[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"scurvy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:scurvy":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100583455","vitamin-c-deficiency-in-hospitalized-adults-systematic-screening-vs-traditional-judgment---a-before-and-after-observational-study-100583455",false,"NCT06876545","\"Vitamin C Deficiency in Hospitalized Adults: Systematic Screening Vs. Traditional Judgment - a Before-and-After Observational Study\"","Identification of Vitamin C Deficiency in Hospitalized Adults Through a Systematic Approach Vs. Traditional Medical Judgment: a Before-and-After Observational Study","Inclusion Criteria:\n\nHospitalized adult patients (≥18 years old) who had Vitamin C testing performed during their hospital stay.\n\nDocumented hemorrhagic manifestations in medical records, including at least one of the following:\n\nHematuria (macroscopic or detected via urine dipstick\u002Fmicroscopy). Ecchymoses (bruising). Petechiae. Epistaxis (nosebleeds). Gastrointestinal bleeding (melena, hematemesis, or positive fecal occult blood test).\n\nCerebral hemorrhage. Medical records available with sufficient clinical and laboratory data to assess eligibility and study variables.\n\nPatients from two distinct periods:\n\nHistorical Control Group: Patients tested for Vitamin C \"as needed\" based on traditional medical judgment.\n\nActive Group: Patients tested systematically according to Scurvy Suspicion upon Hemorrhagic Risk (SFI) criteria after protocol implementation.","ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","OBSERVATIONAL","Brief Summary of the Study The goal of this observational study is to assess the incidence of vitamin C deficiency among hospitalized adults presenting with hemorrhagic signs. The study will also evaluate the effectiveness of a standardized screening protocol compared to traditional clinical judgment.\n\nThe main questions it aims to answer are:\n\nWhat is the incidence of vitamin C deficiency in hospitalized patients with hemorrhagic symptoms? Is a standardized screening protocol more effective than traditional clinical judgment in identifying vitamin C deficiency? Is vitamin C deficiency associated with anemia, other micronutrient deficiencies (folate, B12, albumin, iron), or infectious conditions? Does vitamin C deficiency impact hospital length of stay? Researchers will compare a systematic screening approach based on predefined hemorrhagic criteria (e.g., hematuria, ecchymosis, epistaxis, petechiae, gastrointestinal bleeding, or intracranial hemorrhage) to the traditional physician-judgment approach to determine its effectiveness in identifying vitamin C deficiency.\n\nStudy Design\n\nParticipants will:\n\nBe hospitalized adults (≥18 years old) presenting with documented micro- or macroscopic hemorrhagic signs.\n\nUndergo vitamin C level assessment either as part of the standardized screening protocol (prospective arm) or based on physician judgment (retrospective control group).\n\nHave additional clinical and laboratory data collected, including hemoglobin levels, platelet count, iron status, vitamin B9\u002FB12 levels, and other relevant parameters.\n\nThis non-interventional study will not modify the standard of care but will systematically assess the prevalence of vitamin C deficiency in at-risk patients and evaluate the utility of a structured screening protocol.",[24],"Scurvy",[26],"Scurvy, vitamin C defficiency, hospitalized","NOT_YET_RECRUITING","2025-03-10",{"date":30,"type":31},"2025-03-14","ACTUAL",{"date":33,"type":20},"2025-04-01",{"date":35,"type":20},"2025-04-30",{"name":37,"class":38},"Internist.Ro","OTHER"]