[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sedentary\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sedentary":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,52,82,114,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100603043","interaction-between-inorganic-nitrate-supplementation-and-metformin-in-individuals-with-prediabetes-100603043",false,"NCT07131384","Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes","The Interaction Between Inorganic Nitrate Supplementation and Metformin on Exercise Capacity, Vascular Function, and Insulin Sensitivity in Individuals With Pre-Diabetes","NO3-PreDM","Inclusion Criteria:\n\n* Individuals who can communicate meaningfully with the investigator and can provide written consent.\n* Confirmed prediabetic individuals (ages 18-60 years old) (2-hour glucose of 140-199 mg\u002FdL following OGTT test or HbA1c between 5.7-6.4% tested on two occasions within 6 months).\n* Taking metformin (stable dose for at least a week) or naïve to metformin\n* Sedentary (\\\u003C1 day\u002Fweek of structured exercise)\n* Be able to perform exercise on a cycle ergometer without assistance\n* Stable medication regimen for the last 6 months\n* If female, have a normal menstrual cycle\n\nExclusion Criteria:\n\n* Estimated Glomerular filtration rate (GFR) ≤ 45\n* Body mass index ≥ 40 Kg\u002Fm2\n* HbA1c \\> 6.4%\n* Smokers within the last 5 years\n* Has experienced significant weight loss \\~3 kg in the last three months or is taking any weight loss drugs\n* Current medical condition that prohibits exercising at high intensities\n* Currently on hormone replacement of any kind\n* History of myocardial infarction, cerebrovascular event, acute or unstable disease other than pre-diabetes or obesity\n* Currently taking any of the following medications (calcium channel blockers, statins, ACE or renin inhibitors, angiotensin receptor blockers, organic nitrates (e.g., nitroglycerine) or recent regular use of inorganic nitrates, alpha- or beta-blockers, diuretics, proton pump inhibitors, PDE-5 inhibitors (e.g.,: Cialis, Viagra), or xanthine oxidase inhibitors (e.g.,: Allopurinol))\n* Oral antibiotic use within the previous four weeks, including over-the-counter antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use\n* Oral cancer\u002Fsevere oral disease\n* Uncontrolled hypertension (\\>140\u002F90)\n* Had hysterectomy or oophorectomy\n* Fetuses, neonates, children, prisoners, cognitively impaired, non-English speaking participants","ALL","18 Years","60 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is examining whether short-term supplementation with inorganic nitrate, in the form of beetroot juice, can enhance blood vessel health, insulin sensitivity, and exercise capacity in individuals with prediabetes. We will be comparing the responses in individuals who are taking metformin to those who are naive to metformin. The results from this study may help identify non-pharmacological interventions in prediabetes.",[28,29,30,31,32],"Males","Females","Sedentary","Metformin","Prediabetes",[34,35,36,37,38],"Prediabetic Individuals","Exercise Capacity","Vascular health","Inorganic nitrate","Insulin Sensitivity","RECRUITING","2026-06-02",{"date":42,"type":43},"2026-06-03","ACTUAL",{"date":45,"type":43},"2026-01-01",{"date":47,"type":22},"2027-06-30",{"name":49,"class":50},"University of Virginia","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100623040","supporting-preventive-practices-in-primary-care-amplifying-the-potential-of-opportunistic-interventions-100623040","NCT07391462","Supporting Preventive Practices in Primary Care: Amplifying the Potential of Opportunistic Interventions","Supporting Preventive Practices in Nutrition, Physical Activity and Sedentary Lifestyle in Primary Care: Amplifying the Potential of Opportunistic Interventions in Routine Consultations","APPRENDRE","Patients Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Registered with a participating practice\u002Fpractitioner\n* Score \\\u003C 5 for the \"Stages of Change of Exercise Behaviour Scale\" (pre-contemplation or contemplation stage) and\u002For Stage precontemplation or contemplation for the \"Stages of Change for Healthy Diet Scale\" (Precontemplation = answer to question 1 \\\u003C 5 and answer to question 3 is no and Contemplation = answer to question 1 \\\u003C 5, answer to question 3 is yes, and answer to question 4 is no).\n\nPrimary care professionals:\n\n* GPs practicing in the Rhône-Alpes region\n* Working in ambulatory care\n\nPatients Exclusion Criteria:\n\n* Being under guardianship and curatorship\n* Pathological disordered eating (e.g., anorexia nervosa, bulimia nervosa,...)\n* Acute severe pathology, life threatening condition\n* Engaged in another research on diet or physical activity\n\nPrimary care professionals:\n\n\\- Exclusive specialist practice (e.g., only sonography, angiology, addictiology , cosmetic surgery…)",{"count":61,"type":22},882,"OBSERVATIONAL","In France, as worldwide, the prevalence of chronic conditions is increasing, with high burden on populations and healthcare systems. Behaviour is a key risk factor, and needs to be tackled within the social and environmental context in which it occurs. For example in 2017, the French eat too much processed food and salt, not enough fibers, 34% are overweight and 17% obese, and 80% present excessive sedentary time. In parallel, in France 5.4% of all cancers were attributable to sub-optimal nutrition (especially low fruits consumption and dietary fibers, and high processed meats consumption), and 6.3% to overweight\u002Fobesity or insufficient physical activity. Governments and health systems, including in France, have therefore considered a priority to intervene preventively on health behaviours throughout the lifespan.