[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sedentary-behavior\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sedentary-behavior":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,46,0,25,[9,50,91,118,148,187,215,244,276,302,328,354,383,414,442,465,490,514,542,570,596,626,655,679,698],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100053641","weekend-warrior-exercise-in-sedentary-female-university-students-100053641",false,"NCT07693504","Weekend Warrior Exercise in Sedentary Female University Students","Effects of Weekend Warrior Exercise on Aerobic Capacity and Skeletal Muscle Strength in Sedentary Female University Students: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Female university students aged 18 to 25 years.\n* Self-reported sedentary time of at least 6 hours per day, further assessed using the International Physical Activity Questionnaire (IPAQ).\n* No cardiovascular, pulmonary, neurological, metabolic, or musculoskeletal diseases.\n* Relatively regular menstrual cycles.\n* Able to understand the study procedures, willing to complete the intervention and assessments, and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Any condition identified through clinical assessment or health screening that makes participation in moderate-intensity exercise or exercise-to-exhaustion testing inappropriate.\n* Participation in regular exercise training, a systematic weight-loss or body-shaping program, or another exercise intervention study within the previous 3 months.\n* Recent substantial body-weight fluctuations that may affect body-composition assessment.\n* Cardiovascular, pulmonary, neurological, metabolic, or musculoskeletal diseases, or current use of medications that may affect exercise performance, heart-rate responses, or muscle function.\n* Irregular menstrual cycles.\n* Inability to complete the 8-week intervention, post-intervention assessments, or required study records.",true,"FEMALE","18 Years","25 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"NA","This single-center, single-blind, three-arm randomized controlled trial aims to compare the effects of weekend-concentrated exercise, regularly distributed exercise, and usual lifestyle on aerobic capacity and skeletal muscle strength in sedentary female university students. Sixty participants aged 18 to 25 years will be randomly assigned in a 1:1:1 ratio to a weekend warrior group, a regular exercise group, or a control group.\n\nThe intervention will last 8 weeks. Both exercise groups will complete 150 minutes of moderate-intensity exercise per week, combining resistance exercise and jogging, but the exercise sessions will be distributed differently across the week. The control group will maintain its usual lifestyle without receiving the prescribed exercise intervention.\n\nThe primary outcomes are peak oxygen uptake and isokinetic peak torque. Secondary outcomes include body composition, maximal heart rate, maximal power and time to exhaustion, 12-minute run performance, isokinetic mean torque, physical activity, sleep quality, exercise self-efficacy, emotional status, cognitive function, adherence, feasibility, and exercise-related adverse events.",[29],"Sedentary Behavior",[31,32,33,34,35,36],"Weekend Warrior Exercise","Aerobic Capacity","Skeletal Muscle Strength","Female University Students","Exercise Distribution","Moderate-Intensity Exercise","NOT_YET_RECRUITING","2026-07-10",{"date":40,"type":41},"2026-07-13","ACTUAL",{"date":43,"type":23},"2026-07",{"date":45,"type":23},"2027-10",{"name":47,"class":48},"Chongqing Normal University","OTHER",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":17,"sex":58,"minAge":19,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":49},"100645326","hamstring-tightness-and-lumbar-lordosis-angle-across-functional-sitting-postures-100645326","NCT07682142","HAMSTRING TIGHTNESS AND LUMBAR LORDOSIS ANGLE ACROSS FUNCTIONAL SITTING POSTURES","CORRELATION BETWEEN HAMSTRING TIGHTNESS AND LUMBAR LORDOSIS ANGLE ACROSS FUNCTIONAL SITTING POSTURES IN SEDENTARY ADULTS.","LLA-HT","Inclusion Criteria:\n\n* Healthy adults aged 18-45 years.\n* Sedentary occupation requiring \\> 6 hours of sitting per day.\n* Active Knee Extension (AKE) angle \\>15°.\n* Bilateral hamstring tightness.\n* Sedentary individual as determined by IPAQ (MET≤ 600 min\u002Fweek).\n* Asymptomatic for low back pain at the time of testing.\n\nExclusion Criteria:\n\n* History of significant low back pain requiring medical treatment in the past 12 months.\n* Previous spinal surgery or structural spinal deformities.\n* Lower extremity injury or surgery within the past 6 months.\n* Neurological disorders affecting sensation or movement.\n* Pregnant female or get birth in the last year.\n* Body mass index (BMI) ≥ 30 kg\u002Fm².\n* postural deviations resulting from shortening of the iliopsoas and erector spinae or insufficiency of the core stabilizers and hip extensors","ALL","45 Years",{"count":61,"type":23},110,"OBSERVATIONAL","The goal of this observational study is to learn about the relationship between hamstring tightness and the lumbar lordosis angle in sedentary adults across different sitting postures. The main question it aims to answer is:\n\nIs hamstring tightness related to the lumbar lordosis angle across three functional sitting postures (upright, slumped, and forward-leaning)? It also asks whether hamstring tightness differs between men and women, whether it differs between the dominant and non-dominant leg, and whether the lumbar lordosis angle differs between men and women across the three postures.\n\nParticipants will have their hamstring tightness measured with the Active Knee Extension test and their lumbar lordosis angle measured with a bubble inclinometer while sitting in each of the three postures.",[65,66,29,67],"Hamstring Tightness","Lumbar Lordosis","Posture Sitting Position",[69,70,71,72,73,74,75,76,77,78,79,80,81],"Hamstring tightness","Lumbar lordosis","Sitting posture","Functional sitting postures","Sedentary adults","Active Knee Extension test","AKE test","bubble inclinometer","Pelvic tilt","Lumbopelvic rhythm","Limb dominance","Posterior pelvic tilt","Spinopelvic alignment","2026-06-27",{"date":84,"type":41},"2026-07-02",{"date":86,"type":23},"2026-08-01",{"date":88,"type":23},"2026-12-01",{"name":90,"class":48},"Cairo University",{"id":92,"slug":93,"hasResults":12,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":17,"sex":58,"minAge":99,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":24,"phases":102,"briefSummary":103,"conditions":104,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":49},"100585012","increasing-physical-activity-through-social-support-and-stress-resilience-100585012","NCT06896825","Increasing Physical Activity Through Social Support and Stress Resilience","Increasing Physical Activity Through Social Support and Stress Resilience (I-PASS) Among Older Adults Living Alone With SCD to Lower ADRD Risk","I-PASS","Inclusion Criteria:\n\n* Aged 60 years or older\n* Living alone and community dwelling\n* Engaging in 60 minutes or less per week of self-reported moderate-to-vigorous physical activity at screening (based on Exercise Vital Sign Questionnaire)\n* Self-reported decline in cognitive functioning\n* Self-reported ownership of\u002Fwillingness to use a smartphone with an iOS or Android operating system (necessary for participants to track their activity using a wearable activity monitor).\n* Able to read and speak in English. We hope to offer the intervention in Spanish in the future; however, currently, the study materials are only available in English, and participation will require ability to read and respond to study materials.\n\nExclusion Criteria:\n\n* Endorsing an item on the Physical Activity Readiness Questionnaire (PAR-Q), unless a physician's note is provided\n* Resting blood pressure greater than 200\u002F110 mmHG as assessed at the baseline study assessment (unless a physician's note is provided)\n* Plans to relocate out of metropolitan Phoenix, Arizona area in the next 6 months\n* Participation in another physical activity, nutrition or weight loss program at time of screening or at any time during the intervention\n* Individuals with mild cognitive impairment (MCI), as determined by either a self-report of receiving a diagnosis of MCI from a health care provider or as assessed by the Telephone-Montreal Cognitive Assessment (T-MoCA) at the Baseline Session. A score \\\u003C 18 is an exclusion criterion.\n* Individuals with neurodegenerative (e.g., dementia), developmental (e.g., autism), neurologic (e.g., Parkinson's, epilepsy), or major psychiatric (e.g., bipolar, schizophrenia) diagnoses\n* Being previously prescribed one of the 5 approved Alzheimer's medications, including: Donepezil (Aricept), Rivastigmine (Exelon), Galantamine (Razadyne), Memantine (Namenda), Memantine + Donepezil (Namzaric)\n* Score of 9 or higher on the 15-item Geriatric Depression Scale (GDS) at the Baseline Session \\[scores of 9 and higher are indicative of moderate to severe depression\\]\n* History of stroke\n* Incarcerated individuals (i.e., Prisoners)","60 Years",{"count":101,"type":23},86,[26],"The goal of this clinical trial is to learn the effects of technology enhancements when combined with basic education, goal-setting, and self-monitoring to increase physical activity among older adults living alone, experiencing subjective cognitive decline, and currently engaging minimal physical activity (60 minutes or less of moderate to vigorous physical activity). Further, we will examine key psychosocial mechanisms believed to contribute to successful promotion of physical activity, which include social support and stress resilience.\n\nThe primary questions are to determine whether\n\n* the tech-enhanced condition lead to greater physical activity over time?\n* the tech-enhanced condition lead to social support and stress resilience over time?\n* social support and stress resilience mediate the relationship between the study condition and physical activity?