[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"screening-strategy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:screening-strategy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100570523","enhancing-cervical-cancer-screening-and-treatment-in-women-living-with-hiv-in-kenya-the-enhance-linkage-trial-100570523",false,"NCT06708351","Enhancing Cervical Cancer Screening and Treatment in Women Living With HIV in Kenya, the ENHANCE LINKAge Trial","Enhancing Cervical Cancer Screening and Treatment in Women Living With HIV in Kenya (ENHANCE LINKAGE)","Inclusion Criteria:\n\n* AIM 1 (PATIENTS): Aged 25-49 years\n* AIM 1 (PATIENTS): Female\n* AIM 1 (PATIENTS): Willing to participate in a 90-minute audio-recorded focus group discussion (FGD) and\n* AIM 1 (PATIENTS): Speak English or Swahili\n* AIM 1 (NURSES, CLINICAL STAFF, ADMINISTRATORS): Aged 18 years or older\n* AIM 1 (NURSES, CLINICAL STAFF, ADMINISTRATORS): Involved in implementing intervention components\n* AIM 1 (STAKEHOLDERS): Adults (aged \\>= 18 years) who are healthcare system users, support persons, healthcare providers and administrators, representatives of the government, professional associations, and non-governmental and faith-based organizations\n* AIMS 2 AND 3 (CLINIC PROVIDERS): Aged 18 years and older involved in CC screening, triage, and treatment\n* AIMS 2 AND 3 (WOMEN LIVING WITH HIV): Ages 25-49 years\n\nExclusion Criteria:\n\n* AIM 1: Stakeholder Advisory Board (SAB) members who are not engaged in CC work, individuals who have recently retired from the selected clinics, and patients who are attending the clinic for the first time will be excluded from the study\n* AIMS 2 AND 3 (WOMEN LIVING WITH HIV): Pregnant women, women =\\\u003C 6 weeks postpartum, and women already confirmed to have cervical cancer will be excluded",true,"FEMALE","25 Years","49 Years",{"count":21,"type":22},2280,"ESTIMATED","INTERVENTIONAL",[25],"NA","Background In sub-Saharan Africa (SSA), human papillomavirus (HPV) and HIV create a dual burden of disease that causes significant morbidity and mortality in the form of cervical cancer (CC). Women living with HIV (WLWH) have a six-fold higher risk of developing precancerous lesions that persist and progress to CC, which is the leading cause of cancer mortality among women in Kenya. Significant support from the Go Further campaign, represented by donors such as the President's Emergency Plan for AIDS Relief (PEPFAR), the George W. Bush Institute, UNAIDS, Merck, and Roche, to integrate CC screening into HIV clinics represents an exceptional opportunity to scale CC impact across SSA, but only if implementation science evidence is available to inform strategy. Currently, the impact of Go Further has been undermined by fractured linkages to care and insensitive screening methods; in Kenya, less than 2% of WLWH screened have received appropriate treatment. Implementation science studies are needed to better understand and surmount barriers to integrated care in publicly funded HIV clinics.\n\nBroad objective This study seeks to explore and innovate strategies to overcome patient-, provider-, and system-level barriers to implementing CC screening and referral guidelines, link WLWH who require further diagnostic testing and\u002For treatment with effective and accessible care, and document services for accountability and quality improvement. In this proposal, our team will apply our extensive implementation science expertise and partnerships with Kenya Ministry of Health (MOH) to adapt and test evidence-based strategies (e.g., HPV self-testing, care navigators, and the WEMA mHealth app \\[tested and scaled in Tanzania\\]) that address key multi-level barriers identified through a formative, stakeholder-engaged research phase.\n\nMethodology Using the EPIS framework to guide our project, we will: Aim 1a), Explore (engage a multi-disciplinary stakeholder advisory board to co-design the intervention package and prioritize implementation strategies that align with local capacity, opportunities, and motivations; Aim 1b), Prepare (develop tools and strengthen capacity at clinics to implement the strategies; Aim 2), Implement and evaluate the package of implementation strategies via a cluster-randomized stepped wedge trial in 9 clinics (assessing implementation \\[provision of CC screening with HPV self-testing\\] and effectiveness \\[proportion of HPVpositive WLWH who receive subsequent diagnostic triage and\u002For treatment\\] over months 0-12; and Aim 3), assess Sustainability (costs, cost-effectiveness, and transfer of delivery from study to local staff over months 13-18.\n\nSignificance of the study The overall goal of this study is to employ rigorous empirical methods to adapt and test implementation strategies that expand the scope of HIV care to screen for and treat early precancerous CC lesions in a sustainable, scalable way. Through partnering with Kenya's MOH, this project will have critical institutional support and dissemination capability, and will directly inform public health practice and policy.",[28,29,30],"HIV Infection","Human Papillomavirus-Related Cervical Carcinoma","Screening Strategy","NOT_YET_RECRUITING","2026-05-28",{"date":34,"type":35},"2026-05-29","ACTUAL",{"date":37,"type":22},"2026-07-31",{"date":39,"type":22},"2030-08-31",{"name":41,"class":42},"Emory University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100622425","lung-cancer-screening-in-population-who-had-never-smoked-100622425","NCT07383454","Lung Cancer Screening in Population Who Had Never Smoked","Lung Cancer Screening in Population Who Had Never Smoked and the Validation of Lung Cancer Risk Prediction Model","Inclusion Criteria:\n\n1. Individuals with no history of smoking.