[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"scoliosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:scoliosis":26},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,41,69,99,131,153,172,201,228,248,283,306,339,365,381,402,429,449,474,498,528,557,581,610,634],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100645027","psychometric-properties-of-the-turkish-version-of-the-staffordshire-adolescent-idiopathic-scoliosis-questionnaire-100645027",false,"NCT07676019","Psychometric Properties of the Turkish Version of the Staffordshire Adolescent Idiopathic Scoliosis Questionnaire","Psychometric Properties of the Turkish Version of the Staffordshire Adolescent Idiopathic Scoliosis Questionnaire (SQAIS)","Inclusion Criteria\n\n* Aged between 10 and 19 years.\n* Diagnosed with Adolescent Idiopathic Scoliosis (AIS) by an orthopedic surgeon or spine specialist.\n* Able to read and understand Turkish.\n\nExclusion Criteria\n\n* Diagnosis of congenital, neuromuscular, or syndromic scoliosis.\n* History of severe neurological, psychiatric, or cognitive disorders.\n* Presence of communication impairments that may interfere with understanding or completing the questionnaires.\n* History of major trauma or spinal surgery within the previous 6 months.","ALL","10 Years","19 Years",{"count":21,"type":22},100,"ESTIMATED","OBSERVATIONAL","Patient-Reported Outcome Measures (PROMs) have gained increasing importance in scoliosis research in recent years. Although widely used instruments such as the Scoliosis Research Society-22 (SRS-22) include domains related to body image, their primary purpose is to assess overall health-related quality of life and functional outcomes. In contrast, the Staffordshire Questionnaire for Adolescent Idiopathic Scoliosis (SQAIS) was specifically developed to provide a more detailed and patient-centered evaluation of body image and perceived deformity in individuals with adolescent idiopathic scoliosis (AIS). However, a Turkish version of the questionnaire with established validity and reliability is not currently available.\n\nTherefore, the aim of the planned master's thesis is to conduct the cultural adaptation of the Staffordshire Questionnaire for Adolescent Idiopathic Scoliosis into Turkish and to evaluate its psychometric properties in adolescents with AIS. The study will involve a systematic process of linguistic translation and cross-cultural adaptation. Subsequently, the validity and reliability of the Turkish version will be assessed through analyses of internal consistency, test-retest reliability, construct validity, and criterion validity.\n\nThe findings of this study are expected to provide a valid and reliable instrument for assessing body image and deformity perception among Turkish adolescents with idiopathic scoliosis, thereby contributing an important patient-centered outcome measure to both clinical practice and research.",[26,27],"Scoliosis","Quality of Life","NOT_YET_RECRUITING","2026-06-24",{"date":31,"type":32},"2026-06-30","ACTUAL",{"date":34,"type":22},"2026-07-02",{"date":36,"type":22},"2027-03-02",{"name":38,"class":39},"Acibadem University","OTHER",1,{"id":42,"slug":43,"hasResults":12,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":51,"conditions":52,"keywords":53,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":40},"100480660","body-structure-and-capacity-evaluation-of-adults-with-scoliosis-100480660","NCT05538871","Body Structure and Capacity Evaluation of Adults With Scoliosis","Inclusion criteria for the idiopathic scoliosis group :\n\n* Diagnosis of idiopathic scoliosis\n* Age ⩾18 years old\n* Curve severity over 10°\n* Fluent in English.\n\nInclusion criteria for the degenerative scoliosis group :\n\n* Diagnosis of degenerative (De novo) scoliosis\n* Age ⩾45 years old\n* Curve severity over 10°\n* Fluent in English.\n\nExclusion criteria for the scoliosis groups :\n\n* History of spine surgery or\n* History of diseases affecting the torso or lower extremity function\n* Surgery or trauma\n* Secondary scoliosis\n* Unable to fill out the questionnaires or attend the physical examination,\n* Pregnant or gave birth between 0 and 2 years ago.\n\nInclusion criteria for healthy groups:\n\n* Age ⩾ 18 years\n* Matched for age\u002Fheight\u002Fweight (+\u002F-5 years; +\u002F- 10 lbs; +\u002F- 10cm) to a scoliosis participant\n* Fluent in English\n\nExclusion criteria for healthy groups:\n\n* Serious systemic pathology\n* Spine deformity\n* Spine surgery\n* Pregnant or gave birth between 0 and 2 years ago\n* Unable to fill out the questionnaires or attend the physical examination\n* Received treatments for the spine\u002Fthe lower limbs within the last year",true,"18 Years",{"count":50,"type":22},108,"Adults with scoliosis have not been the focus of much research in physical therapy despite their prevalence being very important. Adults with idiopathic scoliosis have a reported prevalence of about 2-11%. This includes adolescents with idiopathic scoliosis who have become adults but still have a scoliosis. They do not get much treatment as the adolescent treatment focuses on preventing worsening of the curvatures and the risk of progression is significantly reduced once a person reaches skeletal maturity. Still some patients experience self-image, function and pain issues which may be amenable to treatment using specific exercises as was recently shown. With ageing population a growing number of adults with de novo degenerative scoliosis is observed. This is a spinal misalignment due to spine degeneration. Adult degenerative scoliosis with pain is thought to affect about 24% of the ageing adults. This population has not been investigated very much.\n\nBefore planning conservative treatments for adults with scoliosis it would be important to describe what deficit these adults present that may be targeted by physical therapy. The objective of this study is to compare samples of patients with adults degenerative scoliosis, adult idiopathic scoliosis to matched healthy controls (for age, height and weight). Participants will complete questionnaires and a physical exam to identify which limitations they present that may be amenable to treatment with physical therapy. This information will assist planning trials to address the needs of these two neglected patient populations.",[26],[26,54,55,56,57,58],"Degenerative scoliosis","Idiopathic scoliosis","Adult scoliosis","ICF","Deficits","RECRUITING","2026-06-23",{"date":62,"type":32},"2026-06-25",{"date":64,"type":32},"2019-05-06",{"date":66,"type":22},"2027-06",{"name":68,"class":39},"University of Alberta",{"id":70,"slug":71,"hasResults":12,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":81,"studyType":23,"phases":4,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":40},"100640924","the-bridge-pain-study-100640924","NCT07602595","The BRIDGE Pain Study","Biopsychosocial Risk Influences on the Development and Generation of Early-Onset Chronic Pain","BRIDGE","Inclusion Criteria:\n\n* Diagnosis of rheumatic\u002Fautoimmune disease\u002Fpain condition or surgery prior to age 18; Current age 14 to 26 years; Participant (and parent\u002Flegal guardian of participants \\\u003C 18 yo) can read and write in English; At least 1 year from diagnosis of pain or rheumatic disease; For individuals with MSK surgical history, at least 1 year after initial surgical intervention; For individuals with rheumatic disease, their disease must be considered inactive\n\nExclusion Criteria:\n\n* They have active disease, or Other major medical comorbidities have developed after surgery following MSK surgical intervention.","14 Years","26 Years",{"count":80,"type":22},600,"4 Weeks","The purpose of the study is to discover at least two distinct Musculoskeletal pain subtypes. These types are caused by different brain-and-immune system signals that affect how the body feels pain, and they are also shaped by a person's biology, psychology, and social environment.\n\nAim 1. We want to sort adolescents and young adults with long lasting muscle and bone pain into two different groups. To do this, we will look at participants' childhood medical histories, past treatments, when their pain started, the sex they were assigned at birth, what their pain feels like now, tests of how their body senses pain, and immune system markers found in their blood. We think we will find at least two different types of chronic pain groups, plus one group of patients who had a higher risk for pain (because of a rheumatic disease or past surgery) but never developed long term pain.\n\nAim 2. We want to find out if certain patterns of inflammation in the body change how nerve cells react to pain.