[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"scoliosis-correction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:scoliosis-correction":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":36,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100609691","phase-2-intravenous-iron-in-kids-with-iron-deficiency-and-scoliosis-study-100609691",false,"NCT07217873","IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study","IntraVenous Iron in Kids With Iron Deficiency and Scoliosis","IV-KIDS","Inclusion Criteria:\n\n* 10 -19 years old\n* diagnosis of scoliosis or kyphosis\n* scheduled for imminent spinal fusion procedure (\\\u003C6 weeks) at MS-CHONY\n* Iron deficiency or hypoferritinemia, defined as serum ferritin less than or equal to 50 μg\u002FL\n\nExclusion Criteria:\n\n* C-reactive protein \\> 10 mg\u002FL\n* receiving nutritional support by report in the medical chart\n* self-reported history of hypersensitivity reaction to iron-containing supplements\n* self-reported history of receiving intravenous iron supplements\n* self-reported history of iron overloaded state such as hereditary hemochromatosis or hemosiderosis\n* objection to receiving red blood cell transfusions\n* current pregnancy (identified by self-report or documentation of preoperative screening test in the medical record)\n* prisoners\n* patient or parent decides against study participation","ALL","10 Years","19 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE2","PHASE3","Adolescents and young adults undergoing spinal fusion surgery for the correction of scoliosis and other spinal deformity are at high risk of perioperative iron deficiency and anemia, yet the means and evidence for optimizing iron status have not been described in this setting. The proposed study is a randomized controlled trial of preoperative intravenous iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in this vulnerable population. Building evidence for patient blood management interventions such as iron supplementation is vital to ensuring high quality care of surgical patients and may reduce unnecessary transfusions amid recent blood shortages.",[29,30,31,32,33,34,35],"Scoliosis Correction","Iron Deficiency","Transfusion Blood","Surgery Complications","Spinal Fusion","Scoliosis Idiopathic Adolescent","Scoliosis Neuromuscular",[37,38,39,40,41],"scoliosis","iron deficiency","blood transfusion","spinal fusion","iron supplementation","RECRUITING","2025-11-21",{"date":45,"type":46},"2025-11-26","ACTUAL",{"date":43,"type":46},{"date":49,"type":22},"2027-10-31",{"name":51,"class":52},"Columbia University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":66,"conditions":67,"keywords":72,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":53},"100522814","phase-4-different-dose-esketamine-and-dexmedetomidine-for-supplemental-analgesia-and-longterm-outcomes-100522814","NCT06087510","Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes","Impact of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia on Long-term Outcomes After Scoliosis Correction Surgery: Follow-up of a Randomized Trial","Inclusion Criteria:\n\n* Patients aged ≥18 years and body weight≥40 kg;\n* Scheduled to undergo scoliosis correction with pedicle screw fixation;\n* Required patient-controlled intravenous analgesia (PCIA) after surgery.\n\nExclusion Criteria:\n\n* Preoperative sick sinus syndrome, severe sinus bradycardia (heart rate \\\u003C50 beats per minute), atrioventricular block grade II or above without pacemaker, congenital heart disease, arrhythmia, or other serious cardiovascular diseases with a New York Heart Association class ≥III;\n* Patients with moderate or severe obstructive sleep apnea diagnosed preoperatively or according to the STOP-Bang score;\n* History of hyperthyroidism or pheochromocytoma;\n* History of schizophrenia, epilepsy, myasthenia gravis;\n* Severe liver dysfunction (Child-Pugh grade C), severe renal dysfunction (preoperative dialysis), or American Society of Anaesthesiologists grade ≥IV;\n* Barrier in communication;\n* Other conditions that were considered unsuitable for study participation.","18 Years",{"count":63,"type":22},312,[65],"PHASE4","Chronic postsurgical pain (CPSP) refers to pain that occurs or increases after surgery and lasts longer than 3 months. Severe acute postoperative pain is one of the major risk factors of CPSP. Spinal correction surgery is associated with severe pain due to large trauma and long duration. Ketamine and esketamine are N-methyl-D-aspartate receptor antagonists; they have antihyperalgesic effects and may reduce CPSP. Dexmedetomidine is an alpha 2-adrenoceptor agonist with sedative, anxiolytic, and analgesic effect; it is frequently used as an adjuvant to postoperative analgesia. In a previous trial of 200 patients after scoliosis correction surgery, mini-dose esketamine-dexmedetomidine in combination with opioids significantly improved analgesia and sleep quality but did not reduce CPSP. The authors speculate that increasing esketamine dose in the combination may further improve analgesia and, therefore, reduce the occurrence of CPSP.",[29,68,69,70,71],"Postoperative Analgesia","Esketamine","Dexmedetomidine","Chronic Postsurgical Pain",[29,73,69,70,71],"Postoperative analgesia","2025-07-29",{"date":76,"type":46},"2025-07-30",{"date":78,"type":46},"2024-01-24",{"date":80,"type":22},"2026-09",{"name":82,"class":52},"Peking University First Hospital"]