[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"schizophrenia-prodromal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:schizophrenia-prodromal":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,77,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100465409","patientheque-in-patients-with-a-psychosis-100465409",false,"NCT05340348","Patientheque in Patients With a Psychosis","Formation of a Patientheque in Patients With a Beginner Psychosis","LONGIPEP","Inclusion Criteria:\n\n* Major and or minor aged 15 to 30 assessed within the CEVUP (Consultation for the Assessment of Psychological Vulnerability) and cared for at the psychiatry center as part of a first psychotic episode (Diagnosis CIM 10: F20 -F29 first hospitalization). These patients are referred by care and medico-social partners (general practitioners, school doctors, school nurses, educators, addictologists, psychiatrists\n* \"At risk\" status for psychotic disorder (GRD, APS, BLIPS group) or psychosis threshold during the CAARMS test (psychometric scale for the assessment of psychotic symptoms)\n* Consent of the patient or his legal guardian\n\nExclusion Criteria:\n\n* History of psychosis for more than one year\n* \"Not at risk\" status for psychotic disorder on the CAARMS (psychometric scale for the assessment of psychotic symptomatology)\n* IQ\\\u003C70 (WAIS)\n* Neurological disorder or other health problem that may explain the disorders\n* Refusal to participate - History of psychosis for more than one year","ALL","15 Years","30 Years",{"count":21,"type":22},250,"ESTIMATED","INTERVENTIONAL",[25],"NA","Establishment of a patient library for patients who have had a first psychotic episode and who have an \"at risk\" status for psychotic disorder (GRD, APS, BLIPS group) or a psychosis threshold during CAARMS administration. Samples are taken on inclusion, at 2 years, and if relapse or significant clinical event within 5 years of inclusion, on 250 patients for 10 years.",[28,29,30],"Schizophrenia Prodromal","Schizophrenia, Childhood","Schizophrenia",[30,32],"Patient library","RECRUITING","2026-06-24",{"date":36,"type":37},"2026-06-26","ACTUAL",{"date":39,"type":37},"2022-07-25",{"date":41,"type":22},"2032-07-25",{"name":43,"class":44},"University Hospital, Brest","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":45},"100605036","online-intervention-to-improve-motivation-100605036","NCT07157293","Online Intervention To Improve Motivation","An Online Intervention To Enhance Motivation and Goal-Directed Behavior","Online Mot","Inclusion Criteria:\n\n* Diagnosis of schizophrenia or a related psychotic disorder\n* Meeting criteria for being at clinical high risk for psychosis\n\nExclusion Criteria:\n\n* Does not have access to a computer each week","18 Years","65 Years",{"count":57,"type":22},60,[25],"Participants will complete one online intervention lasting 12 weeks. Each week, they will be asked to complete a 20-30 minute session online. The intervention is targeting improved mood and positive affect in order to support increases in motivation and goal-directed behavior. Before and after the intervention, participants will be asked to complete measures to assess symptoms, mood, and behavior.",[28,61,62],"SCHIZOPHRENIA 1 (Disorder)","Psychosis",[64,65,66,67],"negative symptoms","schizophrenia","psychosis","digital health","NOT_YET_RECRUITING","2026-06-23",{"date":34,"type":37},{"date":72,"type":22},"2026-08",{"date":74,"type":22},"2028-08",{"name":76,"class":44},"University of Alabama at Birmingham",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},"100326055","semantic-and-syntactic-computerized-analysis-of-free-speech-100326055","NCT03525054","Semantic and Syntactic Computerized Analysis of Free Speech","ASESID","Inclusion Criteria:\n\n* Major and\u002For minor from 15 to 30 years old\n* Who alleged a suicidal gesture or idea or behavior that has repercussions in their emotional, social or professional life\n* If patients receive neuroleptic treatment that impairs cognitive abilities, a one-week wash-out period will be scheduled prior to assessment.