[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"scoliosis-idiopathic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:scoliosis-idiopathic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,42,72,104,135,179,206,233,260,288,312,337,368,394,419,443,466,485],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100639340","tranexamic-acid-in-pediatric-idiopathic-scoliosis-surgery-100639340",false,"NCT07581457","Tranexamic Acid in Pediatric Idiopathic Scoliosis Surgery","Efficacy and Safety of Two Intravenous Tranexamic Acid Regimens Versus Placebo in Pediatric Idiopathic Scoliosis Surgery: A Randomized Double-Blind Trial","Inclusion Criteria:\n\n* Age 10 to 18 years\n* Diagnosis of idiopathic scoliosis requiring surgical correction (posterior spinal fusion)\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Written informed consent from parents or legal guardians and assent from the child\n\nExclusion Criteria:\n\n* Congenital or acquired coagulopathy\n* History of thromboembolic disease\n* History of seizures or epilepsy\n* Known hypersensitivity to tranexamic acid\n* Renal insufficiency (estimated glomerular filtration rate \\\u003C 60 mL\u002Fmin\u002F1.73 m²)\n* Cardiac arrhythmias or cardiovascular disease requiring antiplatelet or anticoagulant therapy","ALL","10 Years","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will evaluate whether tranexamic acid (TXA), a medication used to reduce bleeding, is effective and safe in children undergoing surgery for idiopathic scoliosis. Significant blood loss is common during this type of surgery and often requires blood transfusions.\n\nParticipants will be randomly assigned to one of three groups: (1) TXA given as an intravenous bolus followed by continuous infusion, (2) TXA given as two intravenous bolus doses, or (3) placebo (saline). Neither the patients nor the medical team will know which treatment is given.\n\nThe main goal is to compare how much blood is lost during and after surgery and whether TXA reduces the need for blood transfusions. The study will also assess safety, including the risk of side effects such as seizures or blood clots.\n\nPatients will be followed for up to 30 days after surgery.",[27,28],"Scoliosis Idiopathic","Scoliosis; Adolescence","RECRUITING","2026-06-29",{"date":32,"type":33},"2026-07-01","ACTUAL",{"date":35,"type":21},"2026-06-01",{"date":37,"type":21},"2027-06-30",{"name":39,"class":40},"Poznan University of Medical Sciences","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":53,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100618413","apparent-diffusion-coefficient-of-the-intervertebral-disc-in-children-pilot-study-100618413","NCT07331298","Apparent Diffusion Coefficient of the Intervertebral Disc in Children: Pilot Study","CADDIE","Inclusion Criteria:\n\n* age: patients between 8 and 16 years old\n* Children undergoing magnetic resonance imaging of the lumbar or spinal region as part of their routine care\n* Scoliotic: spinal deformity characterized by a hump on clinical examination and a radiological deformation in the coronal plane greater than 10 ° with no etiology found (idiopathic)\n* Healthy: no hump on clinical examination, walking patients (level 1 and 2 of the global motor function classification system)\n\nExclusion Criteria:\n\n* existence of medullary and vertebral pathology other than scoliosis, history of disc or vertebral infection (spondylo-discitis) on examination, neuro-ectodermal pathology\n* behavioral disturbances incompatible with the performance of the magnetic resonance imaging examination.\n* Refusal of participation.\n* Thoracic scoliosis","8 Years","16 Years",{"count":52,"type":21},60,"30 Days","OBSERVATIONAL","The pathophysiology of adolescent idiopathic scoliosis is unknown. This pathology develops from 10-11 years of age and progresses until skeletal maturity, or even adulthood for the most severe forms.\n\nCurrent knowledge is limited as to its origin on the one hand and the evolutionary nature of scoliosis on the other.\n\nThe mechanical parameters of the intervertebral disc are incompletely known from the deep location of this organ, its fragile nature in vivo and its susceptibility to desiccation during ex-vivo analysis.\n\nTo complete our knowledge of the mechanical parameters of the intervertebral disc of scoliotic and non-scoliotic children, we are proposing an in vivo, non-invasive and non-irradiating study carried out in children who are the main target of this pathology.\n\nThe objective of this work is to characterize the diffusion parameters (apparent diffusion coefficient ADC) of the intervertebral disc in vivo, in a non-invasive and non-irradiating manner by magnetic resonance imaging in children and adolescents. As this measurement has not been carried out in children and adolescents, we want to perform these MRI scans in children free from scoliosis and carriers of scoliosis.",[27],[58,59,60,61],"apparent diffusion coeficient","intervertebral disc","scoliosis","child","2026-06-25",{"date":64,"type":33},"2026-06-26",{"date":66,"type":33},"2026-01-05",{"date":68,"type":21},"2028-04-01",{"name":70,"class":40},"University Hospital, Limoges",2,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":100,"leadSponsor":102,"locationsCount":71},"100641120","effects-of-core-stabilization-exercises-and-rotation-angular-breathing-exercises-among-idiopathic-scoliosis-patients-100641120","NCT07601893","Effects of Core Stabilization Exercises and Rotation Angular Breathing Exercises Among Idiopathic Scoliosis Patients","Effects of Core Stabilization Exercises and Rotational Angular Breathing Exercises on Cobb's Angle, Trunk Rotation, Inspiratory Capacity and Spinal Appearance Among Idopathic Scoliosis Patients","CSE RAB IS","Inclusion Criteria:\n\n* Adolescents aged 10-17 years\n* Both male and female participants\n* Diagnosed cases of idiopathic scoliosis\n* Cobb's angle between 10° and 25°\n* Both thoracic and lumbar spine scoliosis patients\n* Both C-shaped or S-shaped curve scoliosis patients\n\nExclusion Criteria:\n\n* Previous spinal surgery\n* Significant neuromuscular disorders (e.g, muscular dystrophy, cerebral palsy)\n* Other medical conditions affecting participation (e.g, respiratory or cardiac)\n* Any contraindication to exercise program","17 Years",{"count":82,"type":21},32,[24],"This study is a single-blind, two-arm parallel-group randomized controlled trial designed to evaluate the effects of core stabilization exercises combined with rotational angular breathing exercises on adolescents with idiopathic scoliosis. Participants aged 10-18 years with a Cobb angle between 10° and 25° will be randomly assigned to either an experimental group receiving a structured exercise program or a control group receiving standard care.