\n\nAim 3: We want to understand how different biological, psychological, and social factors are connected to the chronic pain groups we identified. We think we will find certain mental, behavioral, and social risks-as well as protective factors-that help explain why some people develop long-lasting pain and others do not. We expect these factors to play different roles in each pain group, including the group that does not develop chronic pain.",[84,85,86,26,87,88,89],"Juvenile Idiopathic Arthritis (JIA)","Fibromyalgia","Lupus","Pectus Excavatum","Chronic Pain","Musculoskeletal Pain","2026-05-16",{"date":92,"type":32},"2026-05-22",{"date":94,"type":22},"2026-08",{"date":96,"type":22},"2029-08",{"name":98,"class":39},"Children's Hospital Medical Center, Cincinnati",{"id":100,"slug":101,"hasResults":12,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":47,"sex":17,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":40},"100639441","deep-learning-for-early-scoliosis-detection-using-mmwave-radar-gait-data-100639441","NCT07593560","Deep Learning for Early Scoliosis Detection Using mmWave Radar Gait Data","A Deep Learning-Based Approach for Early Scoliosis Detection Using mmWave Radar-Based Gait Data","ScoliRadar-AI","Participation Criteria:\n\n* Being between 2 and 75 years of age at the time of registration\n* Having applied to the pediatric orthopedics outpatient clinic for an assessment of suspected or known scoliosis\n* Being able to walk independently for at least 7 meters without assistive devices\n* Written informed consent from a parent or legal guardian\n* Written informed consent from the participant\n\nExclusion Criteria:\n\n* Severe scoliosis requiring urgent surgical intervention that prevents participation in walking tasks\n* Refusal to give informed consent or consent","2 Years","75 Years",{"count":110,"type":22},200,"Scoliosis is a sideways curvature of the spine that often develops during childhood and adolescence. When detected early, scoliosis can be managed effectively with non-invasive approaches such as bracing and physiotherapy, while late detection frequently leads to surgical intervention. Current screening methods rely on physical examination and X-ray imaging, which exposes children to ionizing radiation and may miss early-stage cases.\n\nThis observational study investigates whether millimeter-wave (mmWave) radar, combined with deep learning (a type of artificial intelligence), can detect early signs of scoliosis by analyzing how a child walks. The radar sensor records subtle movement patterns during walking without using cameras and without producing any identifiable images, fully preserving the participant's privacy. No ionizing radiation is involved.\n\nPediatric participants attending the orthopedic clinic for routine scoliosis evaluation are invited to walk a short distance in front of a mmWave radar sensor. The collected gait recordings are then analyzed using deep learning models, and the results are compared with the participant's standard clinical scoliosis assessment performed by a pediatric orthopedic specialist. The diagnostic performance of the deep learning model is evaluated using sensitivity, specificity, and overall accuracy.\n\nIf the approach proves accurate, it could offer a radiation-free, privacy-preserving, and low-cost alternative for early scoliosis screening in schools, primary healthcare centers, and pediatric orthopedic clinics, ultimately supporting earlier diagnosis and reducing the long-term clinical burden of untreated scoliosis.",[113,26],"Scoliosis Idiopathic Adolescent",[115,116,117,118,119,120,121],"Deep Learning","Artificial Intelligence","Machine Learning","Millimeter Wave Radar","Gait Analysis","Gait","Early Detection","2026-05-12",{"date":124,"type":32},"2026-05-18",{"date":126,"type":22},"2026-06",{"date":128,"type":22},"2028-06",{"name":130,"class":39},"Gebze Technical University",{"id":132,"slug":133,"hasResults":12,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":47,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":139,"conditions":140,"keywords":142,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":40},"100535925","effect-of-adult-spinal-deformity-surgery-on-functional-reach-100535925","NCT06258161","Effect of Adult Spinal Deformity Surgery on Functional Reach","Functional Reach Test as a Clinical Tool for Assessing Postural Balance Limits Among Adult Spinal Deformity Patients","Adult Spinal Deformity Patient Inclusion Criteria:\n\n* Adults over the age of 18\n* Diagnosed with adult spinal deformity according to the SRS-Schwab Adult Spinal Deformity Classification System\n* Indicated for deformity corrective surgery including multilevel spinal fusion of three or more levels\n* Lowest instrumented level includes S1 or pelvic fixation\n* Able to perform functional activities without the use of any assistance or support\n* devices\n\nAdult Spinal Deformity Patient Exclusion Criteria:\n\n* Indicated for spinal fusion due to spinal tumor, trauma, or infection\n* ASD patients who do not plan to be available for all follow-up evaluations at our institution\n* Pregnancy during any time point within the participation duration\n\nAsymptomatic Control Participant Inclusion Criteria:\n\n* Adults over the age of 18\n* No current or prior spine pathology or surgery\n* Able to perform the functional activities without the use of any assistance or support devices\n\nAsymptomatic Control Participant Exclusion Criteria:\n\n* Any current or prior spine or lower extremity pathology or surgery that impacts the subject's ability to perform the functional activities\n* Pregnancy at the time of the evaluation",{"count":5,"type":22},"Adult spinal deformity (ASD) is a common spinal condition that often impacts an individual's ability to stand and maintain an upright posture. Poor balance often limits an individual's ability to perform basic activities of daily life (ADL) and can lead to disability. Current considerations of correcting ASD to improve balance focus on the amount of sway that one exhibits during normal standing. However, current tests do not provide insight into the limits of balance during normal ADL.\n\nThe goal of this research is to develop a new balance assessment that includes a functional reach test (FRT) to provide numerical data on the limits of one's ability to maintain balance. The study will include both ASD patients and matched healthy adults and will compare postural sway measures between them. Wearable motion tracking sensors and a force plate will be used to monitor body movement and changes in the center of pressure under foot during normal standing and during a FRT. Data from this study will inform spine surgeons of ASD patient's risk of balance loss in daily life and enable further research on the effects of surgical techniques to restore balance among ASD surgery patients.",[26,141],"Scoliosis Kyphosis",[143],"Balance","2026-04-30",{"date":146,"type":32},"2026-05-06",{"date":148,"type":32},"2024-06-08",{"date":150,"type":22},"2028-09",{"name":152,"class":39},"University of Kansas Medical Center",{"id":154,"slug":155,"hasResults":12,"nctId":156,"briefTitle":157,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":12,"sex":17,"minAge":159,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":40},"100294026","scoliosis-shared-decision-making-100294026","NCT03107533","Scoliosis Shared Decision Making","Inclusion Criteria:\n\n* Scoliosis curve \\>40 degrees, \\\u003C 65 degrees\n* Risser score \\> 2\n* Age \\> 13 years\n\nExclusion Criteria:\n\n* Risser score of 0 or 1\n* Non-ambulatory scoliosis patients\n* Ages 12 year and under","13 Years",{"count":7,"type":22},"Analysis of video encounters between providers, patients, and families will be used to develop a shared decision making tool for patients deciding between surgery and observation for scoliosis treatment.",[26],"2026-04-20",{"date":165,"type":32},"2026-04-23",{"date":167,"type":32},"2017-03-30",{"date":169,"type":22},"2027-03",{"name":171,"class":39},"Mayo Clinic",{"id":173,"slug":174,"hasResults":12,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":12,"sex":17,"minAge":180,"maxAge":4,"enrollmentInfo":181,"targetDuration":4,"studyType":183,"phases":184,"briefSummary":186,"conditions":187,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":200},"100505825","study-of-an-intrathecal-port-and-catheter-system-for-subjects-with-spinal-muscular-atrophy-100505825","NCT05866419","Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy","Safety and Performance of the ThecaFlex DRx™ System Port and Catheter for Chronic Intrathecal Access, Cerebrospinal Fluid (CSF) Aspiration, and DElivery of Nusinersen in Spinal Muscular Atrophy (SMA) Patients Resistant to Lumbar PunctuRE Trial (PIERRE)","PIERRE","Inclusion Criteria:\n\n1. Subject is 3 years or older\n2. Subject diagnosed with SMA who are candidates for Spinraza treatment as indicated in its label\n3. Subject resistant to lumbar puncture (LP), where resistance is defined as:\n\n   1. Subject with respiratory issues or other comorbidities who is at an increased risk for complications due to the need for repeat anesthesia and imaging radiation exposure to safely perform LP; or\n   2. Subjects for whom the treating physician determines implantation of the ThecaFlex DRx™ System is otherwise in the subject's best interest\n4. Subject has been prescribed nusinersen via chronic intrathecal bolus administration in accordance with the drug labeling and first port access of the ThecaFlex DRx system is planned within 2 weeks of implantation\n5. Subject, per Investigator discretion, is able to undergo a percutaneous or open surgical procedure for index port and catheter implantation where at least 7 cm of the ThecaFlex DRx system catheter will be placed intrathecally\n6. Subject (or subject's legally authorized representative) is willing and able to provide written informed consent; and\n7. Subject and parent\u002Fcaregiver able and willing to complete all clinical investigation procedures, measurements, and visits.