\n\nFor a populational approach to prevention via behaviour change, primary care professionals are best placed to intervene, due to the long-term relationship that can be established with healthcare users in their everyday life environments, and the many opportunities for brief interventions which can be delivered and followed up depending on individual needs. Research suggests that brief interventions can be effective in producing small but important changes in behaviour (Keyworth 2020) particularly if the intervention is based on a theoretical model of behaviour change (e.g., Prochaska's transtheoretical model or Bandura's cognitive social theory).\n\nOne such Public Health program is Making Every Contact Count (MECC), a program developed in England and deployed since 2007 and more recently implemented in Wales and Ireland as well. The development and implementation have been supported by epidemiological, behaviour change and implementation science research and continues to adapt to current challenges in preventive healthcare needs and provision. The \"Healthy Conversation Skills\" is a training program for healthcare professionals within the MECC program that focuses on how they can assess and support their patients' goals to improve behaviours such as physical activity and diet. It has been delivered since 2015 and shown effective (Adam 2020).\n\nIn France, 98% of general practitioners (GPs) consider prevention as part of their professional roles. However, initial and continuous training for primary care professionals focuses mainly on healthcare rather than prevention, and the latter is only addressed through physiological and epidemiological perspective but not on behaviour determinants and change techniques. Actually, there is at the moment limited training on assessing and supporting health behaviour change in primary care professionals in France, which limits the opportunities and effectiveness of a preventive approach to behavioural risk factors in chronic conditions. However, a direct transfer of the \"Healthy Conversation Skills\" program to the French context is unlikely to achieve optimal benefit, as differences in culture and health system organisation are considerable in behavioural care (de Bruin 2018). Collaborative approaches to developing and implementing training programs are recommended. The investigators therefore propose to co-construct a training program tailored to the context of GP practice in France, and study its effectiveness and implementation in supporting changes in diet, physical activity and sedentary time in adult patients from the general population consulting in routine care.",[30,65],"Suboptimal Health Status",[67,68,69,70,71],"primary care","health behaviours","behaviour change techniques","co-construction","implementation science","2026-01-29",{"date":74,"type":43},"2026-02-05",{"date":76,"type":43},"2025-04-01",{"date":78,"type":22},"2029-07-31",{"name":80,"class":50},"Hospices Civils de Lyon",4,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":17,"minAge":91,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":23,"phases":94,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":4},"100601332","the-effects-of-vitamin-c-on-acute-exercise-in-postmenopausal-females-100601332","NCT07109115","The Effects of Vitamin C on Acute-Exercise in Postmenopausal Females","The Effects of Vitamin C on Exercise-Induced Oxidative Stress in Postmenopausal Females","PM-VitC","Inclusion Criteria:\n\n* Post-menopausal (for females; defined as no menstrual cycle for 1-year)\n* Sedentary (\\\u003C150min of moderate-intensity exercise per week or not engaged in a regular exercise program)\n* Non-smoking\n* Weight stable (+\u002F-3 kg over the past 3 months)\n\nExclusion Criteria:\n\n* Overt CVD\n* Any condition or medication contraindicating safe exercise\n* Hormone replacement therapy (last 3-months)\n* Use of vasoactive medications (e.g., calcium channel blockers, statins, ACE inhibitors, ARBs, nitrates, alpha-\u002Fbeta-blockers, diuretics), diabetes, or unstable medication regimens\n* Diabetes\n* Oral antibiotic use within previous four weeks\n* Oral disease or poor oral health as determined by the Oral Health Questionnaire\n* Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use\n* Cancer diagnosis",true,"45 Years",{"count":93,"type":22},30,[25],"This study is looking at whether vitamin C can help improve oxidative stress and blood vessel health in females after menopause. We will see if taking different amounts of vitamin C for a few days changes how the body handles stress from exercise. This could lead to safer ways to protect females from heart disease without using hormone therapy.",[29,28,97,30,98],"Menopause","Healthy Participants",[100,101,102,103,104],"Vitamin C","Postmenopausal Females","Exercise","Oxidative