[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sdhx-related-syndromes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sdhx-related-syndromes":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100547471","impact-of-environmental-exposures-on-tumor-risk-in-sdhx-mutation-carriers-100547471",false,"NCT06408402","Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers","Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx-related Paragangliomas - National Study","PGLEXPO2","Inclusion Criteria:\n\n* Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor\n* Controls: SDHx mutation carriers with no SDHx-related tumor\n\nExclusion Criteria:\n\n* Incapacity to exercise free and informed consent for the study\n* Patient under tutorship or guardianship or legal safeguard","ALL","18 Years",{"count":20,"type":21},1300,"ESTIMATED","OBSERVATIONAL","The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and\u002For domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects carrying a germline mutation in one of the SDHx genes.The primary endpoint will be the proportion of subjects (cases or controls) exposed to SDHi and the association with paraganglioma risk.\n\nIn addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study",[25,26,27,28],"SDH-Related Familial Paraganglioma","SDHx-Related Syndromes","SDH Gene Mutation","Environmental Exposure",[30,31,32],"hereditary paraganglioma","SDHx gene mutation","environmental exposure","NOT_YET_RECRUITING","2024-05-06",{"date":36,"type":37},"2024-05-10","ACTUAL",{"date":39,"type":21},"2024-05-01",{"date":41,"type":21},"2028-05-01",{"name":43,"class":44},"Assistance Publique - Hôpitaux de Paris","OTHER",20]