[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"scoliosis-adolescence\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:scoliosis-adolescence":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,42,74,118,145,167,192,216,246,278,308,330,358,379,405],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100639340","tranexamic-acid-in-pediatric-idiopathic-scoliosis-surgery-100639340",false,"NCT07581457","Tranexamic Acid in Pediatric Idiopathic Scoliosis Surgery","Efficacy and Safety of Two Intravenous Tranexamic Acid Regimens Versus Placebo in Pediatric Idiopathic Scoliosis Surgery: A Randomized Double-Blind Trial","Inclusion Criteria:\n\n* Age 10 to 18 years\n* Diagnosis of idiopathic scoliosis requiring surgical correction (posterior spinal fusion)\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Written informed consent from parents or legal guardians and assent from the child\n\nExclusion Criteria:\n\n* Congenital or acquired coagulopathy\n* History of thromboembolic disease\n* History of seizures or epilepsy\n* Known hypersensitivity to tranexamic acid\n* Renal insufficiency (estimated glomerular filtration rate \\\u003C 60 mL\u002Fmin\u002F1.73 m²)\n* Cardiac arrhythmias or cardiovascular disease requiring antiplatelet or anticoagulant therapy","ALL","10 Years","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will evaluate whether tranexamic acid (TXA), a medication used to reduce bleeding, is effective and safe in children undergoing surgery for idiopathic scoliosis. Significant blood loss is common during this type of surgery and often requires blood transfusions.\n\nParticipants will be randomly assigned to one of three groups: (1) TXA given as an intravenous bolus followed by continuous infusion, (2) TXA given as two intravenous bolus doses, or (3) placebo (saline). Neither the patients nor the medical team will know which treatment is given.\n\nThe main goal is to compare how much blood is lost during and after surgery and whether TXA reduces the need for blood transfusions. The study will also assess safety, including the risk of side effects such as seizures or blood clots.\n\nPatients will be followed for up to 30 days after surgery.",[27,28],"Scoliosis Idiopathic","Scoliosis; Adolescence","RECRUITING","2026-06-29",{"date":32,"type":33},"2026-07-01","ACTUAL",{"date":35,"type":21},"2026-06-01",{"date":37,"type":21},"2027-06-30",{"name":39,"class":40},"Poznan University of Medical Sciences","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100610585","phase-4-tegileridine-for-postoperative-pain-after-adolescent-scoliosis-surgery-100610585","NCT07229495","Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery","Efficacy and Safety of Tegileridine for Postoperative Analgesia Following Adolescent Scoliosis Correction Surgery: A Prospective, Multicentre, Double-Blind, Non-Inferiority, Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 10 years to less than 18 years.\n* Scheduled to undergo posterior spinal fusion (PSF) surgery for scoliosis under general anesthesia.\n* American Society of Anesthesiologists (ASA) physical status classification I to III.\n* The participant and their parent or legal guardian voluntarily provide written informed consent prior to any study-related procedures.\n\nExclusion Criteria:\n\n* History of difficult airway, severe respiratory depression (SpO₂ \\\u003C 90%), acute or severe bronchial asthma.\n* History of severe cardiovascular or cerebrovascular disease, such as myocardial infarction, unstable angina, second-degree or higher atrioventricular block, NYHA Class III or higher heart failure, or stroke.\n* Known or suspected gastrointestinal obstruction, including paralytic ileus.\n* Known hypersensitivity to opioids or any component of the study drug formulation.\n* History of psychiatric disorders (e.g., schizophrenia, depression) or cognitive impairment.\n* Diagnosis of neuromuscular scoliosis or presence of any other chronic pain condition that may interfere with postoperative pain assessment.\n* Chronic use of opioid analgesics or use of any analgesic medication within 48 hours prior to surgery.\n* Planned postoperative admission to the intensive care unit (ICU).\n* Any other condition deemed by the investigator to be inappropriate for participation in the study.","17 Years",{"count":51,"type":21},171,[53],"PHASE4","The goal of this clinical trial is to see if a new pain medicine called Tegileridine is at least as effective as morphine (the standard treatment) for pain relief after spinal surgery in teenagers with scoliosis. This type of study is called a \"non-inferiority\" trial. The study will also carefully compare the safety of both medicines.