\n\nThe intervention will be conducted over 12 weeks, with outcomes assessed at baseline, post-intervention, and follow-up periods. Primary outcomes include Cobb angle, angle of trunk rotation, inspiratory capacity, and spinal appearance. The study aims to determine whether the combined exercise approach is more effective than standard care in improving spinal alignment, respiratory function, and physical appearance.",[86,27],"Idiopathic Adolescent Scoliosis",[88,89,90,91,92,93,94],"Core stabilization exercises","Rotational Angular Breathing Exercises","Cobb's angle","Inspiratory capacity","Idiopathic scoliosis","Spinal Appearance","Trunk rotation","NOT_YET_RECRUITING","2026-06-16",{"date":98,"type":33},"2026-06-18",{"date":98,"type":21},{"date":101,"type":21},"2026-11-15",{"name":103,"class":40},"Lahore University of Biological and Applied Sciences",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":41},"100575639","phase-3-spinal-bracing-in-adults-with-painful-degenerative-scoliosis-a-randomized-controlled-open-trial-100575639","NCT06774898","Spinal Bracing in Adults With Painful Degenerative Scoliosis: a Randomized Controlled Open Trial","BRASCO","Inclusion Criteria:\n\n* Adults aged 40 to 75 years,\n* Degenerative thoracolumbar or lumbar scoliosis with Cobb angle for the largest curve greater than 20°on EOS® full-spine X-ray less than 1 year (this can be a de-novo scoliosis, or a degenerative scoliosis that appears on an idiopathic scoliosis), and\n* Low back pain with a duration more than 3 months\n* Low back pain with an intensity greater than 40 of 100 points on a self-administered numeric rating scale.\n* Patient able to give written informed consent prior to participation in the study Affiliation with a mode of social security (profit or being entitled).\n\nExclusion Criteria:\n\n* Spinal deformity secondary to a specific condition (e.g. fracture, infection, tumour, inflammatory rheumatic disease, neuromuscular disorder, genetic disorder),\n* History of spine surgery,\n* Morphotype and\u002For conditions making spinal bracing technically impossible (e.g. obesity, severe clinical sagittal and\u002For coronal malalignment, recent abdominal surgery etc)\n* Inability to speak and\u002For read French language,\n* Inability or refusal to wear a custom-molded lumbar-sacral orthosis,\n* Patients already wearing a custom-molded lumbar-sacral orthosis,\n* Cognitive disorders,\n* People under tutorship or curatorship,\n* Protected adults, and\n* Patients on AME (state medical aid),\n* Pregnant or breastfeeding women","40 Years","75 Years",{"count":114,"type":21},130,[116],"PHASE3","The purpose of this study is to compare the efficacy on low back pain intensity at 6 months after randomization of a custom-molded lumbar-sacral orthosis as an add-on therapy to usual care in people with painful adult degenerative scoliosis.",[119,27,120],"Degenerative Scoliosis","Thoracolumbar Scoliosis",[122,123,124,125],"Scoliosis","Low back pain","Spine","Bracing","2026-04-27",{"date":128,"type":33},"2026-05-01",{"date":130,"type":21},"2026-09",{"date":132,"type":21},"2030-09",{"name":134,"class":40},"Assistance Publique - Hôpitaux de Paris",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":143,"maxAge":18,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":147,"conditions":148,"keywords":155,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":41},"100523273","studying-melatonin-and-recovery-in-teens-100523273","NCT06093477","Studying Melatonin and Recovery in Teens","SurgerySMART: Studying Melatonin and Recovery in Teens","SurgerySMART","Inclusion Criteria:\n\nPatients\u002Fyouth:\n\n* Age 12-18 years\n* Participants undergoing elective major musculoskeletal surgery for eligible conditions\n* California state resident\n* Regular access to internet and smartphone\n* Can read and understand English or Spanish\n\nParents\u002Fcaregivers\n\n* Biological parent or legal guardian of youth\n* Can read and understand English or Spanish\n\nExclusion Criteria:\n\nPatients\u002Fyouth\n\n* Prescription medication for premorbid insomnia\n* Cognitive impairment or developmental delay\n* Does not agree to a 1-week washout if taking over the counter supplements or other sleep aids prior to the start of the study medication\n* High risk for sleep related breathing disorder\n* Chronic medical condition that is severe\u002Fsystemic or requires regular treatment regimen\n* Psychiatric admission in prior 30 days\n* Patients that underwent major surgery in the last 3 months, or those that have not fully recovered from a prior surgery\n* BMI ≥ 99th percentile\n* Enrollment in another therapeutic study\n* Any serious underlying medical or psychiatric condition, that, in the opinion of the investigator, would contraindicate the patient's participation in the study","12 Years",{"count":145,"type":21},45,[24],"The goal of this feasibility clinical trial is to learn if melatonin can help teens having major musculoskeletal surgery by promoting healthy sleep. Melatonin is available as a dietary supplement that may be effective in promoting