\n\nExclusion Criteria:\n\n1. Subject meets any of the contraindications for use of the ThecaFlex DRx™ System as outlined in the ThecaFlex DRx™ System Instructions for Use\n2. Presence or history of (\\\u003C 6 months prior to the procedure): an implanted microinfusion pump, intrathecal catheter, or other intrathecal drug delivery devices\u002Fcomponent, or implanted shunt for drainage of cerebrospinal fluid (CSF), or reservoir in the CSF space (note: any ThecaFlex Port and Catheter System must not be placed in the same location as a previous indwelling port and catheter)\n3. Subject is pregnant or nursing or plans to become pregnant during the course of the clinical investigation\n4. Any condition or event, which in the opinion of the Investigator may adversely affect the safety and effective implantation and use of the ThecaFlex DRx™ system or confound the clinical investigation, including:\n\n   1. Severe structural impediment that may preclude safe implantation of the catheter and port\n   2. Major medical events within 60 days prior to screening; or\n   3. Relevant surgeries (e.g., head and neck, back, etc.) within 60 days prior to screening or planned during the duration of the clinical investigation\n   4. Space-occupying lesion with mass effect\n   5. Posterior fossa mass\n   6. Arnold-Chiari malformation\n   7. Coagulation abnormalities and\u002For thrombocytopenia\n   8. Insufficient or inadequate skin or underlying fat to adequately protect the port or enough surface area to allow the skin to close safely\n5. Subject is contraindicated for administration of nusinersen per its approved labeling\n6. History of intrathecal granuloma formation\n7. History of bacterial meningitis or aseptic meningitis within 6 months of screening\n8. History of tumors or other spinal abnormalities documented by magnetic resonance imaging (MRI) or computed tomography (CT) that would interfere with the catheter implantation procedures or CSF circulation\n9. History of hydrocephalus\n10. Diagnosed degenerative muscular disease other than SMA\n11. History of depression, cognitive impairment, or another psycho-behavioral problem that in the opinion of the Investigator may preclude safe participation in the clinical investigation and\n12. Serious medical condition that, in the opinion of the investigator, may lead to reduced life expectancy beyond 12 months.\n13. Subject is involved in another Investigation Device Exemption Study.","3 Years",{"count":182,"type":22},90,"INTERVENTIONAL",[185],"NA","The primary objective of the clinical investigation is to demonstrate successful clinical use of the ThecaFlex DRx™ System in delivering nusinersen in subjects with spinal muscular atrophy (SMA).\n\nAll enrolled subjects will undergo implantation of the investigational device (ThecaFlex DRx™ System) and will be followed for 12 months after receiving the implant. The 12-month data will be used to assess the primary endpoint support a Pre-Market Approval (PMA) application.",[188,189,26],"Spinal Muscular Atrophy","Spine Deformity","2026-04-14",{"date":192,"type":32},"2026-04-16",{"date":194,"type":32},"2023-11-27",{"date":196,"type":22},"2030-07",{"name":198,"class":199},"Alcyone Therapeutics, Inc","INDUSTRY",21,{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":208,"enrollmentInfo":209,"targetDuration":4,"studyType":183,"phases":211,"briefSummary":212,"conditions":213,"keywords":215,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":40},"100612585","effects-of-neuromuscular-scoliosis-surgery-on-nutritional-metabolism-100612585","NCT07255495","Effects of Neuromuscular Scoliosis Surgery on Nutritional Metabolism","SORONOUS","Inclusion Criteria:\n\n* Subjects with cerebral palsy\n* Subjects between 10 and 20 years old\n* Neuromuscular scoliosis requiring surgical care (accepted by the patient or their legal representatives)\n* Subjects escaping scoliosis treatment with a brace\n\nExclusion Criteria:\n\n* History of spine surgery\n* Impossible follow-up during the study time\n* Peripheral or non spastic palsy\n* Palsy caused by a medullary injury\n* Subject with a contraindication to DXA scan examination (e.g. coronary stents or cardiac metal sutures, pacemaker or automatic defibrillator)\n* Absence of voluntary and informed consent signed by the patient or their legal representatives\n* Patient or their legal representatives with no social security affiliation\n* Patient or their legal representatives deprived of freedom by a judicial or administrative decision\n* Pregnant, laboring, or breastfeeding woman","20 Years",{"count":210,"type":22},42,[185],"Cerebral palsy is the primary cause of disability in France. It is a non-progressive condition leading to movement and posture troubles, but also to cognitive and sensory problems. Spasticity is one of the most regular consequences. It leads to a muscular failure with permanent contractions. Muscular dysfunction can generate scoliosis (in 60% of cases). Scoliosis can lead to pain, sitting difficulties (with chances of bedsores), and cardiopulmonary complications.\n\nThese children often have cachexia (eating difficulties, trouble with deglutition). It leads to a weakening of their immune defenses, which favors post-operative infections, a weakening of their respiratory muscles, and circulatory difficulties with negative effects on scarring. Cachexia is a pessimistic prognosis.\n\nA back brace can be used to contain the scoliosis but never cures it. Another option for treating this affection would be surgery. Surgery is another treatment. It consists in straightening and holding the spine with metal rods, held by vertebral anchors placed at both ends of the scoliosis. Surgery is the gold standard.\n\nSurgery induces risks such as bleeding, healing complications and infection. The probability to face complications increases with malnutrition.\n\nThe first hypothesis is that surgery could improve the nutrients intakes and the weight of the patient.\n\nThe investigators also believe that it could improve the patient's body composition (body fat and lean mass) and their basic metabolic rate.\n\nThe third hypothesis is that surgery-involved changes (nutrition enhancement, sitting improvement, decrease of respiratory work) could lead to an improvement of the patient's quality and life and respiratory functions.\n\nThe SORONOUS project aim to prove the benefits of this surgery from a nutritional and from a general point of view in order to help make the surgical decision and avoid any care delay. In addition, it aim to identify and quantify the post-operative weight gain; while providing us with a better understanding of the behavior of pre-operative cachexia among these patients.",[214,26],"Cerebral Palsy",[216,217,218],"energy metabolism","quality of life","nutritional support","2026-04-07",{"date":221,"type":32},"2026-04-13",{"date":223,"type":22},"2026-07-01",{"date":225,"type":22},"2029-07-01",{"name":227,"class":39},"University Hospital, Montpellier",{"id":229,"slug":230,"hasResults":12,"nctId":231,"briefTitle":232,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":47,"sex":17,"minAge":48,"maxAge":234,"enrollmentInfo":235,"targetDuration":4,"studyType":183,"phases":237,"briefSummary":238,"conditions":239,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":246,"locationsCount":40},"100627327","investigation-of-pain-perception-according-to-gender-in-individuals-with-scoliosis-100627327","NCT07447193","Investigation of Pain Perception According to Gender in Individuals With Scoliosis","Inclusion Criteria:\n\n* Having a clinical or radiological diagnosis of scoliosis\n* Being between 18-45 years of age\n* Not having undergone scoliosis surgery in the last 6 months\n* Agreeing to participate in the study voluntarily\n\nExclusion Criteria:\n\n* Having a history of neurological disease\n* Acute inflammatory spinal disease\n* Serious cardiovascular or systemic diseases that would prevent participation in exercise","45 Years",{"count":236,"type":22},50,[185],"The aim of this study is to evaluate whether pain perception under spinal pressure created on a physiotherapy roller differs according to gender in individuals diagnosed with scoliosis.",[26],"2026-04-03",{"date":242,"type":32},"2026-04-09",{"date":244,"type":32},"2026-04-01",{"date":31,"type":22},{"name":247,"class":39},"Uskudar