[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sciatica\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sciatica":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,49,72,106,138,158,172,195,230,252,288,316,351,373,399,425],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100641879","comparing-two-soft-tissues-technique-on-piriformis-syndrome-patients-100641879",false,"NCT07661485","Comparing Two Soft Tissues Technique on Piriformis Syndrome Patients","Effect of Myofascial Release as Compared to Post Isometric Relaxation in Improving Pain and Lower Extremity Function in Piriformis Syndrome","MPR-PIR","Inclusion Criteria:\n\n* Positive Lasegue sign\n* Positive FAIR test\n* Grade 1-3 tenderness on palpation of piriformis between sacrum and greater trochanter of femur\n* 4 or more pain intensity on the VAS scale\n\nExclusion Criteria:\n\n* Lower extremity injuries including ligament, tendon injuries, muscle strains as well as nerve injuries\n\n  * Systemic diseases including tuberculosis, multiple sclerosis, Parkinson's disease as well as chronic inflammatory conditions\n  * Congenital deformities including hip dysplasia, limb length discrepancy, scoliosis and congenital pelvic asymmetry\n  * Cognitive issues including dementia, severe depression and severe psychotic disorders\n  * Lumbar Radiculopathy\n  * SIJ Dysfunction\n  * Lower Extremity Fractures\n  * Pregnancy\n  * Malignancy","ALL","20 Years","50 Years",{"count":21,"type":22},26,"ESTIMATED","INTERVENTIONAL",[25],"NA","Piriformis Syndrome is a neuromuscular condition with symptoms of pain, numbness and tingling tracing the route of the sciatic nerve, due to the nerve impingement by the piriformis muscle. Two common manual therapy techniques used to treat musculoskeletal conditions are myofascial release and post-isometric relaxation. The intent of the research is to evaluate the effects of myofascial release (MFR) as compared to post-isometric relaxation (PIR) in improving pain and lower extremity function in piriformis syndrome (LEFS). The study population involved 32 individuals aged between 20 to 50 years who will be randomly assigned to two groups; a group that received MFR and a group that received PIR. Both groups received the baseline treatment for four weeks. The Visual Analog Scale (VAS) will be employed to gauge the amount of pain, while the LEFS was used to measure functional mobility",[28,29,30],"Piriformis Syndrome","Musculoskeletal Abnormalities","Sciatica",[32,33,34,35,36],"myofasical release","Post isometric relaxation","physiotherapy","Radiculopathy","Piriformis syndrome","NOT_YET_RECRUITING","2026-06-25",{"date":40,"type":41},"2026-06-30","ACTUAL",{"date":40,"type":22},{"date":44,"type":22},"2026-09-30",{"name":46,"class":47},"University of Faisalabad","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":48},"100643522","comparing-the-effectiveness-of-tensioner-vs-slider-neurodynamic-techniques-in-patients-with-sciatica-100643522","NCT07632612","Comparing the Effectiveness of Tensioner Vs Slider Neurodynamic Techniques in Patients With Sciatica","Comparing the Effectiveness of Tensioner Vs Slider Neurodynamic Techniques in Patients With Sciatica: A Randomised Control Trial","Inclusion Criteria:\n\n* Patients with radicular pain persisting for 12 weeks to 1 year, with no acute episode in the last 4 weeks\n* Unilateral symptoms radiating below the buttock to thigh, knee, or lower leg\n* Positive Slump Test\n* Positive Straight Leg Raise (SLR) test above 45°\n* Functional limitation during activities such as walking or lifting\n\nExclusion Criteria:\n\n* BMI \\\u003C 20 kg\u002Fm² or \\> 30 kg\u002Fm²\n* Previous history of spinal surgery\n* Presence of red flags (significant motor\u002Fsensory loss, altered reflexes, or bowel\u002Fbladder dysfunction)\n* Peripheral neuropathy\n* History of vertebral fracture or significant spinal\u002Flimb trauma\n* Systemic diseases (e.g., diabetes mellitus, cardiovascular, or renal disease)\n* Progressive neurological deficits (motor weakness, sensory loss, reflex changes)\n* Pregnancy",{"count":57,"type":22},80,[25],"objective of this randomized controlled trial is to examine the efficacy of both tensioner and slider neurodynamic approaches in patients suffering from sciatica. This study seeks to establish which approach is more efficacious in alleviating pain intensity, disability functional, and mobility. The results of this study will assist physical therapists in making an informed decision on the type of neurodynamic therapy for their patients.",[30,61],"Sciatica Pain","RECRUITING","2026-06-02",{"date":65,"type":41},"2026-06-08",{"date":67,"type":22},"2026-06-03",{"date":69,"type":22},"2026-09-10",{"name":71,"class":47},"Ibadat International University, Islamabad",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":17,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":85,"conditions":86,"keywords":93,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":48},"100437952","early-phase-1-brain-mechanisms-supporting-cannabis-induced-pain-relief-100437952","NCT04982965","Brain Mechanisms Supporting Cannabis-induced Pain Relief","Inclusion Criteria:\n\n* Between 21-65 years old\n* Currently 30 days cannabis free\n* Lower back pain for three months or more\n* Are not taking opioids\n* If female and of a child bearing potential age, are not pregnant or nursing mothers\n* Do not have mental or neurological conditions inhibiting sensory\u002Fmotor functions\n* Do not have a lifetime history of dependence on cannabis\n* Do not have a lifetime history of DSM-IV schizophrenia, bipolar disorder, panic disorder, or psychosis\n* Prior THC-containing cannabis experience within the past two years\n* Agrees not to use cannabis outside of the study during participation in the study\n* Agrees not to use opioids or barbiturates during participation in the study\n* Agrees not to drive a motor vehicle within 4 hours following last use of inhaled cannabis during participation in the study\n\nExclusion Criteria:\n\n* Active pulmonary disease\n* Allergy or past adverse effects or negative past experiences from cannabis\n* Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone\n* Any significant illness, including cardiovascular disease, diabetes, renal and liver disease.\n* Any current or history of an immunocompromising disease or condition (such as lupus, psoriasis, multiple sclerosis, etc.)