[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"schizophrenia-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:schizophrenia-patients":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,41,73,96,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100607892","combined-exercise-and-pms-impact-on-biopsychosocial-function-in-older-adults-with-schizophrenia-100607892",false,"NCT07194460","Combined Exercise and PMS: Impact on Biopsychosocial Function in Older Adults With Schizophrenia","Effects of Combined Exercise and Peripheral Magnetic Stimulation on Biopsychosocial Functional Impairments in Older Adults With Schizophrenia","PMS","\\# Eligibility Criteria\n\n* Inclusion Criteria:\n\n  * Participants must be aged ≥60 years.\n  * Diagnosis of schizophrenia based on the International Classification of Diseases - 10th Edition (ICD-10) or Diagnostic and Statistical Manual of Mental Disorders - 5th Edition (DSM-5).\n  * Diagnosis must be made for ≥6 months, with clinical manifestations of schizophrenia (e.g., hallucinations, delusions, thought disorder, etc.).\n  * No history of severe acute psychiatric episodes or hospitalizations within the last 3 months prior to enrollment.\n  * Symptoms must be controllable, with no reliance on acute psychiatric intervention.\n  * Participants must be able to understand the study's purpose and procedures and provide written informed consent. If the participant is unable to provide full informed consent (e.g., due to severe cognitive impairment), informed consent must be obtained from a legal guardian.\n* Exclusion Criteria:\n\n  * Schizoaffective disorder or bipolar disorder with psychosis.\n  * Elderly individuals with multiple chronic diseases but who still maintain good functional status and quality of life.\n  * Presence of severe cardiovascular diseases, liver or kidney dysfunction, cerebrovascular diseases, or other physical conditions that may affect treatment.\n  * Patients with contraindications to peripheral magnetic stimulation (PMS) treatment or EEG.","ALL","60 Years","80 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","This project consists of two randomized parallel - group experiments targeting older adults with schizophrenia, aiming to evaluate the therapeutic effect of Peripheral Magnetic Stimulation (PMS).\n\nExperiment 1 (Efficacy of PMS): During a 4 - week intervention period, participants are randomly assigned to receive active PMS or sham PMS. The primary objective is to determine whether PMS can reduce the clinical symptom burden and improve biopsychosocial functioning compared with sham stimulation through electroencephalogram (EEG) signal acquisition and evaluation. Secondary objectives include the effects on cognition, mood, sleep, and health - related quality of life, as well as safety and tolerability (adverse events monitoring).\n\nExperiment 2 (Comparison of Intervention Effects): The subjects are randomly divided into three groups: exercise combined with PMS group, PMS alone group, and exercise alone group. Each group is arranged by relevant professionals to carry out the corresponding intervention for 4 weeks. The main purpose is to examine the differences in the effects of the three intervention methods (exercise combined with PMS, PMS alone, and exercise alone) in improving patients' conditions, including the impact on exercise - related physical performance, functional mobility, etc. Secondary objectives include the impact on overall function and quality of life, along with safety monitoring.\n\nIn both experiments, outcome indicators are measured from baseline to post - intervention (and, where feasible, short - term follow - up) by assessors who are blinded to group allocation using appropriate tools. It is hypothesized that in Experiment 1, PMS will be superior to sham stimulation; in Experiment 2, the effect of exercise combined with PMS in improving patients' motor and related functions will be better than that of PMS alone or exercise alone, which supports PMS as a scalable auxiliary means for the rehabilitation of this population.",[28],"Schizophrenia Patients","NOT_YET_RECRUITING","2025-09-18",{"date":32,"type":33},"2025-09-26","ACTUAL",{"date":35,"type":22},"2025-09-28",{"date":37,"type":22},"2025-12-05",{"name":39,"class":40},"Yuntong Zhang","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100573013","intermittent-theta-burst-stimulation-to-improve-negative-symptoms-and-cognition-in-schizophrenia-100573013","NCT06740747","Intermittent Theta-Burst Stimulation to Improve Negative Symptoms and Cognition in Schizophrenia","Intermittierende Theta-Burst-Stimulation Zur Verbesserung Von Negativsymptomatik Und Kognition Bei Schizophrenie","ITBS-NKS-2024","Inclusion Criteria:\n\n* Diagnosis of schizophrenia (ICD-10: F20.