\n\nAll participants will engage in self-monitoring of physical activity, will receive weekly text reminders of their physical activity goals for the week, and will receive basic education about the importance of physical activity, social support, and stress resilience for cognitive, physical, and psychological health. Participants in the tech-enhanced condition will also receive access to a study-specific website and virtual coaching to reinforce the information presented. Researchers will then compare the tech-enhanced condition to the basic education condition to determine the benefits of technology to deliver the intervention materials in order to increase physical activity, social support, and stress resilience.\n\nParticipants will:\n\n* Use a Garmin wearable device to monitor their physical activity\n* Be randomly assigned to a basic education condition or tech-enhanced condition\n* Set achievable goals for weekly physical activity, with incremental increases to achieve 7000 average daily steps by the end of the study\n* Respond to surveys to monitor their social support, stress resilience, quality of life, and depression.\n\nThe sample has several risk factors for Alzheimer's disease and related dementias: low physical activity, social isolation risk via living alone, and subjective cognitive impairment. Therefore, a long-term goal includes the determination of the intervention's effectiveness at increasing physical activity, social support, and stress resilience to reduce risk for developing dementia.",[105,106,29,107],"Healthy","Subjective Cognitive Decline (SCD)","Social Isolation in Older Adults","RECRUITING","2026-06-25",{"date":111,"type":41},"2026-06-29",{"date":113,"type":41},"2025-06-23",{"date":115,"type":23},"2027-04",{"name":117,"class":48},"Arizona State University",{"id":119,"slug":120,"hasResults":12,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":17,"sex":125,"minAge":19,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":24,"phases":129,"briefSummary":130,"conditions":131,"keywords":135,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":49},"100644247","multidisciplinary-health-monitoring-for-esports-players-100644247","NCT07665333","Multidisciplinary Health Monitoring for Esports Players","Evaluating the Effectiveness of a Multidisciplinary Health Monitoring and Preventive Intervention Model for Esports Players","Inclusion Criteria:\n\n* Aged 18-35 years\n* Active esports player at university or professional level\n* Regularly engaged in esports training\u002Fplay for at least the past 6 months (\\>=3 days\u002Fweek)\n* Cognitively able to understand and complete the tests and questionnaires\n* Average daily screen\u002Fgaming exposure of \\>=3 hours\n* Willing to participate in the assessment and exercise program and providing written informed consent\n\nExclusion Criteria:\n\n* Serious musculoskeletal injury or surgery within the past 6 months\n* Diagnosed neurological disease (e.g., epilepsy, MS, Parkinson's)\n* Cardiovascular or respiratory disease that contraindicates exercise\n* Diagnosed serious psychiatric disorder (e.g., major depression, bipolar disorder, psychotic disorders) or being in active treatment\n* Regular medication use at a level that could affect physiological or cognitive measurements\n* Any condition that would prevent regular participation throughout the study (e.g., time constraints, lack of motivation)","MALE","35 Years",{"count":128,"type":23},30,[26],"This study aims to develop a holistic, multidisciplinary health monitoring\u002Fscreening module that evaluates the health and performance parameters of esports players, and to apply and assess the effectiveness of an individualized multidisciplinary preventive intervention program (PIP) based on the screening findings. Esports players are frequently exposed to prolonged sitting, repetitive movements, high screen time, and irregular lifestyle habits, which can lead to musculoskeletal problems, visual strain, increased cardiovascular load, sleep disturbances, and psychological effects. Comprehensive, systematic, and multidisciplinary screening models addressing these risks remain limited in the literature.\n\nAmateur and\u002For professional players from the Yeditepe University Esports Club will undergo a multidimensional baseline assessment covering cardiovascular and respiratory parameters, musculoskeletal analysis, visual strain, nutritional status, cognitive function, and mental status. Participants will then be allocated to a control group or an intervention group. The intervention group will complete a 12-week individualized preventive exercise protocol in addition to their usual training, while the control group continues their usual training routine. All measurements will be repeated after 12 weeks to evaluate the effectiveness of the program.",[132,29,133,134],"Musculoskeletal Pain","Diet Habit","Physiological Stress",[136,137,138],"Esport athletes","Preventative intervention","Exercise program","2026-06-23",{"date":141,"type":41},"2026-06-24",{"date":143,"type":23},"2026-09",{"date":145,"type":23},"2029-03",{"name":147,"class":48},"Yeditepe University",{"id":149,"slug":150,"hasResults":12,"nctId":151,"briefTitle":152,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":12,"sex":58,"minAge":19,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":24,"phases":157,"briefSummary":158,"conditions":159,"keywords":168,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":49},"100626901","families-implementing-good-health-traditions-for-life-100626901","NCT07441655","Families Implementing Good Health Traditions for Life","FIGHT for Life","Inclusion Criteria:\n\n1. Family 1.a.) Black Parent\u002FGuardian: age 18 years or older residing in the same household with child (i.e., biological or have legal guardianship for child) 1.b.) Child: age 8-15 years old\n2. Parent\u002FGuardian have HbA1c level 5.7-6.4% (prediabetes)\n3. Parent\u002FGuardian willing to commit to participation in a 20-month research study and have no plans to move from the area over the next 20-months\n4. Parent\u002Fchild are ambulatory and able to participate in physical activity\n\nExclusion Criteria:\n\n1. Individuals with severe psychological disorders that may prevent\u002Finterfere with study participation\n2. Physical impairments that may prevent participation in moderate intensity physical activity;\n3. Previous diagnosis of diabetes\n4. History of congestive heart failure, renal failure, or recent (\\\u003C12 months) cardiovascular events such as myocardial infarction or stroke;\n5. Person taking medications that may affect endpoint analyses\n6. Persons with co-morbid contraindications to physical activity or dietary changes.\n7. Currently pregnant or planning to become pregnant in the next year.",{"count":156,"type":23},70,[26],"This study will provide evidence for the utility of using a community-engaged research approach to implement a tailored, family-oriented adaptation of the Diabetes Prevention Program that will have positive effects on risk factors associated with type 2 diabetes morbidity and mortality among Black families in a Southwest Georgia community.",[160,161,162,163,164,29,165,166,167],"Diabetes","Chronic Disease","Type 2 Diabetes","Healthy Lifestyle","Nutrition, Healthy","Family","Family Research","Family and Household",[169,170,171,172,173,174,175,176,177,178],"diabetes","rural","type 2 diabetes","nutrition","physical activity","diabetes prevention","family research","family and household","chronic disease","sedentary behavior","2026-06-18",{"date":139,"type":41},{"date":182,"type":41},"2026-02-04",{"date":184,"type":23},"2028-04-30",{"name":186,"class":48},"Morehouse School of Medicine",{"id":188,"slug":189,"hasResults":12,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":59,"enrollmentInfo":195,"targetDuration":4,"studyType":24,"phases":197,"briefSummary":198,"conditions":199,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":49},"100482574","exploring-virtual-reality-adventure-training-exergaming-100482574","NCT05563805","Exploring Virtual Reality Adventure Training Exergaming","Exploring Virtual Reality Adventure Training Exergaming (V-RATE) on Veterans' Health Outcomes","V-RATE","Inclusion Criteria:\n\n1. Are between the ages of 18 and 45\n2. Identify as a U.S. military veteran\n\n4\\. Normal vision (no colorblindness)\n\nExclusion Criteria:\n\n1. Unable to walk independently (e.g., use of any mobility assistive device such as brace, wheelchair, cane, crutch, walker, knee scooter)\n2. Self-reported joint problem that limits mobility (e.g., arthritis or other condition that would prevent participation) or ongoing orthopedic injury\n3. Self-reported pregnancy or suspicion of pregnancy\n4. Self-reported motor disorder or impaired sense of motion or balance (such as Parkinsonism)\n5. Self-reported color blindness\n6. Self-reported neurological or cognitive disorder (e.g., TBI, history of seizure)\n7. Self-reported cardiac surgery or any ongoing cardiovascular issues preventing participation or physical activity.",{"count":196,"type":23},40,[26],"The current project aims to design and implement an 8-week Virtual Reality Adventure Therapy Exergaming (V-RATE) intervention focused on women veterans. A randomized controlled trial using a repeated measure design with a 1-month follow-up assessment will be employed to examine effects on physical and mental health outcomes.",[200,29,201,202,203,204,205],"Physical Activity","Depression","Cognitive Function","Post Traumatic Stress Disorder","Quality of Life","Anxiety","2026-05-27",{"date":208,"type":41},"2026-06-01",{"date":210,"type":41},"2022-09-07",{"date":212,"type":23},"2027-08-31",{"name":214,"class":48},"The University of Texas at Arlington",{"id":216,"slug":217,"hasResults":12,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":17,"sex":58,"minAge":19,"maxAge":59,"enrollmentInfo":223,"targetDuration":4,"studyType":24,"phases":225,"briefSummary":226,"conditions":227,"keywords":230,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":241,"leadSponsor":242,"locationsCount":49},"100640669","buerger-allen-exercises-and-peripheral-circulation-in-sedentary-office-workers-100640669","NCT07588893","Buerger-Allen