\n* Any current or history of neurologic conditions, including Parkinson disease, dementia, cognitive impairment, history of seizure disorder, and history of traumatic brain injury\u002Fhead injury\n* Any current major psychiatric illness, such as bipolar disorder, major depression, psychosis, substance use disorder, or schizophrenia\n* Any current or history of suicidal ideation or attempt\n* Overt sensitivity to thermal stimulation\n* Resting blood pressure \\> 140\u002F90\n* Resting heart rate \\> 100 beats\u002Fminute\n* Prisoner\n* Institutionalized\n* Claustrophobia\n* MRI contraindications\n* Participation in any new (within 2 weeks prior or any time after enrollment) pain management procedures during the study period\n* Known history of vasovagal fainting, syncope, or severe adverse reactions associated with blood draws or needle procedures",true,"21 Years","65 Years",{"count":82,"type":22},100,[84],"EARLY_PHASE1","Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments. Cannabis may help reduce pain, but researchers do not fully understand how it affects the brain in people with chronic pain. The purpose of this study is to examine how inhaled cannabis changes brain activity and reduces pain in people with chronic low back pain. Results from this study may help researchers better understand how cannabis works for pain and support the development of improved pain treatments.",[30,87,88,89,90,91,92],"Lumbar Radiculopathy","Lower Back Pain","Degenerative Disc Disease","Chronic Low-back Pain (cLBP)","Chronic Low Back and Leg Pain","Back Pain",[94,95,96,97],"Cannabis","Vaporized cannabis","THC","chronic low back pain","2026-05-30",{"date":67,"type":41},{"date":101,"type":41},"2021-05-07",{"date":103,"type":22},"2027-03-15",{"name":105,"class":47},"University of California, San Diego",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":48},"100625154","findisc-pain-finnish-discectomy-trial-on-the-benefits-and-harms-of-surgery-in-patients-with-lumbar-disc-herniation-100625154","NCT07418944","FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc Herniation","FINDISC-Pain, Finnish Discectomy Trial - a Randomised, Placebo-surgery Controlled Trial. An Efficacy Trial Designed to Prove That Discectomy Can Work.","FINDISC-Pain","Inclusion Criteria:\n\n* Age 18-60 years\n* Diagnosed unilateral lower extremity radiculopathy (sciatica) secondary to lumbar disc herniation (LDH)\n* Single LDH at the level of L3\u002F4, L4\u002F5 or L5\u002FS1 on magnetic resonance imaging\n* Symptom duration minimum 6 weeks\n* NRS worst leg pain 5 or higher\n* Patient has not responded to at least one form of non-operative care\n* Patient willing to undergo surgery\n* Patient willing and able to give consent and comply with study procedures\n* Sufficient proficiency in the language of the study site to provide informed consent and comply with study procedures\n\nExclusion Criteria:\n\n* Doubtful nerve root compression\n* Spinal stenosis or any other confounding spinal condition\n* Far lateral disc herniation\n* Serious neurological deficit\n* Previous spinal surgery\n* Any contraindication to MRI\n* BMI \\> 35 or lumbar subcutaneous fat \\> 50 mm as determined from the MRI\n* ASA classification \\> 2\n* Being pregnant","18 Years","60 Years",{"count":117,"type":22},122,[25],"The FINDISC trial studies whether common back operation, microdiscectomy, is effective and safe for treating sciatica caused by a lumbar disc herniation. The study includes people whose leg pain has not improved after at least six weeks of non-surgical treatment.\n\nThe FINDISC trial aims to recruit and randomly allocate 122 participants to receive either the actual operation (discectomy) or a placebo (sham) surgery. The placebo (sham) procedure involves anesthesia and an approach similar to the real operation, but no removal of disc material or bone. Participants and healthcare staff, excluding the surgical team, will not know which treatment was given. The study compares pain relief, recovery, daily functioning, quality of life, and harms between the two groups.\n\nThe goal of the study is to provide reliable evidence to help patients and clinicians decide whether microdiscectomy offers meaningful benefits compared with placebo surgery.",[121,30],"Lumbar Disc Herniation With Radiculopathy",[123,124,125,126,127,128],"randomized controlled trial","Placebos","Surgery","placebo-controlled trial","discectomy","patient acceptable symptoms state","2026-05-20",{"date":131,"type":41},"2026-05-22",{"date":133,"type":41},"2026-02-19",{"date":135,"type":22},"2030-12",{"name":137,"class":47},"Helsinki University Central Hospital",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":23,"phases":147,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":154,"leadSponsor":156,"locationsCount":48},"100621683","efficacy-of-sciatic-nerve-electrical-stimulation-and-therapeutic-exercise-in-the-management-of-low-back-related-leg-pain-100621683","NCT07373808","Efficacy of Sciatic Nerve Electrical Stimulation and Therapeutic Exercise in the Management of Low-back Related Leg Pain","Inclusion Criteria:\n\n* Neuropathic-like LBRLP (sciatica).\n* S-LANSS score ≥ 12 points.\n* LBRLP lasting more than 6 months.\n* Age between 18 and 70 years.\n* LBRLP in the past 4 weeks has been severe enough to limit usual activities or change daily routines for more than 1 day.\n* At least one period of 6 months to 1 year during which the participant did not go a full month without LBRLP.\n* LBRLP intensity of at least 3\u002F10 on the NPRS.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Acute injury or recent major trauma history.\n* Relevant painful conditions of the hip joint or pelvic\u002Fsacroiliac region.\n* Symptoms compatible with cauda equina syndrome (loss of bladder\u002Fbowel control, sexual dysfunction, paralysis of lower limbs, etc.).\n* Previous surgery on the spine, pelvis or hip.\n* Prior treatment with anesthetic or anti-inflammatory blocks or with radiofrequency (facet, sacroiliac, radicular, epidural, etc.) in the past two years.\n* Any neurological or systemic disease that could limit participation in the study.\n* Inability to communicate in Spanish or understand study instructions and content.\n* General contraindications for invasive physiotherapy and electrotherapy techniques.","70 Years",{"count":146,"type":22},88,[25],"This clinical study focuses on people who experience long-term low-back related leg pain (commonly called sciatica). This type of pain is often associated with nerve irritation or compression in the lower spine and can cause symptoms like shooting or burning pain, tingling, numbness, or weakness in the leg. Many patients continue to suffer from this problem for months or years, and available treatments (including painkillers, anti-inflammatory drugs, or even surgery) do not always provide lasting relief. Because of this, there is a strong need to explore safe, non-drug, non-surgical therapies. The purpose of this study is to test the efficacy and safety of a treatment called Percutaneous Electrical Nerve Stimulation (PENS) when applied near the sciatic nerve, the large nerve that runs from the lower back through the buttock and down the leg, in combination with a therapeutic exercise program. PENS uses very thin sterile needles inserted under ultrasound guidance