University",{"id":249,"slug":250,"hasResults":12,"nctId":251,"briefTitle":252,"officialTitle":252,"acronym":253,"eligibilityCriteria":254,"healthyVolunteers":12,"sex":17,"minAge":255,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":183,"phases":259,"briefSummary":260,"conditions":261,"keywords":268,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":40},"100443196","respiratory-muscles-and-work-of-breathing-in-children-100443196","NCT05051254","Respiratory Muscles and Work of Breathing in Children","WOB&MR_Ped","Inclusion Criteria:\n\n* Patients aged less than 18 years old with primary or secondary impairment of respiratory muscles and followed at Necker Hospital\n* Patients under spontaneous breathing or noninvasive or invasive mechanical ventilation\n* Written informed consent\n\nExclusion Criteria:\n\n* No social insurance\n* Significant psychomotor retardation\n* Absence of cooperation\n* Significant agitation\n* Hemodynamic instability\n* Acute condition or temporary drug treatments that may interfere with the results of the respiratory muscle explorations","0 Years","17 Years",{"count":258,"type":22},550,[185],"Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology of respiratory impairment and guide therapeutic management. The use of an invasive technique (esogastric probe) makes it possible to specifically explore the diaphragm, the accessory inspiratory muscles and the expiratory muscles in order to detect dysfunction or paralysis of these muscles, and to estimate the work of breathing in order to better guide the respiratory management.\n\nThe primary objective of the study is to evaluate the respiratory effort in children with primary or secondary impairment of the respiratory muscles during spontaneous breathing or during mechanical ventilation.",[262,263,264,265,26,266,267],"Neuromuscular Diseases","Congenital Diaphragmatic Hernia","Lung Diseases","Cardiac Diseases","Diaphragmatic Impairment","Respiratory Muscle Impairment",[269,270,271,272,273,274],"Respiratory muscle testing","Respiratory muscle strength","Work of breathing","Esogastric pressures","Diaphragmatic dysfunction","Diaphragmatic paralysis","2026-03-30",{"date":240,"type":32},{"date":278,"type":32},"2022-01-19",{"date":280,"type":22},"2028-01",{"name":282,"class":39},"Assistance Publique - Hôpitaux de Paris",{"id":284,"slug":285,"hasResults":12,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":47,"sex":17,"minAge":290,"maxAge":48,"enrollmentInfo":291,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":292,"conditions":293,"keywords":294,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":303,"leadSponsor":304,"locationsCount":4},"100626304","scoliosis-and-functional-outcomes-in-children-with-juvenile-idiopathic-arthritis-100626304","NCT07433894","Scoliosis and Functional Outcomes in Children With Juvenile Idiopathic Arthritis","Comprehensive Evaluation of Scoliosis and Its Association With Functional Status, Postural Alignment, and Disease Activity in Children With Juvenile Idiopathic Arthritis","Inclusion Criteria\n\n* Age between 8 and 18 years at the time of enrollment\n* Diagnosis of juvenile idiopathic arthritis (JIA) according to ILAR criteria\n* Written informed consent obtained from parent\u002Flegal guardian and assent from the child\u002Fadolescent, when appropriate\n\nExclusion Criteria\n\n* Known scoliosis due to non-JIA causes (e.g., congenital vertebral anomalies, neuromuscular disorders, or syndromic scoliosis)\n* History of prior spinal surgery or current brace treatment for scoliosis\n* History of significant spinal trauma or spinal infection\u002Ftumor affecting spinal alignment\n* Presence of coexisting chronic conditions that significantly affect posture, gait, or functional testing (e.g., severe neurologic impairment) and may confound assessments\n* Inability to undergo required assessments (e.g., inability to stand for radiographs or complete functional measures)","8 Years",{"count":110,"type":22},"Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that may affect musculoskeletal development and posture in children. Spinal involvement, including scoliosis, is not routinely evaluated in clinical practice despite its potential impact on functional status and quality of life.\n\nThis cross-sectional study aims to assess the presence of scoliosis in children with JIA and to investigate its association with functional status, postural alignment, and disease activity. Clinical and functional parameters will be analyzed to better understand the impact of spinal deformities in this population.",[26],[295,26,296,297,298],"Juvenile Idiopathic Arthritis","Functional Outcomes","Postural Alignment","Pediatric Rheumatology","2026-02-25",{"date":301,"type":32},"2026-02-27",{"date":244,"type":22},{"date":223,"type":22},{"name":305,"class":39},"Istanbul University",{"id":307,"slug":308,"hasResults":12,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":12,"sex":17,"minAge":314,"maxAge":4,"enrollmentInfo":315,"targetDuration":4,"studyType":183,"phases":317,"briefSummary":318,"conditions":319,"keywords":324,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":40},"100625370","evaluation-of-the-accuracy-of-the-ecential-robotics-robot-in-spinal-surgery-100625370","NCT07421752","Evaluation of the Accuracy of the eCential Robotics Robot in Spinal Surgery","Evaluation of the Accuracy of the eCential Robotics Robot in Spinal Surgery at Amiens Picardie University Hospital","Robotec Amiens","Inclusion Criteria:\n\n* Patients aged 5 years or older.\n* Treated at CHU Amiens Picardie for spinal surgery requiring implantation of pedicle screws.\n* Informed consent signed by patient or legal representative and child.\n* Membership of a social security scheme.\n* Negative pregnancy test for adolescent women of childbearing age\n\nExclusion Criteria:\n\n* Patient managed by a practitioner with no experience of the eCential Robotics robot.\n* Patient requiring a technique without implantation of pedicle screws.\n* Patients already suffering from deterministic radiation effects\n* Pregnant, parturient or breast-feeding women.\n* Patients under guardianship or curators, under safeguard of justice or deprived under public law.","5 Years",{"count":316,"type":22},45,[185],"Spinal surgery has evolved considerably over the years, and the introduction of advanced technologies has played a crucial role in improving clinical outcomes. The use of surgical robots, such as the eCential Robotic system, has emerged as an innovative solution for optimizing the precision and safety of procedures, particularly the placement of pedicle screws in the spine.\n\nThe eCential Robotics surgical robot offers several advantages for the placement of pedicle screws in the spine. Various studies have demonstrated a significant improvement in screw accuracy and stability, reducing revision surgery rates with surgical robots. The system enables advanced preoperative planning based on three-dimensional imaging, improving understanding of the patient's specific anatomy. This study will also provide a clinical basis for the CE marking process.\n\nThe objective of this prospective study is to collect data confirming safety, performance and clinical benefits of the eCential Robotics robot when used during spine and pelvic surgeries.",[320,321,322,323,26],"Pedicle Screw Accuracy","Robot","Navigation","Spine",[325,326,327,328,329],"Pedicle screw accuracy","robot","navigation","spine","scoliosis","2026-02-17",{"date":332,"type":32},"2026-02-19",{"date":334,"type":32},"2025-11-21",{"date":336,"type":22},"2028-11",{"name":338,"class":39},"Centre Hospitalier Universitaire, Amiens",{"id":340,"slug":341,"hasResults":12,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":345,"eligibilityCriteria":346,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":349,"conditions":350,"keywords":354,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":364},"100430451","prospective-evaluation-of-complex-adult-spinal-deformity-cad-treated-with-minimally-invasive-surgery-100430451","NCT04885244","Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery","Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery (MIS)","MIS","Inclusion Criteria:\n\n1. \\>18 years of age at the time of treatment\n2. Diagnosis of adult congenital, degenerative, idiopathic, neuromuscular, inflammatory or iatrogenic spinal deformity\n3. EOS full body or standing 36\" AP \\& Lateral images of entire spine\n4. Surgery to be schedule to take place within 6 months (otherwise PROMs\u002FRadiographic images to be recollected)\n\n   AND Either:\n5. One of the following Radiographic criteria:\n\n   1. PI-LL ≥ 25 degrees\n   2. Thoracolumbar\u002Flumbar scoliosis ≥ 20 degrees\n   3. SVA \\>10cm\n   4. PT \\> 30 OR\n6. One of the Following Procedural criteria:\n\n   1. Surgery to include \\> 3 levels percutaneous posterior spinal instrumentation or 3 level stand-alone interbody. (Levels = vertebra (i.e. percutaneous screws at L2, L3, L4 would be eligible for posterior instrumentation and\u002For L3-L4, L4-L5 would be eligible as stand-alone for interbodies)\n   2. Posterior UIV and LIV must be placed percutaneously\n   3. Single-position surgery ≥ 3 levels fused (Levels=vertebra; S1 is counted as a level; S2 \\&\u002For pelvis\u002Filium is not)\n   4. Staged ≥ 3 levels fused with percutaneous pedicle screws\n   5. 