\n\nThe main questions it aims to answer are:\n\nIs Tegileridine no worse than morphine at controlling pain in the first 24 hours after surgery? How do the side effects (like sleepiness or nausea) of Tegileridine compare to those of morphine? Researchers will compare two different doses of Tegileridine against morphine. Neither the participants nor the doctors assessing them will know which medicine is being given.\n\nParticipants in this study will:\n\nReceive one of the three pain medicine options through a pump (called a PCA pump) that they can control themselves after surgery.\n\nUse the pump for up to 48 hours. Regularly rate their pain levels using a simple number scale. Have their health closely monitored by the study team during this time.",[28,56,57],"Pain After Surgery","Analgesia, Patient-controlled",[59,60,61,62,63],"Tegileridine","Postoperative Pain","Adolescent","Patient-Controlled Analgesia","Scoliosis","NOT_YET_RECRUITING","2026-06-15",{"date":67,"type":33},"2026-06-17",{"date":32,"type":21},{"date":70,"type":21},"2027-09-30",{"name":72,"class":40},"Peking Union Medical College Hospital",6,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":18,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":94,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":41},"100523273","studying-melatonin-and-recovery-in-teens-100523273","NCT06093477","Studying Melatonin and Recovery in Teens","SurgerySMART: Studying Melatonin and Recovery in Teens","SurgerySMART","Inclusion Criteria:\n\nPatients\u002Fyouth:\n\n* Age 12-18 years\n* Participants undergoing elective major musculoskeletal surgery for eligible conditions\n* California state resident\n* Regular access to internet and smartphone\n* Can read and understand English or Spanish\n\nParents\u002Fcaregivers\n\n* Biological parent or legal guardian of youth\n* Can read and understand English or Spanish\n\nExclusion Criteria:\n\nPatients\u002Fyouth\n\n* Prescription medication for premorbid insomnia\n* Cognitive impairment or developmental delay\n* Does not agree to a 1-week washout if taking over the counter supplements or other sleep aids prior to the start of the study medication\n* High risk for sleep related breathing disorder\n* Chronic medical condition that is severe\u002Fsystemic or requires regular treatment regimen\n* Psychiatric admission in prior 30 days\n* Patients that underwent major surgery in the last 3 months, or those that have not fully recovered from a prior surgery\n* BMI ≥ 99th percentile\n* Enrollment in another therapeutic study\n* Any serious underlying medical or psychiatric condition, that, in the opinion of the investigator, would contraindicate the patient's participation in the study","12 Years",{"count":84,"type":21},45,[24],"The goal of this feasibility clinical trial is to learn if melatonin can help teens having major musculoskeletal surgery by promoting healthy sleep. Melatonin is available as a dietary supplement that may be effective in promoting longer, higher quality sleep. This study will assess the feasibility and acceptability of melatonin for teens undergoing major musculoskeletal surgery, as well as determine optimal measured outcomes (sleep, pain, health-related quality of life) at short- and long-term follow-up.",[88,27,28,89,90,91,92,93],"Juvenile; Scoliosis","Scoliosis;Congenital","Kyphosis","Spondylolisthesis","Pectus Surgery","Hip Surgery",[95,96,97,98,99,100,101,102,103,104,105,106,107,108],"sleep","pain medicine","pediatric pain medicine","melatonin","pilot feasibility trial","acute pain","chronic pain","CPSP","chronic postsurgical pain","spinal fusion surgery","adolescent","perioperative melatonin","hip surgery","pectus surgery","2026-03-16",{"date":111,"type":33},"2026-03-18",{"date":113,"type":33},"2024-05-30",{"date":115,"type":21},"2028-03-31",{"name":117,"class":40},"Stanford University",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":41},"100534745","yoga-for-back-pain-in-adolescent-scoliosis-100534745","NCT06242821","Yoga for Back Pain in Adolescent Scoliosis","Back Pain Management in AIS: Impact of Yoga as Adjunct Treatment","AIS","Inclusion Criteria:\n\n* Non-operatively treated AIS patients at Johns Hopkins Hospital with back pain who are candidates for physical therapy.\n* Cobb angle: greater than 25 degrees,\n* Visual Analog Scale (VAS) Pain score greater than 41\u002F0\n* Braced and Unbraced Patients\n\nExclusion Criteria:\n\n* Scoliosis due to causes other than AIS.