[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sebum-deficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sebum-deficiency":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100560021","the-effects-of-topical-almond-oil-and-tretinoin-on-facial-wrinkles-100560021",false,"NCT06571721","The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles","Prospective, Double-Blinded, Randomized Study of Topical Almond Oil and Tretinoin on Facial Wrinkles","Inclusion Criteria:\n\n* Post-menopausal women of Fitzpatrick skin types 1, 2, and 3\n* Individuals with facial fine lines and wrinkles\n\nExclusion Criteria:\n\n* Individuals who are pregnant or breastfeeding\n* Prisoners\n* Adults unable to consent\n* Those with a nut allergy or tocopherol allergy\n* Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking\n* Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes)\n* Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment\n* Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention\n* Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment:\n* Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.\n* Antioxidant ingredients such as vitamin C or vitamin E.\n* Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study.\n* Topicals that contain a nut oil or nut extract as part of their ingredient list.",true,"FEMALE","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.",[27,28,29,30,31],"Collagen Degeneration","Wrinkle","Pigmentation","Elastic Skin","Sebum Deficiency",[33,34,35,29],"Facial Wrinkles","Skin biophysical properties","Photoaging","RECRUITING","2024-08-26",{"date":39,"type":40},"2024-08-28","ACTUAL",{"date":42,"type":40},"2024-07-22",{"date":44,"type":21},"2025-07-22",{"name":46,"class":47},"Integrative Skin Science and Research","INDUSTRY"]