\n* Affiliated with or beneficiary of a health insurance\u002Fsocial security system\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* History of psychosis\n* Risk of self-harm or violence not compatible with outpatient treatment\n* QI\\\u003C70 (WAIS)\n* Neurological disorder or major health problem\n* Impossibility to interrupt neuroleptic treatment for one week\n* Refusal to participate",{"count":85,"type":22},215,"OBSERVATIONAL","Subtle speech disorganization could be predictive of a transition to schizophrenia of ultra-high-risk patients. The aim of our longitudinal multicenter cohort study is to identify specific linguistic markers of the psychotic transition to validate a french predictive model of this transition using computerized speech analysis techniques",[89,62,90,28,91],"Psychotic Disorders","Schizophrenia and Related Disorders","Diagnosis, Psychiatric",[89,91,28,93,94,95,96,97,98],"Ultra High Risk","Prediction Of Psychosis","Machine Learning","Automated Language Analysis","Semantic Coherence","Syntaxic Complexity","2026-05-29",{"date":101,"type":37},"2026-06-02",{"date":103,"type":37},"2018-05-18",{"date":105,"type":22},"2030-05-02",{"name":43,"class":44},3,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":115,"sex":17,"minAge":54,"maxAge":19,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":5},"100627279","perception-and-integration-of-sensory-information-in-the-early-stages-of-psychosis-100627279","NCT07446569","Perception and Integration of Sensory Information in the Early Stages of Psychosis","PRIOR-ePSY","Inclusion criteria:\n\nAll groups:\n\n* Age between 18 and 30 years\n* Normal or corrected-to-normal visual acuity\n* Affiliated with or dependent on a social security health insurance plan\n* Provided informed consent and co-signed the study consent form with the investigator\n* Proficient in French\n\nControl group (TEM) specific criteria:\n\n* No current psychiatric disorder (DSM-IV Axis I), except anxiety disorders\n* No lifetime history of (hypo)manic episodes or psychotic disorders\n* No first-degree family history of schizophrenia spectrum disorders\n* No regular use (more than one month continuously) in the past 6 months of the following medications: benzodiazepines, hypnotics, antidepressants, antipsychotics, mood stabilizers, or psychostimulants\n\nClinical High-Risk (CHR) group specific criteria:\n\n-Meet CHR criteria according to CAARMS: Attenuated positive symptoms (APS) below clinical threshold in intensity or frequency OR Brief Limited Intermittent Psychotic Symptoms (SPLI) OR Genetic Risk\n\nFirst-Episode Psychosis (PEP) group specific criteria:\n\n-Meet PEP criteria according to CAARMS (psychosis threshold reached)\n\nExclusion criteria:\n\n* Pregnant, postpartum, or breastfeeding women\n* Individuals deprived of liberty by judicial or administrative decision\n* Individuals in a life-threatening emergency\n* Adults under legal protection measures\n* Adults unable to provide consent and not under legal protection\n* Impairment that makes participation in the study or understanding of information difficult or impossible\n* Alcohol dependence (AUDIT score ≥12 for men, ≥11 for women)\n* Current substance use disorder (DAST score \\>6)\n* Cannabis use disorder (CUDIT-R score ≥13)\n* History of neurological disorders, including progressive neurological disease\n* Progressive retinal disease\n* Chronic glaucoma\n* Ophthalmologic conditions affecting visual acuity\n* Current eye infection\n* Hearing disorders affecting auditory acuity\n\nCriteria incompatible with the electroretinographic device:\n\n* Presence of photosensitive epilepsy\n* Allergy to components of the electrode gel\n* Behavioral problems causing extreme agitation or aggression\n* Eye or surrounding tissue lesions that may come into contact with the device",true,{"count":117,"type":22},294,[25],"The goal of this observational study is to investigate the early sensory system in clinical high risk (CHR), first episode psychosis (FEP) individuals and heathly controls. The main questions it aims to answer are:\n\n* Can anomalies in visual and auditory sensory processing serve as early markers of psychosis risk?\n* How are these sensory anomalies related to clinical symptom severity and emotional recognition deficits?\n\nResearchers will compare CHR and PEP participants to healthy controls to see if sensory processing differences can help identify individuals at higher risk of developing psychosis.\n\nParticipants will:\n\n* Complete behavioral tasks evaluating visual processing (contrast sensitivity, contour integration, facial emotion recognition, visual inference using Necker cubes) and auditory processing (tone-matching, auditory emotion recognition). A temporal perception component will also be assessed within the auditory and emotion recognition tasks, rather than as a separate task.\n* Undergo electrophysiological assessments of retinal function using flash stimulation to record retinal potentials (a-wave, b-wave, phNR, oscillatory potentials).\n* Provide demographic, clinical, and neuropsychological data during study visits.\n* For CHR participants, attend follow-up visits up to 6 months post initial assessments to evaluate psychotic symptom progression.",[121,28],"Early Psychosis","2026-02-26",{"date":124,"type":37},"2026-03-03",{"date":126,"type":22},"2026-04",{"date":128,"type":22},"2028-11",{"name":130,"class":44},"Centre Psychothérapique de Nancy"]