Exercises and Peripheral Circulation in Sedentary Office Workers","Acute Effects of Buerger-Allen Exercises on Lower Extremity Circulatory Parameters in Sedentary Office Workers: A Single-Group Pretest-Posttest Clinical Trial","BAE-CIRC","Inclusion Criteria:\n\n* Healthy sedentary office workers\n* Age between 18 and 45 years\n* Sitting for at least 6 hours per day for work-related activities\n* Not meeting regular physical activity recommendations\n* Willing to participate voluntarily and provide written informed consent\n\nExclusion Criteria:\n\n* History of peripheral arterial disease, deep vein thrombosis, or other vascular disorders\n* Cardiovascular, neurological, or musculoskeletal conditions that may affect lower extremity circulation or prevent exercise participation\n* Diabetes mellitus\n* Current smoking\n* Pregnancy\n* Use of medications that may significantly affect peripheral circulation\n* Lower extremity injury or surgery within the previous 6 months\n* Participation in regular structured exercise programs",{"count":224,"type":23},35,[26],"This study aims to evaluate the acute effects of Buerger-Allen exercises on lower extremity circulation in sedentary office workers. Prolonged sitting is associated with reduced venous return, impaired peripheral circulation, and endothelial dysfunction. Buerger-Allen exercises are simple position-based exercises designed to enhance arterial blood flow, venous return, and tissue perfusion. Thirty-five healthy sedentary adults aged 18 to 45 years will participate in this single-group pretest-posttest clinical trial. Skin surface temperature, capillary refill time, ankle-brachial index, peripheral oxygen saturation, and heart rate will be measured before and after a single 20-minute exercise session. The findings may support the use of Buerger-Allen exercises as a practical, low-cost physiotherapy strategy to improve peripheral circulation and reduce the adverse vascular effects of prolonged sitting.",[29,228,229],"Peripheral Circulation","Vascular Function",[231,228,29,232,233,234,235,236],"Buerger-Allen Exercise","Office Workers","Capillary Refill Time","Ankle-Brachial Index","Infrared Thermography","Physiotherapy","2026-05-09",{"date":239,"type":41},"2026-05-15",{"date":208,"type":23},{"date":88,"type":23},{"name":243,"class":48},"Istanbul Gelisim University",{"id":245,"slug":246,"hasResults":12,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":12,"sex":58,"minAge":19,"maxAge":251,"enrollmentInfo":252,"targetDuration":4,"studyType":24,"phases":254,"briefSummary":255,"conditions":256,"keywords":260,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":49},"100484219","stand-up-for-your-health-with-a-sit-stand-desk-100484219","NCT05585190","Stand up for Your Health With a Sit-stand Desk","Stand Up for Your Health: A Randomized Study","Inclusion Criteria:\n\n1. Overweight or obese (body mass index of 25 kg\u002Fm2 or higher)\n2. Employees with \"sedentary\" jobs, defined as spending at least 75% of their (8 hours or more) workday sitting at a desk (at home or in an office)\n3. Defined as \"at-risk\" for diabetes, defined as either:\n\n   1. Prediabetes (HbA1c of 5.7% to 6.4%) or a fasting glucose of 100 to 125 mg\u002FdL\n   2. Having one or more additional risk factors: (beyond BMI\\>25)\n\n      * Age 45 years or older\n      * Family history of diabetes mellitus in a first-degree relative\n      * Physical inactivity (no structured exercise activity)\n      * History of gestational diabetes, hypertension, or dyslipidemia\n      * African American, Alaska Native, American Indian, Asian American, Hispanic\u002FLatino, Native Hawaiian, or Pacific Islander ethnicity\n\nExclusion Criteria:\n\n1. Established cardiovascular disease (myocardial infarction, coronary stent, coronary artery bypass grafting, cardiac transplant, or angina)\n2. Established congestive heart failure or cardiomyopathy\n3. Established peripheral vascular disease\n4. Established diabetes (HbA1c ≥ 6.5% or on diabetes medications or insulin)\n5. Chronic musculoskeletal disorders involving the lower extremities, such as arthritis of the knees or hips, or regular use of ambulatory assist devices such as a walker or cane\n6. Neuropathy of any etiology\n7. Positional syncope or history of orthostasis\n8. Less than 4 days\u002Fweek at any single office (or work-from-home) location.\n9. Current use of a standing desk for work\n10. Tobacco use within the previous 12 months\n11. Current illicit drug use or excessive alcohol use (defined as more than 14 drinks\u002Fweek for women, more than 28 drinks\u002Fweek for men)\n12. Steroid use ≥21 days\u002Fyear\n13. Fasting triglyceride level ≥ 500 mg\u002FdL\n14. Thyroid disease\n15. Uncontrolled or untreated hypertension(\\>150\u002F90 mm Hg)\n16. Pregnant or lactating (or plans to become pregnant in the next 6 months)\n17. LDL cholesterol ≥ 190mg\u002FdL\n18. Currently enrolled or plans to diet or join a weight loss program over the next 6 months.\n19. Non-English speaker","79 Years",{"count":253,"type":23},198,[26],"More than 84 million - or 1 out of every 3 U.S. adults - have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years. Average medical expenditures among diabetics are about 2.3 times higher than expenditures for people without diabetes. Physical inactivity and elevated body mass index (BMI) are major risk factors for the disease. Sedentary behavior is becoming increasingly prevalent with the growth of a 'work from home' culture, most recently driven by the COVID-19 pandemic. Cross-sectional epidemiologic data report significant associations between high amounts of sedentary (sitting) time and prevalent cardiovascular disease and diabetes. In our pilot study of 15 subjects with sedentary office jobs, 6 months of sit-stand desk use resulted in a 23% improvement in insulin resistance, most substantial in those who decreased daily sitting by over 90 minutes\u002Fday. Additional improvements in vascular endothelial function and triglyceride levels were seen without any change in exercise activity, step counts, or body weight. These findings not only corroborate epidemiologic findings on this topic but suggest causality and warrant a randomized control trial.\n\nThe investigators hypothesize that adult subjects at-risk for diabetes will improve insulin sensitivity, metabolic and vascular (endothelial) health with a sit-stand desk intervention at work (whether in the office or at home), in the context of a randomized, controlled trial. The investigators will randomize 198 sedentary office workers with a BMI≥25 at risk for type 2 diabetes mellitus in a 1:1:1 ratio of three groups: (a) sit-stand desk intervention targeting 2 hours standing per day; (b) sit-stand desk intervention targeting 3 hours standing per day; or (c) control arm over 6 months. The block randomization design will allow for important dose-response analyses.\n\nThe investigators will objectively quantify standing time, sedentary time, sedentary bouts, daily steps, and exercise activity times using a compact and re-usable accelerometer that adheres to the subject's thigh. This will provide objective assessments of activity levels and sedentary times for 7 full days each at baseline, 3 and 6 months. The device is equipped with an inclinometer to classify posture (sitting verses standing).",[257,258,259,29],"Pre Diabetes","Obesity","Metabolic Syndrome",[257,258,259,261,262,200,263,264,265,266],"Cardiovascular","Sit-stand desk","Overweight","Sedentary","Standing desk","Insulin resistance","2026-04-28",{"date":269,"type":41},"2026-05-04",{"date":271,"type":41},"2023-02-06",{"date":273,"type":23},"2027-12-31",{"name":275,"class":48},"Medical College of Wisconsin",{"id":277,"slug":278,"hasResults":12,"nctId":279,"briefTitle":280,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":12,"sex":58,"minAge":19,"maxAge":4,"enrollmentInfo":282,"targetDuration":4,"studyType":24,"phases":284,"briefSummary":285,"conditions":286,"keywords":290,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":49},"100587054","interrupting-sedentary-time-to-improve-cardiometabolic-health-and-toxicity-in-patients-with-lymphoma-receiving-chemotherapy-the-istand-trial-100587054","NCT06923397","Interrupting Sedentary Time to Improve Cardiometabolic Health and Toxicity in Patients With Lymphoma Receiving Chemotherapy: The iSTAND Trial","Inclusion Criteria:\n\n* Ability to understand and the willingness to sign informed consent prior to any study- related procedures.\n* Patients diagnosed with lymphoma.\n* Will receive first line R-CHOP or POLA-R-CHP chemotherapy regimens, patients do not need to be within a certain timeframe from diagnosis.\n* Aged ≥18 years; due to the rarity of the disease in those \\\u003C18 years, this age bracket will not be included.\n* Engaging in ≤60-minutes of structured moderate or vigorous intensity exercise.\n* Have physician clearance to participate in exercise.\n* Speak English.\n* Willing to travel to Dana-Farber Cancer Institute for necessary data collection and exercise sessions.\n* Access to a phone that can receive text messages.\n\nExclusion Criteria:\n\n* Unstable comorbidities that prevent participation in moderate-to-vigorous intensity exercise. Patients with unstable comorbidities likely require supervised exercise for safety, and part of this study involves unsupervised exercise; therefore, for safety reasons, these persons are excluded.\n* Participate in more than 60 minutes of structured moderate-to-vigorous exercise per week over the last month. Excess additional exercise is a confounding factor in assessing the effect of the current interrupted sedentary time intervention.\n* Patients receiving treatment for other active malignancies (except basal cell carcinoma). This study is exclusively targeting lymphoma chemotherapy-related effects.\n* Patients currently taking weight loss drugs.\n* Subjects who in the opinion of the investigators may not be able to comply with the safety monitoring requirements of the study.