\n* AIS patients who have undergone surgery for scoliosis or back pain\n* Age less than 10 years of age or greater than 20 years of age\n* Unable to access zoom on any electronic device","20 Years",{"count":128,"type":21},500,[24],"The Problem: Adolescent Idiopathic Scoliosis (AIS), the pre-eminent spinal pathology affecting over 5% of children and adolescents, presents a pronounced spinal curvature exceeding 10 degrees, with prevalence amongst female adolescents at a ratio of 3:1 compared to males. A significant portion of these patients are not immediate candidates for surgical intervention. The acute shortage of viable non-operative management strategies, which is becoming increasingly imperative given the current barriers to physical therapy access and the growing opioid crisis. The investigator's research intends to explore the addition of a structured yoga protocol to standard of care. This research will thus explore the potential for improved relief and quality-of-life improvements for AIS patients not ready for surgery.\n\nSignificance: AIS is a pervasive condition which correlates with chronic and episodic lower back pain, diminished sleep quality, and depressive symptoms. This extensive comorbid association coupled with the financial pressure to patients and the healthcare system cannot be understated.\n\nNeeds Statement: There is a lack of sufficient non-operative management options for AIS. Many patients face limited access and require supplementary management strategies to address the patient's conditions effectively, creating a significant unmet need for non-pharmacological pain management interventions. This need is further highlighted in the context of the escalating opioid crisis, a leading cause of death among adolescents and young adults.\n\nHypothesis: The introduction of a structured yoga protocol can serve as a non-inferior or even superior alternative to traditional standard of care i management of AIS, addressing both the physical and psychosocial aspects intertwined with the condition.\n\nIMPACT: Change in Problem Significance: This research trial aims to enhance current standard of care for patients grappling with AIS. If the trial demonstrates superiority of yoga, it will delineate a paradigm shift in the current care standards for AIS patients, fostering a move towards a more cost-effective and holistic approach. Yoga could help alleviate the burdens on the healthcare system by reducing costs and enhancing accessibility for patients.\n\nImprovement in Pediatric Orthopedics Practice: By paving the way for non-pharmacological interventions, the trial aspires to mitigate the reliance on opioids for pain management in the pediatric demographic, therefore promoting overall well-being. This project not only seeks to develop alternative pain management strategies amidst a growing opioid epidemic but also champions the cause of improving the quality of life for the pediatric population battling chronic conditions like AIS. It echoes the urgent call to innovate and expand upon the current strategies in place, steering the medical community towards a future where integrative approaches are not the exception but the norm. Ultimately, this research aspires to guide the trajectory of pediatric orthopedics towards a healthcare system that is more inclusive, accessible, and holistically oriented, thereby enhancing the quality of life for pediatric patients grappling with conditions like AIS.\n\n2\\. Objectives (include all primary and secondary objectives) Goals\u002FObjectives: To create a randomized clinical trial aimed to evaluate the efficacy of yoga in conjunction with standard of care treatments for AIS patients.\n\nSPECIFIC AIMS Aim 1: Evaluate the feasibility and challenges of implementing a yoga protocol for AIS patients.\n\nMethodology: Online class attendance, survey completions, and follow-up appointments.\n\nAnticipated Results: Adequate participant adherence and data reliability.\n\nAim 2: Compare clinical outcomes between patients who receive traditional care modalities versus those who added yoga to treatment plan.\n\nMethodology: Utilize validated tools such as the SRS-22 questionnaire and monitor outcomes including depression scale, sleep quality, analgesic usage, activity levels, and Cobb angle.\n\nAnticipated Results: Significant physical and psychological improvements in the yoga group.",[132,27,28,63],"Scoliosis Idiopathic Adolescent Treatment",[134,135],"Adolescent Idiopathic Scoliosis","yoga","2026-01-15",{"date":138,"type":33},"2026-01-16",{"date":140,"type":33},"2025-01-01",{"date":142,"type":21},"2027-03-01",{"name":144,"class":40},"Johns Hopkins University",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":16,"minAge":152,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":155,"phases":4,"briefSummary":156,"conditions":157,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":41},"100287138","scoliosis-survey-to-development-treatment-decision-tool-100287138","NCT03017755","Scoliosis Survey to Development Treatment Decision Tool","Your Scoliosis Journey: