\\. Any contraindication or inability to undergo baseline and\u002For follow up MRI or X-ray as required per protocol;\n* 5\\. Any other condition or situation that the investigator believes may interfere with the safety of the subject or the intent and conduct of the study;\n\nExclusion Criteria:\n\n* 1\\. Performed intraoperative discotomy;\n* 2\\. Performed intraoperative iatrogenic instability of the lumbar segment (facetectomy, foraminotomy, etc.)","ALL","18 Years",{"count":19,"type":20},165,"ESTIMATED","INTERVENTIONAL",[23],"NA","Sagittal spinal imbalance may be caused by orthopedic problems, compression of the neural structures of the spinal canal, and pain syndrome (functional imbalance). Sagittal imbalance in combination with appropriate clinical symptoms may require surgical correction of the spine with fixation. However, in some cases, patients experience spontaneous correction of sagittal balance after isolated decompression without any correction or fusion. Therefore, it is necessary to clarify whether isolated decompression may cause spontaneous correction of sagittal imbalance in patients with degenerative lumbar stenosis.",[26,27,28,29],"LUMBAR STENOSIS","Sagittal Imbalance","Degeneration Lumbar Spine","Lumbar Decompression",[31,32,33],"lumbar stenosis","sagittal imbalance","lumbar decompression","RECRUITING","2026-07-01",{"date":37,"type":38},"2026-07-02","ACTUAL",{"date":40,"type":38},"2025-10-06",{"date":42,"type":20},"2027-10-06",{"name":44,"class":45},"N.N. Priorov National Medical Research Center of Traumatology and Orthopedics","OTHER",3,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100430451","prospective-evaluation-of-complex-adult-spinal-deformity-cad-treated-with-minimally-invasive-surgery-100430451","NCT04885244","Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery","Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery (MIS)","MIS","Inclusion Criteria:\n\n1. \\>18 years of age at the time of treatment\n2. Diagnosis of adult congenital, degenerative, idiopathic, neuromuscular, inflammatory or iatrogenic spinal deformity\n3. EOS full body or standing 36\" AP \\& Lateral images of entire spine\n4. Surgery to be schedule to take place within 6 months (otherwise PROMs\u002FRadiographic images to be recollected)\n\n   AND Either:\n5. One of the following Radiographic criteria:\n\n   1. PI-LL ≥ 25 degrees\n   2. Thoracolumbar\u002Flumbar scoliosis ≥ 20 degrees\n   3. SVA \\>10cm\n   4. PT \\> 30 OR\n6. One of the Following Procedural criteria:\n\n   1. Surgery to include \\> 3 levels percutaneous posterior spinal instrumentation or 3 level stand-alone interbody. (Levels = vertebra (i.e. percutaneous screws at L2, L3, L4 would be eligible for posterior instrumentation and\u002For L3-L4, L4-L5 would be eligible as stand-alone for interbodies)\n   2. Posterior UIV and LIV must be placed percutaneously\n   3. Single-position surgery ≥ 3 levels fused (Levels=vertebra; S1 is counted as a level; S2 \\&\u002For pelvis\u002Filium is not)\n   4. Staged ≥ 3 levels fused with percutaneous pedicle screws\n   5. 3 column osteotomy with percutaneous fixation\n   6. ACR incorporating open or percutaneous fixation as long as UIV and LIV are percutaneous screws\n\nExclusion Criteria:\n\n1. Deformity due to acute trauma\n2. Active spine tumor or infection\n3. Patient is unwilling or unable to complete questionnaires\n4. Women who are pregnant\n5. Prisoners\n6. Open Posterior spinal fusion is planned (Open Anterior, i.e. ALIF, is acceptable)",{"count":56,"type":20},500,"OBSERVATIONAL","Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients treated with minimally invasive approach, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.",[60,61,62,27],"Adult Spinal Deformity","Scoliosis","Kyphosis",[61,62,27,64],"Spinal Deformity","2026-02-12",{"date":67,"type":38},"2026-02-17",{"date":69,"type":38},"2021-07-28",{"date":71,"type":20},"2034-12-31",{"name":73,"class":45},"International