[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"self-stigma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:self-stigma":61},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100629414","gender-differences-in-depression-severity-gender-sensitive-symptoms-resilience-and-stigma-in-major-depressive-disorder-100629414",false,"NCT07474363","Gender Differences in Depression Severity, Gender-Sensitive Symptoms, Resilience, and Stigma in Major Depressive Disorder","A Comparative Examination of Depression Severity, Gender-Sensitive Depressive Symptoms, Psychological Resilience, and Stigma Levels in Women and Men With Major Depressive Disorder","GD-GSS-R-S-MDD","Inclusion Criteria:\n\n* Male and female patients aged 18 to 65 years\n* Diagnosis of Major Depressive Disorder according to DSM-5 at the time of study participation\n* Provision of voluntary informed consent\n\nExclusion Criteria:\n\n* Intellectual disability\n* Severe neurological disorders\n* Comorbid psychiatric diagnoses\n* Depressive disorder secondary to an organic medical condition\n* Depressive disorder secondary to substance use","ALL","18 Years","65 Years",{"count":21,"type":22},90,"ESTIMATED","OBSERVATIONAL","Depression is a common and serious mental health condition that affects mood, thoughts, behavior, and overall quality of life. It arises from a complex interaction of biological, psychological, and environmental factors. While depression is more frequently diagnosed in women, research suggests that men may experience and express depressive symptoms differently. Men are more likely to display symptoms such as irritability, anger, impulsivity, or increased alcohol use, and they may be less likely to seek professional psychological support due to social expectations and fear of stigma.\n\nStigma-both self-stigma (internalized negative beliefs about having a mental illness) and perceived social stigma (concerns about being judged by others)-can negatively influence individuals' willingness to seek help and adhere to treatment. In addition, psychological resilience, defined as the ability to cope effectively with stress and adversity, may play an important role in how individuals experience depressive symptoms and respond to treatment.\n\nThis study aims to compare women and men diagnosed with Major Depressive Disorder in terms of depression severity, gender-sensitive depressive symptoms, self-stigma, perceived social stigma, and levels of psychological resilience. It will also examine the relationships among these factors to better understand how gender-related differences influence the experience and management of depression.\n\nFindings from this study may contribute to improved recognition of gender-specific features of depression, reduction of stigma, and the development of more individualized and effective mental health interventions for both women and men.",[26,27,28,29,30],"Major Depressive Disorder (MDD)","Gender Differences","Resilience, Psychological","Self Stigma","Social Stigma","RECRUITING","2026-03-23",{"date":34,"type":35},"2026-03-25","ACTUAL",{"date":37,"type":35},"2025-06-01",{"date":39,"type":22},"2026-11",{"name":41,"class":42},"Eskisehir Osmangazi University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":43},"100559669","a-group-based-treatment-for-self-stigma-in-people-with-mental-disorders-in-north-east-italy-100559669","NCT06567145","A Group-based Treatment for Self-stigma in People With Mental Disorders in North-east Italy","Assessing the Effectiveness and Feasibility of Group-based Treatment for Self-stigma in People With Mental Disorders: a Pragmatic Multisite Randomized Controlled Trial in Routine Mental Health Services in North-east Italy","NECT-ITA","Inclusion Criteria:\n\n1. Participants must be 18 years or older.\n2. Individuals must have a diagnosis of schizophrenia, schizoaffective disorder, schizoid disorder, schizophreniform disorder, bipolar I or II disorder, or major depressive disorder, according to DSM-5 criteria.\n3. Participants must be outpatients with clinical stability for at least 3 months, with no changes in pharmacological treatment during this period.\n4. Participants must have sufficient knowledge of written and spoken Italian.\n5. Participants must score above 1 on the ISMI (Internalized Stigma of Mental Illness) scale, indicating at least moderate levels of self-stigma.\n\nExclusion Criteria:\n\n1. Individuals unable to provide informed consent are excluded.\n2. Participants with intellectual disabilities are excluded.\n3. Individuals with primary diagnosis of personality disorder or substance dependence condition are excluded.\n4. Participants engaged in other programs that could influence self-stigma (e.g., social cognitive rehabilitation, social skills training) during the study are excluded.",{"count":53,"type":22},416,"INTERVENTIONAL",[56],"NA","Self-stigma refers to the internalization of negative stereotypes by individuals with mental disorders, leading to beliefs that they are dangerous, aggressive, or incapable of working. This phenomenon has harmful effects on various aspects of life, such as adherence to treatment, self-esteem, quality of life, and can increase feelings of despair and suicide risk. To address these issues, the Narrative Enhancement and Cognitive Therapy (NECT) was developed. NECT is a group-based intervention consisting of 20 sessions designed to reduce self-stigma in individuals with mental disorders.\n\nThis study aims to evaluate the efficacy and feasibility of NECT in 416 patients from 26 mental health centers in Northeast Italy. It is structured as a pragmatic, multicenter, randomized controlled trial with two parallel arms. The study will assess the impact of NECT on several psychological dimensions, including levels of self-stigma, self-esteem, hope, empowerment, perception of recovery, mental well-being, and stigma-related stress. The findings of this research are expected to contribute to the understanding of effective treatments for patients with mental disorders, particularly those burdened by high levels of self-stigma, and to improve their recovery outcomes.",[59,60,61],"Stigma","Mental Disorders","Self-stigma",[63,64,65,66,67,68],"stigma","narrative enhancement cognitive therapy","narrative therapy","cognitive therapy","mental disorders","self-stigma","2024-11-21",{"date":71,"type":35},"2024-11-26",{"date":73,"type":35},"2024-10-01",{"date":75,"type":22},"2025-10-01",{"name":77,"class":42},"Universita di Verona"]