A Survey for Patients Treated for Scoliosis and Their Families","Inclusion Criteria:\n\n* Subject (and\u002For parent of subject) who has previously been treated for Adolescent Idiopathic Scoliosis (AIS)\n\nExclusion Criteria:\n\n* Age less than or equal to 12 years","13 Years",{"count":154,"type":21},5000,"OBSERVATIONAL","This is a survey to help understand the influences related to the decision for Adolescent Idiopathic Scoliosis treatment (observation vs. bracing vs. surgery). The investigator then plans to create a decision aid to help families when making a decision about the treatment choice being presented to them.",[28],"2025-12-29",{"date":160,"type":33},"2026-01-02",{"date":162,"type":33},"2017-04-11",{"date":164,"type":21},"2026-12-15",{"name":166,"class":40},"Mayo Clinic",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":174,"targetDuration":4,"studyType":22,"phases":176,"briefSummary":177,"conditions":178,"keywords":179,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":41},"100502190","conservative-management-for-adolescent-idiopathic-scoliosis-100502190","NCT05819034","Conservative Management for Adolescent Idiopathic Scoliosis","Orthotic Management for Controlling Scoliotic Curve Progression in Adolescent Idiopathic Scoliosis","The inclusion criteria will be:\n\n* Adolescents of both sexes with an age range between 10-17 years.\n* They were diagnosed with Adolescent idiopathic scoliosis by an orthopedic specialist, confirmed through (loaded) X- rays.\n* They have mild non-structural scoliosis with Cobb's angle measurement of between 10 and 25 degrees\n* They have Single major thoracolumbar curve located between T6-7 to L1-2, apex at T12 or L1.\n* They have good health conditions except for scoliosis.\n* They can understand and communicate with no mental abnormalities.\n\nThe exclusion criteria will be:\n\n* Adolescents with cerebral palsy or other degenerative neurological disorders;\n* Participants with nutritional disorders e.g. diabetes or vascular disorders.\n* Participants with a scoliotic curve with angle \\> 25° will be excluded.\n* Participants will be excluded from this study if they have inflexible spinal deformities interfering with spinal mobility,\n* Participants who were subjected to any corrective surgery to their spine within the previous two years.\n* Participants will be also excluded if their skin were sensitive or inflamed to any materials used.\n* Participants who have seizures, perceptual disorders, visual problems, and auditory deficits\n* Participants who have leg length discrepancy\n* Participants who have scoliosis developed as a consequence of traumatic scoliosis.",{"count":175,"type":21},60,[24],"Idiopathic scoliosis is a living problem that resists correction. The underlying cause of the such disorder is unknown but directed more toward muscular disorders. However recent clinical observation showed a possible neuromuscular compromise early in those patients. The main purpose of this study is to develop a treatment procedure to correct the degree of bony curvature in patients with Idiopathic scoliosis through developing a neuromuscular corrective approach that might be a more effective conservative treatment protocol for such disorder.",[28],[180,181,182],"Adolescents Idiopathic Scoliosis","Physical Therapy","Orthosis","2025-09-08",{"date":185,"type":33},"2025-09-15",{"date":187,"type":33},"2024-02-01",{"date":189,"type":21},"2025-12-20",{"name":191,"class":40},"Umm Al-Qura University",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":18,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":205,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":41},"100374325","erector-spinae-plane-blockade-in-pediatric-scoliosis-surgery-patients-100374325","NCT04153994","Erector Spinae Plane Blockade in Pediatric Scoliosis Surgery Patients","Pediatric Scoliosis Surgery: Enhanced Recovery With Erector Spinae Plane Blockade Utilizing Surgically Placed Catheters","Inclusion Criteria:\n\n* ASA I-III\n* Diagnosed with Idiopathic scoliosis\n* Undergoing single-stage posterior spinal instrumentation and fusion\n\nExclusion Criteria:\n\n* Thorascopic tethering procedure\n* Two-stage procedure\n* Abnormal developmental profile\n* Congenital\u002Fneuromuscular scoliosis\n* Requiring PICU admission\n* Known allergy to lidocaine\n* Known cardiac, renal or liver disease or dysfunction\n* Pre-existing pain complaints, i.e. on regular analgesic medications\n* Current psychiatric diagnosis, e.g. anxiety, depression, eating disorder, defined according to DSM criteria.