-)\n* Age: 18-65 years\n* Ability to give informed consent\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Any electronic implants\n* Non-MRI-compatible metal implants (e.g., pacemaker, cochlear implant, insulin pump, metal fragment injuries, work in the metal-processing industry)\n* Non-TMS-compatible metal implants (compatible items include: earrings, piercings, dental fillings, crowns, implants)\n* Claustrophobia\n* Epilepsy\n* History of traumatic brain injury within the last 3 months\n* History of stroke\n* Active central nervous system (CNS) infection\n* History of CNS infection within the last 3 months\n* Pregnancy\n* Current drug, medication, or alcohol abuse\n* Simultaneous participation in another clinical trial\n* Planned changes in psychopharmacological medication within the next 2 weeks\n* Severe physical illnesses that could endanger the patient, affect the examinations or make the MRI scanning cause additional burden","18 Years","65 Years",{"count":52,"type":22},60,[25],"The planned randomized, sham-controlled, double-blind, monocentric study aims to evaluate the effectiveness of intermittent Theta-Burst Stimulation (iTBS) on negative symptoms and cognitive deficits in schizophrenia. Both the cerebellar vermis and the left dorsolateral prefrontal cortex will be stimulated successively within the same session.\n\nThe goal of this trial is to learn if intermittent theta-burst stimulation (iTBS) of the cerebellum and the left dorsolateral prefrontal cortext (DLPFC) can treat negative symptoms and improve cognition in patients with schizophrenia. The main question it aims to answer is:\n\nDoes iTBS of the cerebellum and the left DLPFC improve negative symptoms in patients with schizophrenia? Researchers will compare iTBS to sham stimulation to see if iTBS improves negative symptoms.\n\nParticipants will:\n\n* Receive 10 sessions of iTBS over the course of 2 weeks\n* Undergo extensive examination before iTBS treatment, immediately after iTBS treatment and 4 weeks after iTBS treatment. The examination includes assessment of negative symptoms; psychometric assessment of cognition, social cognition, depressive symptoms; functional magnetic resonance imaging; assessment of eye movements; blood and saliva sampling; assessment of adverse events and stimulation associated sensations.\n\nThe study thus seeks to determine whether iTBS of the fronto-cerebellar network might improve negative symptoms and cognition by altering the network's functional activity. Additionally, it will investigate whether a pro-inflammatory cytokine profile could affect iTBS outcomes and whether inflammatory markers could be affected by iTBS.",[28],[57,58,59,60,61],"iTBS","intermittent theta-burst stimulation","negative symptoms","cognition","schizophrenia","RECRUITING","2025-07-16",{"date":65,"type":33},"2025-07-20",{"date":67,"type":33},"2025-04-08",{"date":69,"type":22},"2026-12-31",{"name":71,"class":40},"Hannover Medical School",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":17,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":72},"100590738","act-based-psychoeducation-for-schizophrenia-caregivers-100590738","NCT06971328","ACT-Based Psychoeducation for Schizophrenia Caregivers","Effects of Acceptance and Commitment-Based (ACT) Psychoeducation on Caregiver Burden, Posttraumatic Growth and Psychological Resilience in Caregivers of Patients With Schizophrenia","Inclusion Criteria:\n\n* Providing primary care to an individual diagnosed with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders (DSM) V\n* Living with the patient and providing care for at least 6 months\n* Being over 18 years of age\n* Being literate\n* Not having been diagnosed with any mental illness\n* Agreeing to participate in the study and being a volunteer\n\nExclusion Criteria:\n\n* The patient must live in a different house and spend less than 6 hours together per day\n* Having previously attended ACT or Psychoeducation programs",true,"18 Months",{"count":83,"type":22},34,[25],"Schizophrenia is an important mental health problem that requires caregivers because it causes disability. With the efforts to move from a hospital-based model to a community-based model in mental health services, the care of schizophrenia patients is mainly provided by their families at home, creating a significant care burden on caregivers or, on the contrary, post-traumatic development is reported. Psychiatric nurses are responsible for evaluating the patient together with their family by taking these conditions into consideration when providing care to individuals with mental illness. As a principle of humanistic and holistic care, nursing interventions to be implemented by psychiatric nurses to develop caregivers' coping methods, reduce their care burden and contribute to their post-traumatic development are extremely important in terms of the effectiveness and efficiency of care. Acceptance and Commitment (ACT)-based psychoeducation, whose effectiveness has been reported in the literature, is an important application in providing care to patients and families in psychiatric nursing practices. ACT is among the third generation therapies that aim to keep individuals in the moment with awareness, adopt the willingness to accept events instead of struggling with them, and create an important source of power in taking actions in line with life values. In this study, 17 out of 34 individuals determined by statistical methods