\n* Unable to travel to DFCI Longwood campus for necessary data collection and chemotherapy infusions.",{"count":283,"type":23},24,[26],"This study aims to see if a 12-week exercise program designed to reduce long periods of inactivity is feasible in newly diagnosed lymphoma participants receiving R-CHOP or POLA-R-CHP chemotherapy treatments, and whether it can improve heart health and reduce chemotherapy drug side effects.",[287,288,289,29],"Lymphoma","Lymphoma, Hodgkin","Lymphoma, Non-Hodgkin",[287,291,288,289,292,29],"Hodgkin Lymphoma","Non-Hodgkin Lymphoma","2026-04-09",{"date":295,"type":41},"2026-04-13",{"date":297,"type":41},"2025-06-05",{"date":299,"type":23},"2026-12-31",{"name":301,"class":48},"Dana-Farber Cancer Institute",{"id":303,"slug":304,"hasResults":12,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":17,"sex":58,"minAge":19,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":24,"phases":311,"briefSummary":312,"conditions":313,"keywords":317,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":49},"100466406","breaking-up-prolonged-sedentary-behavior-to-improve-cardiometabolic-health-100466406","NCT05353322","Breaking up Prolonged Sedentary Behavior to Improve Cardiometabolic Health","Breaking up Prolonged Sedentary Behavior to Improve Cardiometabolic Health: An Adaptive Dose-Finding Study","Inclusion Criteria:\n\n* 18 years of age or older\n* Ability to read, write and speak English or Spanish\n* Limited or no chronic medical conditions \\[examples include but not limited to: CVD, diabetes, chronic obstructive pulmonary disease (COPD), HIV\u002FAIDS; participants with high blood pressure\u002Fhypertension and\u002For high cholesterol\u002Fhyperlipidemia may be included if they are currently prescribed and taking medication for these conditions\\]\n* Do not take medication (over-the-counter or herbal) to control glucose (such as a diabetes control medication)\n* Not currently pregnant\n* Do not currently smoke cigarettes\n* No pre-existing musculoskeletal conditions (including but not limited to osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis) that would prevent participation in intermittent physical activity\n* No allergies to common food allergens including wheat, eggs, milk or other dairy, gluten, fructose, peanuts or other nuts\n* No dietary restrictions such as vegan, gluten free, halal\n\nExclusion Criteria:\n\n• Unable to provide consent",{"count":310,"type":23},324,[26],"The purpose of this Phase 1 research study is to answer two questions: (1) How frequent should periods of prolonged sedentary time be interrupted? and (2) What is the appropriate duration or length of time of these breaks in sedentary time? To address these questions, this project will conduct a state-of-the-art adaptive dose finding study under controlled laboratory conditions to determine the minimally effective dose (the smallest dose) that yields cardiometabolic benefit for two separate sedentary break elements (frequency and duration). Study findings will ultimately determine how often and for how long people should break up periods of prolonged sedentary time to transiently improve established cardiovascular risk factors; key foundational information critical to the success of future long-term trials and ultimately public health guidelines.\n\nPrimary Aim: To determine the minimally effective dose combination(s) of frequency and duration needed to provide cardiometabolic benefit during an 8-hour experimentation period. Specifically, the study will determine:\n\n1a. For each fixed duration, the minimum sedentary break frequency (e.g., every 30 min, 60 min, 120 min) that demonstrates a reduction in systolic BP, diastolic BP, or glucose compared with a sedentary control condition.\n\n1b. For each fixed frequency, the minimum sedentary break duration (e.g., activity breaks of 1 min, 5 min, 10 min) that demonstrates a reduction in systolic BP, diastolic BP, or glucose compared with a sedentary control.\n\nSecondary Aim: It is also critical to public health strategy to assess the acceptability\u002Ffeasibility of various sedentary break doses as too high a dose will yield poor uptake. To address this need, the maximally tolerated dose (the highest dose that does not cause undue physical\u002Fpsychological distress) for frequency and duration of sedentary breaks will also be determined via assessment of 4 constructs: physical exhaustion\u002Ffatigue, affect (e.g., mood, emotion), tolerability (e.g., completion of dose protocol), and safety (e.g., hypoglycemia). Maximally tolerated dose will be defined as the highest dose where \\\u003C20% of participants exhibit an adverse outcome.",[29,314,315,316],"Cardiometabolic Risk Factors","Blood Pressure","Glucose",[29,200,315,316,318,319],"Insulin","Dose-finding","2026-04-06",{"date":293,"type":41},{"date":323,"type":41},"2022-06-30",{"date":325,"type":23},"2028-03-31",{"name":327,"class":48},"Columbia University",{"id":329,"slug":330,"hasResults":12,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":4,"eligibilityCriteria":334,"healthyVolunteers":17,"sex":58,"minAge":335,"maxAge":336,"enrollmentInfo":337,"targetDuration":4,"studyType":24,"phases":339,"briefSummary":340,"conditions":341,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":353},"100543972","promoting-physical-activity-in-older-hispaniclatinoa-adults-100543972","NCT06362824","Promoting Physical Activity in Older Hispanic\u002FLatino(a) Adults","De Pie y a Movernos Study: Promoting Physical Activity in Older Hispanic\u002FLatino(a) Adults","Inclusion Criteria:\n\n* be 55-89 and self-identify as Hispanic\u002FLatino(a)\n* able to participate for up to 20 weeks in the study\n* willing to be randomized to the intervention or active comparison program\n* willing to follow study procedures depending on program assignment\n* available M-F for study phone calls between 8am-5pm\n* able to walk one block unassisted,\n* able to speak and can read Spanish or English,\n* have a smartphone (85% of the Hispanic\u002FLatino(a) population has a smartphone)\n* willing to wear an ActiGraph for up to 2 weeks, twice during the course of the study\n* willing to complete study questionnaires via weblink, paper, or phone call\n* have an email address and be willing to share it with the team\n* have a US mailing address where they receive mail regularly (confirmed in pre-screen)\n\nExclusion criteria are as follows:\n\n* score less than or equal to 4 on the Six-Item Screener (Callahan et al., 2002)\n* unable to hear phone conversation, even with a hearing aid\n* planned surgeries or travel that would interfere with participation\n* had a fall in the last year that resulted in hospitalization\n* had a cancer diagnosis that requires treatment in the past year (other than skin cancer)\n* had a diagnosis of heart attack or irregular heart beat (arrythmia) in the past year\n* been advised recently by their doctor to avoid physical activity\n* does not want to share cognitive health information collected during the study with researchers at UCSD\n* unwilling to share their email address\n* unwilling to obtain an email address if they do not already have one\n* currently participating in another institution's physical activity study","55 Years","89 Years",{"count":338,"type":23},130,[26],"In this randomized controlled trial, study staff will randomize 130 Hispanic\u002FLatino adults without dementia and over age 55 from Southern California and from Kaiser Permanente Washington (State) to either the culturally adapted De Pie physical activity intervention or an active comparison program focusing on general brain health topics. The purpose of this study is to determine if 12 weeks of the culturally adapted and fully remote De Pie y a Movernos intervention improves self-efficacy, habit strength, social support, and enjoyment for physical activity (PA), thus promoting adherence to moderate-intensity physical activity (MIPA) guidelines (150 minutes\u002Fweek).",[29,342,343],"Physical Inactivity","Alzheimer Disease, Protection Against","2026-04-02",{"date":346,"type":41},"2026-04-08",{"date":348,"type":41},"2024-09-24",{"date":350,"type":23},"2027-05-31",{"name":352,"class":48},"Kaiser Permanente",2,{"id":355,"slug":356,"hasResults":12,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":17,"sex":58,"minAge":362,"maxAge":99,"enrollmentInfo":363,"targetDuration":4,"studyType":24,"phases":365,"briefSummary":366,"conditions":367,"keywords":369,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":381,"locationsCount":49},"100463582","sitting-interruption-and-whole-body-cardiovascular-health-100463582","NCT05316571","Sitting Interruption and Whole-body Cardiovascular Health","Sitting Interruption and Whole-body Cardiovascular Health: Linking Physiological Responses to Risk Behaviors","SWITCH","Inclusion Criteria:\n\n* Aged between 30-60 years\n* Insufficiently active: self-reported exercise \\\u003C90 minutes per week for the past 3 months\n* Sedentary: self-reported sitting \\>8 hours per day\n* Self-reported ability to walk 4 blocks and climb 2 flights of stairs\n* Possession of cellular phone able to receive text messages\n\nExclusion Criteria:\n\n* Use of assisted-walking devices\n* Comorbid condition that would limit the ability to reduce sedentary behavior (e.g., musculoskeletal condition, current chemotherapy)\n* Plans for major surgery within next 3 months\n* Recent history (\\\u003C1 year) of ischemic heart disease, chronic heart failure, stroke, or chronic kidney disease\n* Recent (\\\u003C 1 year) or planned bariatric surgery\n* Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg\n* Current or recent (within last 6 months) pregnancy; current or recent (within last 3 months) breastfeeding\n* Morbidly obesity (BMI \\>40 kg\u002Fm\\^2) or underweight (BMI \\\u003C18.5 kg\u002Fm\\^2)\n* Use of anti-hypertensive drugs\n* Use of glucose-controlling medication\n* Heavy alcohol consumption (\\>15 drinks per week)","30 Years",{"count":364,"type":23},56,[26],"There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke. However, the public currently