\n2. Aged 40 to 80 years.\n3. Willing to provide written informed consent and complete questionnaire assessments.\n4. After undergoing examinations, willing to provide relevant biological information, including but not limited to: blood samples, urine samples, pulmonary function test results, imaging data, and tissue specimens obtained from invasive biopsies or surgical procedures (if applicable).\n\nExclusion Criteria:\n\n1. History of lung cancer, or a diagnosis of any malignancy other than skin cancer or cervical carcinoma in situ within the past five years.\n2. Undergoing chest computed tomography (CT) scans within the past 18 months.\n3. Unexplained hemoptysis within the past one month.\n4. Unexplained weight loss exceeding 6 kilograms within the past one year.\n5. Pregnancy.","ALL","40 Years","80 Years",{"count":55,"type":22},2500,[25],"Study design: prospective, single arm.\n\nObjectives: survey lung cancer detection rate of low-dose computed tomography (LDCT) screening in individuals who had never smoked.\n\nParticipants will undergo questionnaires, and collecting specimens including blood, urine, and medical informations including results of pulmonary function tests, and LDCT screening upon inclusion. The participants will be followed up according to current standards of clinical practice.",[59,60,61,30],"Lung Cancer (Diagnosis)","Non-Small Cell Lung Cancer","Small Cell Carcinoma of Lung",[63,64,65,66,67],"Low dose computed tomography (LDCT)","Lung cancer in individuals who had never smoked (LCINS)","Lung cancer risk prediction model (LCRPM)","Lung cancer","Non-small cell lung cancer (NSCLC)","2026-01-26",{"date":70,"type":35},"2026-02-03",{"date":72,"type":22},"2026-02-01",{"date":74,"type":22},"2034-12",{"name":76,"class":42},"Chung Shan Medical University",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":104,"leadSponsor":106,"locationsCount":43},"100596229","the-effect-of-animation-based-education-on-menopausal-womens-attitudes-behaviors-and-screening-test-participation-regarding-breast-cancer-100596229","NCT07042737","The Effect of Animation-Based Education on Menopausal Women's Attitudes, Behaviors, and Screening Test Participation Regarding Breast Cancer","The Effect of Education Provided to Women in Menopause Through Animation on Breast Cancer Attitudes, Behaviors, and Screening Test Participation","Menopause","Inclusion Criteria:\n\n* Not having been diagnosed with breast cancer,\n* not performing regular self-examinations (those who performed self-examinations at least once a month were excluded),\n* not having had a mammogram (those who had a mammogram within the first six months after training were excluded),\n* not having undergone a clinical breast examination (those who underwent a clinical breast examination within the first 6 months after the training were excluded),\n* not breastfeeding or being pregnant, being literate, owning a smartphone,\n* having internet access,\n* not having uterine abnormalities,\n* having ovaries,\n* not having used sex hormones.\n\nExclusion Criteria:\n\n* never experiencing menopausal symptoms,\n* undergoing surgical menopause,\n* currently or previously using hormonal therapy,\n* having a psychiatric disorder,\n* having menstruated in the past year,\n* incomplete forms,\n* not fully participating in video-based education programs.",{"count":86,"type":22},136,[25],"The aim of this study was to determine the effect of education provided to women in menopause through animation on their attitudes toward breast cancer, behaviors, and screening test participation. The study will include a total of 136 women in the menopausal period, comprising 68 experimental group participants and 68 control group participants who have applied to the Orduyeri and Kırtepe Family Health Centers affiliated with the Bartın Public Health Institution. Women who agree to participate in the project, which will run from January to August 2025, will receive 40-45 minute training sessions in a suitable room at the ASM. The training sessions will be conducted in groups of 8-12 people. The training content will include information about the purpose, duration, and rules of the training. After providing information about the project, a pre-test will be administered. Through face-to-face interviews, researchers assigned to the project will show animated videos enriched with sound and images via an online program they have prepared. These videos will be 10-12 minutes long, and an interim test will be conducted. Three months after the pre-test, the women participating in the study will be contacted, and a final test will be administered in their own homes. Project data will be collected using the Personal Information Form, Champion Health Belief Scale, and Breast Cancer Awareness Scale. Descriptive statistics, independent sample t-tests, chi-square tests, and repeated measures analysis of variance (ANOVA) tests will be used in the statistical analysis of the project.",[90,91,92,93,30],"Menopausal Women","Education Nursing","Breast Cancer Females","Motivation",[95,96,97,98,99],"education through animation","menopause","breast cancer","screening test","motivation","2025-06-20",{"date":102,"type":35},"2025-06-29",{"date":100,"type":22},{"date":105,"type":22},"2026-10-20",{"name":107,"class":42},"Inonu University"]