\n* Requiring non-standard post-op pain management\n* Any history of seizures\n* Unplanned staged procedure\n* Weight \\\u003C 5th centile or \\> 85th centile for age\n* Porphyria",{"count":200,"type":21},50,[24],"Providing effective analgesia after spinal fusion for idiopathic scoliosis remains a challenge with significant practice variation existing among high volume spine surgery centers. Even in the era of multimodal analgesia, opioids are the primary analgesics used for pain control after pediatric scoliosis surgery, but have multiple known adverse effects. The erector spinae plane block (ESPB) is a newly described fascial plane block performed by injecting local anesthetic between the erector spinae muscle and the transverse process. Additionally, there are case reports describing the ESPB as part of a multi-modal analgesic plan in adult degenerative spine surgery as well as adult spinal deformity surgery, demonstrating effective analgesia and no clinical motor blockade. Although it is known that the inflammatory reaction plays a crucial role in the mechanism of acute pain after major surgery, the effectiveness of the current regional approach on inflammatory response is not well studied.",[204,28],"Scoliosis; Juvenile",[206,207],"Erector Spinae Plane Blockade","Pediatric Scoliosis","2025-04-30",{"date":210,"type":33},"2025-05-01",{"date":212,"type":33},"2020-08-28",{"date":214,"type":21},"2025-12",{"name":117,"class":40},{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":222,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":155,"phases":4,"briefSummary":226,"conditions":227,"keywords":230,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":41},"100355985","quality-of-life-hrqol-of-ais-patients-who-require-bracing-or-surgery-using-srs-22-questionnaire-100355985","NCT03915106","Quality of Life (HRQoL) of AIS Patients Who Require Bracing or Surgery Using SRS-22 Questionnaire","Evaluation of Health-related Quality of Life (HRQoL) of Adolescent Idiopathic Scoliosis (AIS) Patients Who Require Bracing or Surgery Using SRS-22 Questionnaire","QolAISSRS22","Inclusion Criteria:\n\n* AIS patients who attend the scoliosis clinic at specialized outpatient clinic in Prince of Wales hospital and require wearing brace, or patients who suffer from severe scoliosis and require surgery on their first clinic visit\n* Can read and understand either English or Chinese\n\nExclusion Criteria:\n\n* To observe (i.e. not require to wear brace) after clinic visit\n* Cannot read or understand either English or Chinese",{"count":225,"type":21},2000,"Adolescent Idiopathic Scoliosis (AIS) is an unexpected curvature of spine at teenage. AIS causes mainly unpleasant appearance, and sometime comes with pain and difficult to locate or move around. When the spinal curve, or \"Cobb angle\", increases with time, the investigators call it severe condition when the Cobb angle is 60 degrees or above. The severe suffering patients need to be operated to correct their spinal curve by using metallic rods and metallic screws (implants) to fix the spine. In order to avoid this surgery, the investigators use \"brace\", a hard fitting case, trying to control the spinal curve degree by using forces from outside. (bracing) to intervene the spinal curve progression is highly recommended for patients with particular clinical characteristics. However, bracing is not always a present experience apart from function restriction. Clinical recommendation requires the patients to brace over 20 hours everyday, which means the patients have to be \"braced\" around the clock. Patients' perception on being \"braced\" all day, apart from discomforts under bracing, self-image and mental health after bracing are also important psycho-social factors which have yet to be addressed. Based on our clinical experience, 1-2% of AIS patients, undergoing bracing or not (i.e. at observation stage), require surgical intervention due to rapid spinal progression in a short period of time. By definition, surgery will be arranged for patients with major spinal curve ≥50. The use of health-related-quality-of-life (HRQoL) questionnaires allow clinical professionals to explore many different kinds of interests on patients, including the patient's feeling on his\u002Fher medical condition and satisfaction with provided care. Scoliosis Research Society (SRS) patient outcome tool has been a well-accepted HRQoL questionnaire to look for the perception of patients with spinal problems of their status. The SRS-22 questionnaire that has been well accepted as its trustworthy on the score results and SRS-22 is good to be used in patients under different conditions across the disease. This is very important to obtain and compare the scores over time in order to look for any consistent changes. Apart from AIS patients requiring bracing, surgical cases are also very important group of patients to monitor their quality