longer, higher quality sleep. This study will assess the feasibility and acceptability of melatonin for teens undergoing major musculoskeletal surgery, as well as determine optimal measured outcomes (sleep, pain, health-related quality of life) at short- and long-term follow-up.",[149,27,28,150,151,152,153,154],"Juvenile; Scoliosis","Scoliosis;Congenital","Kyphosis","Spondylolisthesis","Pectus Surgery","Hip Surgery",[156,157,158,159,160,161,162,163,164,165,166,167,168,169],"sleep","pain medicine","pediatric pain medicine","melatonin","pilot feasibility trial","acute pain","chronic pain","CPSP","chronic postsurgical pain","spinal fusion surgery","adolescent","perioperative melatonin","hip surgery","pectus surgery","2026-03-16",{"date":172,"type":33},"2026-03-18",{"date":174,"type":33},"2024-05-30",{"date":176,"type":21},"2028-03-31",{"name":178,"class":40},"Stanford University",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":22,"phases":189,"briefSummary":190,"conditions":191,"keywords":193,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":41},"100625857","effect-of-kinesio-taping-combined-with-schroth-therapy-in-young-adults-with-idiopathic-scoliosis-100625857","NCT07428083","Effect of Kinesio Taping Combined With Schroth Therapy in Young Adults With Idiopathic Scoliosis","Comparison of Schroth Therapy and Kinesiotaping in Lower Back and Back Pain in Young Adults With Idiopathic Scoliosis: A Double-Blind Placebo-Controlled Randomized Study","Inclusion Criteria:\n\n* Individuals aged between 18 and 30 years.\n* Radiologically confirmed diagnosis of idiopathic scoliosis.\n* Cobb angle between 10° and 30° and considered candidates for conservative treatment.\n* Risser stage 5.\n* History of low back or back pain within the last 3 months (defined as NRS ≥ 4).\n* No acute orthopedic or neurological condition that would prevent participation in physical exercise interventions.\n* Willingness to participate voluntarily and provide written informed consent.\n* Ability to attend treatment sessions regularly throughout the study period.\n\nExclusion Criteria:\n\n* Diagnosis of non-structural (functional) scoliosis, congenital scoliosis, or neuromuscular scoliosis.\n* History of previous spinal surgery.\n* Participation in scoliosis-specific exercise therapy within the last 6 months.\n* Presence of open wounds, dermatological conditions, or allergy to taping materials.\n* History of psychiatric disorders or neurological diseases.","30 Years",{"count":188,"type":21},51,[24],"In this study, the effects of Kinesio Taping methods applied in combination with Schroth therapy on pain and functional capacity in young adults diagnosed with idiopathic scoliosis will be evaluated.\n\nThis study is designed as a randomized controlled trial. Participants will be randomly assigned to one of three groups:\n\nGroup 1: Schroth therapy combined with Kinesio Taping\n\nGroup 2: Schroth therapy alone\n\nGroup 3: Schroth therapy combined with sham Kinesio Taping\n\nKinesio Taping will be applied for 4 weeks. The tape will remain in place for 5 consecutive days, followed by a 2-day rest period for the skin, and this cycle will be repeated throughout the intervention period.\n\nSchroth therapy will be administered 3 times per week for 4 weeks.\n\nAssessments will be conducted at baseline (Week 0), during treatment (Week 2), at the end of treatment (Week 4), and at follow-up (Week 8).\n\nThe primary outcome measures will be pain intensity assessed by the Numeric Rating Scale (NRS) and functional disability assessed by the Oswestry Disability Index (ODI). Secondary outcome measures will include the Scoliosis Research Society-22 (SRS-22) questionnaire and the Patient Global Impression of Change (PGIC) scale.",[27,192],"Kinesio Taping",[194,195,196],"Scoliosis idiopathic","Kinesio taping","Schroth therapy","2026-02-26",{"date":199,"type":33},"2026-03-02",{"date":201,"type":21},"2026-02-01",{"date":203,"type":21},"2026-11-01",{"name":205,"class":40},"Fatih Sultan Mehmet Training and Research Hospital",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":11,"sex":16,"minAge":214,"maxAge":80,"enrollmentInfo":215,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":232},"100623934","post-market-clinical-follow-up-study-of-nemost-v2-100623934","NCT07403084","Post-market Clinical Follow-up Study of NEMOST V2","Post-market Clinical Follow-up Study of NEMOST V2 Growing Domino","NEMOST V2","Inclusion Criteria:\n\n* Idiopathic, congenital, neuromuscular, or syndromic scoliosis : Progressive spinal deformity not managed by orthopedic treatment, and requiring primary surgical intervention.\n* The patient, as well as their parents or legal guardians, are informed of the participation in the study.\n* Patients aged from 5 to 17 yeas old, excepted the one who still have a potential for growth\n\nExclusion Criteria:\n\n* signs of local inflammation;\n* acute or chronic, local or systemic infections ;\n* non-reducible scoliosis ;\n* pathological obesity ;\n* allergy or intolerance to implanted materials;\n* insufficiency or absence of tissue coverage. The NEMOST implant should not be used in a spine that has already been instrumented or fused.","5 Years",{"count":216,"type":21},140,[24],"The NEMOST spinal implant is a growth domino intended for the surgical treatment of progressive scoliosis in children.\n\nAs part of post-market surveillance, EUROS is conducting a retrospective and prospective study to collect clinical and radiological data on the NEMOST growth domino.\n\nRetrospective and prospective multicenter post-market surveillance clinical study.\n\nThis study is interventional, non-randomized, and uncontrolled. The primary objective of this clinical study is to monitor complications related to the NEMOST growth domino during a 5-year postoperative follow-up in patients treated for progressive scoliosis in children.