[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"scleroderma-associated-pulmonary-arterial-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:scleroderma-associated-pulmonary-arterial-hypertension":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100200324","hormonal-metabolic-and-signaling-interactions-in-pah-100200324",false,"NCT01884051","Hormonal, Metabolic, and Signaling Interactions in PAH","Hormonal, Metabolic, and Signaling Interaction in Pulmonary Arterial Hypertension","Inclusion Criteria:\n\nProject 1\n\nInclusion:\n\n1. Diagnosis of IPAH (idiopathic pulmonary arterial hypertension), HPAH (heritable pulmonary arterial hypertension), or APAH (associated pulmonary arterial hypertension), family members of affected persons\n2. Age 0-90, age 12-90 for skin biopsy\n\nExclusion:\n\n1. Other diagnosis\n2. Age greater than 90, age less than 12 or greater than 90 for skin biopsy\n\nProject 2\n\nInclusion:\n\n1. Diagnosis of IPAH, HPAH, or APAH, family members of affected persons\n2. 0-90\n3. Subjects with reasonably easy access to clinic for blood collection and other testing\n4. Subject able to tolerate fasting state prior to sample collection and EndoPAT (endothelial function assessment) testing\n\nExclusion:\n\n1. Other diagnosis\n2. 0-90\n3. Subjects with difficulty reaching clinic for blood collection and other testing\n4. Subjects unable to tolerate fasting state\n\nProject 3\n\nInclusion:\n\n1. Diagnosis of IPAH, HPAH, or APAH, family members of affected persons\n2. 7-90\n\nExclusion:\n\n1. Other diagnosis\n2. Age less than 7 or greater than 90\n\n   \\-\n\n   Exclusion Criteria:\n\n   \\-",true,"ALL","90 Years",{"count":20,"type":21},1899,"ESTIMATED","OBSERVATIONAL","Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences of the disease.",[25,26,27,28],"Idiopathic Pulmonary Arterial Hypertension","Heritable Pulmonary Arterial Hypertension","Scleroderma Associated Pulmonary Arterial Hypertension","Appetite Suppressant Associate PAH",[30],"Pulmonary arterial hypertension","RECRUITING","2025-09-15",{"date":34,"type":35},"2025-09-16","ACTUAL",{"date":37,"type":4},"2012-09",{"date":39,"type":21},"2032-07",{"name":41,"class":42},"Vanderbilt University Medical Center","OTHER"]