of life before and after surgery, and every follow-up visit after surgery.",[28,61,228,229],"Quality of Life","SRS",[231,232,233,234,235,236],"scoliosis","adolescent idiopathic scoliosis","bracing","surgery","quality of life","questionnaire","2025-02-10",{"date":239,"type":33},"2025-02-12",{"date":241,"type":33},"2019-07-01",{"date":243,"type":21},"2029-07",{"name":245,"class":40},"Chinese University of Hong Kong",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":252,"eligibilityCriteria":253,"healthyVolunteers":254,"sex":16,"minAge":255,"maxAge":4,"enrollmentInfo":256,"targetDuration":4,"studyType":22,"phases":258,"briefSummary":259,"conditions":260,"keywords":265,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":275,"locationsCount":41},"100558666","study-comparing-the-pathkeeper-system-for-pedicle-screw-positioning-in-spine-surgery-with-traditional-care-100558666","NCT06554093","Study Comparing the PathKeeper System for Pedicle Screw Positioning in Spine Surgery With Traditional Care","A Prospective, Dual Canter, Double Armed, Open Label, Clinical Study to Evaluate the Performance of the PathKeeper System for Pedicle Screw Positioning in Spine Surgery","PKSforPSP","Inclusion Criteria:\n\n* Men and women\n* 16 and above years old\n* Patients who are about to undergo open, instrumented spinal surgery\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Men and women\n* 16 and above years old\n* Patients who are about to undergo open, instrumented spinal surgery\n* Signed informed consent form",true,"16 Years",{"count":257,"type":21},32,[24],"The goal of this is to evaluate performance of the Pathkeeper Surgical System. The main question\\[s\\]it aims to answer are: 1) evaluate pedicle screw position Participants will in compare Experimental arm: PathKeeper System (PKS) with control arm",[63,28,261,262,263,264],"Scoliosis Kyphosis","Scoliosis Lumbar Region","Scoliosis Thoracic Region","Pathologic Fracture",[266,267,268],"fusion","screw positioning","screw insertion","2025-02-03",{"date":271,"type":33},"2025-02-05",{"date":273,"type":21},"2025-10-30",{"date":273,"type":21},{"name":276,"class":277},"Deep Health Ltd.","INDUSTRY",{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":285,"enrollmentInfo":286,"targetDuration":4,"studyType":22,"phases":288,"briefSummary":289,"conditions":290,"keywords":292,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":41},"100573954","effects-of-expiratory-muscle-strength-training-in-adolescent-idiopathic-scoliosis-100573954","NCT06752993","Effects of Expiratory Muscle Strength Training in Adolescent Idiopathic Scoliosis","Effects of Expiratory Muscle Strength Training on Cobb Angle, Respiratory Muscle Strength, Core Stabilization, Functional Exercise Capacity and Quality of Life in Adolescent Idiopathic Scoliosis","Inclusion Criteria:\n\n* Individuals diagnosed with idiopathic scoliosis,\n* aged between 10 and 19 years,\n* with a Cobb angle ranging from 10 to 45 degrees.\n\nExclusion Criteria:\n\n* Individuals who have undergone spinal surgery,\n* who have received conservative or surgical treatment for scoliosis,\n* individuals with neurological, neuromuscular, systemic, rheumatological, or musculoskeletal disorders, or conditions affecting balance and walking,\n* individuals with a history of cardiac or pulmonary diseases that could affect respiratory function and exercise capacity.","19 Years",{"count":287,"type":21},24,[24],"Adolescent idiopathic scoliosis result in deterioration of core muscles and respiratory system. Core muscles provide trunk stabilization as well as responsible for respiratory system. Especially tr. abdominis, rectus abdominis, external oblic and internal oblic muscle, which are core muscles, highly active during forced expiration while diaphragm muscle also active during inspiration. Thus, expiratory muscle strength training has effect not only respiratory muscle strength but also trunk stabilization. While, effects of expiratory muscle strength training in adolesecent idiopathic scoliosis is a topic that needs to be investigated, this topic has not been investigated until today. Hence, this current study aimed to investigate the effects of expiratory muscle strength training on cobb angle, respiratory muscle strength, core stabilization, functional exercise capacity and quality of life.",[291,28],"Adolescent Idiopathic Scoliosis (AIS)",[293,294,295,296,297,298],"Adolescent idiopathic scoliosis","Expiratory muscle strength training","Cobb angle","Core stability","Functional exercise capacity","Respiratory muscle stregth","2024-12-20",{"date":301,"type":33},"2024-12-31",{"date":303,"type":21},"2025-01-04",{"date":305,"type":21},"2025-07-02",{"name":307,"class":40},"Gazi