next to the nerve. A gentle electrical current is then applied for about 30 minutes to stimulate the nerve in a controlled way. This may help calm down nerve sensitivity, reduce inflammation, and decrease pain. We will compare PENS with three other options: Transcutaneous Electrical Nerve Stimulation (TENS): A commonly used therapy where mild electrical stimulation is applied through adhesive patches placed on the skin; Dry needling without electrical current: Thin needles are inserted under ultrasound guidance but no current is applied; and placebo treatment: A simulated version of the therapy with no active current, designed to look and feel similar so that participants do not know which treatment they are receiving. In addition to these treatments, all participants will take part in a structured exercise program aimed at strengthening the lower back, pelvis, and legs. Exercises like curl-ups, planks, bridges, bird-dogs, and squats will be supervised weekly for six weeks, with guidance to continue practicing at home. Exercise is included because it is known to help improve mobility, strength, and recovery in people with back problems. The study is designed as a randomized, controlled, double-blind trial, which means that participants are assigned to one of the four groups by chance (like flipping a coin), and neither the patients nor the therapists who collect the measurements will know which treatment has been given. This design ensures fairness and reliability of the results. We will measure: Back and leg pain levels, using a simple 0-10 scale; Disability, meaning how much the pain limits daily activities, measured with a well-known questionnaire; Quality of life, both physical and mental health aspects; Nerve-related pain features, like burning or electric-like sensations; and patients' global impression of improvement and any side effects. Assessments will take place before starting the treatment, at the end of the 6-week program, and then again at 3 and 6 months. This allows us to see both the short-, mid- and long-term effects. Safety considerations: Previous research shows that PENS and similar techniques are generally very safe. The most common side effects are mild and short-lasting, including temporary soreness, heaviness in the leg, or a small bruise. Serious complications are extremely rare. To minimize risks, all procedures will be carried out by experienced physiotherapists, using real-time ultrasound to guide needle placement and ensure accuracy. Only sterile, single-use needles are employed. By comparing PENS, TENS, dry needling, and placebo, this study seeks to determine whether PENS in combination with therapeutic exercise provides superior benefits in reducing pain, improving function, and enhancing quality of life for patients with sciatica-type low back pain. If successful, this treatment could become a valuable alternative to drugs or surgery, offering patients a safe and effective therapy to better manage their condition and regain daily function.",[30],"2026-05-13",{"date":152,"type":41},"2026-05-14",{"date":150,"type":41},{"date":155,"type":22},"2027-12",{"name":157,"class":47},"Universidad Complutense de Madrid",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":162,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":144,"enrollmentInfo":163,"targetDuration":4,"studyType":23,"phases":164,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":167,"startDateStruct":168,"completionDateStruct":169,"leadSponsor":171,"locationsCount":48},"100621956","immediate-and-1-week-efficacy-of-a-single-session-of-sciatic-nerve-electrical-stimulation-in-the-management-of-low-back-related-leg-pain-100621956","NCT07377357","Immediate and 1-week Efficacy of a Single Session of Sciatic Nerve Electrical Stimulation in the Management of Low-back Related Leg Pain",{"count":146,"type":22},[25],"This clinical study focuses on people who experience long-term low-back related leg pain (commonly called sciatica). This type of pain is often associated with nerve irritation or compression in the lower spine and can cause symptoms like shooting or burning pain, tingling, numbness, or weakness in the leg. Many patients continue to suffer from this problem for months or years, and available treatments (including painkillers, anti-inflammatory drugs, or even surgery) do not always provide lasting relief. Because of this, there is a strong need to explore safe, non-drug, non-surgical therapies. The purpose of this study is to test the immediate and short-term efficacy and safety of a single session of a treatment called Percutaneous Electrical Nerve Stimulation (PENS) when applied near the sciatic nerve, the large nerve that runs from the lower back through the buttock and down the leg. PENS uses very thin sterile needles inserted under ultrasound guidance next to the nerve. A gentle electrical current is then applied for about 30 minutes to stimulate the nerve in a controlled way. This may help calm down nerve sensitivity, reduce inflammation, and decrease pain. The investigators will compare PENS with three other options: Transcutaneous Electrical Nerve Stimulation (TENS): A commonly used therapy where mild electrical stimulation is applied through adhesive patches placed on the skin; Dry needling without electrical current: Thin needles are inserted under ultrasound guidance but no current is applied; and placebo treatment: A simulated version of the therapy with no active current, designed to look and feel similar so that participants do not know which treatment they are receiving. The study is designed as a randomized, controlled, double-blind trial, which means that participants are assigned to one of the four groups by chance (like flipping a coin), and neither the patients nor the therapists who collect the measurements will know which treatment has been given. This design ensures fairness and reliability of the results. The investigators will measure: Back and leg pain levels, using a simple 0-10 scale; Disability, meaning how much the pain limits daily activities, measured with a well-known questionnaire; Quality of life, both physical and mental health aspects; Nerve-related pain features, like burning or electric-like sensations; Flexibility and movement, through the Straight Leg Raise test; Sensitivity to pressure and nerve stiffness, using ultrasound elastography, which is a safe imaging technique; and patients' global impression of improvement and any side effects. Assessments will take place before and immediately after the treatment session and after 1 week, allowing the investigators to see both the immediate and short-term effects. Safety considerations: Previous research shows that PENS and similar techniques are generally very safe. The most common side effects are mild and short-lasting, including temporary soreness, heaviness in the leg, or a