3 column osteotomy with percutaneous fixation\n   6. ACR incorporating open or percutaneous fixation as long as UIV and LIV are percutaneous screws\n\nExclusion Criteria:\n\n1. Deformity due to acute trauma\n2. Active spine tumor or infection\n3. Patient is unwilling or unable to complete questionnaires\n4. Women who are pregnant\n5. Prisoners\n6. Open Posterior spinal fusion is planned (Open Anterior, i.e. ALIF, is acceptable)",{"count":348,"type":22},500,"Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients treated with minimally invasive approach, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.",[351,26,352,353],"Adult Spinal Deformity","Kyphosis","Sagittal Imbalance",[26,352,353,355],"Spinal Deformity","2026-02-12",{"date":330,"type":32},{"date":359,"type":32},"2021-07-28",{"date":361,"type":22},"2034-12-31",{"name":363,"class":39},"International Spine Study Group Foundation",12,{"id":366,"slug":367,"hasResults":12,"nctId":368,"briefTitle":369,"officialTitle":369,"acronym":4,"eligibilityCriteria":370,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":371,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":369,"conditions":373,"keywords":374,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":375,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":379,"locationsCount":380},"100430670","prospective-multicenter-case-control-analysis-of-the-versatie-posterior-fixation-system-to-prevent-proximal-junctional-failure-in-long-posterior-spinal-fusion-constructs-for-adult-patients-100430670","NCT04888104","Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional Failure in Long Posterior Spinal Fusion Constructs for Adult Patients","Inclusion Criteria:\n\n1. \\>18 years of age at the time of treatment\n2. EOS full body or standing 36\" AP \\& Lateral images of entire spine\n3. Posterior spine fusion with pedicle screw fixation construct of 5 or more levels\n4. Pedicle screw fixation to be supplemented proximally with NuVasive VersaTie system\n5. Upper instrumented vertebra (UIV) terminating at a newly instrumented level\n6. Lowest instrumented vertebra (LIV) sacrum\u002Fpelvis\n7. Surgery scheduled to take place in the next 6 months\n\nExclusion Criteria:\n\n1. Active spine tumor or infection\n2. Deformity due to acute trauma\n3. Prisoners\n4. Women who are pregnant\n5. Patient is unwilling or unable to complete questionnaires",{"count":372,"type":22},225,[351,26,352],[26,352,353],{"date":330,"type":32},{"date":377,"type":32},"2021-07-09",{"date":361,"type":22},{"name":363,"class":39},9,{"id":382,"slug":383,"hasResults":12,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":387,"eligibilityCriteria":388,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":389,"targetDuration":18,"studyType":23,"phases":4,"briefSummary":391,"conditions":392,"keywords":393,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":395,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":401},"100377408","complex-adult-deformity-surgery-cads-100377408","NCT04194138","Complex Adult Deformity Surgery (CADS)","Multi-Center Prospective Evaluation of Complex Adult Spinal Deformity Surgery","CADS","Criteria:\n\nInclusion Criteria:\n\n1. Diagnosis of adult congenital, degenerative, idiopathic or iatrogenic spinal deformity\n2. Full body EOS radiographic assessment (sagittal and coronal visualization from skull to foot)\n3. Complex patients are defined as and meeting any one of the subsequent criteria:\n\n   1. Radiographic criteria:\n\n      * PI-LL ≥ 25 degrees\n      * TPA ≥ 30 degrees\n      * SVA\\>15cm\n      * Thoracic scoliosis ≥ 70 degrees\n      * Thoracolumbar\u002Flumbar scoliosis ≥ 50 degrees\n      * Global coronal malalignment \\>7cm\n   2. Procedural criteria:\n\n      * Posterior spinal fusion \\> 12 levels\n      * 3 column osteotomy or ACR\n   3. Geriatric criteria:\n\n      * Age \\>65 years and minimum 7 levels of spinal instrumentation during surgery\n\nExclusion Criteria:\n\n1. Age \\\u003C18 years of age\n2. Active spine tumor or infection\n3. Deformity due to acute trauma\n4. Neuromuscular conditions\u002Fdiseases (Parkinson's, Multiple Sclerosis, Post-polio syndrome)\n5. Syndromic scoliosis\n6. Inflammatory arthritis\u002Fauto immune diseases (Rheumatoid arthritis, Lupus, Ankylosing Spondylitis)\n7. Prisoners\n8. Women who are pregnant\n9. Non English speaking patients",{"count":390,"type":22},1500,"Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.",[351,26,352,353],[26,352,353,394],"Spinal deformity",{"date":330,"type":32},{"date":397,"type":32},"2018-07-30",{"date":399,"type":22},"2032-07-31",{"name":363,"class":39},18,{"id":403,"slug":404,"hasResults":12,"nctId":405,"briefTitle":406,"officialTitle":407,"acronym":408,"eligibilityCriteria":409,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":208,"enrollmentInfo":410,"targetDuration":4,"studyType":183,"phases":411,"briefSummary":412,"conditions":413,"keywords":417,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":40},"100534745","yoga-for-back-pain-in-adolescent-scoliosis-100534745","NCT06242821","Yoga for Back Pain in Adolescent Scoliosis","Back Pain Management in AIS: Impact of Yoga as Adjunct Treatment","AIS","Inclusion Criteria:\n\n* Non-operatively treated AIS patients at Johns Hopkins Hospital with back pain who are candidates for physical therapy.\n* Cobb angle: greater than 25 degrees,\n* Visual Analog Scale (VAS) Pain score greater than 41\u002F0\n* Braced and Unbraced Patients\n\nExclusion Criteria:\n\n* Scoliosis due to causes other than AIS.\n* AIS patients who have undergone surgery for scoliosis or back pain\n* Age less than 10 years of age or greater than 20 years of age\n* Unable to access zoom on any electronic device",{"count":348,"type":22},[185],"The Problem: Adolescent Idiopathic Scoliosis (AIS), the pre-eminent spinal pathology affecting over 5% of children and adolescents, presents a pronounced spinal curvature exceeding 10 degrees, with prevalence amongst female adolescents at a ratio of 3:1 compared to males. A significant portion of these patients are not immediate candidates for surgical intervention. The acute shortage of viable non-operative management strategies, which is becoming increasingly imperative given the current barriers to physical therapy access and the growing opioid crisis. The investigator's research intends to explore the addition of a structured yoga protocol to standard of care. This research will thus explore the potential for improved relief and quality-of-life improvements for AIS patients not ready for surgery.\n\nSignificance: AIS is a pervasive condition which correlates with chronic and episodic lower back pain, diminished sleep quality, and depressive symptoms. This extensive comorbid association coupled with the financial pressure to patients and the healthcare system cannot be understated.\n\nNeeds Statement: There is a lack of sufficient non-operative management options for AIS. Many patients face limited access and require supplementary management strategies to address the patient's conditions effectively, creating a significant unmet need for non-pharmacological pain management interventions. This need is further highlighted in the context of the escalating opioid crisis, a leading cause of death among adolescents and young adults.\n\nHypothesis: The introduction of a structured yoga protocol can serve as a non-inferior or even superior alternative to traditional standard of care i management of AIS, addressing both the physical and psychosocial aspects intertwined with the condition.\n\nIMPACT: Change in Problem Significance: This research trial aims to enhance current standard of care for patients grappling with AIS. If the trial demonstrates superiority of yoga, it will delineate a paradigm shift in the current care standards for AIS patients, fostering a move towards a more cost-effective and holistic approach. Yoga could help alleviate the burdens on the healthcare system by reducing costs and enhancing accessibility for patients.\n\nImprovement in Pediatric Orthopedics Practice: By paving the way for non-pharmacological interventions, the trial aspires to mitigate the reliance on opioids for pain management in the pediatric demographic, therefore promoting overall well-being. This project not only seeks to develop alternative pain management strategies amidst a growing opioid epidemic but also champions the cause of improving the quality of life for the pediatric population battling chronic conditions like AIS. It echoes the urgent call to innovate and expand upon the current strategies in place, steering the medical community towards a future where integrative approaches are not the exception but the norm. Ultimately, this research aspires to guide the trajectory of pediatric orthopedics towards a healthcare system that is more inclusive, accessible, and holistically oriented, thereby enhancing the quality of life for pediatric patients grappling with conditions like AIS.