has no clear guidance on how to limit or interrupt their sedentary behaviors. This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.",[29,368],"Sedentary Time",[29,370,371,261,372,373],"Interruption","Sitting","Arterial Stiffness","Pulse Wave Velocity","2026-03-13",{"date":376,"type":41},"2026-03-16",{"date":378,"type":41},"2022-08-15",{"date":380,"type":23},"2026-05-31",{"name":382,"class":48},"University of North Carolina, Chapel Hill",{"id":384,"slug":385,"hasResults":12,"nctId":386,"briefTitle":387,"officialTitle":387,"acronym":388,"eligibilityCriteria":389,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":59,"enrollmentInfo":390,"targetDuration":4,"studyType":24,"phases":391,"briefSummary":392,"conditions":393,"keywords":396,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":412,"locationsCount":49},"100610094","effectiveness-of-interventions-to-promote-physical-activity-during-pregnancy-100610094","NCT07223112","Effectiveness of Interventions to Promote Physical Activity During Pregnancy","SLMM","Eligibility Criteria\n\n* 18 to 45 years old\n* speak English\n* 8 to 12 weeks pregnant (gestation)\n* singleton pregnancy (no twins or more)\n* self-report less than 150 minutes\u002Fweek of moderate-intensity physical activity\n* have or are willing to identify a physical activity partner\n* have a cell phone with the capacity for Fitbit application (app.); secure transmission of Fitbit data; receive coaching text messages or, if not, a computer they can use to synch the fitbit, send data, and receive email messages in lieu of texts.\n\nExclusion Criteria\n\n• Women with physical activity restrictions (e.g., placenta previa) that prevent them from completing ACOG recommended pregnancy physical activity",{"count":22,"type":23},[26],"Pregnant women are more sedentary (sit, recline, lie down more) on average than non-pregnant women (more than 12 versus less than 8 waking sedentary hours\u002Fday). Sedentary behavior has been related to psychological distress, pregnancy weight gain, impaired sleep and very large size infants, while adequate physical activity has been found to improve mental health, decrease risk of high blood pressure in pregnancy and lower risk of preterm birth infants (less than 37 weeks gestation). Decreased sedentary behavior and increased physical activity may be crucial and neglected lifestyle behavior changes that can be promoted to reduce these and other maternal health and birth outcome problems among pregnant women.",[394,29,395],"Pregnancy","Insufficient Physical Activity",[397,398,399,400,401,402,403,404,405],"Sit Less, Move More effectiveness for pregnant women","physical activity habit formation","sedentary behavior habit reversal","sedentary time disruption","wearable device","nudging","health coach","social support","behavior change","2026-03-10",{"date":408,"type":41},"2026-03-11",{"date":410,"type":41},"2026-02-01",{"date":212,"type":23},{"name":413,"class":48},"University of Central Florida",{"id":415,"slug":416,"hasResults":12,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":4,"eligibilityCriteria":420,"healthyVolunteers":17,"sex":58,"minAge":19,"maxAge":421,"enrollmentInfo":422,"targetDuration":4,"studyType":24,"phases":423,"briefSummary":424,"conditions":425,"keywords":427,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":438,"leadSponsor":440,"locationsCount":49},"100627325","lumbar-stabilization-exercises-in-sedentary-adults-100627325","NCT07447167","Lumbar Stabilization Exercises in Sedentary Adults","The Effect of a Lumbar Stabilization Exercise Program on Quality of Life and Motor Control in Sedentary Adults","Inclusion Criteria:\n\n* Healthy adults with a sedentary lifestyle (no regular structured exercise in the past 2-3 months)\n\n  * Ability to participate in a moderate-intensity exercise program\n  * Ability to understand instructions and complete assessment questionnaires\n\nExclusion Criteria:\n\n* Regular participation in structured exercise programs within the previous 2-3 months\n\n  * Diagnosed lumbar disc herniation with neurological deficits\n  * History of spinal or lower limb surgery within the past year\n  * Acute musculoskeletal injury or exacerbation of low back pain within the past 4 weeks\n  * Neurological or neuromuscular disorders\n  * Active inflammatory rheumatic disease\n  * Cardiopulmonary contraindications to moderate-intensity exercise\n  * Pregnancy or postpartum period\n  * Use of medications significantly affecting balance or physical performance\n  * Inability to understand study instructions or comply with study procedures","65 Years",{"count":196,"type":23},[26],"This pilot randomized controlled trial will examine the effects of a four-week lumbar spine stabilization exercise program on motor control, dynamic balance, and quality of life in healthy sedentary adults. Prolonged sedentary behavior has been associated with impaired neuromuscular function and increased risk of musculoskeletal disorders, even in asymptomatic individuals.\n\nForty sedentary adults will be randomly assigned to either an intervention group, which will follow a structured lumbar stabilization exercise program, or to a control group, which will receive ergonomic and stretching guidelines.\n\nOutcomes will be assessed before and after the intervention using the SF-12v2 quality of life questionnaire, the Functional Movement Screen (FMS) and the Y-Balance Test. Physical activity levels will be monitored using the IPAQ-SF. The study aims to determine whether lumbar stabilization exercises improve health-related quality of life, motor control and dynamic balance in sedentary adults.",[29,426,204],"Motor Control Impairment",[428,429,430,178,431,432],"prevention","back pain","lumbar spine stabilization exercises","sedentary work","lack of physical activity","2026-03-02",{"date":435,"type":41},"2026-03-04",{"date":437,"type":23},"2026-02",{"date":439,"type":23},"2026-03",{"name":441,"class":48},"University of West Attica",{"id":443,"slug":444,"hasResults":12,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":4,"eligibilityCriteria":448,"healthyVolunteers":17,"sex":58,"minAge":19,"maxAge":362,"enrollmentInfo":449,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":450,"conditions":451,"keywords":455,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":457,"startDateStruct":459,"completionDateStruct":461,"leadSponsor":463,"locationsCount":49},"100627798","physical-fitness-assessment-in-professional-and-amateur-e-sports-players-100627798","NCT07453316","Physical Fitness Assessment in Professional and Amateur E-Sports Players","Comparing the Physical Fitness Levels of Professional and Amateur E-Sports Players","Inclusion Criteria:\n\n* Adults aged 18 to 30 years\n* Able to read and understand Turkish\n* Professional e-sports players:\n* ≥25 hours per week of structured gaming\n* Affiliated with a competitive team or organization\n* Participates in official tournaments at least once per month\n* Receives income or sponsorship related to gaming\n\nAmateur e-sports players:\n\n* ≤15 hours per week of recreational gaming\n* Not affiliated with a professional team or league\n* Does not receive income or sponsorship from gaming\n* Voluntary agreement to participate and provide informed consent\n\nExclusion Criteria:\n\n* History of respiratory, cardiovascular, or neurological disorders\n* History of surgery within the last 6 months\n* Current use of medication that may affect physical performance\n* Currently undergoing physical therapy or rehabilitation\n* Any musculoskeletal injury that may impair performance during physical fitness testing.",{"count":196,"type":23},"The aim of this observational cross-sectional study is to compare the physical fitness characteristics of professional and amateur e-sports players and to determine whether differences exist between the two groups in terms of physical fitness parameters.",[452,453,29,454],"Physical Fitness","Musculoskeletal Health","E-Athletes",[456],"E-Sports, Physical Fitness, Professional Gamers, Amateur Gamers, Sedentary Lifestyle, Musculoskeletal Health, Reaction Time, Balance, Aerobic Capacity",{"date":458,"type":41},"2026-03-05",{"date":460,"type":23},"2026-03-09",{"date":462,"type":23},"2027-03-09",{"name":464,"class":48},"Istinye University",{"id":466,"slug":467,"hasResults":12,"nctId":468,"briefTitle":469,"officialTitle":470,"acronym":4,"eligibilityCriteria":471,"healthyVolunteers":12,"sex":58,"minAge":362,"maxAge":335,"enrollmentInfo":472,"targetDuration":4,"studyType":24,"phases":474,"briefSummary":475,"conditions":476,"keywords":479,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":483,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":488,"locationsCount":49},"100603622","effect-of-home-based-exercise-plan-mediated-by-use-of-digital-health-app-on-kinesiophobia-and-functional-capacity-100603622","NCT07138911","Effect of Home-based Exercise Plan Mediated by Use of Digital Health App on Kinesiophobia and Functional Capacity","Effect of Home-based Exercise Plan Mediated by Use of Digital Health App on Kinesiophobia and Functional Capacity in Sedentary Post Myocardial Infarction Patient.","Inclusion Criteria:\n\n* 3 months post myocardial infarction patient\n* Sitting hours \\>8\n* IPAQ \\\u003C 600 Mets minutes\n\nExclusion Criteria:\n\n* Unstable Angina\n* Recurrent Myocardial infarction\n* Recent surgery or Procedure\n* Heart failure, Arrhythmia",{"count":473,"type":23},88,[26],"To evaluate the effect of home-based exercise plan mediated by a digital health application on kinesiophobia and functional capacity in sedentary post myocardial infarction patients. Evidence suggest that digital health application significantly improve physical activity level in patient following cardiac event by providing personalized exercise plan, real time feed back, progress tracking and motivational features which enhanced adherence and engagement in rehabilitation program. This study could offer a viable le solution for overcoming barrier to rehabilitation particularly for those unable to access traditional clinic-based