small bruise. Serious complications are extremely rare. To minimize risks, all procedures will be carried out by experienced physiotherapists, using real-time ultrasound to guide needle placement and ensure accuracy. Only sterile, single-use needles are employed. By comparing PENS, TENS, dry needling, and placebo, this study seeks to determine whether a single session of PENS provides superior benefits in reducing pain, improving function, and enhancing quality of life for patients with sciatica-type low back pain. If successful, this treatment could become a valuable alternative to drugs or surgery, offering patients a safe and effective therapy to better manage their condition and regain daily function.",[30],{"date":152,"type":41},{"date":150,"type":41},{"date":170,"type":22},"2027-11",{"name":157,"class":47},{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":23,"phases":181,"briefSummary":182,"conditions":183,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":4},"100638982","electroacupuncture-for-insomnia-in-patients-with-chronic-sciatica-due-to-lumbar-disc-herniation-a-randomized-controlled-trial-100638982","NCT07576348","Electroacupuncture for Insomnia in Patients With Chronic Sciatica Due to Lumbar Disc Herniation: a Randomized Controlled Trial","Inclusion Criteria:\n\nParticipants will be eligible if they meet all of the following criteria:\n\n1. Aged 18-75 years, of either sex;\n2. Diagnosis with lumbar disc herniation accompanied by unilateral chronic sciatica (disease duration ≥ 3 months);\n3. Experiencing moderate to severe radiating leg pain (below the knee), defined as a Numerical Rating Scale (NRS) score ≥ 4 at screening within the past 24 h;\n4. Diagnosis of chronic insomnia, with a Pittsburgh Sleep Quality Index (PSQI) total score \\> 7;\n5. Onset or exacerbation of insomnia temporally associated with the onset or worsening of sciatica symptoms;\n6. Willing to participate and able to provide written informed consent.\n\nExclusion Criteria:\n\nParticipants will be excluded if any of the following criteria are met:\n\n1. Spinal or structural conditions: lumbar spinal stenosis, spondylolisthesis, vertebral fracture, spinal infection (e.g., tuberculosis), or tumor;\n2. Surgical indications: cauda equina syndrome, conus medullaris syndrome, or other conditions requiring urgent surgical intervention;\n3. Severe systemic diseases: unstable cardiovascular, hepatic, renal, respiratory, or hematological disorders, or metabolic conditions that may significantly affect study outcomes (e.g., uncontrolled diabetes or thyroid disease);\n4. Neurological or psychiatric disorders: major neurological diseases (e.g., epilepsy, Parkinson's disease, dementia, multiple sclerosis) or severe psychiatric disorders (e.g., schizophrenia);\n5. Clinically significant depression or anxiety, defined as Patient Health Questionnaire-9 (PHQ-9) ≥ 10 and\u002For Generalized Anxiety Disorder-7 (GAD-7) ≥ 10;\n6. Other primary sleep disorders, including obstructive sleep apnea, narcolepsy, or restless legs syndrome;\n7. Use of centrally acting medications: regular use (≥ 3 days\u002Fweek within 4 weeks prior to enrolment) of medications affecting the central nervous system (e.g., opioids, sedative-hypnotics, antidepressants) without an adequate washout period (≥ 2 weeks or longer depending on drug half-life);\n8. Irregular sleep patterns, including night shift work (≥ 2 times\u002Fweek between 22:00-06:00) or highly irregular sleep-wake cycles;\n9. Pregnancy or lactation;\n10. History of substance abuse or dependence;\n11. Lumbar spine surgery or interventional procedures within the past 3 months;\n12. History of acupuncture treatment;\n13. Implanted electronic devices (e.g., pacemakers) or metal implants at acupuncture sites;\n14. Participation in another clinical trial within the past 3 months;\n15. Severe sensory or cognitive impairment affecting assessment compliance;\n16. Any other condition deemed by investigators to compromise safety or data integrity.","75 Years",{"count":180,"type":22},114,[25],"The goal of this clinical trial is to learn if electroacupuncture can improve sleep in people with chronic sciatica caused by lumbar disc herniation. It will also assess the safety of this treatment. The main questions it aims to answer are whether electroacupuncture improves sleep quality and whether it reduces pain and improves daily function. Researchers will compare electroacupuncture to a sham treatment, which looks like real acupuncture but has little or no therapeutic effect, to determine its effectiveness. Participants will be randomly assigned to receive electroacupuncture or sham treatment, will receive treatment three times per week for four weeks, and will complete questionnaires about their sleep, pain, and daily activities.",[30,184,185],"Lumbar Disc Herniation","Insomnia","2026-05-04",{"date":188,"type":41},"2026-05-08",{"date":190,"type":22},"2026-05",{"date":192,"type":22},"2027-03",{"name":194,"class":47},"Shanghai Yueyang Integrated Medicine Hospital",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":201,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":23,"phases":205,"briefSummary":206,"conditions":207,"keywords":210,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":48},"100635923","mirror-image-spine-correction-exercises-versus-conservative-physiotherapy-for-lumbar-radiculopathy-100635923","NCT07558993","Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar Radiculopathy","Randomized, Parallel-Group, Superiority Trial of Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar Nerve Root Microstructural Integrity Assessed by Diffusion Tensor Imaging in Adults With Lumbar Radiculopathy","MIRROR-LR","Inclusion Criteria:\n\n* Adults aged 18 years or older. Clinical diagnosis of unilateral lumbar radiculopathy. Presence of at least two of the following: dermatomal radiating leg pain, neurological deficit, positive neural tension test.\n\nMRI-confirmed lumbar nerve root compression or irritation consistent with symptoms.\n\nPain intensity of 3\u002F10 or greater. Able to undergo MRI and Diffusion Tensor Imaging (DTI). Able to understand study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Previous lumbar spine surgery. Bilateral radiculopathy or unclear diagnosis. Tumor, infection, fracture, inflammatory spinal disease, or cauda equina syndrome.\n\nSevere progressive neurological deficit requiring urgent treatment. Contraindications to MRI (pacemaker, incompatible implants, severe claustrophobia).\n\nRecent lumbar injections or surgery. Other neurological or musculoskeletal disorders affecting outcomes. Pregnancy if MRI contraindicated by local policy. Cognitive impairment or inability to follow instructions.",{"count":204,"type":22},64,[25],"Lumbar radiculopathy is a common condition caused by irritation or compression of a lumbar nerve root, often resulting in radiating leg pain, numbness, weakness, and functional limitation. Conservative physiotherapy is commonly used as first-line treatment, but outcomes vary among patients.