[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sensory-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sensory-function":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,78,116],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100624391","sensory-stimulation-as-a-driver-of-diet-induced-thermogenesis-100624391",false,"NCT07409025","Sensory Stimulation as a Driver of Diet-induced Thermogenesis","SEnsory stimulatioN aS A Driver of dieT-induced Thermogenesis - the SENSATION Trial","SENSATION","Inclusion Criteria:\n\n* healthy volunteers of any gender\n* BMI between 18-25 kg\u002Fm2\n* age between 18 and 40 years\n\nExclusion Criteria:\n\n* concomitant medication except for prescription free analgetics (paracetamol, NSAIDs) and oral contraceptives\n* clinically significant concomitant disease states (e.g. renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus),\n* allergy to local anaesthetic or any of the study meal ingredients\n* known or suspected non-compliance, drug or alcohol abuse\n* smoker \u002F habitual tobacco use\n* habitual excessive alcohol consumption\n* inability to follow the procedures of the study\n* participation in another study with investigational drug within the 30 days preceding and during the present study\n* previous enrolment into the current study\n* enrolment of the investigator, his\u002Fher family members, employees and other dependent persons\n* uncontrolled hypo- or hyperthyroidism\n* pregnancy or lactation",true,"ALL","18 Years","40 Years",{"count":22,"type":23},24,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study aims to assess the influence of sensory stimulation on diet-induced energy expenditure by way of a clinical cross-over trial in 24 healthy participants either receiving a meal bolus with (orally) and without sensory stimulation (nasogastric-tube).",[29,30],"Diet-induced Thermogenesis","Sensory Function",[32,33],"Diet-induced thermogenesis","Sensory Stimulation","NOT_YET_RECRUITING","2026-05-21",{"date":37,"type":38},"2026-05-22","ACTUAL",{"date":40,"type":23},"2026-06-15",{"date":42,"type":23},"2027-06",{"name":44,"class":45},"University Hospital, Basel, Switzerland","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":54,"minAge":19,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":24,"phases":57,"briefSummary":58,"conditions":59,"keywords":65,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":74,"leadSponsor":76,"locationsCount":46},"100616643","longitudinal-evaluation-of-direct-neurotization-technique-in-breast-reconstruction-with-fully-autologous-components-100616643","NCT07308275","Longitudinal Evaluation of Direct Neurotization Technique in Breast Reconstruction With Fully Autologous Components","Longitudinal Evaluation of Direct Neurotization Technique in Breast Reconstruction With Fully Autologous Components: An Assessment of BREAST-Q Sensation Module, Cutaneous Pressure Threshold, Neuregulin 1 (NRG1) Expression, Nerve Fiber Cross-sectional Area, Intraepidermal Nerve Fiber Density (IENFD), and Breast Morphometry","Inclusion Criteria:\n\n* Female patients aged ≥18 years.\n* Patients with unilateral breast cancer who have undergone or will undergo unilateral mastectomy.\n* Patients undergoing breast reconstruction.\n* Patients with unilateral breast cancer regardless of adjuvant therapy status (receiving radiotherapy and\u002For chemotherapy or receiving no adjuvant therapy).\n* Willing to comply with all scheduled examinations and tissue sampling procedures.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* History of peripheral neuropathy (e.g., diabetes mellitus with neuropathic complications).\n* Bilateral mastectomy.\n* Presence of skin or soft-tissue conditions of the breast that may interfere with sensory assessment.\n* Active smokers (use of tobacco, vape, or other nicotine products within 14 days prior to neurotization).\n* Refusal or inability to attend follow-up evaluations.","FEMALE",{"count":56,"type":23},28,[26],"This clinical trial aims to evaluate whether direct neurotization using fully autologous components during autologous breast reconstruction improves postoperative breast sensation and sensory-related quality of life in women undergoing unilateral mastectomy. Direct neurotization involves coapting the recipient intercostal nerve to an autologous nerve graft placed within the flap to facilitate reinnervation.