program",[477,478,29],"Myocardial Infarction","Kinesiophobia",[480,481,478,477,264],"Digital health app","Functional capacity","2026-02-23",{"date":484,"type":41},"2026-02-25",{"date":486,"type":41},"2025-08-13",{"date":484,"type":23},{"name":489,"class":48},"Riphah International University",{"id":491,"slug":492,"hasResults":12,"nctId":493,"briefTitle":494,"officialTitle":495,"acronym":4,"eligibilityCriteria":496,"healthyVolunteers":12,"sex":58,"minAge":19,"maxAge":421,"enrollmentInfo":497,"targetDuration":4,"studyType":24,"phases":499,"briefSummary":500,"conditions":501,"keywords":504,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":507,"startDateStruct":509,"completionDateStruct":510,"leadSponsor":512,"locationsCount":49},"100620521","sedentary-status-and-multidimensional-outcomes-in-fibromyalgia-100620521","NCT07358702","Sedentary Status and Multidimensional Outcomes in Fibromyalgia","Comparison of Body Awareness, Respiratory Muscle Strength, Kinesiophobia, Central Sensitization, Functional Status and Sleep Quality in Sedentary and Non-Sedentary Fibromyalgia Individuals","Inclusion Criteria - Sedentary Fibromyalgia Participants\n\n* Physical activity level below 600 MET-min\u002Fweek according to the International Physical Activity Questionnaire (IPAQ)\n* Diagnosis of fibromyalgia according to the 2016 ACR criteria\n* Age between 18 and 65 years\n* Ability to understand and respond to study assessments\n\nExclusion Criteria - Sedentary Fibromyalgia Participants\n\n* Conditions posing risk during assessments, including unstable angina, decompensated heart failure, or myocardial infarction within the past month\n* Uncontrolled diabetes, hypertension \\>180\u002F110 mmHg, and\u002For severe neuropathy\n* Diagnosed severe cognitive impairment\n* Pregnancy or suspected pregnancy Inclusion Criteria - Non-Sedentary Fibromyalgia Participants\n* Physical activity level above 600 MET-min\u002Fweek according to the IPAQ\n* Diagnosis of fibromyalgia according to the 2016 ACR criteria\n* Age between 18 and 65 years\n* Ability to understand and respond to study assessments\n\nExclusion Criteria - Non-Sedentary Fibromyalgia Participants\n\n* Conditions posing risk during assessments, including unstable angina, decompensated heart failure, or myocardial infarction within the past month\n* Uncontrolled diabetes, hypertension \\>180\u002F110 mmHg, and\u002For severe neuropathy\n* Diagnosed severe cognitive impairment\n* Pregnancy or suspected pregnancy",{"count":498,"type":23},66,[26],"Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and functional limitations. Pain, fatigue, and fear of movement often lead individuals with FMS to adopt sedentary behaviors, which may further exacerbate symptoms and reduce physical capacity. Factors such as impaired body awareness, reduced respiratory muscle strength, kinesiophobia, central sensitization, poor functional status, and sleep disturbances play an important role in disease severity and quality of life in individuals with FMS.\n\nAlthough physical inactivity is common in fibromyalgia, limited evidence exists regarding the differences in these multidimensional clinical parameters between sedentary and non-sedentary individuals with FMS. Therefore, the aim of this study is to compare body awareness, respiratory muscle strength, kinesiophobia, central sensitization, functional status, and sleep quality between sedentary and non-sedentary individuals diagnosed with fibromyalgia syndrome. The findings of this study may contribute to a better understanding of the impact of sedentary behavior on clinical outcomes in fibromyalgia and help guide more comprehensive and individualized rehabilitation approaches.",[502,29,478,503],"Fibromyalgia","Central Sensitisation",[505,29,506],"Fibromyalgia Syndrome","Functional Status",{"date":508,"type":41},"2026-02-06",{"date":239,"type":23},{"date":511,"type":23},"2027-01-15",{"name":513,"class":48},"Izmir Democracy University",{"id":515,"slug":516,"hasResults":12,"nctId":517,"briefTitle":518,"officialTitle":519,"acronym":520,"eligibilityCriteria":521,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":522,"enrollmentInfo":523,"targetDuration":4,"studyType":24,"phases":525,"briefSummary":526,"conditions":527,"keywords":532,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":538,"leadSponsor":540,"locationsCount":49},"100620796","mat-pilates-on-body-awareness-and-physical-activity-levels-in-sedentary-emerging-adulthood-women-100620796","NCT07362277","Mat Pilates on Body Awareness and Physical Activity Levels in Sedentary Emerging Adulthood Women","The Effect of Mat Pilates on Body Composition and Physical Activity Levels in Sedentary Women Emerging Adulthood","mat pilates","Inclusion Criteria:\n\n* Possess the ability to read and understand Turkish, be between the ages of 18 and 29,\n* I have a sedentary lifestyle, possess the cognitive ability to understand and interpret survey questions, and for sedentary participants, not have engaged in regular exercise for 2 months, have a Physical Activity Score (IPAQ) -short form of less than 600 Metabolic Equivalent of Task (MET) minutes per week, and body weight below 130 kg.\n\nExclusion Criteria:\n\n* Participants with chronic, neurological, orthopedic, rheumatic systemic and\u002For lung disease, those who exercise\u002Fsport, have a history of malignancy, are pregnant, have a history of fracture in the last year,\n* I have chronic kidney or liver disease, have cardiovascular disease, and have peripheral vestibular disorder were excluded.","29 Years",{"count":524,"type":23},54,[26],"This study investigating the effects of mat pilates on body awareness and physical activity levels in sedentary women transitioning to adulthood, 27 control groups and 27 mat pilates exercise groups will be included. The groups will be compared at the end of an 8-week exercise program. Participants' socio-demographic characteristics, body awareness (using the Body Awareness Questionnaire), and physical activity level (using the Tegner Physical Activity Questionnaire and the International Physical Activity Questionnaire short-form scales) will be assessed.",[528,529,29,530,531],"Exercise Therapy","Awareness","Woman's Role","Exercise",[528,529,29,530,531],"2026-01-22",{"date":535,"type":41},"2026-01-23",{"date":537,"type":41},"2025-12-05",{"date":539,"type":23},"2026-02-20",{"name":541,"class":48},"Necmettin Erbakan University",{"id":543,"slug":544,"hasResults":12,"nctId":545,"briefTitle":546,"officialTitle":547,"acronym":531,"eligibilityCriteria":548,"healthyVolunteers":17,"sex":58,"minAge":19,"maxAge":549,"enrollmentInfo":550,"targetDuration":4,"studyType":24,"phases":552,"briefSummary":553,"conditions":554,"keywords":557,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":561,"lastUpdatePostDateStruct":562,"startDateStruct":564,"completionDateStruct":566,"leadSponsor":568,"locationsCount":49},"100587036","the-effect-of-exercise-on-metabolic-alteration-100587036","NCT06923163","The Effect of Exercise on Metabolic Alteration","Metabolic Response of Sedentary Participants to a Long-term Exercise Intervention","Inclusion Criteria:\n\n* Sedentary individuals\n* BMI ≥ 18.5 kg\u002Fm2\n\nExclusion Criteria:\n\n* Individuals who have undergone major surgery in the past 6 months (excluding tooth extraction);\n* Individuals on long-term medication;\n* Individuals with metabolic and cardiovascular diseases such as diabetes, hypoglycemia, and hypertension;\n* Individuals with exercise-related injuries, including joint diseases and fractures;\n* Individuals diagnosed with infectious diseases such as HIV, tuberculosis, malaria, etc.;\n* Individuals with mental and neurological disorders including anorexia nervosa;\n* Individuals who have attempted weight loss or gain through various methods in the past three months;\n* Individuals in preconception, pregnancy, and lactation periods;\n* Individuals with autism and those with metal implants in their bodies.","40 Years",{"count":551,"type":23},80,[26],"The goal of this clinical trial is to study the effectiveness of aerobic exercise in treating obesity in adults and to assess the efficacy of exercise. The primary research questions it seeks to address are as follows:\n\n* To what extent does exercise increase the total energy expenditure of participants?\n* Why and how does the energy expenditure from exercise not fully compensate for the total energy expenditure (TEE)?\n* Researchers will assess the efficacy and potential challenges of using exercise as a treatment for obesity by comparing the measurement data before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).\n\nParticipants will engage in the following activities:\n\n* Engage in running sessions supervised five times a week for a duration of 12 weeks.\n* Attend laboratory sessions both before and after the exercise intervention period for metabolic and anthropometric measurements, as well as sample collection.\n* Return to the laboratory for further metabolic and anthropometric measurements and sample collection8 weeks post-completion of exercise intervention.",[29,555,556],"Healthy Participants","Adult",[558,559,560],"Metabolic response","Energy expenditure","Energy compensation","2026-01-19",{"date":563,"type":41},"2026-01-21",{"date":565,"type":41},"2025-05-01",{"date":567,"type":23},"2027-12",{"name":569,"class":48},"Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences",{"id":571,"slug":572,"hasResults":12,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":4,"eligibilityCriteria":576,"healthyVolunteers":17,"sex":58,"minAge":19,"maxAge":577,"enrollmentInfo":578,"targetDuration":4,"studyType":24,"phases":580,"briefSummary":581,"conditions":582,"keywords":583,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":588,"lastUpdatePostDateStruct":589,"startDateStruct":590,"completionDateStruct":592,"leadSponsor":594,"locationsCount":49},"100574076","impact-of-high-volume-upper-limb-training-on-physical-and-cognitive-outcomes-100574076","NCT06754579","Impact of High-Volume Upper Limb Training on Physical and Cognitive Outcomes","Effect of High-Volume Upper Extremity Exercises on Physical and Cognitive Performance in Sedentary Adults","Inclusion Criteria:\n\n* Individuals aged between 18-50 years.