\n\n2\\. Objectives (include all primary and secondary objectives) Goals\u002FObjectives: To create a randomized clinical trial aimed to evaluate the efficacy of yoga in conjunction with standard of care treatments for AIS patients.\n\nSPECIFIC AIMS Aim 1: Evaluate the feasibility and challenges of implementing a yoga protocol for AIS patients.\n\nMethodology: Online class attendance, survey completions, and follow-up appointments.\n\nAnticipated Results: Adequate participant adherence and data reliability.\n\nAim 2: Compare clinical outcomes between patients who receive traditional care modalities versus those who added yoga to treatment plan.\n\nMethodology: Utilize validated tools such as the SRS-22 questionnaire and monitor outcomes including depression scale, sleep quality, analgesic usage, activity levels, and Cobb angle.\n\nAnticipated Results: Significant physical and psychological improvements in the yoga group.",[414,415,416,26],"Scoliosis Idiopathic Adolescent Treatment","Scoliosis Idiopathic","Scoliosis; Adolescence",[418,419],"Adolescent Idiopathic Scoliosis","yoga","2026-01-15",{"date":422,"type":32},"2026-01-16",{"date":424,"type":32},"2025-01-01",{"date":426,"type":22},"2027-03-01",{"name":428,"class":39},"Johns Hopkins University",{"id":430,"slug":431,"hasResults":12,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":234,"enrollmentInfo":436,"targetDuration":4,"studyType":183,"phases":437,"briefSummary":438,"conditions":439,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":40},"100617932","biomechanical-study-of-lever-positioning-manipulation-on-scoliosis-100617932","NCT07325045","Biomechanical Study of Lever Positioning Manipulation on Scoliosis","Biomechanical Parameter Quantification and Finite Element Simulation of Lever Positioning Manipulation in Patients With Thoracolumbar Scoliosis","Inclusion Criteria:\n\n1. Age between 10 and 45 years, stable vital signs, no severe diseases in other systems;\n2. Diagnosed with scoliosis via standard anterior-posterior and lateral spinal radiographs, with a Cobb angle of 10° \\\u003C θ \\\u003C= 45°, and no severe complications;\n3. No history of spinal surgery;\n4. Voluntarily willing to participate in this study as a subject to undergo LPM procedures, and signing the informed consent form by themselves or their guardian. Note: Only patients meeting all of the above four criteria can be included in this study.\n\nExclusion Criteria:\n\n1. Individuals with severe osteoporosis, spinal fractures, tumors, infections, or lesions within the spinal canal;\n2. Those with related complications, such as cardiopulmonary insufficiency (NYHA class \\>= II) or severe neurological disorders;\n3. Those with compression fractures or spinal cord injuries;\n4. Individuals with cognitive impairment or mental disorders who cannot cooperate with biomechanical testing;\n5. Those with a history of spinal surgery;\n6. Those with severe skin lesions or dermatological diseases at the operation site;\n7. Women who are menstruating, pregnant, planning pregnancy, or in the postpartum period;\n8. Those with other conditions that may reduce the likelihood of completing the procedure, such as a fear of manual therapy;\n9. Individuals with unclear surface markers, affecting motion capture accuracy (e.g., BMI \\>= 35 kg\u002Fm\\^2).",{"count":5,"type":22},[185],"Research background Scoliosis is a common three-dimensional spinal deformity, especially in adolescents. In severe cases, it can lead to thoracic deformation and cardiopulmonary dysfunction. At present, clinical treatment is mainly based on Cobb angle to take observation, brace or surgical intervention, but there are problems such as poor compliance and large trauma. As a non-invasive massage therapy, leverage positioning manipulation has shown orthopedic effects in clinical practice, but its biomechanical mechanism has not been systematically quantified, which restricts its standardization and promotion.\n\nPurpose of the study The purpose of this study is to quantify the mechanical and kinematic parameters of lever positioning manipulation in the treatment of scoliosis through biomechanical testing and finite element simulation technology, to construct an individualized finite element model, to analyze the stress and strain distribution of each structure of the spine under the intervention of manipulation, to reveal its biomechanical mechanism, and to provide scientific basis for the standardization of manipulation and the optimization of curative effect.\n\nResearch contents and methods The study is divided into two parts : In the first part, 30 patients with scoliosis were recruited. Through the integrated mechanical sensor and motion capture system, the mechanical parameters ( such as preload force, maximum pull force ) and kinematic parameters ( such as angle, angular velocity ) during the manipulation were recorded in real time. In the second part, based on the CT data of patients, the three-dimensional finite element model of T10-L2 segment was constructed by using Mimics, Geomagic, SolidWorks and ANSYS software to simulate the loading process of manipulation and analyze the stress and strain response of vertebral body, intervertebral disc and ligament complex under the action of manipulation.\n\nExpected results and significance This study will systematically quantify the biomechanical characteristics of lever positioning manipulation for the first time, and clarify its mechanism of action in the treatment of thoracolumbar scoliosis. Through the finite element simulation, the stress distribution is visualized, which provides data support for the precision and individualization of manipulation, promotes the transformation of massage manipulation from ' experience dependence ' to ' quantitative science ', and lays a theoretical foundation for the development of intelligent orthopedic equipment in the future.\n\nEthics and quality control The study has passed the ethical review, and all participants will sign the informed consent. The manipulation was performed by the same experienced physician, and the data collection and analysis process was strictly controlled to ensure that the results were true and reliable.",[26],"2026-01-06",{"date":442,"type":32},"2026-01-08",{"date":444,"type":22},"2026-01-10",{"date":446,"type":22},"2028-12-31",{"name":448,"class":39},"The Third Affiliated hospital of Zhejiang Chinese Medical University",{"id":450,"slug":451,"hasResults":12,"nctId":452,"briefTitle":453,"officialTitle":454,"acronym":455,"eligibilityCriteria":456,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":256,"enrollmentInfo":457,"targetDuration":4,"studyType":183,"phases":459,"briefSummary":460,"conditions":461,"keywords":463,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":466,"lastUpdatePostDateStruct":467,"startDateStruct":469,"completionDateStruct":471,"leadSponsor":473,"locationsCount":40},"100603380","paravertebral-muscles-assessment-using-high-resolution-mri-in-idiopathic-or-neuromuscular-scoliosis-children-100603380","NCT07135765","Paravertebral Muscles Assessment Using High-resolution MRI in Idiopathic or Neuromuscular Scoliosis Children","Paravertebral Muscles Assessment Using High-resolution MRI in Children Suffering From Idiopathic or Neuromuscular Scoliosis","MRISCOL","Inclusion Criteria:\n\n* Children and adolescents aged 10 to 17 years old,\n* Scoliosis (idiopathic or neuromuscular) that is not collapsing\n* Cobb angle \\\u003C40°\n* Female preferred\n* Patient able to walk\n* Average or low BMI \\\u003C20kg\u002Fm2\n* Signature of informed consent by legal guardians\n* Affiliation with a social security scheme (beneficiary or dependent).\n\nExclusion Criteria:\n\n* Refusal of the patient and\u002For parents to participate in the study\n* Inability to cooperate\n* Subject with a contraindication to MRI\n* History of spinal surgery\n* Not affiliated with a social security scheme (beneficiary or entitled person)",{"count":458,"type":22},10,[185],"Scoliosis is a common three-dimensional spinal deformity defined by vertebral rotation.\n\nApart from collapse scoliosis, clinical and radiological similarities have been observed in children with secondary scoliosis of neuromuscular origin and children with idiopathic scoliosis in terms of the location and type of curvature.\n\nIt seems relevant to study the axial musculature in these children in more detail, particularly the deep muscles (transversospinales muscles) that have a stabilising and rotational function (multifidi and rotatores).\n\nMRI is a non-invasive, non-irradiating technique used in the aetiological diagnosis of idiopathic scoliosis before adolescence and in the diagnosis of secondary scoliosis. However, the muscles are not specifically studied during these examinations. They are performed to analyse the spinal cord and rule out hinge deformities, although this technique does provide information on the paravertebral muscles.