Spine Study Group Foundation",12,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":85,"studyType":57,"phases":4,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":90,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},"100377408","complex-adult-deformity-surgery-cads-100377408","NCT04194138","Complex Adult Deformity Surgery (CADS)","Multi-Center Prospective Evaluation of Complex Adult Spinal Deformity Surgery","CADS","Criteria:\n\nInclusion Criteria:\n\n1. Diagnosis of adult congenital, degenerative, idiopathic or iatrogenic spinal deformity\n2. Full body EOS radiographic assessment (sagittal and coronal visualization from skull to foot)\n3. Complex patients are defined as and meeting any one of the subsequent criteria:\n\n   1. Radiographic criteria:\n\n      * PI-LL ≥ 25 degrees\n      * TPA ≥ 30 degrees\n      * SVA\\>15cm\n      * Thoracic scoliosis ≥ 70 degrees\n      * Thoracolumbar\u002Flumbar scoliosis ≥ 50 degrees\n      * Global coronal malalignment \\>7cm\n   2. Procedural criteria:\n\n      * Posterior spinal fusion \\> 12 levels\n      * 3 column osteotomy or ACR\n   3. Geriatric criteria:\n\n      * Age \\>65 years and minimum 7 levels of spinal instrumentation during surgery\n\nExclusion Criteria:\n\n1. Age \\\u003C18 years of age\n2. Active spine tumor or infection\n3. Deformity due to acute trauma\n4. Neuromuscular conditions\u002Fdiseases (Parkinson's, Multiple Sclerosis, Post-polio syndrome)\n5. Syndromic scoliosis\n6. Inflammatory arthritis\u002Fauto immune diseases (Rheumatoid arthritis, Lupus, Ankylosing Spondylitis)\n7. Prisoners\n8. Women who are pregnant\n9. Non English speaking patients",{"count":84,"type":20},1500,"10 Years","Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.",[60,61,62,27],[61,62,27,89],"Spinal deformity",{"date":67,"type":38},{"date":92,"type":38},"2018-07-30",{"date":94,"type":20},"2032-07-31",{"name":73,"class":45},18,{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":105,"sex":16,"minAge":106,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":127},"100616770","gait-and-paraspinal-semg-in-degenerative-spinal-diseases-100616770","NCT07309926","Gait and Paraspinal sEMG in Degenerative Spinal Diseases","Comparative Analysis of Spatiotemporal Gait Parameters and Paraspinal Surface Electromyography Parameters in Degenerative Spinal Diseases: A Cross-Sectional Study Using Motion Capture and Electromyographic Ensemble Averaging","TDGKSEPDSD","Inclusion Criteria:\n\n1. Patients with the following single disease: degenerative scoliosis, coronal imbalance, lumbar spinal stenosis, lumbar disc herniation, spinal cord-type cervical spondylosis;\n2. Age ≥ 60 years, regardless of gender;\n3. Planned to undergo elective open spinal fusion surgery;\n4. Voluntarily participate in the study, understand and agree to the study content, and sign the informed consent form.\n\nExclusion Criteria:\n\n1. History of previous spinal surgery;\n2. Combined with other neuromuscular diseases (such as Parkinson's disease), inflammatory diseases (such as ankylosing spondylitis), infectious diseases (such as spinal tuberculosis), sepsis, tumors, or lower limb joint diseases that may cause low back and lower limb pain, affecting physical activity;\n3. Suffering from severe cardiovascular, cerebral, liver, or kidney disease;\n4. Suffering from mental illness, dementia, or unable to cooperate to complete clinical research.