\n* Defined as engaging in less than 150 minutes of moderate-intensity physical activity per week\n\nExclusion Criteria:\n\n* diagnosis of neurological, cardiovascular, musculoskeletal, or other systemic diseases that may affect physical activity or exercise capacity.\n* diagnosed cognitive impairments or psychiatric disorders that could interfere with test participation.\n* acute injuries or surgeries within the past six months that could restrict movement or participation.","50 Years",{"count":579,"type":23},32,[26],"Engaging in regular and appropriately structured physical activities is a critical component of an individual's lifestyle and represents a lifelong habit essential for promoting overall well-being. Research increasingly emphasizes the significance of such activities, particularly in the prevention and management of various health conditions (Martin, Richardson, Weiller, \\& Jackson, 2004).A sedentary lifestyle is considered one of the most serious health issues faced by individuals in the modern world.Previous research has established high-intensity interval training (HIIT) as an effective method for enhancing cardiovascular health, sparking interest in the relationship between exercise intensity and cognitive function. Most studies to date have focused on treadmill and lower extremity ergometer exercises; however, evidence regarding the efficacy of high-volume upper extremity exercises in improving physical and cognitive performance among sedentary adults remains limited and inconsistent. Upper extremity motor function has been proposed as a potential biomarker for cognitive impairment and may contribute to distinguishing healthy aging trajectories. This study aims to compare the effects of high-volume and low-volume upper extremity exercise in sedentary adults, testing the hypothesis that one exercise regimen may be superior in enhancing both physical and cognitive performance, as well as cognitive function.",[29],[584,585,586,587],"upper limb","reaction time","pyhsical performance","cognitive performance","2026-01-16",{"date":563,"type":41},{"date":591,"type":41},"2025-01-01",{"date":593,"type":23},"2026-12-30",{"name":595,"class":48},"Tarsus University",{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":600,"acronym":601,"eligibilityCriteria":602,"healthyVolunteers":17,"sex":58,"minAge":19,"maxAge":4,"enrollmentInfo":603,"targetDuration":4,"studyType":24,"phases":605,"briefSummary":606,"conditions":607,"keywords":608,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":618,"lastUpdatePostDateStruct":619,"startDateStruct":621,"completionDateStruct":623,"leadSponsor":625,"locationsCount":49},"100476572","stand--move-at-work-ii-effectiveness-and-implementation-of-a-worksite-wellness-program-100476572","NCT05485675","Stand & Move at Work II: Effectiveness and Implementation of a Worksite Wellness Program","SMWII","Worksite-Level Inclusion Criteria:\n\n* More than 80% of employees work full time (30+ hours per week).\n* At least 45 employees in the worksite with sit-stand workstations working at least three days per week\n* Occupations require primarily desk-based work (e.g., computer- and telephone-based)\n* Willing to allow the researchers to distribute online research surveys to all employees in order to allow the program to be evaluated.\n* Allow 30 randomly selected individuals to wear an activity monitor in several 7-day intervals across two years.\n* Willing to be randomized to either intervention.\n* Willing to identify one or more worksite champions to implement the Stand \\& Move at Work™ program.\n\nWorksite-level exclusion criteria:\n\n* Involved in previous interventions to reduce sitting and increase standing and moving at work in the last 24 months.\n* Involved in the Stand and Move I intervention.\n* Another worksite within the same organization is participating in the program and contamination across those worksites cannot be avoided.\n\nEmployee-level inclusion criteria:\n\n* 18 years or older\n* Willing to provide informed consent",{"count":604,"type":23},4800,[26],"This is a 2-arm group-randomized hybrid effectiveness-implementation (HEI type 2) study to test an evidence-based intervention (EBI) known as Stand \\& Move at Work(SMW) to reduce sedentary time in the workplace, and to test the role of expert facilitation (SMW+) for improving intervention fidelity.",[29],[609,610,611,612,613,614,615,178,616,617],"worksite health","sit-stand workstations","multilevel intervention","implementation science","fidelity","facilitation","effectiveness","posture","Light physical activity","2026-01-13",{"date":620,"type":41},"2026-01-14",{"date":622,"type":41},"2022-10-07",{"date":624,"type":23},"2027-02-28",{"name":117,"class":48},{"id":627,"slug":628,"hasResults":12,"nctId":629,"briefTitle":630,"officialTitle":631,"acronym":632,"eligibilityCriteria":633,"healthyVolunteers":17,"sex":58,"minAge":577,"maxAge":421,"enrollmentInfo":634,"targetDuration":4,"studyType":24,"phases":635,"briefSummary":636,"conditions":637,"keywords":640,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":646,"lastUpdatePostDateStruct":647,"startDateStruct":649,"completionDateStruct":651,"leadSponsor":653,"locationsCount":49},"100545081","multi-organ-responses-to-chronic-physical-activity-and-inactivity-100545081","NCT06377254","Multi-organ Responses to CHronic Physical Activity and INactivity","Concurrent Multi-organ Responses to CHronic Physical Activity and INactivity Intervention, to Increase Research Discovery in Human Health and Wellbeing","CHAIN","Inclusion Criteria:\n\n* Group 1 ('non-sedentary') self-reporting \\\u003C6 sedentary hrs\u002Fday, not actively involved in exercise training or a regular physical activity regimen (\\>8,000 steps\u002Fday).\n* Group 2 ('sedentary') self-reporting ≥8 waking hrs\u002Fday in sedentary activities and\u002For ≤5,000 steps\u002Fday.\n* Aged 50-65y.\n* Overweight (BMI 25-35 kg\u002Fm2).\n* Waist circumference ≥94cm (males) and ≥80cm (females).\n* Willing to alter physical activity levels as instructed for 6 months\n* Without neurological or psychiatric diseases, motor or cognitive restrictions\n* Ability to give informed consent\n\nExclusion Criteria:\n\n* Regular medication use that could interfere with measures\n* A history, or evidence, of chronic cardiovascular, metabolic, musculoskeletal, renal or respiratory diseases.\n* Experiencing 'long-COVID', inflammatory bowel disease or malignancy.\n* Uncontrolled hypertension. Stage 1 hypertension (BP ≤160\u002F100mmHg) with no other signs of cardiovascular disease, and blood pressure (BP) managed by routine medication will not be an exclusion.\n* People employed in jobs that would preclude reducing step count and night-shift workers.\n* Females who are pre\u002Fperi-menopausal, (due to effect of oestrogen fluctuations on primary outcomes and the longitudinal study design), but individuals stable on hormone replacement therapy are eligible.\n* Contraindications for MRI.\n* Allergy or sensitivity to local anaesthesia, or dressing adhesive",{"count":196,"type":23},[26],"Life expectancy has been increasing for the last 150 years, but the maintenance of health has not kept pace with increased lifespan, and on average, UK adults spend the last decade of life in poor-health, with major consequences for society and the individual.\n\nPersistent physical inactivity is thought to be a key contributing factor to the risk of poor health and functional decline occurring in middle-aged and older adults. It is therefore concerning that most middle-aged adults spend \\>8hrs\u002Fday being sedentary, with average step count of 3000-4000 steps\u002Fday.\n\nTo be able to holistically assess the effectiveness of future strategies to address age-related decline in health, and devise public health messages to help individuals reach older age in better health, it is essential that the complex physiological effects that activity and inactivity have across biological systems are characterised.\n\nThe goal of this intervention study is to compare the impact of physical activity and inactivity on body functioning. Twenty moderately active participants will decrease their physical activity for three months to match the average amount carried out by middle-aged people in the UK. They will then undertake 3-months of reconditioning training to restore their fitness. In addition, twenty sedentary participants will increase their physical activity to UK recommended levels for six months.\n\nBefore and at points during the intervention period, participants will be asked to make some measurements at home and attend the University of Nottingham to have multiple assessments made. These include;\n\n* fitness, muscle strength and function tests,\n* completion of questionnaires and computer-based brain puzzles\n* having muscle and fat tissue biopsies and blood samples taken.\n* The study also involves having MRI scans.\n\nThis 5-year study will commence in January 2024, with participant recruitment starting in March 2024 and finishing in May 2027.",[29,259,638,639],"Age-related Cognitive Decline","Age-Related Sarcopenia",[641,642,643,644,645],"Physical activity","middle-age","Physical inactivity","overweight","lifestyle","2025-11-26",{"date":648,"type":41},"2025-12-04",{"date":650,"type":41},"2024-03-12",{"date":652,"type":23},"2028-10-31",{"name":654,"class":48},"University of Nottingham",{"id":656,"slug":657,"hasResults":12,"nctId":658,"briefTitle":659,"officialTitle":660,"acronym":661,"eligibilityCriteria":662,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":663,"targetDuration":4,"studyType":24,"phases":665,"briefSummary":666,"conditions":667,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":670,"lastUpdatePostDateStruct":671,"startDateStruct":673,"completionDateStruct":675,"leadSponsor":677,"locationsCount":49},"100551036","multiple-risk-factor-intervention-trial-in-breast-cancer-survivors-100551036","NCT06454864","Multiple Risk Factor Intervention Trial in Breast Cancer Survivors","Multiple Risk Factor Intervention Trial In Breast Cancer Survivors","MsFITBC","Inclusion Criteria:\n\n* Biologically female\n* Diagnosis of stage I, II, or III breast cancer, post-menopausal at the time of diagnosis (haven't had a menstrual cycle within 12 months or greater)\n* Receipt of aromatase inhibitors for 12 months or more in the past, but do not have to be currently on aromatase inhibitors.