\n\nThe secondary objective of this clinical study is to monitor the performance of the NEMOST growth domino during a 5-year postoperative follow-up in patients treated for progressive scoliosis in children.\n\nThe study will include 140 patients.",[220,27,221],"Scoliosis Neuromuscular","Consent Forms","2026-02-04",{"date":224,"type":33},"2026-02-11",{"date":226,"type":33},"2025-12-19",{"date":228,"type":21},"2033-12-19",{"name":230,"class":231},"EUROS","INDUSTRY",5,{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":241,"enrollmentInfo":242,"targetDuration":4,"studyType":22,"phases":244,"briefSummary":245,"conditions":246,"keywords":248,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":41},"100534745","yoga-for-back-pain-in-adolescent-scoliosis-100534745","NCT06242821","Yoga for Back Pain in Adolescent Scoliosis","Back Pain Management in AIS: Impact of Yoga as Adjunct Treatment","AIS","Inclusion Criteria:\n\n* Non-operatively treated AIS patients at Johns Hopkins Hospital with back pain who are candidates for physical therapy.\n* Cobb angle: greater than 25 degrees,\n* Visual Analog Scale (VAS) Pain score greater than 41\u002F0\n* Braced and Unbraced Patients\n\nExclusion Criteria:\n\n* Scoliosis due to causes other than AIS.\n* AIS patients who have undergone surgery for scoliosis or back pain\n* Age less than 10 years of age or greater than 20 years of age\n* Unable to access zoom on any electronic device","20 Years",{"count":243,"type":21},500,[24],"The Problem: Adolescent Idiopathic Scoliosis (AIS), the pre-eminent spinal pathology affecting over 5% of children and adolescents, presents a pronounced spinal curvature exceeding 10 degrees, with prevalence amongst female adolescents at a ratio of 3:1 compared to males. A significant portion of these patients are not immediate candidates for surgical intervention. The acute shortage of viable non-operative management strategies, which is becoming increasingly imperative given the current barriers to physical therapy access and the growing opioid crisis. The investigator's research intends to explore the addition of a structured yoga protocol to standard of care. This research will thus explore the potential for improved relief and quality-of-life improvements for AIS patients not ready for surgery.\n\nSignificance: AIS is a pervasive condition which correlates with chronic and episodic lower back pain, diminished sleep quality, and depressive symptoms. This extensive comorbid association coupled with the financial pressure to patients and the healthcare system cannot be understated.\n\nNeeds Statement: There is a lack of sufficient non-operative management options for AIS. Many patients face limited access and require supplementary management strategies to address the patient's conditions effectively, creating a significant unmet need for non-pharmacological pain management interventions. This need is further highlighted in the context of the escalating opioid crisis, a leading cause of death among adolescents and young adults.\n\nHypothesis: The introduction of a structured yoga protocol can serve as a non-inferior or even superior alternative to traditional standard of care i management of AIS, addressing both the physical and psychosocial aspects intertwined with the condition.\n\nIMPACT: Change in Problem Significance: This research trial aims to enhance current standard of care for patients grappling with AIS. If the trial demonstrates superiority of yoga, it will delineate a paradigm shift in the current care standards for AIS patients, fostering a move towards a more cost-effective and holistic approach. Yoga could help alleviate the burdens on the healthcare system by reducing costs and enhancing accessibility for patients.\n\nImprovement in Pediatric Orthopedics Practice: By paving the way for non-pharmacological interventions, the trial aspires to mitigate the reliance on opioids for pain management in the pediatric demographic, therefore promoting overall well-being. This project not only seeks to develop alternative pain management strategies amidst a growing opioid epidemic but also champions the cause of improving the quality of life for the pediatric population battling chronic conditions like AIS. It echoes the urgent call to innovate and expand upon the current strategies in place, steering the medical community towards a future where integrative approaches are not the exception but the norm. Ultimately, this research aspires to guide the trajectory of pediatric orthopedics towards a healthcare system that is more inclusive, accessible, and holistically oriented, thereby enhancing the quality of life for pediatric patients grappling with conditions like AIS.\n\n2\\. Objectives (include all primary and secondary objectives) Goals\u002FObjectives: To create a randomized clinical trial aimed to evaluate the efficacy of yoga in conjunction with standard of care treatments for AIS patients.\n\nSPECIFIC AIMS Aim 1: Evaluate the feasibility and challenges of implementing a yoga protocol for AIS patients.\n\nMethodology: Online class attendance, survey completions, and follow-up appointments.\n\nAnticipated Results: Adequate participant adherence and data reliability.\n\nAim 2: Compare clinical outcomes between patients who receive traditional care modalities versus those who added yoga to treatment plan.\n\nMethodology: Utilize validated tools such as the SRS-22 questionnaire and monitor outcomes including depression scale, sleep quality, analgesic usage, activity levels, and Cobb angle.