Stress","Vascular Health","NOT_YET_RECRUITING","2025-07-30",{"date":108,"type":43},"2025-08-07",{"date":110,"type":22},"2025-09-01",{"date":112,"type":22},"2027-09-01",{"name":49,"class":50},{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":90,"sex":17,"minAge":121,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":23,"phases":125,"briefSummary":126,"conditions":127,"keywords":4,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":4},"100584895","effects-of-inspiratory-muscle-fatigue-and-warm-up-on-respiratory-variables-handgrip-strength-and-walking-capacity-in-sedentary-older-adults-100584895","NCT06895304","Effects of Inspiratory Muscle Fatigue and Warm-up on Respiratory Variables, Handgrip Strength, and Walking Capacity in Sedentary Older Adults","Effects of Inspiratory Muscle Fatigue and Warm-up on Respiratory Variables, Handgrip Strength, and Walking Capacity in Sedentary Older Adults: A Randomized Clinical Trial.","Inclusion Criteria:\n\n* Being over 60 years old.\n* Physical independence in terms of gait and transfers\n* Engaging in less than 150 minutes of physical activity per week.\n\nExclusion Criteria:\n\n* Having any pathology that prevents the performance of physical activity.\n* Subjects with impaired cognitive abilities.\n* Subjects with tympanic perforation or middle-inner ear pathology.\n* Subjects with chronic respiratory, cardiac, renal, or metabolic pathology..\n* Subjects who have undergone lower limb surgery within the past 12 months.","65 Years","99 Years",{"count":124,"type":22},33,[25],"Respiratory muscle training represents an effective method increasingly utilized in both sports and healthcare domains, employing various devices, among which threshold devices are prominent. The aim of this study is to determine the relationship between inspiratory muscle fatigue or warm-up and muscular strength in upper and lower limbs, in sedentary older adults, as well as the association between such fatigue and other variables, including maximal inspiratory pressure, diaphragmatic ultrasonography, functionality and handgrip strength.\n\nAccording to our hypothesis, the execution of a protocol inducing inspiratory muscle fatigue or activation in sedentary older adults could influence muscular strength, respiratory function and exercise capacity.\n\nIn this study, subjects will be divided into three groups: the fatigue group , the activation group and the control group.\n\nMeasurements of variables, such as maximal inspiratory pressure, diaphragmatic strength (ultrasound image) and functional capacity, will be conducted.",[30,128],"Healthy","2025-03-19",{"date":131,"type":43},"2025-03-26",{"date":133,"type":22},"2025-03-31",{"date":135,"type":22},"2025-04-10",{"name":137,"class":50},"Sierra Varona SL",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":121,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":23,"phases":148,"briefSummary":149,"conditions":150,"keywords":154,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":51},"100568823","acute-effects-of-intermittent-hypoxia-hyperoxia-in-older-adults-100568823","NCT06686238","Acute Effects of Intermittent Hypoxia-Hyperoxia in Older Adults","Acute Effects of a Hypoxia-hyperoxia Exposure Session on Sedentary Older Adults on Heart Rate Variability, Blood Pressure, and Oxygen Saturation, a Randomized Double-blind Placebo-controlled Clinical Trial","Inclusion Criteria:\n\n* Being over 60 years old.\n* Having no previous experience in hypoxic training.\n* Engaging in less than 150 minutes of physical activity per week.\n\nExclusion Criteria:\n\n* Having any pathology that prevents the subject from being independent in terms of walking and functionality.\n* Subjects with impaired cognitive abilities.\n* Subjects with pulmonary hypertension, decompensated heart or respiratory disease.\n* To have or have had cancer","90 Years",{"count":147,"type":22},16,[25],"The supply of oxygen is essential for energy production, recovery from efforts, and human life. Intermittent Hypoxia-Hyperoxia Exposure (IHHE) is a novel technique in which the subject is exposed to a respiratory environment with reduced oxygen fraction, controlled through a specific software, using a facial mask and a hypoxic generation device. The objective of this study is to determine if there is a relationship between intermittent hypoxia-hyperoxia exposure and cardiorespiratory condition, blood pressure, and arterial oxygen saturation.\n\nAccording to our hypothesis, acute IHHE in elderly adults may influence cardiorespiratory condition, blood pressure, and arterial oxygen saturation.\n\nThe study will be conducted as a randomized clinical trial. The subjects will be divided into two groups: the experimental group will undergo an IHHE session, breathing air with an oxygen concentration (FiO2) ranging from 10-14% for 1-5 minutes, with 1-3 minutes of rest in hyperoxia (FiO2 30-40%) for a total of 4-8 cycles, based on their acute response to hypoxia. The placebo group will undergo a 5-cycle protocol with an FiO2 of 21%.",[151,152,153,30],"Older Adults","Cardiovascular Health","Blood Pressure",[155,156,157],"hypoxic exposure","older adults","heart rate variability","2024-11-25",{"date":160,"type":43},"2024-11-27",{"date":162,"type":22},"2024-12-05",{"date":164,"type":22},"2024-12-26",{"name":137,"class":50}]