\n* Willing and able to complete all study assessments\n* BMI ≥ 25 kg\u002Fm2\n* Able to commit to come to the University once per week for 24 weeks.\n\nExclusion Criteria:\n\n* Received chemotherapy within the past 11 months\n* Diagnosed with metastatic cancer\n* Currently taking tamoxifen\n* Currently receiving chemotherapy, targeted therapy or radiation treatment\n* Distant recurrence or diagnosis of metastatic cancer since early-stage breast cancer diagnosis\n* Diagnosed cardiovascular diseases, type 2 diabetes, non-alcoholic fatty liver disease, uncontrolled thyroid condition, or respiratory disease (e.g., COPD or severe or uncontrolled asthma).\n* Major signs or symptoms of cardiovascular diseases, diabetes, or renal disease (taken from the American College of Sports Medicine's Guidelines for Exercise Testing and Prescription 11th edition Table 2.1: pain or discomfort in the chest, neck, jaw, arms with rest or exercise, shortness of breath at rest or with mild exertion, dizziness or syncope, loss of balance or passing out, ankle edema, palpitations or tachycardia, intermittent claudication, known heart murmur, unusual fatigue with usual activities.)\n* American Heart Association's absolute or relative contraindications for symptom-limited maximal exercise testing (myocardial infarction, aortic or coronary artery stenosis, heart failure, pulmonary embolism or deep vein thrombosis, inflammation of the heart (myocarditis, pericarditis, and\u002For endocarditis), uncontrolled cardiac arrhythmia, advanced or complete electrical heart block, stroke or transient ischemia attack, blood pressure \\>200mmHg\u002F100mmHg, a cancer diagnosis other than skin cancer)\n* Unable to provide informed consent or communicate in English\n* Pregnant or breast-feeding currently or in the past 3 months\n* Mobility limitations to aerobic exercise (i.e., wheelchair, walker use, limp impeding walking)\n* Smoking cigarettes or marijuana within the past 3 months\n* Taking exogenous hormones in any format currently or in the past 3 months\n* Contraindications to research MRI (e.g., pacemaker, magnetic implants)\n* BMI exceeding 40 kg\u002Fm2\n* Extreme claustrophobia\n* Self-report \\>30 min\u002Fweek of moderate-to-vigorous intensity aerobic physical activity\n* Following a diet that largely restricts entire food groups or time of eating (e.g., vegan, ketogenic, carnivore, one meal a day) in last 3 months\n* Experienced significant weight loss (i.e., \\>5 kg) in past 3 months\n* Currently taking weight loss medications\n* Diagnosed history of an eating disorder or self-report of potential undiagnosed eating disorder\n* Plans to be away\u002Funavailable for a substantial period of the intervention overall (i.e., \\>4 weeks throughout the 6 months or \\>2 weeks within the first 12 weeks of the intervention).\n* Allergies to local anesthetics",{"count":664,"type":23},45,[26],"This study aims to produce new evidence on the efficacy of exercise and diet for cardiometabolic risk reduction in BC survivors. Using a 3-arm RCT with to 6 months of 1) exercise following Health Canada guidelines; 2) the same exercise plus counselling to follow Canada's Dietary Guidelines to improve diet quality; or 3) stretching group, this study will answer the following questions:\n\n* What is the impact of exercise on cardiometabolic health and body composition in BC survivors?\n* What is the effect modification of adding a diet quality intervention to exercise on cardiometabolic health and body composition?\n* Is there a link between the capacity of skeletal muscle adaptation to exercise (and diet) and insulin resistance in BC survivors?\n\nThe investigators hypothesize that: 1) exercise will improve cardiometabolic and body composition outcomes 2) improvements in cardiometabolic outcomes will be enhanced by the addition of diet quality, which will be essential or additive for Matsuda index, metabolic syndrome, Framingham CVD risk, thigh myosteatosis, muscle mass, VO2peak, 3) skeletal muscle insulin signalling transduction will be impaired in BC survivors via dampened expression of insulin-responsive proteins (e.g. GLUT4) and co-occur with impaired muscle quality (e.g., higher rates of fat depots, presence of fibrous tissue) negatively impacting insulin signalling.",[668,29,669],"Metabolic Disturbance","Breast Cancer Female","2025-09-26",{"date":672,"type":41},"2025-10-01",{"date":674,"type":41},"2024-07-01",{"date":676,"type":23},"2027-04-01",{"name":678,"class":48},"University of Toronto",{"id":680,"slug":681,"hasResults":12,"nctId":682,"briefTitle":683,"officialTitle":684,"acronym":4,"eligibilityCriteria":685,"healthyVolunteers":17,"sex":58,"minAge":421,"maxAge":4,"enrollmentInfo":686,"targetDuration":4,"studyType":24,"phases":687,"briefSummary":688,"conditions":689,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":690,"lastUpdatePostDateStruct":691,"startDateStruct":693,"completionDateStruct":695,"leadSponsor":696,"locationsCount":49},"100548946","sit-less-and-move-more-feasibility-study-100548946","NCT06427603","Sit Less and Move More: Feasibility Study","Sit Less and Move More: A Feasibility Study on Physical Active Break Intervention and Improving Cardiometabolic Health","Inclusion Criteria:\n\n1. are community-dwelling older adults aged 65 years or above,\n2. are smartphone users,\n3. sit for \\>= 6 hours per day\n4. are overweight\n\nExclusion Criteria:\n\n1. are unable to walk independently with\u002Fwithout walking aids due to a physical disability;\n2. have health conditions that hinder the adherence to intervention",{"count":128,"type":23},[26],"Intervention aiming to improve cardiometabolic health and physical function by reducing prolonged sitting",[29],"2025-09-19",{"date":692,"type":41},"2025-09-24",{"date":694,"type":23},"2025-10",{"date":437,"type":23},{"name":697,"class":48},"Hong Kong Metropolitan University",{"id":699,"slug":700,"hasResults":12,"nctId":701,"briefTitle":702,"officialTitle":703,"acronym":704,"eligibilityCriteria":705,"healthyVolunteers":12,"sex":58,"minAge":19,"maxAge":706,"enrollmentInfo":707,"targetDuration":4,"studyType":24,"phases":709,"briefSummary":710,"conditions":711,"keywords":717,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":690,"lastUpdatePostDateStruct":723,"startDateStruct":724,"completionDateStruct":726,"leadSponsor":728,"locationsCount":49},"100483704","association-of-a-digital-signature-of-physical-activity-and-sedentary-lifestyle-with-the-development-of-multimorbidities-in-chronic-diseases-emob-100483704","NCT05578495","Association of a Digital Signature of Physical Activity and Sedentary Lifestyle With the Development of Multimorbidities in Chronic Diseases (eMOB)","Association of a Digital Signature of Physical Activity and Sedentary Lifestyle With the Development of Multimorbidities Over 4 Years of Follow-up in Chronic Diseases (eMOB) : a Prospective Cohort","eMOB","Inclusion Criteria:\n\n* Patient follow-up at CHU Clermont-Ferrand for a chronic disease in one of the following observational cohorts:\n\n  * Inflammatory rheumatic disease(rheumatoid arthritis, spondyloarthritis) included in the RCVRIC cohort (CPP Sud-Est VI N° ID-RCB- A01847-40)\n  * Pre-surgical knee and hip osteoarthritis (Evalmob) (ID-RCB N° 2019- A01017-50)\n  * Major depressive disorder included in the FACE-DR cohort (CNIL agreement: DR- 2015-673) and Bipolar disorder included in the FACE-BD cohort (CPP Ile de France IX; January 18, 2010) of the Adult Psychiatry Department B\n  * Type 2 diabetes included in the cohort of the sport medicine service \"Rehabilitation T2\" (CNIL agreement 0164)\n  * Obesity included in the \"Obesity\" sports medicine service cohort (CNIL agreement 0164)\n  * COPD included in the \"COPD Rehabilitation\" sports medicine service cohort (CNIL agreement 0164)\n  * Chronic pain cohort (eDOL) (CPP West II N° ID-RCB 2020-A02027-32)\n* Affiliation to a social security system.\n* Able to provide written informed consent to participate in the research.\n\nExclusion Criteria:\n\n* Inability to practice physical activity\n* Pregnant or breastfeeding\n* Refusal to participate\n* Minors or adults under the protection of the law or under the protection of justice.","90 Years",{"count":708,"type":23},700,[26],"Physical activity (PA) and sedentary lifestyle are determinants in the development of chronic diseases and associated quality of life alterations. PA levels are correlated with quality of life and morbidity in chronic lung disease (COPD), cardiovascular disease, diabetes, cancer, chronic inflammatory rheumatism, fibromyalgia and anxiety disorders. In these diseases, low-intensity PA often represents the main PA and the quantity of PA is correlated with health parameters.\n\nThis study aims to identify a typical profile (signature) in relation to the appearance of other chronic diseases, complications of your disease, from recording your physical activity and sedentary lifestyle by sensors evaluating very precisely the movements and taking into account the characteristics and disability related to your disease. The results of this study would therefore make it possible to identify this signature even before the appearance of complications or other diseases.",[531,29,712,713,714,715,716],"Non Communicable Diseases","Comorbidities and Coexisting Conditions","Comorbidity","Multimorbidity","Digital Technology",[200,718,719,720,715,721,722],"Sedentary Lifestyle","Chronic Diseases","Comorbidities","Personal digital health","Personalized medecine",{"date":692,"type":41},{"date":725,"type":41},"2023-12-07",{"date":727,"type":23},"2030-12",{"name":729,"class":48},"University Hospital, Clermont-Ferrand"]