\n\nAnticipated Results: Significant physical and psychological improvements in the yoga group.",[247,27,28,122],"Scoliosis Idiopathic Adolescent Treatment",[249,250],"Adolescent Idiopathic Scoliosis","yoga","2026-01-15",{"date":253,"type":33},"2026-01-16",{"date":255,"type":33},"2025-01-01",{"date":257,"type":21},"2027-03-01",{"name":259,"class":40},"Johns Hopkins University",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":16,"minAge":267,"maxAge":50,"enrollmentInfo":268,"targetDuration":4,"studyType":22,"phases":270,"briefSummary":271,"conditions":272,"keywords":273,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":71},"100606582","inspiratory-muscle-training-in-children-and-adolescents-with-idiopathic-scoliosis-undergoing-schroth-therapy-100606582","NCT07177430","Inspiratory Muscle Training in Children and Adolescents With Idiopathic Scoliosis Undergoing Schroth Therapy.","The Effect of Inspiratory Muscle Training on Respiratory Function, Exercise Tolerance and Core Stability in Children and Adolescents With Idiopathic Scoliosis Undergoing Schroth Therapy.","Inclusion Criteria:\n\n* diagnosed idiopathic scoliosis,\n* age: 11-16 years (girls after their first period, boys after voice mutation),\n* spinal curvature angle \\> 20° according to Cobb,\n* guardian's consent to participate in the study;\n\nExclusion Criteria:\n\n* chronic respiratory diseases,\n* inhalant allergies,\n* limited contact with the patient, preventing the examination from being performed;","11 Years",{"count":269,"type":21},56,[24],"This study evaluates the effectiveness of inspiratory muscle training in children and adolescents with idiopathic scoliosis undergoing therapy with the Schroth method.\n\nThe intervention- inspiratory muscle training- aims to improve respiratory function, increase exercise tolerance, and strengthen core stability in the participants.\n\nThe proposed training may enhance the effectiveness of therapy conducted using the Schroth method and improve participants' performance in activities of daily living.\n\nThe project aims to assess the impact of inspiratory muscle training in children and adolescents with idiopathic scoliosis on respiratory system function, exercise tolerance, and core stability.",[27],[274,275,276,277,278],"Inspiratory Muscle Training","Schroth method","Exercise tolerance","Core stability","Respiratory function","2025-11-30",{"date":281,"type":33},"2025-12-05",{"date":283,"type":33},"2025-10-13",{"date":285,"type":21},"2027-07",{"name":287,"class":40},"Wroclaw University of Health and Sport Sciences",{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":297,"conditions":298,"keywords":301,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":308,"leadSponsor":310,"locationsCount":41},"100614175","reliability-of-the-scoliosis-caregiver-response-and-emotional-scale-scares-questionnaire-100614175","NCT07276178","Reliability of the Scoliosis Caregiver Response and Emotional Scale (SCaRES) Questionnaire","Reliability of the Turkish Version of the Scoliosis Caregiver Response and Emotional Scale (SCaRES) Questionnaire","Inclusion Criteria:\n\n* Individuals who are an adult (parent or primary caregiver) responsible for the care of an individual diagnosed with scoliosis between the ages of 10 and 18.\n* Individuals who are able to read and understand Turkish.\n* Individuals who are actively involved in the child's treatment process (e.g., use of a brace, exercise program, follow-up appointments).\n* Individuals who volunteer to participate in the study.\n\nExclusion Criteria:\n\n* Participants whose children have a history of other comorbidities (neurological, etc.),\n* Children whose children have a history of spinal surgery,\n* Individuals who do not have an active role in the care process (e.g., parents who only provide financial support),\n* Caregivers with intellectual disabilities, serious psychiatric diagnoses, or cognitive impairments that limit communication,\n* Participants with incomplete or invalid survey forms.",{"count":296,"type":21},23,"The aim of this study is to examine the psychometric properties of the Turkish version of the Scoliosis Caregiver Response and Emotional Scale (SCaRES) questionnaire; to evaluate the reliability of the Turkish form and to ensure its usability in clinical and research fields.",[27,299,300],"Scoliosis Idiopathic Adolescent","Caregiver Anxiety",[299,302,303],"Reliability","Caregiver","2025-11-28",{"date":306,"type":33},"2025-12-10",{"date":306,"type":21},{"date":309,"type":21},"2026-03-10",{"name":311,"class":40},"Hasan Kalyoncu University",{"id":313,"slug":314,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":318,"eligibilityCriteria":319,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":80,"enrollmentInfo":320,"targetDuration":4,"studyType":22,"phases":322,"briefSummary":323,"conditions":324,"keywords":325,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":41},"100603380","paravertebral-muscles-assessment-using-high-resolution-mri-in-idiopathic-or-neuromuscular-scoliosis-children-100603380","NCT07135765","Paravertebral Muscles Assessment Using High-resolution MRI in Idiopathic or Neuromuscular Scoliosis Children","Paravertebral Muscles Assessment Using High-resolution MRI in Children Suffering From Idiopathic or Neuromuscular Scoliosis","MRISCOL","Inclusion Criteria:\n\n* Children and adolescents aged 10 to 17 years old,\n* Scoliosis (idiopathic or neuromuscular) that is not collapsing\n* Cobb angle \\\u003C40°\n* Female preferred\n* Patient able to walk\n* Average or low BMI \\\u003C20kg\u002Fm2\n* Signature of informed consent by legal guardians\n* Affiliation with a social security scheme (beneficiary or dependent).\n\nExclusion Criteria:\n\n* Refusal of the patient and\u002For parents to participate in the study\n* Inability to cooperate\n* Subject with a contraindication to MRI\n* History of spinal surgery\n* Not affiliated with a social security scheme (beneficiary or entitled person)",{"count":321,"type":21},10,[24],"Scoliosis is a common three-dimensional spinal deformity defined by vertebral rotation.\n\nApart from collapse scoliosis, clinical and radiological similarities have been observed in children with secondary scoliosis of neuromuscular origin and children with idiopathic scoliosis in terms of the location and type of curvature.