\n\nThe muscles of interest should be analysed using the usual sequences, with the addition of a sequence (DTI) specific to the study of deep muscles in children undergoing axial MRI. This adds 5 minutes to the standard MRI procedure.\n\nSeveral morphological muscle parameters would be thus obtained on specific interest areas and then compared between right and left side and between two groups of children, 5 suffering from idiopathic scoliosis and 5 with neuromuscular scoliosis.\n\nIdiopathic scoliosis corresponds to a heterogeneous group of patients in terms of the location, number and progression of the curves. The research hypothesis is that there may be a subgroup of patients with idiopathic scoliosis whose progression and\u002For aetiology is muscular in origin.\n\nMRI could then become a routine examination in the assessment of all scoliosis, whether idiopathic or not.",[26,415,462],"Scoliosis Neuromuscular",[329,464,415,462,328,465],"MRI","Children","2025-08-20",{"date":468,"type":32},"2025-08-22",{"date":470,"type":32},"2025-07-17",{"date":472,"type":22},"2027-08",{"name":282,"class":39},{"id":475,"slug":476,"hasResults":12,"nctId":477,"briefTitle":478,"officialTitle":479,"acronym":4,"eligibilityCriteria":480,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":481,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":483,"conditions":484,"keywords":487,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":40},"100088509","clinical-orthopaedic-data-bank-acute-and-chronic-100088509","NCT00411060","Clinical Orthopaedic Data Bank (Acute and Chronic)","Orthopaedic Data Bank; Collection and Storage of Data Relating to Orthopaedic Disorders","Inclusion Criteria:\n\n* All patients seen in the UF\\&Shands Orthopaedics and Sports Medicine Institute will be asked to sign an informed consent.\n\nExclusion Criteria:\n\n* No exclusions, all patients interested in participation will be asked to sign an informed consent.",{"count":482,"type":22},10000,"Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF) and Shands Orthopaedics and Sports Medicine Institute.",[485,486,26,214],"Osteoarthritis","Osteosarcoma",[488],"Rotator Cuff Tear","2025-08-05",{"date":491,"type":32},"2025-08-06",{"date":493,"type":4},"2007-01",{"date":495,"type":22},"2026-08-14",{"name":497,"class":39},"University of Florida",{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":502,"acronym":4,"eligibilityCriteria":503,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":48,"enrollmentInfo":504,"targetDuration":4,"studyType":183,"phases":506,"briefSummary":507,"conditions":508,"keywords":509,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":520,"startDateStruct":522,"completionDateStruct":524,"leadSponsor":526,"locationsCount":40},"100597528","synergic-effects-of-schroth-method-with-and-without-core-stabilization-exercises-in-idiopathic-scoliosis-patients-100597528","NCT07059663","Synergic Effects of Schroth Method With and Without Core Stabilization Exercises in Idiopathic Scoliosis Patients","Inclusion Criteria:\n\n* • Age 10 to 18\n\n  * X-ray diagnosed of idiopathic scoliosis with Cobb Angle 10˚- 30˚\n  * Participants with Idiopathic Scoliosis\n  * Both genders will be included\n  * Scoliosis with Down syndrome.\n\nExclusion Criteria:\n\n* Any neurological condition such as cerebral palsy or epilepsy.\n* Any other orthopedic condition such as hip dysplasia, osteogenesis imperfecta, or leg length discrepancy.\n* Surgical history of the spine, such as spinal fusion and decompression surgery.\n* Severe systemic disorders such as autoimmune disorders, severe cardiovascular conditions\n* Non-Idiopathic Scoliosis",{"count":505,"type":22},72,[185],"A randomized controlled trial was conducted on 72 patients diagnosed with idiopathic scoliosis at the University of Lahore Teaching Hospital. The study aimed to explore the synergistic effects of the Schroth method with and without core stabilization exercises. Participants were randomly allocated into two groups: Group A, which received both the Schroth method and core stabilization exercises, and Group B, which received only the Schroth method. The intervention lasted for 10 weeks, with assessments conducted at baseline, the 5th week, and the 10th week. Outcome measures included Cobb angle (spinal curvature), lumbar extensor endurance (Sorensen test), chest mobility, and quality of life (SRS-22 questionnaire). The study found significant improvements in all outcome measures for both groups, with Group A showing superior results. The addition of core stabilization exercises to the Schroth method resulted in better reductions in Cobb angle, enhanced lumbar extensor endurance, and improved chest mobility and quality of life, indicating a synergistic effect of the combined approach. The findings suggest that incorporating core stabilization exercises into scoliosis treatment protocols can lead to superior clinical outcomes.",[26,415],[510,511,512,513,514,515,516,517,394,518],"Schroth Method","Idiopathic Scoliois","Core Stabilization Exercises","Cobb Angle","Lumbar Extensor Endurance","Chest mobility","SRS-22 questionnaire","Postural correction","Physiotherapy","2025-07-10",{"date":521,"type":32},"2025-07-15",{"date":523,"type":22},"2025-07-30",{"date":525,"type":22},"2026-01-30",{"name":527,"class":39},"University of Lahore",{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":534,"eligibilityCriteria":535,"healthyVolunteers":47,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":536,"targetDuration":4,"studyType":183,"phases":538,"briefSummary":540,"conditions":541,"keywords":543,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":547,"lastUpdatePostDateStruct":548,"startDateStruct":550,"completionDateStruct":552,"leadSponsor":554,"locationsCount":556},"100557651","phase-4-a-comparison-between-palonosetron-versus-granisetron-as-ponv-prophylaxis-in-scoliotic-patients-undergoing-spine-surgery-100557651","NCT06540885","A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery","A Comparison Between Palonosetron Versus Granisetron As Postoperative Nausea and Vomiting Prophylaxis In Idiopathic Scoliosis Surgery: A Randomized Control Trial","PONV","Inclusion Criteria:\n\n* Age: 10 years and above\n* American Society of Anesthesiologists (ASA) class I-II\n\nExclusion Criteria:\n\n* Active smoker\n* Obesity with body mass index (BMI) of 34 and above\n* Body weight of less than 30kg\n* History of gastro-esophageal reflux disease (GERD)\u002F other gastrointestinal diseases associated with vomiting\n* History of motion sickness\n* History of allergy to 5-HT3 (serotonin) receptor antagonists or dexamethasone\n* History of nausea or vomiting withing 24 hours before surgery\n* History of administration of antiemetics\u002F steroids\u002F psychoactive medications within 24 hours before the surgery\n* History of cardiac arrhythmias\n* Prolonged QT (QTc is prolonged if \\> 430ms in men or \\>450ms in women)",{"count":537,"type":22},74,[539],"PHASE4","The aim of this clinical trial is to compare the effectiveness of two Serotonin (5- HT3) receptor antagonist, palonosetron and granisetron, administered along with dexamethasone as a preventive measure against early and delayed postoperative nausea and vomiting (PONV) in adult and adolescent patients with idiopathic scoliosis (IS) undergoing posterior spinal fusion (PSF) surgery under total intravenous anesthesia (TIVA).\n\nThe main questions the study aims to answer are:\n\nHow effective is palonosetron compared to granisetron, when both combined with dexamethasone, in preventing PONV after scoliosis surgery? Are there any differences in the need for rescue antiemetics, occurrence of adverse effects related to the study drugs, and patient satisfaction between the two treatment groups? Participants in the study will be randomly assigned to receive either palonosetron or granisetron in addition to dexamethasone as part of their anesthesia and antiemetic regimen. The incidence and\u002F or severity of nausea, vomiting and retching will be assessed at 1 hour, 4 hours, 12 hours, 24 hours and 48 hours after surgery.",[542,26],"Postoperative Nausea and Vomiting",[544,545,546],"Antiemetics","Granisetron","Palonosetron","2025-04-22",{"date":549,"type":32},"2025-04-25",{"date":551,"type":32},"2025-01-06",{"date":553,"type":22},"2026-09-30",{"name":555,"class":39},"University of Malaya",2,{"id":558,"slug":559,"hasResults":12,"nctId":560,"briefTitle":561,"officialTitle":562,"acronym":4,"eligibilityCriteria":563,"healthyVolunteers":12,"sex":564,"minAge":18,"maxAge":77,"enrollmentInfo":565,"targetDuration":4,"studyType":183,"phases":567,"briefSummary":568,"conditions":569,"keywords":570,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":572,"lastUpdatePostDateStruct":573,"startDateStruct":575,"completionDateStruct":577,"leadSponsor":579,"locationsCount":556},"100254295","anisotropic-textile-braces-for-adolescent-idiopathic-scoliosis-100254295","NCT02589106","Anisotropic Textile Braces for Adolescent Idiopathic Scoliosis","Safety and Efficacy of Anisotropic Textile Braces for Adolescent