[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"scoliosis-neuromuscular\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:scoliosis-neuromuscular":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100623934","post-market-clinical-follow-up-study-of-nemost-v2-100623934",false,"NCT07403084","Post-market Clinical Follow-up Study of NEMOST V2","Post-market Clinical Follow-up Study of NEMOST V2 Growing Domino","NEMOST V2","Inclusion Criteria:\n\n* Idiopathic, congenital, neuromuscular, or syndromic scoliosis : Progressive spinal deformity not managed by orthopedic treatment, and requiring primary surgical intervention.\n* The patient, as well as their parents or legal guardians, are informed of the participation in the study.\n* Patients aged from 5 to 17 yeas old, excepted the one who still have a potential for growth\n\nExclusion Criteria:\n\n* signs of local inflammation;\n* acute or chronic, local or systemic infections ;\n* non-reducible scoliosis ;\n* pathological obesity ;\n* allergy or intolerance to implanted materials;\n* insufficiency or absence of tissue coverage. The NEMOST implant should not be used in a spine that has already been instrumented or fused.","ALL","5 Years","17 Years",{"count":21,"type":22},140,"ESTIMATED","INTERVENTIONAL",[25],"NA","The NEMOST spinal implant is a growth domino intended for the surgical treatment of progressive scoliosis in children.\n\nAs part of post-market surveillance, EUROS is conducting a retrospective and prospective study to collect clinical and radiological data on the NEMOST growth domino.\n\nRetrospective and prospective multicenter post-market surveillance clinical study.\n\nThis study is interventional, non-randomized, and uncontrolled. The primary objective of this clinical study is to monitor complications related to the NEMOST growth domino during a 5-year postoperative follow-up in patients treated for progressive scoliosis in children.\n\nThe secondary objective of this clinical study is to monitor the performance of the NEMOST growth domino during a 5-year postoperative follow-up in patients treated for progressive scoliosis in children.\n\nThe study will include 140 patients.",[28,29,30],"Scoliosis Neuromuscular","Scoliosis Idiopathic","Consent Forms","RECRUITING","2026-02-04",{"date":34,"type":35},"2026-02-11","ACTUAL",{"date":37,"type":35},"2025-12-19",{"date":39,"type":22},"2033-12-19",{"name":41,"class":42},"EUROS","INDUSTRY",5,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100609691","phase-2-intravenous-iron-in-kids-with-iron-deficiency-and-scoliosis-study-100609691","NCT07217873","IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study","IntraVenous Iron in Kids With Iron Deficiency and Scoliosis","IV-KIDS","Inclusion Criteria:\n\n* 10 -19 years old\n* diagnosis of scoliosis or kyphosis\n* scheduled for imminent spinal fusion procedure (\\\u003C6 weeks) at MS-CHONY\n* Iron deficiency or hypoferritinemia, defined as serum ferritin less than or equal to 50 μg\u002FL\n\nExclusion Criteria:\n\n* C-reactive protein \\> 10 mg\u002FL\n* receiving nutritional support by report in the medical chart\n* self-reported history of hypersensitivity reaction to iron-containing supplements\n* self-reported history of receiving intravenous iron supplements\n* self-reported history of iron overloaded state such as hereditary hemochromatosis or hemosiderosis\n* objection to receiving red blood cell transfusions\n* current pregnancy (identified by self-report or documentation of preoperative screening test in the medical record)\n* prisoners\n* patient or parent decides against study participation","10 Years","19 Years",{"count":55,"type":22},120,[57,58],"PHASE2","PHASE3","Adolescents and young adults undergoing spinal fusion surgery for the correction of scoliosis and other spinal deformity are at high risk of perioperative iron deficiency and anemia, yet the means and evidence for optimizing iron status have not been described in this setting. The proposed study is a randomized controlled trial of preoperative intravenous iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in this vulnerable population. Building evidence for patient blood management interventions such as iron supplementation is vital to ensuring high quality care of surgical patients and may reduce unnecessary transfusions amid recent blood shortages.",[61,62,63,64,65,66,28],"Scoliosis Correction","Iron Deficiency","Transfusion Blood","Surgery Complications","Spinal Fusion","Scoliosis Idiopathic Adolescent",[68,69,70,71,72],"scoliosis","iron deficiency","blood transfusion","spinal fusion","iron supplementation","2025-11-21",{"date":75,"type":35},"2025-11-26",{"date":73,"type":35},{"date":78,"type":22},"2027-10-31",{"name":80,"class":81},"Columbia University","OTHER",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":19,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":82},"100603380","paravertebral-muscles-assessment-using-high-resolution-mri-in-idiopathic-or-neuromuscular-scoliosis-children-100603380","NCT07135765","Paravertebral Muscles Assessment Using High-resolution MRI in Idiopathic or Neuromuscular Scoliosis Children","Paravertebral Muscles Assessment Using High-resolution MRI in Children Suffering From Idiopathic or Neuromuscular Scoliosis","MRISCOL","Inclusion Criteria:\n\n* Children and adolescents aged 10 to 17 years old,\n* Scoliosis (idiopathic or neuromuscular) that is not collapsing\n* Cobb angle \\\u003C40°\n* Female preferred\n* Patient able to walk\n* Average or low BMI \\\u003C20kg\u002Fm2\n* Signature of informed consent by legal guardians\n* Affiliation with a social security scheme (beneficiary or dependent).\n\nExclusion Criteria:\n\n* Refusal of the patient and\u002For parents to participate in the study\n* Inability to cooperate\n* Subject with a contraindication to MRI\n* History of spinal surgery\n* Not affiliated with a social security scheme (beneficiary or entitled person)",{"count":92,"type":22},10,[25],"Scoliosis is a common three-dimensional spinal deformity defined by vertebral rotation.\n\nApart from collapse scoliosis, clinical and radiological similarities have been observed in children with secondary scoliosis of neuromuscular origin and children with idiopathic scoliosis in terms of the location and type of curvature.\n\nIt seems relevant to study the axial musculature in these children in more detail, particularly the deep muscles (transversospinales muscles) that have a stabilising and rotational function (multifidi and rotatores).\n\nMRI is a non-invasive, non-irradiating technique used in the aetiological diagnosis of idiopathic scoliosis before adolescence and in the diagnosis of secondary scoliosis. However, the muscles are not specifically studied during these examinations. They are performed to analyse the spinal cord and rule out hinge deformities, although this technique does provide information on the paravertebral muscles.\n\nThe muscles of interest should be analysed using the usual sequences, with the addition of a sequence (DTI) specific to the study of deep muscles in children undergoing axial MRI. This adds 5 minutes to the standard MRI procedure.\n\nSeveral morphological muscle parameters would be thus obtained on specific interest areas and then compared between right and left side and between two groups of children, 5 suffering from idiopathic scoliosis and 5 with neuromuscular scoliosis.\n\nIdiopathic scoliosis corresponds to a heterogeneous group of patients in terms of the location, number and progression of the curves. The research hypothesis is that there may be a subgroup of patients with idiopathic scoliosis whose progression and\u002For aetiology is muscular in origin.\n\nMRI could then become a routine examination in the assessment of all scoliosis, whether idiopathic or not.",[96,29,28],"Scoliosis",[68,98,29,28,99,100],"MRI","spine","Children","2025-08-20",{"date":103,"type":35},"2025-08-22",{"date":105,"type":35},"2025-07-17",{"date":107,"type":22},"2027-08",{"name":109,"class":81},"Assistance Publique - Hôpitaux de Paris"]