[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"senile-pruritus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:senile-pruritus":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100640420","the-effect-of-intraoperative-esketamine-infusion-on-pruritus-in-elderly-surgical-patients-100640420",false,"NCT07597486","The Effect of Intraoperative Esketamine Infusion on Pruritus in Elderly Surgical Patients","The Effect of Intraoperative Esketamine Infusion on Pruritus in Elderly Surgical Patients: A Single-Center Randomized Controlled Trial","Inclusion Criteria:\n\n1. Meet the diagnostic criteria for senile pruritus:\n\n   1. Aged ≥ 65 years old;\n   2. Presenting with only skin pruritus without obvious primary skin lesions, with or without scratch-induced skin lesions;\n   3. Daily or nearly daily pruritus lasting for more than 6 weeks.\n2. Patients undergoing elective general anesthesia for orthopedic knee arthroplasty.\n3. Patients aged ≥ 65 years old, with ASA physical status classification Ⅰ-Ⅲ; BMI ranging from 18 to 30 kg\u002Fm², with no restriction on gender.\n4. Patients have fully understood the nature of this study, are capable of understanding and completing evaluation scales preoperatively, voluntarily participate in this trial, and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Those who are allergic to the pharmaceutical ingredients of this study or have an allergic constitution;\n2. Those with a history of allergy to general anesthetics, opioids, or non-steroidal anti-inflammatory drugs;\n3. Those with severe cognitive impairment, a history of neurological diseases, chronic pain, drug addiction, alcoholism, long-term opioid use, or administration of opioids within 48 hours before surgery;\n4. Patients with ASA physical status classification Grade IV-V;\n5. Those with severe coronary heart disease\u002Farrhythmia\u002Fcardiac insufficiency, bronchial asthma, severe hypertension, severe hematopoietic system dysfunction, severe abnormal liver and kidney function, or significant electrolyte disorders;\n6. Those with a history of gastrointestinal diseases (peptic ulcer, Crohn's disease, ulcerative colitis);\n7. Those with respiratory insufficiency or respiratory failure;\n8. Those with BMI \\\u003C 18 kg\u002Fm² or BMI \\> 30 kg\u002Fm²;\n9. Those with poor compliance who cannot complete the trial in accordance with the research protocol;\n10. Those who have participated in other clinical drug trials within the past 4 weeks;\n11. Those deemed unsuitable for enrollment by the researchers for any reason. -","ALL","65 Years","80 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","To explore the effect of intraoperative esketamine on pruritus in elderly patients undergoing elective general anesthesia for knee replacement surgery",[27],"Senile Pruritus",[29,30],"esketamine","pruritus","NOT_YET_RECRUITING","2026-05-18",{"date":34,"type":35},"2026-05-19","ACTUAL",{"date":37,"type":21},"2026-05-15",{"date":39,"type":21},"2027-09-30",{"name":41,"class":42},"Tianjin Medical University General Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":18,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100554988","effects-of-acupuncture-for-senile-pruritus-100554988","NCT06506240","Effects of Acupuncture for Senile Pruritus","Effects of Acupuncture for Senile Pruritus: Study Protocol for a Randomised Controlled Trial","Inclusion Criteria:\n\nParticipants aged between 60 and 80 years who meet diagnostic criteria for SP, with an average severity score of itching in the past week of ≥4 points on the Numerical Rating Scale (NRS), and who voluntarily provide written informed consent are eligible for inclusion.\n\nExclusion Criteria:\n\nParticipants will be excluded if they meet any of the following criteria:\n\n1. Severe skin damage or infection;\n2. Severe underlying diseases including cardiovascular diseases, hepatobiliary diseases, kidney diseases, hematologic diseases, autoimmune diseases, infectious diseases, severe malnutrition, or malignancies;\n3. Mental illness, cognitive dysfunction, or language disorders;\n4. Received acupuncture therapy for pruritus within the past month;\n5. Have a history of drug abuse.","60 Years",{"count":53,"type":21},108,[24],"Senile pruritus (SP), characterized by idiopathic itching in individuals aged 60 years and older without primary skin lesions, significantly impacts sleep and quality of life. Effective alternative treatments are needed. Acupuncture has been suggested as a potential intervention to alleviate itching; however, its role in managing SP remains uncertain. This study aims to evaluate the effects and safety of acupuncture for SP. This single-centre, parallel, two-arm, randomized, sham-controlled trial will enroll 108 patients diagnosed with SP in a 1:1 ratio to either the acupuncture or sham acupuncture group. Participants, outcome assessors, and the statistician will be blinded. Treatment will consist of 18 sessions over 6 weeks. The primary outcome is change from baseline in the Numerical Rating Scale (NRS) score for average itching severity at week 6, assessed weekly via weekly diary of pruritus assessment. Secondary outcomes include changes in NRS score for maximum itching severity, daily episodes of itching, itchy area of body surface, overall dry skin score (ODS), the Dermatology Life Quality Index (DLQI), the Pittsburgh Sleep Quality Index (PSQI), the Hospital Anxiety and Depression Scale (HADS), and Patient Global Impression of Change (PGIC). Adverse events will be monitored throughout the study period. The intention-to-treat (ITT) population will include participants who complete baseline assessments and receive at least one treatment session.",[27],[58,59,60],"Acupuncture","Senile pruritus","Randomized controlled trial","RECRUITING","2024-11-18",{"date":64,"type":35},"2024-11-20",{"date":66,"type":35},"2024-03-01",{"date":68,"type":21},"2026-02-28",{"name":70,"class":42},"Guang'anmen Hospital of China Academy of Chinese Medical Sciences"]