University",{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":254,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":315,"targetDuration":4,"studyType":22,"phases":317,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":327,"locationsCount":329},"100330490","phase-2-the-role-of-vitd-in-rehabilitation-of-idiopathic-adolescent-scoliosis-100330490","NCT03582917","The Role of VitD in Rehabilitation of Idiopathic Adolescent Scoliosis","ScoliVit","Inclusion Criteria:\n\n* Idiopathic Adolescent Scoliosis\n* Risser sign \\\u003C3-4\n\nExclusion Criteria:\n\n* Neuromuscular diseases\n* metabolic disease\n* Liver, lung, thyroid and parathyroid gland disorders.",{"count":316,"type":21},80,[318],"PHASE2","The purpose of this current prospective study is to determine the role of vitamin D in the development and restoration of spinal deformities in adolescence.",[28],"2024-12-04",{"date":323,"type":33},"2024-12-06",{"date":325,"type":33},"2018-09-20",{"date":189,"type":21},{"name":328,"class":40},"University of Ioannina",2,{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":338,"enrollmentInfo":339,"targetDuration":4,"studyType":155,"phases":4,"briefSummary":341,"conditions":342,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":41},"100408660","personalized-spine-study-group-pssg-registry-100408660","NCT04601363","Personalized Spine Study Group (PSSG) Registry","Personalized Spine Study Group (PSSG) Registry of Patients With Personalized Spine Rod Implantation","PSSG","Inclusion Criteria:\n\n* Patient has been\u002F will be operated and instrumented with patient-specific rod or spine hardware (control cohort)\n* Patient able to consent or assent\n\nExclusion Criteria:\n\n* Patient unable to sign an informed consent form\n* Patient unable to complete a self-administered questionnaire\n* Patient is pregnant or planning on becoming pregnant during the duration of their study participation\n* Patient is older than 85\n* Patient is younger than 10","85 Years",{"count":340,"type":21},1000,"The primary objective of the study is a data collection initiative. The study will collect clinical and radiographic outcomes of patients implanted with patient specific rods. The secondary objective is to collect clinical and radiographic outcomes of patients with hardware as a control cohort to the patient-specific rods.",[28,343,344,345,346,347,348],"Degenerative Disc Disease","Spinal Fusion","Kyphoscoliosis","Pseudoarthrosis of Spine","Spinal Stenosis","Kyphoses, Scheuermann","2024-10-01",{"date":351,"type":33},"2024-10-03",{"date":353,"type":33},"2020-10-29",{"date":355,"type":21},"2030-04",{"name":357,"class":40},"University of Colorado, Denver",{"id":359,"slug":360,"hasResults":11,"nctId":361,"briefTitle":362,"officialTitle":362,"acronym":4,"eligibilityCriteria":363,"healthyVolunteers":11,"sex":16,"minAge":364,"maxAge":365,"enrollmentInfo":366,"targetDuration":4,"studyType":22,"phases":367,"briefSummary":368,"conditions":369,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":377,"locationsCount":41},"100507488","virtual-realitys-effect-on-decreasing-pain-and-subsequent-opioid-use-in-pediatric-patients-in-the-post-operative-period-following-scoliosis-repair-100507488","NCT05888038","Virtual Reality's Effect on Decreasing Pain and Subsequent Opioid Use in Pediatric Patients in the Post-Operative Period Following Scoliosis Repair","Inclusion Criteria:\n\n* all pediatric patients post scoliosis repair\n* age 7-21\n\nExclusion Criteria:\n\n* age less than 7 years;\n* history of seizures, epilepsy,\n* history of motion sickness\u002Fbalance problems,\n* susceptibility to migraines\n* currently pregnant","7 Years","21 Years",{"count":200,"type":21},[24],"The goal of this study is to determine whether introducing VR in the immediate post-operative period following scoliosis repair can reduce perceived pain and stress in pediatric patients and in turn ultimately decrease opioid use. Based on previous studies that have been performed in other fields of pediatrics showing a decrease in pain and stress with VR use, the investigators hypothesize that VR will significantly decrease patient's reported level of pain and stress immediately following the VR session, and that patients will require less opioids during their inpatient stay as a result.",[204,28,63],"2024-09-10",{"date":372,"type":33},"2024-09-19",{"date":374,"type":33},"2022-09-03",{"date":376,"type":21},"2024-09-30",{"name":378,"class":40},"Northwell Health",{"id":380,"slug":381,"hasResults":11,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":4,"eligibilityCriteria":385,"healthyVolunteers":11,"sex":16,"minAge":364,"maxAge":285,"enrollmentInfo":386,"targetDuration":4,"studyType":22,"phases":388,"briefSummary":389,"conditions":390,"keywords":393,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":41},"100548681","massage-therapy-after-thoracic-or-lumbar-surgery-100548681","NCT06424158","Massage