\n\nIt seems relevant to study the axial musculature in these children in more detail, particularly the deep muscles (transversospinales muscles) that have a stabilising and rotational function (multifidi and rotatores).\n\nMRI is a non-invasive, non-irradiating technique used in the aetiological diagnosis of idiopathic scoliosis before adolescence and in the diagnosis of secondary scoliosis. However, the muscles are not specifically studied during these examinations. They are performed to analyse the spinal cord and rule out hinge deformities, although this technique does provide information on the paravertebral muscles.\n\nThe muscles of interest should be analysed using the usual sequences, with the addition of a sequence (DTI) specific to the study of deep muscles in children undergoing axial MRI. This adds 5 minutes to the standard MRI procedure.\n\nSeveral morphological muscle parameters would be thus obtained on specific interest areas and then compared between right and left side and between two groups of children, 5 suffering from idiopathic scoliosis and 5 with neuromuscular scoliosis.\n\nIdiopathic scoliosis corresponds to a heterogeneous group of patients in terms of the location, number and progression of the curves. The research hypothesis is that there may be a subgroup of patients with idiopathic scoliosis whose progression and\u002For aetiology is muscular in origin.\n\nMRI could then become a routine examination in the assessment of all scoliosis, whether idiopathic or not.",[122,27,220],[60,326,27,220,327,328],"MRI","spine","Children","2025-08-20",{"date":331,"type":33},"2025-08-22",{"date":333,"type":33},"2025-07-17",{"date":335,"type":21},"2027-08",{"name":134,"class":40},{"id":338,"slug":339,"hasResults":11,"nctId":340,"briefTitle":341,"officialTitle":341,"acronym":4,"eligibilityCriteria":342,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":343,"targetDuration":4,"studyType":22,"phases":345,"briefSummary":346,"conditions":347,"keywords":348,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":41},"100597528","synergic-effects-of-schroth-method-with-and-without-core-stabilization-exercises-in-idiopathic-scoliosis-patients-100597528","NCT07059663","Synergic Effects of Schroth Method With and Without Core Stabilization Exercises in Idiopathic Scoliosis Patients","Inclusion Criteria:\n\n* • Age 10 to 18\n\n  * X-ray diagnosed of idiopathic scoliosis with Cobb Angle 10˚- 30˚\n  * Participants with Idiopathic Scoliosis\n  * Both genders will be included\n  * Scoliosis with Down syndrome.\n\nExclusion Criteria:\n\n* Any neurological condition such as cerebral palsy or epilepsy.\n* Any other orthopedic condition such as hip dysplasia, osteogenesis imperfecta, or leg length discrepancy.\n* Surgical history of the spine, such as spinal fusion and decompression surgery.\n* Severe systemic disorders such as autoimmune disorders, severe cardiovascular conditions\n* Non-Idiopathic Scoliosis",{"count":344,"type":21},72,[24],"A randomized controlled trial was conducted on 72 patients diagnosed with idiopathic scoliosis at the University of Lahore Teaching Hospital. The study aimed to explore the synergistic effects of the Schroth method with and without core stabilization exercises. Participants were randomly allocated into two groups: Group A, which received both the Schroth method and core stabilization exercises, and Group B, which received only the Schroth method. The intervention lasted for 10 weeks, with assessments conducted at baseline, the 5th week, and the 10th week. Outcome measures included Cobb angle (spinal curvature), lumbar extensor endurance (Sorensen test), chest mobility, and quality of life (SRS-22 questionnaire). The study found significant improvements in all outcome measures for both groups, with Group A showing superior results. The addition of core stabilization exercises to the Schroth method resulted in better reductions in Cobb angle, enhanced lumbar extensor endurance, and improved chest mobility and quality of life, indicating a synergistic effect of the combined approach. The findings suggest that incorporating core stabilization exercises into scoliosis treatment protocols can lead to superior clinical outcomes.",[122,27],[349,350,351,352,353,354,355,356,357,358],"Schroth Method","Idiopathic Scoliois","Core Stabilization Exercises","Cobb Angle","Lumbar Extensor Endurance","Chest mobility","SRS-22 questionnaire","Postural correction","Spinal deformity","Physiotherapy","2025-07-10",{"date":361,"type":33},"2025-07-15",{"date":363,"type":21},"2025-07-30",{"date":365,"type":21},"2026-01-30",{"name":367,"class":40},"University of Lahore",{"id":369,"slug":370,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":11,"sex":16,"minAge":374,"maxAge":80,"enrollmentInfo":375,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":377,"conditions":378,"keywords":381,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":41},"100592376","zhejiang-adolescent-spine-and-vision-health-cohort-a-longitudinal-database-analysis-100592376","NCT06992622","Zhejiang Adolescent Spine and Vision Health Cohort: A Longitudinal Database Analysis","Inclusion Criteria:\n\n* Diagnosis of idiopathic scoliosis at their first clinic visit\n* Skeletally immature (Risser Sign 0-3)\n* Cobb angle between 11-40 degrees\n* Age between 6 and 17\n\nExclusion Criteria:\n\n* • Patients with scoliosis other than idiopathic, or with other musculoskeletal or neurodevelopmental conditions that might be responsible for the scoliosis\n\n  * History of previous spine surgery or spinal injury\n  * Tumor or malignant tumor in the spine\n  * Leg length discrepancy more than 20 mm\n  * Previous diagnosis or treatment of SDB more than 6 months ago\n  * Plans to relocate within the next 24 months","6 Years",{"count":376,"type":21},73000,"The aim of study: 1. To investigate the prevalence of scoliosis, other spinal deformities, myopia, and visual impairments in adolescents (aged 6-18) in Zhejiang Province.