\n\nThis randomized controlled trial will compare Mirror Image Spine Correction Exercises with standardized conservative physiotherapy in adults with lumbar radiculopathy. Participants will be randomly assigned to one of two treatment groups for 12 weeks.\n\nThe primary outcome is lumbar nerve root microstructural integrity measured using Diffusion Tensor Imaging (DTI), including Fractional Anisotropy and other diffusion parameters. Secondary outcomes include pain intensity, disability, spinal alignment, and adverse events.\n\nThe purpose of this study is to determine whether a targeted posture-correction exercise approach provides greater improvement than conventional physiotherapy.",[35,208,30,209],"Radiculopathy Lumbar","Disc Disease Lumbar",[211,212,213,214,215,216,217,218,219,220],"Mirror Image Exercise","Physiotherapy","Diffusion Tensor Imaging","DTI","Conservative Physiotherapy","Low Back Pain","Nerve Root Compression","Postural Correction","Randomized Controlled Trial","Rehabilitation","2026-04-23",{"date":223,"type":41},"2026-04-30",{"date":225,"type":22},"2026-09-01",{"date":227,"type":22},"2027-09-30",{"name":229,"class":47},"University of Sharjah",{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":4,"enrollmentInfo":237,"targetDuration":4,"studyType":23,"phases":239,"briefSummary":241,"conditions":242,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":248,"leadSponsor":250,"locationsCount":48},"100630935","phase-4-dose-dependent-steroid-injections-100630935","NCT07494136","Dose Dependent Steroid Injections","Dose Dependent Response to Interlaminar Steroid Injections for Lumbar Radiculopathy","Inclusion Criteria:\n\n* Adults able to consent\n* Lumbar radiculopathy with MRI-confirmed pathology\n* No history of back surgery\n* Use of interlaminar approach lumbar spine injections\n* No use of oral pain medication other than Tylenol or Acetaminophen during the 6 weeks after injection\n\nExclusion Criteria:\n\n* Adults unable to consent\n* Individuals who are not yet adults (infants, children, teenagers)\n* Pregnant women\n* History of back surgery\n* Use of oral pain meds other than Tylenol or Acetaminophen during the 6 weeks after injection",{"count":238,"type":22},150,[240],"PHASE4","This study aims to evaluate the efficacy of interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, to evaluate the efficacy of interlaminar steroid injections at improving quality of life and function in lumbar radiculopathy at varying doses, and to evaluate difference in efficacy between triamcinolone and dexamethasone interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, with the overarching hypotheses that there is no difference in reported pain reduction, quality of life, or function among patients receiving low, moderate, or high doses, and no difference in reported pain reduction between triamcinolone and dexamethasone.",[87,30,243],"Back Pain With Radiation","2026-03-20",{"date":246,"type":41},"2026-03-27",{"date":190,"type":22},{"date":249,"type":22},"2027-05",{"name":251,"class":47},"University of Miami",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":80,"enrollmentInfo":259,"targetDuration":4,"studyType":23,"phases":261,"briefSummary":263,"conditions":264,"keywords":270,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":287},"100613260","phase-1-study-to-evaluate-safety-of-c-1101-versus-sterile-saline-in-adults-with-chronic-painful-lumbosacral-radiculopathy-100613260","NCT07264270","Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy","A Phase 1, Randomized, Double-Blind, Single Dose Escalation Study to Assess the Safety and Tolerability of Transforaminal Epidural Administration of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy","Inclusion Criteria:\n\n* Diagnosis of painful LSR (sciatica) radiating to or below the knee, with an inadequate response to conservative care\n* Body mass index \\\u003C 35 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Presence of clinically significant disease or any other painful condition that may interfere with assessments.\n* Any condition that currently requires blood or platelet transfusions.\n* Diagnosed with schizophrenia, bipolar disorder, or major depressive disorder.\n* Increased risk of bleeding or is taking anticoagulants or platelet aggregation inhibitors.\n* History or presence of autonomic neuropathy, diabetic neuropathy, or other peripheral neuropathies.\n* History of myocardial infarction within the last 6 months or congestive heart failure.\n* The presence of an active malignancy or tumor.\n* Have undergone a surgical procedure for back pain.\n* Recent use of immunosuppressants, oral steroids, or intravenous steroids.",{"count":260,"type":22},24,[262],"PHASE1","The purpose of this study is to evaluate the safety and tolerability of C-1101 administered as a single dose, transforaminal epidural injection compared to sterile saline",[265,266,267,30,268,269],"Lumbosacral Radicular Pain","Sciatic Radiculopathy","Sciatic Leg Pain","Lumbosacral Radicular Syndrome","Lumbosacral Radiculopathy",[30,271,272,273,269,274,275,276],"Sciatic Nerve Pain","LSR","back pain","Chronic Painful Lumbosacral Radiculopathy","non-opioid pain medication","transforaminal epidural injection","2026-03-16",{"date":279,"type":41},"2026-03-17",{"date":281,"type":41},"2025-12-03",{"date":283,"type":22},"2026-12-01",{"name":285,"class":286},"Consano Bio","INDUSTRY",3,{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":292,"acronym":4,"eligibilityCriteria":293,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":80,"enrollmentInfo":294,"targetDuration":4,"studyType":296,"phases":4,"briefSummary":297,"conditions":298,"keywords":300,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":48},"100621174","the-role-of-temporal-changes-in-pain-response-after-transforaminal-epidural-steroid-injection-on-treatment-success-100621174","NCT07367191","The Role of Temporal Changes in Pain Response After Transforaminal Epidural Steroid Injection on Treatment Success","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Pre-procedural Numeric Rating Scale (NRS) pain score of 4 or higher\n* Presence of segmental lumbar disc herniation demonstrated on magnetic resonance imaging (MRI) consistent with clinical findings\n* Undergoing fluoroscopy-guided transforaminal epidural steroid injection due to insufficient response to conservative treatments, as determined by the algology clinic\n\nExclusion Criteria:\n\n* Presence of spondylolisthesis, scoliosis, or lumbar spinal stenosis accompanying lumbar disc herniation\n* Presence of malignancy\n* History of lumbar spine surgery for disc herniation\n* Transforaminal epidural steroid injection within the previous 6 months\n* Requirement for repeat epidural steroid injection during the data collection or follow-up period\n* Inability to be contacted for follow-up assessments by telephone",{"count":295,"type":22},120,"OBSERVATIONAL","Transforaminal epidural steroid injection (TFESI) is a commonly used minimally invasive procedure for the treatment of lumbar radicular pain secondary to disc herniation. Although TFESI has been shown to provide significant pain relief in a substantial proportion of patients, the onset, duration, and temporal pattern of pain relief after the procedure vary considerably among individuals. The relationship between early pain response patterns and long-term treatment success remains poorly understood.