\n\nThe study's primary questions are:\n\n1. Does direct neurotization using fully autologous nerve grafts improve cutaneous sensory recovery, as assessed by Semmes-Weinstein monofilament thresholds measured at standardized breast locations?\n2. Does neurotization enhance patient-reported sensory outcomes and quality of life, as assessed by the BREAST-Q Sensation Module?\n\nAs secondary objectives, the study will assess whether biological predictors of nerve regeneration correlate with sensory outcomes. These include:\n\n1. Neuregulin-1 (NRG1) expression in flap tissue biopsy;\n2. Cross-sectional area of the recipient nerve fibres;\n3. Breast morphometry measured at baseline and follow-up;\n4. Intraepidermal nerve fibre density (IENFD) on skin biopsy.\n\nParticipants will be randomly assigned to receive either:\n\n1. Neurotized autologous breast reconstruction using fully autologous graft components, or\n2. Standard (non-neurotized) autologous breast reconstruction.\n\nThe study will compare these groups to determine whether neurotization accelerates or enhances the return of breast sensation over a 6-month follow-up period, with evaluations at 1 month, 3 months, and 6 months after surgery.\n\nParticipants will undergo:\n\n1. Autologous breast reconstruction with or without direct neurotization as part of their planned cancer surgery.\n2. Sensory testing using Semmes-Weinstein monofilaments at baseline, 1, 3, and 6 months.\n3. Completion of BREAST-Q questionnaires evaluating breast sensation, symptoms, and quality of life at each follow-up visit.\n\n3\\. Intraoperative tissue sampling for NRG1 analysis and nerve morphometry. 4. Skin biopsy (if applicable) to assess intraepidermal nerve fibre density. 5. Breast morphometry assessment using a breast morphometry measurement software tool.\n\nThis study seeks to provide high-quality evidence on the effectiveness of direct neurotization using fully autologous components in restoring breast sensation and to explore biological predictors that may influence sensory recovery after autologous breast reconstruction.",[60,61,62,63,30,64],"Breast Reconstruction After Mastectomy","Neurotization","Mastectomy and Breast Reconstruction","Peripheral Nerve Regeneration","Quality of Life (QOL)",[66,67,68,69],"breast neurotization","mastectomy","breast sensory","quality of life","2025-12-15",{"date":72,"type":38},"2025-12-29",{"date":70,"type":23},{"date":75,"type":23},"2027-04-15",{"name":77,"class":45},"Fakultas Kedokteran Universitas Indonesia",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":18,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":24,"phases":88,"briefSummary":89,"conditions":90,"keywords":97,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":46},"100602378","additional-effects-of-proprioceptive-neuromuscular-facilitation-with-otago-exercises-on-fall-risk-in-diabetes-mellitus-patients-100602378","NCT07122726","Additional Effects of Proprioceptive Neuromuscular Facilitation With Otago Exercises on Fall Risk in Diabetes Mellitus Patients","Inclusion Criteria:\n\n* Diabetes type 2 patients\n* 50-75 years of age\n* Both Males and Female Gender\n* Duration of diabetes more than 5 years\n* Participants positive for Michigan Neuropathy Screening Instrument\n* Patients having berg balance scale score \\>20\n\nExclusion Criteria:\n\n* Surgical procedure involving knee, ankle, or hip joints.\n* Foot Ulcers and Deformities.\n* Diagnosis of neurological diseases (CVA, MS, Parkinson disease etc.) besides DPN.\n* Absence of Visual Impairment and Hearing loss Patients having comprehension difficulties\n* Physical disability that prevents from performing the exercises","50 Years","75 Years",{"count":87,"type":23},30,[26],"Diabetes Mellitus is considered as one of the most prevalent issues among global population and 50% of all the diabetic patients particularly diabetes type II develop peripheral neuropathy. Diabetic Peripheral Neuropathy (DPN) affects feet and legs first, followed by the hands and arms.