\n\n2.To track 8-year dynamic changes in spinal curvature and analyze associations between scoliosis, vision disorders, and potential risk factors.\n\n3.To deliver scoliosis health education during screenings.\n\n4.To mitigate scoliosis progression through early detection and intervention.",[27,379,380],"Myopia","Vision Disorders",[382,383,384],"Adolescent idiopathic scoliosis","Longitudinal progression","Spine-vision comorbidity","2025-05-19",{"date":387,"type":33},"2025-05-28",{"date":389,"type":33},"2024-09-30",{"date":391,"type":21},"2032-12-30",{"name":393,"class":40},"Second Affiliated Hospital of Wenzhou Medical University",{"id":395,"slug":396,"hasResults":11,"nctId":397,"briefTitle":398,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":11,"sex":16,"minAge":401,"maxAge":186,"enrollmentInfo":402,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":404,"conditions":405,"keywords":406,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":418},"100503097","pmcf-post-market-clinical-follow-up-study-on-the-tether-in-uk-united-kingdom-100503097","NCT05830825","PMCF (Post-Market Clinical Follow-up) Study on The Tether™ in UK (United Kingdom)","The Tether™ - Vertebral Body Tethering System Post-Market Clinical Follow-Up Study in UK","Inclusion Criteria:\n\n* Diagnosis of progressive idiopathic scoliosis;\n* Skeletally immature, based on both Risser (\\\u003C5) and Sanders (\\\u003C8) assessments;\n* Major Cobb angle ≥30° and ≤65°;\n* Osseous structure dimensionally adequate to accommodate screw fixation, as determined by radiographic imaging;\n* Failed bracing and\u002For be intolerant to brace wear;\n* Lenke Type 1 curves (i.e., main thoracic);\n* Signed Informed Consent Form by legal guardian or by the patient if ≥ 16 years old.\n* The decision to treat patients with The Tether™ - VBT System was made by the patient's clinician outside of this research\n\nExclusion Criteria:\n\n* Presence of any systemic infection, local infection, or skin compromise at the surgical site;\n* Prior spinal surgery at the level(s) to be treated;\n* Known poor bone quality defined as a T-score -1.5 or less;\n* Skeletal maturity;\n* Any other medical or surgical condition which would preclude the potential benefit of spinal surgery, such as coagulation disorders, allergies to the implant materials, and patients unwillingness or inability to cooperate with post-operative care instructions;\n* Unwillingness, inability, or living situation (e.g., custody arrangements, homelessness, detention) that would preclude ability to return to the study site for follow-up visits as described in protocol and Informed Consent;\n* Patients who are pregnant at the time of enrollment.","0 Years",{"count":403,"type":21},100,"The goal of this observational study is to collect information about The Tether™ device in participants with progressive idiopathic scoliosis, Lenke Type 1 curves. The main purpose is to provide assessment of:\n\n* ongoing safety\n* probable benefits Participants who will receive The Tether™ during spine surgery will have to attend follow-up visits which are part of standard-of-care.",[27],[407,408],"Vertebral Body Tethering","Fusionless Spine Surgery","2025-03-20",{"date":411,"type":33},"2025-03-21",{"date":413,"type":33},"2024-07-18",{"date":415,"type":21},"2033-12",{"name":417,"class":231},"LDR Médical SAS",3,{"id":420,"slug":421,"hasResults":11,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":4,"eligibilityCriteria":425,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":186,"enrollmentInfo":426,"targetDuration":4,"studyType":22,"phases":428,"briefSummary":429,"conditions":430,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":41},"100559362","a-suggested-rehabilitation-protocol-for-the-treatment-of-c-shape-scoliosis-100559362","NCT06563141","A Suggested Rehabilitation Protocol for the Treatment of C-shape Scoliosis","A Suggested Rehabilitation Protocol for the Treatment of C-shape Scoliosis: a Randomized Control Trial","Inclusion Criteria:\n\n1. Adult individuals aged 18 to 30 years (after complete ossification and before the start of the ageing process and joint changes) as mentioned in studies.\n2. Thoracolumbar scoliosis with Cobb angle between 10 to 30 degrees because a curve below 10 degrees has no effect and above 30 is indicated for surgery.\n\nExclusion Criteria:\n\n1. History of orthopaedic surgeries.\n2. History of road traffic accidents (RTA).\n3. Myopathy.\n4. True leg length discrepancy.\n5. Neuropathy.\n6. Mental disorders.\n7. Bone tumor.\n8. Heart disease or circulatory problems.\n9. Early osteoporosis.",{"count":427,"type":21},70,[24],"This study aims to compare the effectiveness of mechanical traction and 3D apical vertebral mobilization and active exercises on Cobb's angle, spinal ROM, and function in patients with C-shaped scoliosis.",[431,27,432,433],"Idiopathic Scoliosis","Rehabilitation","C-shape","2024-08-17",{"date":436,"type":33},"2024-08-20",{"date":438,"type":33},"2024-07-01",{"date":440,"type":21},"2025-05-01",{"name":442,"class":40},"Cairo University",{"id":444,"slug":445,"hasResults":11,"nctId":446,"briefTitle":447,"officialTitle":448,"acronym":4,"eligibilityCriteria":449,"healthyVolunteers":11,"sex":16,"minAge":374,"maxAge":450,"enrollmentInfo":451,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":453,"conditions":454,"keywords":457,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":465,"locationsCount":41},"100554709","idiopathic-scoliosis-new-onset-and-melatonin-phase-delay-in-children-100554709","NCT06502613","Idiopathic Scoliosis New Onset and Melatonin Phase Delay in Children","Melatonin Phase Delay May Increase Risk of Children and Adolescent Idiopathic Scoliosis.","Inclusion Criteria:\n\n* Collect saliva according to standards and complete melatonin testing\n\n  * Complete scoliometer or X-ray assess scoliosis\n  * Skeletally immature (Risser Sign 0-3)\n  * Age between 6 and 15\n  * Patients can understand and