\n\nThis prospective observational study aims to evaluate whether temporal changes in pain intensity following TFESI, particularly during the early post-procedural period, are associated with clinical treatment success at mid- and long-term follow-up. Pain intensity will be assessed using the Numeric Rating Scale (NRS) at predefined time points following the procedure, and treatment success will be defined as a ≥50% reduction in NRS score compared with baseline.",[184,87,299,30],"Radicular Low Back Pain",[301,302,303,304,305,306],"TFESI","Temporal Pain Response","Numeric Rating Scale","NRS","Transforaminal Epidural Steroid Injection","Treatment Success","2026-01-16",{"date":309,"type":41},"2026-01-26",{"date":311,"type":22},"2026-02-15",{"date":313,"type":22},"2026-10-15",{"name":315,"class":47},"Marmara University",{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":320,"acronym":321,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":323,"enrollmentInfo":324,"targetDuration":4,"studyType":23,"phases":326,"briefSummary":327,"conditions":328,"keywords":331,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":48},"100602554","a-multicomponent-intervention-for-patients-with-lumbosacral-radiculopathy-move-more-100602554","NCT07125027","A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE","Move-MORE","Inclusion Criteria:\n\n* ● Adults age 18-65 years at the time of enrollment\n\n  * Ability to stand for 10 minutes\n  * Presence of lumbosacral radicular pain within the past week that extends below the knee (i.e., pain radiating from the low back into the leg in a nerve root distribution) with or without accompanying low back pain, of at least 12 weeks' duration, AND\n  * Tampa Scale of Kinesiophobia score ≥ 23\n  * At least one positive physical examination finding consistent with lumbosacral radiculopathy, including at least one of the following:\n\n    * Positive straight leg raise test (eliciting radicular pain below the knee at ≤70 degrees of elevation);\n    * Positive Valsalva maneuver (eliciting radiculcar pain below the knee);\n    * Positive slump test;\n    * Neurological deficit in a lumbar nerve root distribution, including at least one of the following:\n\n      * Dermatomal sensory loss,\n      * Myotomal weakness, or\n      * Reduced or absent deep tendon reflexes (e.g., patellar or Achilles reflex) corresponding to the affected nerve root.\n  * Daily access to the internet via cell phone, tablet, or computer\n  * Willing to engage with Move-MORE 4-5 times per week on your own\n  * Willing to attend a two-hour-long virtual Zoom meeting once per week for eight weeks\n  * Willing to attend two in-person study visits and a follow-up visit\n  * Willing to complete 18 questionnaires pertaining to your pain symptoms, quality of life, psychosocial experiences, and your experiences in the trial\n  * Willing to wear an actigraphy device all day, every day, and while sleeping, for the duration of study participation and willing to keep it charged\n  * Willing to respond to a daily online survey for the duration of study participation\n  * Able to speak, read, and understand the English language\n  * Able to provide written informed consent\n  * Moderately motivated to participate as reported on a numeric rating scale (≥ 4\u002F10)\n\nExclusion Criteria:\n\n* ● Participants will be excluded if they have clinical signs or symptoms of lumbosacral radiculopathy with progressive neurologic deficits (loss of motor or sensory function) or intolerable pain.\n\n  * Participants with lumbosacral radiculopathy with progressive neurologic deficits will be referred for immediate medical attention, and are not eligible for participation in this study.\n\n    ● Participants will be excluded if they have clinical signs or symptoms suggestive of cauda equina syndrome, including any of the following:\n  * New-onset urinary retention or overflow incontinence not attributable to other known causes;\n  * Fecal incontinence;\n  * New onset of saddle anesthesia (loss of sensation in the buttocks, perineum, and inner thighs);\n  * Severe or progressive bilateral lower extremity weakness;\n\n    * Participants with suspected cauda equina syndrome will be referred for immediate medical attention, and are not eligible for participation in this study.\n\n      * Presence of moderate to severe foot drop, defined as noticeable weakness in ankle dorsiflexion that interferes with walking or requires the use of an assistive device (e.g., ankle-foot orthosis). Participants with suspected or worsening foot drop will be referred for further evaluation and are not eligible for study participation.\n      * Current use of a spinal cord stimulator\n      * Have received epidural steroid injection in the prior 3 months\n      * Have received a surgical intervention for low back pain or lumbosacral radiculopathy in the previous 6 months\n      * Current active mindfulness meditation practice 1 time\u002Fweek or more, and\u002For history of formal training in mindfulness\u002Fmeditation practice\n      * Concurrent diagnosis of cancer\n      * Current unmanaged or uncontrolled mental illness known to cause psychosis: schizophrenia, schizotypal disorders, bipolar I disorder with psychosis, major depressive disorder with psychosis\n      * Diagnosis of Borderline Personality Disorder or score \\>6 on the McLean Screening Instrument for Borderline Personality Disorder\n      * Initiation of or changes to an exercise regimen within 2 weeks prior to screening and\u002For enrollment\n      * Major medical or surgical event requiring hospitalization (for any reason other than a minor scheduled medical procedure) within 3 months prior to screening; or, scheduled or will be scheduled to occur within the 20 weeks (i.e., five months) after enrollment\n      * Currently participating in another interventional research study or participated in another interventional study within 2 weeks prior to screening\n      * Any reason the Clinical Investigator or Principal Investigator believes confers increased risk to the potential participant, if they were to enroll in the study","66 Years",{"count":325,"type":22},32,[25],"The Move-MORE study is designed to evaluate a multicomponent mindfulness and movement program for patients with lumbosacral radiculopathy. The program brings together mindfulness training to help participants develop awareness of their body and manage pain-related stress, gentle movement practice to improve comfort with physical activity and support function, and motivational interviewing to strengthen motivation, confidence, and the ability to make healthy changes.