Idiopathic Scoliosis","Inclusion Criteria:\n\n* Aged 10 to 14 years\n* Diagnosis of AIS\n* a Cobb's angle between 20 to 30 degrees\n* a Risser grade of the iliac crest of ≤ 2\n* Pre-menarche or post- menarche by no more than 1 year\n* Ability to read and understand English or Chinese\n* Physical and mental ability to adhere to anisotropic textile braces protocol\n\nExclusion Criteria:\n\n* Contraindications for x-ray exposure\n* Diagnosis of other musculoskeletal or developmental illness that might be responsible for the spinal curvature\n* History of previous surgical or orthotic treatment for AIS\n* Contraindications for pulmonary and\u002F or exercise tests\n* Psychiatric disorders\n* Recent trauma\n* Recent traumatic (emotional) event","FEMALE",{"count":566,"type":22},15,[185],"One of the most common types of 3-dimensional spinal deformities with unknown etiology in youths is adolescent idiopathic scoliosis (AIS). The spinal curvature increases as puberty progresses. Generally, rigid orthotic bracewear is prescribed as non-invasive treatment for moderate AIS if treatment begins early and the orthosis is worn with compliance. Obviously, teenage patients are reluctant to accept a rigid orthosis due to aesthetics and the physical constraint. Therefore, semi-rigid and flexible orthoses have been developed, but their efficacy is still controversial and there are other issues, such as high pain scores. There is clearly room for improvement. Therefore, a garment-type of bracewear will be designed and developed to correct spinal deformity, reduce the possibility of spinal curve progression, and satisfy the needs of the patients as well as take their psychological concerns into consideration.",[26],[571],"Anisotropic Textile Braces","2025-03-11",{"date":574,"type":32},"2025-03-13",{"date":576,"type":32},"2017-01",{"date":578,"type":22},"2025-12-31",{"name":580,"class":39},"The Hong Kong Polytechnic University",{"id":582,"slug":583,"hasResults":12,"nctId":584,"briefTitle":585,"officialTitle":586,"acronym":587,"eligibilityCriteria":588,"healthyVolunteers":47,"sex":17,"minAge":589,"maxAge":4,"enrollmentInfo":590,"targetDuration":4,"studyType":183,"phases":592,"briefSummary":593,"conditions":594,"keywords":598,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":602,"lastUpdatePostDateStruct":603,"startDateStruct":605,"completionDateStruct":607,"leadSponsor":608,"locationsCount":40},"100558666","study-comparing-the-pathkeeper-system-for-pedicle-screw-positioning-in-spine-surgery-with-traditional-care-100558666","NCT06554093","Study Comparing the PathKeeper System for Pedicle Screw Positioning in Spine Surgery With Traditional Care","A Prospective, Dual Canter, Double Armed, Open Label, Clinical Study to Evaluate the Performance of the PathKeeper System for Pedicle Screw Positioning in Spine Surgery","PKSforPSP","Inclusion Criteria:\n\n* Men and women\n* 16 and above years old\n* Patients who are about to undergo open, instrumented spinal surgery\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Men and women\n* 16 and above years old\n* Patients who are about to undergo open, instrumented spinal surgery\n* Signed informed consent form","16 Years",{"count":591,"type":22},32,[185],"The goal of this is to evaluate performance of the Pathkeeper Surgical System. The main question\\[s\\]it aims to answer are: 1) evaluate pedicle screw position Participants will in compare Experimental arm: PathKeeper System (PKS) with control arm",[26,416,141,595,596,597],"Scoliosis Lumbar Region","Scoliosis Thoracic Region","Pathologic Fracture",[599,600,601],"fusion","screw positioning","screw insertion","2025-02-03",{"date":604,"type":32},"2025-02-05",{"date":606,"type":22},"2025-10-30",{"date":606,"type":22},{"name":609,"class":199},"Deep Health Ltd.",{"id":611,"slug":612,"hasResults":12,"nctId":613,"briefTitle":614,"officialTitle":615,"acronym":4,"eligibilityCriteria":616,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":617,"enrollmentInfo":618,"targetDuration":107,"studyType":23,"phases":4,"briefSummary":620,"conditions":621,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":625,"lastUpdatePostDateStruct":626,"startDateStruct":628,"completionDateStruct":630,"leadSponsor":632,"locationsCount":40},"100368790","evaluation-of-the-effects-of-a-rehabilitation-program-in-individuals-with-spine-pain-100368790","NCT04081896","Evaluation of the Effects of a Rehabilitation Program in Individuals with Spine Pain","Evaluation of the Effects of Exercise-based Rehabilitation in Individuals with Spine Pain","Inclusion Criteria:\n\n* over 18 years of age\n* under 89 years of age\n* Patients who have been prescribed physical rehabilitation for management of spine pain\n\nExclusion Criteria:\n\n* under 18 years of age\n* over 89 years of age\n* Patients who are unable or medically unsafe to participate in physical rehabilitation for management of spine pain as determined by the prescribing physician","89 Years",{"count":619,"type":22},5000,"SpineZone is an innovative physical therapy program with its focus on treatment of cervical, thoracic, and lumbar conditions through the use of a multi-disciplinary, technology enabled platform. Standard physical therapy modalities including psychologically informed physical therapy are employed in addition to online coaching with a fundamental tenant of core strengthening. Treatments are tracked and modified in a multi-disciplinary format taking all radiographic studies into direct consideration. The goal of this study is to utilize a registry of participants undergoing either in-clinic or online rehabilitation treatment for spine pain at the SpineZone clinical in order to understand the clinical outcomes and costs of different rehabilitation modalities in this patient population.",[622,623,26,624],"Neck Pain","Low Back Pain","Thoracic Injuries","2024-11-26",{"date":627,"type":32},"2024-11-29",{"date":629,"type":32},"2019-04-15",{"date":631,"type":22},"2029-04-15",{"name":633,"class":39},"SpineZone Medical Fitness, Inc",{"id":635,"slug":636,"hasResults":12,"nctId":637,"briefTitle":638,"officialTitle":639,"acronym":4,"eligibilityCriteria":640,"healthyVolunteers":12,"sex":17,"minAge":641,"maxAge":642,"enrollmentInfo":643,"targetDuration":4,"studyType":183,"phases":645,"briefSummary":646,"conditions":647,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":648,"lastUpdatePostDateStruct":649,"startDateStruct":651,"completionDateStruct":653,"leadSponsor":654,"locationsCount":40},"100550783","effect-of-regional-anesthesia-or-intravenous-infusion-of-lidocaine-on-morphine-use-after-scoliosis-repair-surgery-100550783","NCT06451562","Effect of Regional Anesthesia or Intravenous Infusion of Lidocaine on Morphine Use After Scoliosis Repair Surgery","A Controlled Study to Compare the Effect of Regional Anesthesia by an Erector Spine Plane Block and Intravenous Infusion of Lidocaine on the Rate of Intravenous Morphine Use After Scoliosis Repair Surgery","Inclusion Criteria:\n\nPatients over the age of 12 with normal cognition, who are scheduled to undergo surgery to correct scoliosis and treatment with IV PCA independently for pain relief after surgery; The patients' parents\u002Fguardian (in the case of a minor) or the patient himself (in the case of an adult) signed an informed consent form for participation in the study; Patients should be able to operate the PCA device independently\n\nExclusion Criteria:\n\nPatients who do not agree to participate in the study even if their parents signed an informed consent\n\nPatients who are unable to operate the PCA device independently\n\nPatients under treatment with opioids or cannabis for chronic pain for more than a month;\n\nDrug use of any kind;\n\nAlcoholism;\n\nPatients with depression, anxiety or post-trauma;\n\nModerate-severe insufficiency of one of the systems - respiratory\u002Fcardiac\u002Fhepatic\u002Frenal;\n\nSensitivity to one of the drugs in the research protocol.","12 Years","25 Years",{"count":644,"type":22},105,[185],"The goal of the surgical correction of scoliosis is to prevent progression of the curve or progression of restrictive lung disease. After scoliosis surgery, patients experience severe pain. The standard treatment for pain relief after scoliosis surgery is the administration of opiates. However, treatment with these substances involves side effects such as respiratory depression, nausea and vomiting, inhibition of bowel activity and itching. To lower the dose of opiates, different types of painkillers and other techniques can be added.\n\nThe purpose of the study is to compare the effect of instillation of lidocaine (which is an analgesic and anti-inflammatory) or regional anesthesia using Erector spinae plane on the dose of morphine consumption, the intensity of pain, the side effects and the quality of recovery during the first 48 hours after surgery to repair scoliosis.",[26],"2024-11-10",{"date":650,"type":32},"2024-11-12",{"date":652,"type":32},"2024-09-01",{"date":553,"type":22},{"name":655,"class":656},"Assaf-Harofeh Medical Center","OTHER_GOV"]