among the caregivers of schizophrenia patients will be included in the control group and monitored, while 17 will receive 8 sessions of ACT-based psychoeducation in the intervention group, and the effects of the education on caregiver burden, post-traumatic development, and psychological resilience will be evaluated. There are very few studies in the literature where ACT-based psychoeducation is applied to caregivers of schizophrenia patients. Although studies examining the effects on individuals' caregiver burden and psychological resilience are limited, no study has been found examining its effects on post-traumatic development, and this constitutes the original value of the study. As a result of this study, it is expected that ACT-based education will reduce the caregiver burden in schizophrenia caregivers and increase their psychological resilience through post-traumatic development.",[28],"2025-05-11",{"date":89,"type":33},"2025-05-14",{"date":91,"type":22},"2025-07-07",{"date":93,"type":22},"2027-06-01",{"name":95,"class":40},"Ataturk University",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":104,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":23,"phases":106,"briefSummary":107,"conditions":108,"keywords":113,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":4},"100583138","the-effect-of-psychosocial-skills-focused-group-psychoeducation-in-schizophrenia-patients-100583138","NCT06872424","The Effect of Psychosocial Skills Focused Group Psychoeducation in Schizophrenia Patients","The Effect of Psychosocial Skills Focused Group Psychoeducation on Functional Improvement, Treatment Compliance and Mental Well-Being in Schizophrenia Patients: a Randomised Controlled Study","Schizophrenia","Inclusion Criteria:\n\n1. Having a diagnosis of schizophrenia according to DSM-5 diagnostic criteria\n2. To have continuity in the Community Mental Health Center\n3. Being in remission (period without psychotic exacerbation) as a result of the evaluation of the outpatient clinic doctor,\n4. To be mentally capable of understanding the questions posed\n5. To have the cognitive competence to understand the training provided\n6. Not having any visual or auditory disability\n7. Graduating from at least primary school\n\nExclusion Criteria:\n\n1. Refusing to participate in the study\n2. Being under 18 years of age\n3. Being illiterate in Turkish\n4. Having Mental Retardation","18 Weeks",{"count":83,"type":22},[25],"The aim of this study was to evaluate the effect of psychosocial skills-oriented group psychoeducation on functional recovery, treatment adherence and mental well-being in patients with schizophrenia. This research will be conducted in Giresun Community Mental Health Center. The study was planned as a randomized controlled pretest-posttest design. In addition to the Sociodemographic Information Form prepared by the researchers, the Functional Recovery Scale in Schizophrenia, the Modified Morisky Treatment Adherence Scale and the Warwick-Edinburgh Mental Well-Being Scale will be used to collect the data. The sample size was calculated as 34 people (experimental group= 17, control group= 17). Forms and scales will be applied to the experimental and control groups before psychoeducation and scales will be applied again to both groups after psychoeducation.",[28,109,110,111,112],"Psychoeducation","Functional Status","Treatment Outcome","Mental Development",[102,109,114,115,116],"Functional recovery","Treatment adherence","Mental well-being","2025-03-10",{"date":119,"type":33},"2025-03-12",{"date":121,"type":22},"2025-04-15",{"date":123,"type":22},"2025-08-15",{"name":125,"class":40},"Gazi University",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":80,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":134,"targetDuration":136,"studyType":137,"phases":4,"briefSummary":138,"conditions":139,"keywords":142,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":72},"100569548","effects-of-lurasidone-on-left-ventricle-systolic-functions-100569548","NCT06695676","Effects of Lurasidone on Left Ventricle Systolic Functions","Evaluation of Left Ventricle Systolic Functions of Patients On Lurasidone","Lurasidone","Inclusion Criteria:\n\n* Aged 18 to 65 years\n* Diagnosed with schizophrenia or bipolar disorder by the psychiatry clinic of our center and indicated to use lurasidone molecule\n* Hasn't been diagnosed with coronary artery disease, any kind of heart failure or severe valvular disease\n\nExclusion Criteria:\n\n* Patients who do not agree to participate to the trial\n* Patient who do not meet the inclusion criteria",{"count":135,"type":22},62,"6 Months","OBSERVATIONAL","The goal of our study to learn if lurasidone molecule which is used on patients with schizophrenia or bipolar disorder has any cardiotoxic effect.",[140,28,141],"Lurasidone Cardiotoxicity","Bipolar Disorders",[143,144,132,145],"Global Longitudinal Strain","Cardiotoxicity","antipsychotic drugs","2024-11-17",{"date":148,"type":33},"2024-11-19",{"date":150,"type":22},"2024-11",{"date":152,"type":22},"2025-06-01",{"name":154,"class":40},"Aydin Adnan Menderes University"]