complete the MEQ-5, PSQ, and PSQI Questionnaire at baseline and follow-up visits\n  * Informed Consent Form signed by subject or the guardian\n\nExclusion Criteria:\n\n\\-","15 Years",{"count":452,"type":21},956,"This study aimed to investigate the prevalence and clinical significance of melatonin phase delay in children with new onset and progressive idiopathic scoliosis (IS).",[27,455,456],"Circadian Rhythm","Melatonin",[456,122],"2024-07-14",{"date":460,"type":33},"2024-07-16",{"date":462,"type":21},"2024-08-01",{"date":464,"type":21},"2027-07-15",{"name":393,"class":40},{"id":467,"slug":468,"hasResults":11,"nctId":469,"briefTitle":470,"officialTitle":470,"acronym":4,"eligibilityCriteria":471,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":472,"targetDuration":214,"studyType":54,"phases":4,"briefSummary":474,"conditions":475,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":476,"lastUpdatePostDateStruct":477,"startDateStruct":479,"completionDateStruct":481,"leadSponsor":483,"locationsCount":321},"100401310","the-tether---vertebral-body-tethering-system-post-approval-study-100401310","NCT04505579","The Tether™ - Vertebral Body Tethering System Post Approval Study","Inclusion Criteria:\n\n* Diagnosis of progressive idiopathic scoliosis\n* Skeletally immature, based on both Risser (\\\u003C5) and Sanders (\\\u003C8) assessments\n* Major Cobb angle ≥30° and ≤65°\n* Osseous structure dimensionally adequate to accommodate screw fixation, as determined by radiographic imaging\n* Failed or intolerant to bracing\n\nExclusion Criteria:\n\n* Presence of any systemic infection, local infection, or skin compromise at the surgical site\n* Prior spinal surgery at the level(s) to be treated\n* Documented poor bone quality, defined as a T-score -1.5 or less\n* Any other medical or surgical condition which would preclude the potential benefit of spinal surgery, such as coagulation disorders, allergies to the implant materials, and patient's unwillingness or inability to cooperate with post-operative care instructions\n* Unwillingness, inability, or living situation (e.g. custody arrangements, homelessness, detention) that would preclude ability to return to the study site for follow-up visits as described in protocol and Informed Consent\n* Unwillingness to sign Informed Consent Form and participate in study procedures",{"count":473,"type":21},200,"This study is an opportunity to provide continued reasonable assurance of the safety and probable benefit of The Tether HUD. The study will collect long term safety and efficacy information from patients who have had their idiopathic scoliosis treated via anterior vertebral body tethering (AVBT) with The Tether.",[27],"2024-02-21",{"date":478,"type":33},"2024-02-22",{"date":480,"type":33},"2020-10-29",{"date":482,"type":21},"2027-12-31",{"name":484,"class":231},"ZimVie",{"id":486,"slug":487,"hasResults":11,"nctId":488,"briefTitle":489,"officialTitle":489,"acronym":4,"eligibilityCriteria":490,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":18,"enrollmentInfo":491,"targetDuration":4,"studyType":22,"phases":493,"briefSummary":494,"conditions":495,"keywords":496,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":507},"100432699","a-prospective-analysis-of-long-term-clinical-outcomes-and-3d-spine-growth-in-anterior-vertebral-body-tethering-100432699","NCT04914507","A Prospective Analysis of Long-Term Clinical Outcomes and 3D Spine Growth in Anterior Vertebral Body Tethering","Inclusion Criteria: Skeletally immature patients that receive AVBT surgical treatment to obtain and maintain correction of progressive idiopathic scoliosis. Specifically:\n\n* Diagnosis of idiopathic scoliosis\n* Planned recipient of AVBT surgical treatment\n* Skeletally immature\n* Major Cobb angle ≥30° and ≤65°\n* Osseous structure dimensionally adequate to accommodate screw fixation, as determined by radiographic imaging\n* Failed or intolerant to bracing\n\nExclusion Criteria:\n\n* Presence of any systemic infection, local infection, or skin compromise at the anticipated surgical site\n* Prior spinal surgery at the level(s) to be treated\n* Evidence of documented poor bone quality\n* Any other medical or surgical condition which would preclude the potential benefit of spinal surgery, such as coagulation disorders, allergies to the implant materials, and patient's unwillingness or inability to cooperate with post-operative care instructions as determined by the treating physician\n* Unwillingness, inability, or living situation (e.g. custody arrangements, homelessness, detention) that would preclude ability to return to the study site for follow-up visits as described in protocol and Informed Consent\n* Unwillingness to sign Informed Consent Form and participate in study procedures",{"count":492,"type":21},106,[24],"Anterior vertebral body tethering (AVBT) is a novel, minimally invasive, growth modulation technique that was recently approved by the FDA under a Humanitarian Device Exemption (HDE). The goal of AVBT is to control curve progression by applying compression on the convex side of the spine deformity. While there has been great initial enthusiasm about the technique as an alternate treatment option to spinal fusion for skeletally immature children with scoliosis, there is a need to better understand the long-term outcomes.\n\nThe purpose of this study is to report the long-term clinical outcomes of skeletally immature patients treated with AVBT, specifically:\n\n1. The effect on three-dimensional spine growth as compared to normal controls\n2. Maintenance of major Cobb angle less than or equal to 50 degrees at skeletal maturity\n3. Complications associated with both the procedure and the device",[27],[497],"anterior vertebral body tethering","2023-11-14",{"date":500,"type":33},"2023-11-15",{"date":502,"type":33},"2021-09-09",{"date":504,"type":21},"2029-09",{"name":506,"class":40},"Pediatric Spine Foundation",12]