\n\nThe main objectives are to determine whether it is feasible for participants to use each component of the program when delivered online, to assess how acceptable and engaging each component is, and to evaluate the impact on pain, physical function, and daily activity levels. The study intervention will be conducted entirely remotely. Participants will complete online surveys, brief daily check-ins on their phone, and wear a small activity monitor on the hip to measure movement. They will also undergo quantitative sensory testing to evaluate pain sensitivity. At the end of the program, participants will share feedback about their experiences via qualitative interviews.\n\nThe findings will help identify which parts of the program provide the greatest benefit, with the ultimate goal of developing a more targeted and effective digital program for people with this condition.",[269,30,329,208,330],"Chronic Low Back Pain With a Neuropathic Component","Chronic Pain (Back \u002F Neck)",[332,333,334,335,336,337,338,339,35,269,87,340,341,92],"Mindfulness","Physical Activity","Motivational Interviewing","Meditation","Tai Chi\u002FQi Gong","Movement","Mindfulness-Oriented Recovery Enhancement","Mindfulness-Based Interventions","Chronic low back pain","Low back pain","2025-11-10",{"date":344,"type":41},"2025-11-12",{"date":346,"type":41},"2025-08-15",{"date":348,"type":22},"2026-11",{"name":350,"class":47},"National University of Natural Medicine",{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":4,"enrollmentInfo":358,"targetDuration":4,"studyType":296,"phases":4,"briefSummary":360,"conditions":361,"keywords":363,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":48},"100599116","artificial-intelligence-ai-based-prediction-of-treatment-response-in-sciatica-patients-receiving-transforaminal-epidural-steroid-injection-100599116","NCT07080307","Artificial Intelligence (AI)-Based Prediction of Treatment Response in Sciatica Patients Receiving Transforaminal Epidural Steroid Injection","Artificial Intelligence-Based Predictive Models for Estimating Treatment Response in Sciatica Patients Treated With Transforaminal Epidural Steroid Injection (TFESI)","Inclusion Criteria:\n\n* Age 18 years or older\n* Presence of clinical and radiological radiculopathy findings consistent with L4, L5, or S1 nerve root involvement\n* Symptoms present for at least 3 months\n* Resistant to conservative treatment\n* Scheduled for transforaminal epidural steroid injection (TFESI) by a pain medicine specialist\n* Being willing to participate in the study and having signed a consent form\n\nExclusion Criteria:\n\n* Malignancy\n* Coagulation disorders\n* Pregnancy\n* History of allergic reaction to the injected substances\n* History of major psychiatric disorders\n* Presence of known coagulopathy\n* Receiving systemic steroid treatment for any reason\n* Having received an epidural steroid injection within the last 3 months",{"count":359,"type":22},1500,"This prospective observational study aims to develop artificial intelligence (AI)-based predictive models to estimate treatment response in patients with sciatica undergoing transforaminal epidural steroid injection (TFESI). Approximately 1500 adult patients diagnosed with sciatica and scheduled for TFESI at Marmara University Training and Research Hospital Algology Clinic will be enrolled. Clinical, radiological, laboratory, and psychological data will be systematically collected before the procedure and at multiple follow-up points (1 hour, 3 weeks, 3 months, and 6 months post-treatment). Pain relief, measured by a 50% or greater reduction in the Numeric Rating Scale (NRS), will be the primary outcome. The study will use these comprehensive data sets to train and validate AI algorithms, aiming to create a decision-support system that can predict individual patient responses to TFESI and improve personalized treatment planning.",[30,216,362,35,184],"Lumbar Spinal Stenosis",[364],"sciatica, radiculopathy, lumbar disc herniation, spinal stenosis, low back pain","2025-07-15",{"date":367,"type":41},"2025-07-23",{"date":369,"type":22},"2025-07",{"date":371,"type":22},"2026-10",{"name":315,"class":47},{"id":374,"slug":375,"hasResults":11,"nctId":376,"briefTitle":377,"officialTitle":378,"acronym":30,"eligibilityCriteria":379,"healthyVolunteers":11,"sex":17,"minAge":380,"maxAge":19,"enrollmentInfo":381,"targetDuration":4,"studyType":23,"phases":383,"briefSummary":384,"conditions":385,"keywords":386,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":48},"100569642","effects-of-ssmc-with-and-without-myofascial-release-in-patients-with-sciatica-100569642","NCT06696898","Effects of SSMC With and Without Myofascial Release in Patients With Sciatica","Effects of Somatosensory Motor Control With and Without Myofascial Release on Pain, Lumbar Range of Motion and Functional Disability in Patients With Sciatica","Inclusion Criteria:\n\n* Patient Diagnosed with sciatica (confirmed by clinical examination and imaging)\n* Patient with Unilateral sciatica pain\n* Patient Experiencing symptoms for at least 3 months\n* Pain (VAS) score ≥ 5) in the lumbar and\u002For lower extremity region in patients.\n* The disability with a score of at least 20% by the Oswestry Disability Index (\n* Stable patient , no recent changes in treatment regimen for sciatica within the past 4 weeks\n\nExclusion Criteria:\n\n* Patients with Lumbar spine surgery history within the past 6 months (11)\n* Patients who have been Another clinical trial participant within the past 3 months (1).\n* Patients with Physical therapy interventions contraindicated like in Severe cardiovascular disease and Uncontrolled hypertension Acute disc herniation requiring urgent surgical intervention (10).\n* Patients with Significant comorbidities like malignancy, spinal infection and Severe osteoporosis affecting spine stability (14).