\n\nThis study will involve two groups, one performing the Otago Exercise Program, and the other performing a combined PNF and Otago exercise protocol. This study aims to assess the additional effects of Proprioceptive Neuromuscular Facilitation with Otago Exercise Program on Risk of fall which will be assessed by assessing balance, Fear of Fall and Sensory Function.\n\nKey outcome measures, including the Berg Balance Scale, Fall Efficacy Scale, Functional Reach test and Semmes Weinstein Monofilament Test will be used in evaluating the effectiveness of the exercise interventions. The participants would be screened through Michigan Neuropathy Screening Instrument and Berg Balance scale for inclusion criteria, and outcome measures will be assessed by using Berg Balance Scale, Fall efficacy scale, Functional Reach Test and Semmes Weinstein Monofilament testing method on the day of starting the intervention and on the last day of intervention. Intervention will be given for a total of 40-50 minutes per session, 3 sessions\u002Fweek for consecutive 6 weeks And than the data will be recorded at the end of 6 weeks again.",[91,92,93,94,30,95,96],"Postural Balance","Fall Risk","Diabetes (DM)","Fear of Falling","Diabetic Neuropathy Peripheral","Proprioceptive Neuromuscular Facilitation",[98,99,100,101,102,103,104,105],"Balance","Fall risk","Fear of fall","sensory function","Otago Exercises","Proprioceptive neuromuscular facilitation","Diabetic Peripheral Neuropathy","Diabetes Mellitus","RECRUITING","2025-08-07",{"date":109,"type":38},"2025-08-14",{"date":111,"type":38},"2024-09-13",{"date":113,"type":23},"2026-01-10",{"name":115,"class":45},"Foundation University Islamabad",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":84,"enrollmentInfo":124,"targetDuration":4,"studyType":24,"phases":126,"briefSummary":127,"conditions":128,"keywords":133,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":46},"100598223","effects-of-thumb-manipulation-on-hand-grip-strength-function-and-sensation-100598223","NCT07068698","Effects of Thumb Manipulation on Hand Grip Strength, Function, and Sensation","The Effects of Thumb Manipulation on Hand Grip Strength, Hand Function, and Sensory Parameters","THUMBFUN","Inclusion Criteria:\n\n* Aged between 18 and 50\n* Willing to participate in the study\n* Have signed the informed consent form\n* Able to use verbal and written communication skills\n\nExclusion Criteria:\n\n* Having contraindications that may prevent manipulation\n* Having a history of congenital or acquired orthopedic or neurological conditions affecting the upper extremity\n* Having a history of rheumatological diseases\n* Having a history of trauma or surgery affecting the upper extremity",{"count":125,"type":23},60,[26],"This randomized controlled study will aim to investigate the effects of thumb manipulation on hand grip strength, function, and sensation in healthy individuals. A total of 60 volunteers aged between 18 and 50 years will be recruited from Ortadağ Special Education and Rehabilitation Center. Participants will be randomly assigned to either a chiropractic manipulation group (n=30) or a control group (n=30), with an equal distribution of males and females in each group. The intervention group will receive thumb manipulation twice weekly for 4 weeks, while the control group will not receive any intervention. Outcome measures will include two-point discrimination (assessed with a discriminator), hand grip strength (measured using a dynamometer), pinch strength (evaluated with a pinch meter), and hand function (measured by the Duruöz Hand Index). Statistical analyses will be performed with a significance level set at p\\\u003C0.05. It is expected that participants in the manipulation group will show greater improvements in all measured parameters compared to the control group, suggesting a positive effect of thumb manipulation on hand-related sensorimotor functions in healthy individuals.",[129,130,131,132,30],"Thumb Manipulation","Hand Grip Strength","Hand Sensory Function","Hand Function in Healthy Individuals",[134,135,136,137,138],"Thumb manipulation","Chiropractic","Hand grip strength","Hand function","Healthy individuals","2025-07-07",{"date":141,"type":38},"2025-07-16",{"date":143,"type":23},"2025-07-06",{"date":145,"type":23},"2025-09-06",{"name":147,"class":45},"SEFA HAKTAN HATIK"]