Therapy After Thoracic or Lumbar Surgery","The Impact of Massage Therapy on Post-Surgical Pain, Anxiety, Quality of Life, and Opioid Analgesia Exposure on Children After Thoracic or Lumbar Surgery","Inclusion Criteria:\n\n* Patients scheduled to undergo their first thoracic or lumbar spinal fusion surgery\n* Able to participate and perform in a massage therapy as a recovery option\n* Participant needs to be verbal\n* Ability to understand study procedures and to comply with them for the entire length of the study\n\nExclusion Criteria:\n\n* Prospective patients scheduled to undergo any spinal fusion other than a thoracic or lumbar spinal fusion surgery.\n* Prospective patients scheduled to undergo a second or multiple thoracic or lumbar spinal fusion surgery\n* Previous cardiac surgery\n* Chronic pain syndromes\n* Chronic opioid usage\n* History of psychosis\n* Prolonged bleeding\n* Intubation greater than 24 hours\n* Illicit\u002Frecreation drug use\n* Paralysis diagnosis\n* History of chronic pain requiring medical intervention\n* Neuromuscular scoliosis diagnosis\n* Cerebral palsy diagnosis\n* Developmental delay characteristics",{"count":387,"type":21},100,[24],"The purpose of this research is to look at the effect of massage therapy on the pain, anxiety, and quality of life that pediatric patients have after undergoing spinal fusion surgery. This is a single-site, prospective, randomized, interventional study design that will involve post-thoracic and post-lumbar spinal fusion surgeries of pediatric patients from 7 to 19 years of age that present to Cook Children's Medical Center in Fort Worth, Texas. These patients will be identified prior to their scheduled spinal fusion surgery and recruited to enroll in the study. The planned spinal fusion surgeries are not considered part of this research project, but rather considered standard of care and would occur whether the patient is enrolled in this project or not. Enrolled participants will be followed during their inpatient stay and through their subsequent follow-up visits at weeks 2, 6, and 12. Participants will be randomly assigned to either a massage therapy group or a group that receives the standard (normal) care for recovery after surgery. The final study involvement will occur at week 16 (post-hospital discharge) where a study team member will administer a quality of life (PedsQL) questionnaire via phone or mail with the subject. Data will be collected after study related procedures are completed.",[28,391,392],"Adolescent Idiopathic Scoliosis, Thoracic Region","Adolescent Idiopathic Scoliosis, Lumbar Region",[344,394,395,63],"Massage Therapy","Pain Management","2024-05-22",{"date":398,"type":33},"2024-05-23",{"date":400,"type":33},"2021-02-17",{"date":402,"type":21},"2026-08-01",{"name":404,"class":40},"Cook Children's Health Care System",{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":411,"eligibilityCriteria":412,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":126,"enrollmentInfo":413,"targetDuration":4,"studyType":155,"phases":4,"briefSummary":415,"conditions":416,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":41},"100450456","instrumented-posterolateral-arthrodesis-for-adolescent-idiopathic-scoliosis-100450456","NCT05145725","Instrumented POsterolateral Arthrodesis for Adolescent Idiopathic Scoliosis","Instrumented POsterolateral Arthrodesis for Adolescent Idiopathic Scoliosis: Observational Study","APOSIA","Inclusion Criteria:\n\n* Patient between 12 and 20 years old\n* Scoliosis in adolescents for whom surgery has been proposed based on radiological criteria (Cobb angle\\> 25 ° for thoracolumbar and lumbar scoliosis,\\> 35 ° for thoracic scoliosis and\\> 40 ° for double major scoliosis)\n* Patient affiliated or beneficiary of a social security scheme or attached to a beneficiary of a social security scheme\n* Patient and legal representative having been informed and not opposing this research\n\nExclusion Criteria:\n\n* Patient over 20 years old\n* Non-surgical scoliosis\n* Refusal to participate in the study by the child or parents",{"count":414,"type":21},866,"The study population concerns adolescent patients with idiopathic scoliosis which requires surgical management and who have a longer waiting period of 6 months.\n\nThe aim of this study is to research the predictive factors of an improvement in the quality of life of adolescents who have had surgery.",[28,417],"Arthrodesis","2024-02-28",{"date":420,"type":33},"2024-02-29",{"date":422,"type":33},"2021-03-18",{"date":424,"type":21},"2036-03-18",{"name":426,"class":40},"Elsan"]