\n* Inability in patients to communicate effectively in Urdu or English, hindering comprehension of study instructions and assessments.","25 Years",{"count":382,"type":22},74,[25],"Sciatica involves a radiating pain along the sciatic nerve, extending from the lower back through the hips and buttocks to each leg. Typically resulting from a herniated disk or spinal stenosis, this condition causes nerve compression that leads to pain, inflammation, and often numbness in the affected leg. Studies have shown that sensorimotor training with myofascial release can be effective in improving pain, lumbar range of motion and functional disability. The aim of this study is to evaluate the effects of Sensorimotor control training with and without myofascial releases on Pain, Lumbar range of motion and functional disability due to sciatica. Participants which meet inclusion criteria will be randomly allocated using online randomization tool into two groups. Group A will receive somatosensory control training with Routine Physical Therapy for 45 minutes with short resting interval for Group B will receive Somatosensory training with myofascial release technique for 45min. Each group will receive treatment sessions of 3 days per week for 12 weeks.",[61,30],[387,388,389],"Sensorimotor Training","PNF Exercises","Functional Disability","2024-11-18",{"date":392,"type":41},"2024-11-20",{"date":394,"type":41},"2024-09-01",{"date":396,"type":22},"2025-05-30",{"name":398,"class":47},"Riphah International University",{"id":400,"slug":401,"hasResults":11,"nctId":402,"briefTitle":403,"officialTitle":404,"acronym":4,"eligibilityCriteria":405,"healthyVolunteers":78,"sex":406,"minAge":114,"maxAge":407,"enrollmentInfo":408,"targetDuration":4,"studyType":23,"phases":410,"briefSummary":411,"conditions":412,"keywords":415,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":48},"100557339","effects-of-myofacial-release-technique-and-sciatic-nerve-slider-technique-in-sciatica-100557339","NCT06536829","Effects of Myofacial Release Technique and Sciatic Nerve Slider Technique in Sciatica","Effects of Myofacial Release Technique With and Without Sciatic Nerve Slider Technique on Pain Range of Motion and Functional Disability Among Cricket Players With Sciatica.","Inclusion Criteria:\n\n* Age group between 18-35 yrs.\n* Male cricketers\n* Pre diagnosed Patients suffering from sciatica referred from Orthopedic.\n* History of low back pain atleast 03 months before enrollement.\n* Pain while examing when straight leg test (SLR) is performed.\n* Patients who are willing to particiapate in the study\n\nExclusion Criteria:\n\n* History of any systemic disease\n* History of trauma\n* History of previous fracture in lower limb.\n* History of prior Surgery\n* Corticosteroid injection for lumber radiculopathy within previous 03 momths;\n* Any known malignancy \u002Fneoplasma involved side.\n* Diagnosed\u002Fknown psychiatric illness.","MALE","35 Years",{"count":409,"type":22},36,[25],"Sciatica is not a medical condition itself, but is a symptom of whatever condition is affecting your sciatic nerve. Pain in the lower back, hip and legs is the most common symptom. However, tingling, numbness and weakness are also symptoms of a damaged sciatic nerve. Physical therapy is a popular and effective way of treating the pain from sciatica. Myofascial release (MFR) is another useful option for sciatica due to the fact that it focuses the connective tissues of the body, including muscles and the fibrous tissues, often called fascia, encircling the joints.This study will be conducted to compare the Effects of myofacial release technique with and without sciatic nerve slider technique on Pain, Range of Motion and Functional Disability among cricket players with Sciatica. This study will be conducted because, no such evidence found in literature to find out the effects of myofacial release technique with sciatic nerve slider technique for sciatica. Myofacial release technique and sciatic nerve slider technique are useful, because these can reduce patients number of visits for the treatment and are easy to use, feasible and cost effective. The sciatic nerve is the largest nerve in the human body. It is formed at the point where five nerves from the lower back all come together, and stretches all the way from the hips to the bottoms of the feet. When this important nerve becomes compressed, inflamed or irritated, it causes the pain in the lower back and legs known as sciatica. A physical therapist uses a number of proven methods to help relieve sciatic pain. One of the most commonly employed methods is known as myofascial release therapy. Myofascial release is a method that a physical therapist can use to treat many sources of pain that are caused by damage to the nervous system. It involves the therapist using hands-on, manual techniques to release areas of tension and pain in the body. Here are three reasons that myofascial release is an effective tool for treating sciatica.",[413,30,414],"Sciatic Neuropathy","Range of Motion",[416],"Myofacial release tehnique (MFR), cricketer","2024-07-31",{"date":419,"type":41},"2024-08-05",{"date":421,"type":41},"2024-06-26",{"date":423,"type":22},"2024-09-26",{"name":398,"class":47},{"id":426,"slug":427,"hasResults":11,"nctId":428,"briefTitle":429,"officialTitle":429,"acronym":430,"eligibilityCriteria":431,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":4,"enrollmentInfo":432,"targetDuration":4,"studyType":23,"phases":434,"briefSummary":435,"conditions":436,"keywords":438,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":454,"locationsCount":456},"100356729","transforaminal-epidural-injection-in-acute-sciatica-100356729","NCT03924791","Transforaminal Epidural Injection in Acute Sciatica","TEIAS","Inclusion Criteria:\n\n* Diagnosed with sciatica by GP\n* NRS leg pain of 6 or more on a 10-point NRS scale\n* Minimum duration of symptoms of 3 weeks and maximum duration of 8 weeks\n\nExclusion Criteria:\n\n* Age under 18 years\n* Condition preventing to receive transforaminal epidural injection\n* Severe scoliosis\n* Transforaminal epidural injection received in 6 months before randomization date\n* Surgery for sciatica at the same level\n* Surgery for sciatica at another level within one year before inclusion\n* Pregnancy",{"count":433,"type":22},142,[25],"Patients suffering from sciatica are treated conservatively for the first 8 weeks due to the favourable prognosis. This period is preferably extended up to 14-16 weeks after which patients may opt for surgery. However, patients may experience severe discomfort due to pain in the leg which can lead to decreased physical activity and socio-economic problems. An adequate therapy to alleviate symptoms during this period of 'wait-and-see' is lacking. In this study, patients will be randomized to treatment with transforaminal epidural injections or standard oral pain medication.",[30,437,266],"Sciatica Due to Intervertebral Disc Disorder",[30,439,440,441,442,443,444,445,446],"Acute sciatica","Transforaminal epidural injection","Leg pain","Lumbar spine","Back pain","Lumbar surgery","Herniated intervertebral lumbar disk","Cost-effectiveness","2023-10-18",{"date":449,"type":41},"2023-10-19",{"date":451,"type":41},"2019-06-01",{"date":453,"type":22},"2026-07",{"name":455,"class":47},"C.L.A.Vleggeert-Lankamp",2]