\n\n   * Skin rupture in the waist;",true,"60 Years",{"count":108,"type":20},120,"This cross-sectional observational study aims to quantitatively compare three-dimensional gait parameters, surface electromyography (EMG) patterns, and radiological parameters among patients with different degenerative spinal conditions-including lumbar disc herniation (LDH), lumbar spinal stenosis (LSS), lumbar sagittal imbalance (LSI), degenerative lumbar scoliosis (DLS), and cervical spondylotic myelopathy (CSM)-alongside a healthy control group. The analysis focuses on spatiotemporal gait characteristics (step length, stride length, cadence), lower limb kinematics and kinetics (hip\u002Fknee\u002Fankle joint angles, moments, and powers during stance and swing phases), and surface EMG amplitudes (thoracic erector spinae, multifidus, gluteus maximus, and rectus abdominis muscles) during standardized walking tasks. Additionally, radiological parameters (e.g., pelvic incidence-lumbar lordosis mismatch, C2-C7 sagittal vertical axis, coronal Cobb angle) will be correlated with gait and muscle activation deviations. The study employs motion capture systems, force plates, and high-density EMG to objectively differentiate disease-specific movement impairments. Findings from this study may establish biomechanical and neuromuscular signatures for each degenerative condition, providing a framework for personalized rehabilitation strategies, gait retraining, and surgical outcome assessment in spinal disorders. Comparative analysis with healthy controls will further elucidate pathological alterations in gait and muscle recruitment patterns caused by degenerative spinal diseases.",[60,111,112,27,113,114,115,116],"Degenerative Scoliosis","Sagittal Deformity","Coronal Vertical Axis","Lumbar Spinal Stenosis","Lumbar Disc Herniation","Cervical Spondylosis With Myelopathy","NOT_YET_RECRUITING","2025-12-15",{"date":120,"type":38},"2025-12-30",{"date":122,"type":20},"2025-12-10",{"date":124,"type":20},"2029-12-01",{"name":126,"class":45},"Xuanwu Hospital, Beijing",1,{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":21,"phases":138,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":127},"100552212","a-novel-classification-of-sagittal-spinal-alignment-to-aid-surgical-planning-for-adult-spinal-deformity-100552212","NCT06470152","A Novel Classification of Sagittal Spinal Alignment to Aid Surgical Planning for Adult Spinal Deformity","Pelvic Incidence-Dependent Clustering of Sagittal Spinal Alignment: A Novel Classification to Aid Surgical Planning for Adult Spinal Deformity","CSSAASD","Inclusion Criteria:\n\n1. ≥ 18 years of age at the time of treatment;\n2. Complete radiographic data, including standing posteroanterior and lateral whole-spine radiographs, lumbar computed tomography, and lumbar magnetic resonance imaging;\n3. Radiographic evidence of ASD: sagittal vertical axis ≥ 50 mm, pelvic tilt ≥ 25°, pelvic incidence-lumbar lordosis mismatch ≥ 10°, and\u002For thoracic kyphosis ≥ 60°.\n\nExclusion Criteria:\n\n1. Any type of previous spinal surgery;\n2. Other musculoskeletal problems impeding walking ability, syndromic or neuromuscular diseases such as Parkinson\\'s disease, inflammatory conditions such as ankylosing spondylitis, infectious conditions such as spinal tuberculosis, metabolic diseases such as severe osteoporosis, and\u002For serious general medical conditions such as sepsis or malignancy;\n3. Pathology of deformity as follows: post-traumatic deformity, adult idiopathic scoliosis of the thoracic spine, or de-novo lumbar scoliosis;\n4. Hip joint Kellgren-Lawrence grade ≥ II, history of hip joint and\u002For knee joint pain, and\u002For previous joint replacement.",{"count":137,"type":20},200,[23],"Surgical outcomes, including radiographic outcomes, patient-reported outcomes, postoperative complications, and revision surgery rates, were compared in patients with adult spinal deformity who underwent correction surgery with reference to our pelvic incidence-dependent (PI-dependent) clustering of sagittal spinal alignment and existing standards (sagittal age-adjusted score \\[SAAS\\], global alignment and proportion \\[GAP\\] score, and Roussouly classification). Our findings may provide tangible guidance for surgical decision-making in ASD.",[60,112,141,27],"Sagittal Alignment","2024-06-17",{"date":144,"type":38},"2024-06-24",{"date":146,"type":20},"2024-12-01",{"date":148,"type":20},"2027-12-01",{"name":126,"class":45}]