[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sciatica-acute\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sciatica-acute":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100623475","comparing-ultrasound-guided-transgluteal-nerve-block-to-standard-care-100623475",false,"NCT07397117","Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care","Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care for Emergency Department Patients With Low Back Pain and Sciatic Radiculopathy: A Randomized Controlled Trial","TGSNB vs SoC","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Presentation to ED with:\n* Acute or acute-on-chronic pain consistent with sciatica, defined as unilateral lumbosacral radicular pain radiating from the lower back or gluteal region to the posterior leg, may extend distal to the knee.\n* Pain score ≥ 5\u002F10 on Numeric Rating Scale (NRS)\n\nExclusion Criteria:\n\n* Known allergy to study medications (e.g., local anesthetics)\n* Coagulopathy or current anticoagulation therapy\n* Suspected or confirmed spinal infection, or tumor\n* Neurological deficits (bowel or bladder dysfunction, leg weakness)\n* Inability to provide informed consent","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare transgluteal sciatic nerve block to standard of care to treat sciatic back pain in adult patients who present to the emergency department.\n\nThe main question it aims to answer is: Is a transgluteal sciatic nerve block better than standard of care in improving pain in ER patients with sciatic back pain?\n\nIf there is a comparison group: Researchers will compare patients who receive transgluteal sciatic nerve blocks to patients who receive standard of care to see if pain scores improve in ER patients with sciatic back pain.\n\nParticipants will be randomized into the transgluteal sciatic nerve block group or the control group (standard of care). Participants will be asked to answer questions about their pain and will be asked to walk a timed short distance.",[27],"Sciatica Acute",[29,30,31,32],"sciatica","sciatic back pain","lumbar radiculopathy","sciatic radiculopathy","RECRUITING","2026-05-29",{"date":36,"type":37},"2026-06-02","ACTUAL",{"date":39,"type":37},"2026-05-26",{"date":41,"type":21},"2027-01-31",{"name":43,"class":44},"University of California, San Francisco","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":72},"100528162","phase-4-efficacy-of-m640-in-acute-lumbosacral-musculoskeletal-conditions-100528162","NCT06157177","Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.","Efficacy of Modified Release Metaxalone 640 mg in Acute Lumbosacral Musculoskeletal Conditions With Spinal Stenosis and Sciatica","Inclusion Criteria:\n\n* No clinically significant conditions impacting quality or quantity of pain\n* Baseline Numeric Pain Scale ≥ 6\n* Capable of answering text or email survey reminders\n* Low back pain with or without sciatica\n\nExclusion Criteria:\n\n* Current use of other skeletal relaxants\n* Current use of other pain relievers\n* Current use of cimetidine or monoamine oxidase inhibitors",true,"80 Years",{"count":56,"type":21},50,[58],"PHASE4","The goal of this clinical trial is to learn if a modification to metaxalone 640 mg can reduce low back and leg pain. The participants will be 18 to 80 years old, healthy with newly occurring back or leg pain. The main question aims to compare a group taking active treatment and a group taking a look-alike substance containing no active treatment. All participants will answer questions on Day 1, before treatment, and on 7-day after treatment, about:\n\n* Amount and quality of pain\n* Interference with physical activity\n* Interference with sleep",[27,61],"Lumbar Spinal Stenosis","2026-05-08",{"date":64,"type":37},"2026-05-12",{"date":66,"type":37},"2023-11-15",{"date":68,"type":21},"2026-11-15",{"name":70,"class":71},"Primus Pharmaceuticals","INDUSTRY",24,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":53,"sex":17,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":45},"100605346","snag-and-snme-in-non-specific-sciatic-pain-100605346","NCT07161323","SNAG and SNME in Non-Specific Sciatic Pain","Comparison of the Acute Effects of Sustained Natural Apophyseal Glide and Sciatic Nerve Mobilization Exercises in Non-Specific Sciatic Nerve Pain","CASE-SNAG","Inclusion Criteria:\n\n* Adults between the ages of 20 and 50,\n* Individuals describing non-specific sciatic pain characterized by unilateral low back pain accompanied by radiating symptoms to the leg,\n* Duration of pain longer than 12 weeks,\n* Presence of pain during the Slump Test and Straight Leg Raise Test,\n* No history of any physical therapy or intervention in the past month.\n\n  b: Exclusion Criteria:\n* Individuals diagnosed with herniated disc or spinal stenosis by a physician,\n* Physician-diagnosed secondary neurological conditions,\n* History of spinal surgery,\n* Individuals describing the origin of their pain as the lower back (without leg involvement),\n* Presence of neurological symptoms (e.g., foot drop, significant muscle weakness),\n* Serious medical conditions that may affect treatment or outcomes (e.g., cancer, infections, or inflammatory diseases),\n* Pregnancy or recent childbirth (within the past year),\n* Use of medications that may affect pain perception or mobility (e.g., opioids),\n* Inability to comply with the weekly treatment schedule.","20 Years","50 Years",{"count":84,"type":21},30,[24],"This study is designed as a crossover trial. All participants who meet the inclusion criteria and voluntarily agree to participate will be evaluated using the assessment methods detailed below. Subsequently, participants will be randomly assigned into two groups. The first group (Mulligan Concept Group - MCG) will receive the SNAG technique, while the second group (Neural Mobilization Group - NMG) will perform the Sciatic Nerve Mobilization Exercise (SNME). After the intervention, participants will be evaluated a second time. Ten days after this session, participants will be invited back. Those who were in the MCG group during the first session will be re-evaluated and then receive the SNGE intervention. Participants who were in the SNGE group during the first session will be re-evaluated and then receive the SNAG intervention. Following this second intervention, participants will be evaluated once again.\n\nAssessments will be done are Demographic Form, Visual Analogue Scale, Oswestry Disability Index, Joint Range of Motion, Five-times Sit-to-stand Test, Sit and Reach Test",[88,27,89],"Sciatica Pain","Mulligan Mobilization",[91,92,93,94,95],"Sciatic Nerve Pain","Mulligan Concept","Manual Therapy","Pain Management","Non-Specific Sciatica","2025-09-01",{"date":98,"type":37},"2025-09-08",{"date":100,"type":37},"2025-07-01",{"date":102,"type":21},"2026-07-01",{"name":104,"class":44},"Istinye University"]