[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"scar-conditions-and-fibrosis-of-skin\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:scar-conditions-and-fibrosis-of-skin":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100643757","phase-1-scar-remodeling-after-burn-injury-using-allogeneic-adipose-derived-stromal-cells-100643757",false,"NCT07635875","Scar Remodeling After Burn Injury Using Allogeneic Adipose-derived Stromal Cells","ScarASC","Inclusion Criteria:\n\n* Adults ≥ 18 years of age\n* Males and females\n* Hypertrophic scars (age of scar \\> 2 years) after burn injuries on the front thorax or extremities.\n* Two uniform 6 cm x 6 cm areas of burn scar tissue on the front thorax or extremities. The scar should be large enough to separate the areas by a minimum of two centimeters.\n* Ability to understand information about the project.\n\nExclusion Criteria:\n\n* Significant comorbidities or lack of cognitive abilities to follow instructions.\n* Not being able to participate due to language or other personal issues.\n* Pregnancy or breastfeeding\n* Current or previous steroid therapy (systemic or local) within one year.\n* Scar revision surgery within one year in the affected areas.\n* Keloids.\n* Active cancer or previous cancer within two years (skin cancers do not apply)\n* Penicillin and Streptomycin allergy.",true,"ALL","18 Years",{"count":20,"type":21},39,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","The present project serves to test whether stem cell therapy offers a new treatment option for the scars of burn survivors. In Denmark, 12.000 people seek medical assistance every year for burn injuries leaving thousands of people with the devastating condition of hypertrophic scarring. Affected patients experience pain, itching, numbness, and reduced range of motion, which profoundly impact their quality of life. We hypothesize that adipose-derived stem cells can improve scar quality. To test this, we have conducted an integrated phase I + II trial (the ScarASC trials). ScarASC will be the first randomized controlled trial to use stem cells in burn patients. Two scar areas in each patient will be randomly injected with A) allogeneic adipose-derived stem cells and B) the control medium (placebo). We maintain a patient-centered scope, with our primary endpoint being a patient-reported outcome measure. However, we also obtain objective scar assessments using three-dimensional photographs, the scar elevation index, and gene\u002Fprotein expression regulation.",[28,29,30],"Scar Conditions and Fibrosis of Skin","Scar Quality Assessment and Safety","Scar Tissue",[32,33,34,35,36,37],"Mesenchymal stromal cell therapy","Cell therapy","Regenerative medicine","Scar tissue","Clinical trial","ATMP","RECRUITING","2026-06-03",{"date":41,"type":42},"2026-06-09","ACTUAL",{"date":44,"type":42},"2026-04-16",{"date":46,"type":21},"2028-05-31",{"name":48,"class":49},"Rigshospitalet, Denmark","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100610870","dermabrasion-for-free-flap-aesthetic-enhancement-100610870","NCT07233200","Dermabrasion for Free Flap Aesthetic Enhancement","Serial Dermabrasion for Aesthetic Enhancement of Free Flap Skin Paddles and Donor Sites: A Prospective Split-Flap\u002FScar Controlled Study","Inclusion Criteria:\n\n1. Adults aged 18 years or older.\n2. History of successful free flap reconstruction with a cutaneous skin paddle in the head and neck region.\n3. Patients with benign (eg. osteoradionecrosis, trauma) or malignant (eg. squamous cell carcinoma) diagnoses requiring free flap reconstruction.\n4. Benign free flap patients must be a minimum 3 months post-operative to ensure flap maturity. Malignant free flap patients must be a minimum of 3 months post-operative or post-radiation with no further cancer treatment (eg. radiation, surgery, chemotherapy) planned at that time.\n5. Flap skin paddle must be of sufficient size and external to allow for split-treatment design (minimum 4 cm in diameter). Donor site scar must also be sufficient size (minimum 6 cm in length)\n6. Patients must have ability to provide informed consent.\n7. Willingness and ability to comply with the treatment and follow-up schedule.\n\nExclusion Criteria:\n\n1. Inability to give informed consent.\n2. Evidence of active flap or radiation skin complications (e.g., infection, partial necrosis, wound breakdown).\n3. Completion of head and neck radiation therapy within 3 months of first dermabrasion treatment date.\n4. Uncontrolled diabetes mellitus (HbA1c \\> 8.0%).\n5. Current antibiotic use or known immunocompromised state.\n6. History of keloid formation or hypertrophic scarring.\n7. Fitzpatrick skin type VI or higher (due to increased risk of pigmentary changes).\n8. Use of isotretinoin medication within the past 3 month (known to induce photosensitivity).\n9. Current use of blood thinners that cannot be safely paused.\n10. Known photosensitivity disorders.\n11. Active malignancy requiring ongoing treatment.\n12. Inability or unwillingness to avoid sun exposure during the treatment period.\n13. Inability to perform or adhere to prescribed wound care.\n14. Inability or unwillingness to attend follow-up visits.",{"count":59,"type":21},40,[61],"NA","The purpose of this study is to evaluate the aesthetic benefit and safety of serial dermabrasion for free flap skin paddles and donor site scars in head and neck reconstruction.",[28],[65,66,67,68],"scar","head and neck reconstruction","dermabrasion","aesthetics","NOT_YET_RECRUITING","2025-11-14",{"date":72,"type":42},"2025-11-18",{"date":74,"type":21},"2026-07-01",{"date":76,"type":21},"2028-01",{"name":78,"class":49},"Milton S. Hershey Medical Center"]