[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"separation-anxiety-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:separation-anxiety-disorder":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,82,114,143],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100618288","an-examination-of-the-performance-of-qbmobile-in-differential-diagnosis-associated-with-adhd-symptoms-100618288",false,"NCT07329673","An Examination of the Performance of QbMobile in Differential Diagnosis Associated With ADHD Symptoms","An Examination of the Performance of QbMobile in Differential Diagnosis Associated With ADHD Symptoms.","Inclusion Criteria:\n\n* Provide written informed consent (including parent\u002Flegal guardians consent when this is required for individuals under 18 years old and assent as is required based on the age of participant) for QbMobile;\n* Aged \\> 6 years and \\\u003C 60 years old;\n* Referred for an initial assessment for ASD, MDD, Bipolar Disorder or Anxiety Disorder (Separation Anxiety Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder (GAD)) or has a prior diagnosis of one of the included disorders but is not currently receiving treatment;\n* Meets DSM-5 or ICD-11 criteria for a primary diagnosis of ASD, MDD, Bipolar Disorder or Anxiety Disorder per sites standard clinical procedures;\n* Have adequate sensory and physical ability to complete QbMobile;\n* Possess or have access to an iPhone model that supports QbMobile.\n\nExclusion Criteria:\n\n* Intellectual disability designated by IQ\\\u003C70;\n* Has a DSM-5 or ICD-11 diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, brief psychotic disorder, psychotic disorder due to another medical condition, PTSD, antisocial personality disorder, or borderline personality disorder;\n* Has a primary diagnosis of ADHD (combined, inattentive, or hyperactivity\u002Fimpulsive presentation);\n* Has a concurrent medical diagnosis that could significantly affect test performance such as brain injuries, Parkinson's disease, current epilepsy or active seizures, amyotrophic lateral sclerosis (ALS), multiple sclerosis, dementias (e.g. vascular dementia, Alzheimer disease, etc);\n* Has other conditions that could affect test performance (migraine or other types of severe headache, chronic or acute pain);\n* Use of prescription medications (e.g., anxiolytics, sedative medications) taken on the day before completing QbMobile that could significantly affect performance;\n* Substance use (e.g., alcohol, drugs) that may affect performance on the day of the tests.","ALL","6 Years","60 Years",{"count":20,"type":21},300,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to evaluate QbMobile's ability to collect objective data to identify specific symptom profiles in differential diagnoses (ASD, MDD, Bipolar Disorder and Anxiety Disorder) that are common with ADHD.",[25,26,27,28,29,30],"Bi-Polar Disorder","Autism Spectrum Disorder (ASD)","Major Depression Disorders","Separation Anxiety Disorder","Social Anxiety Disorder","Generalized Anxiety Disorder (GAD)","RECRUITING","2026-05-04",{"date":34,"type":35},"2026-05-06","ACTUAL",{"date":37,"type":35},"2026-01-01",{"date":39,"type":21},"2026-11",{"name":41,"class":42},"Qbtech AB","INDUSTRY",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":43},"100610481","stepped-care-treatment-for-anxiety-resilience-100610481","NCT07228143","Stepped Care Treatment for Anxiety Resilience","Stepped Care Cognitive Behavioral Therapy for Children and Adolescents With Anxiety","STAR","Inclusion Criteria:\n\n* A primary diagnosis of OCD or an anxiety disorder including separation anxiety disorder, social phobia, generalized anxiety disorder, specific phobia, agoraphobia, panic disorder, as determine by an IE using the DIAMOND-KID diagnostic interview.\n* Score of ≥ 14 on the PARS (items 2-7) which corresponds to clinically significant anxiety.\n* The child is 7-17 years old.\n* Residence in Texas and located in the state of Texas during treatment sessions.\n\nExclusion Criteria:\n\n* -Psychosis, cognitive disability, any condition that would limit the caregiver's ability to follow instructions.\n* Parent substance use disorder within the past 3 months, which could impact their ability to implement step 1\n* Child or parent is suicidal. A delayed entry once the parent or child is stabilized (\\>6 months post suicidality) and no longer has suicidal ideation will be allowed if appropriate.\n* New pharmacological interventions or treatment changes: Initiation of an antidepressant within 12 weeks before study enrollment or 6 weeks for an antipsychotic, benzodiazepine, or attention deficit hyperactivity disorder (ADHD) medication before enrollment, or any change in established psychotropic medication (e.g., antidepressants, anxiolytics) within 6 weeks before study enrollment (4 weeks for antipsychotic, anti-anxiety, benzodiazepine, or ADHD medication changes). Medications will remain stable during treatment.","7 Years","17 Years",{"count":55,"type":21},106,"INTERVENTIONAL",[58],"NA","Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD. Yet, many children do not receive care due to barriers such as limited provider availably, high treatment costs, and constrained family resources (e.g., time). To combat these barriers, other treatment methods have been developed.\n\nThe stepped care treatment models maximize resources by providing low-intensity, low-cost interventions as a first time treatment, while stepping up care for those needing more intensive treatment. Specifically, a stepped care model for CAD that begins with a parent-focus intervention has great promise to deliver efficacious and cost-effective treatment without having to engage the child.\n\nWhile stepped care approaches show promise in treating CAD with comparable efficacy to standard CBT, there remains a large research-to-practice gap. The stepped care model for CAD that begins with a parent-focused intervention has yet been explored, and very little is known about intervention mediators that explain mechanisms of change.\n\nThis research is being done to improve the reach and quality of services using a stepped care model, offering an affordable and practical solution to the widespread gap in youth mental health care.",[30,61,28,62,63,64],"Social Anxiety Disorder (SAD)","Specific Phobia","Obsessive Compulsive Disorder (OCD)","Panic Disorder (With or Without Agoraphobia)",[66,67,68,69,70,71],"Anxiety","Child","Adolescents","Obsessive compulsive disorder","stepped care","psychotherapy","2026-02-27",{"date":74,"type":35},"2026-03-02",{"date":76,"type":35},"2026-01-05",{"date":78,"type":21},"2028-04-30",{"name":80,"class":81},"Andrew Wiese","OTHER",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":89,"maxAge":53,"enrollmentInfo":90,"targetDuration":4,"studyType":56,"phases":92,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":43},"100588517","stepped-versus-stratified-care-for-anxiety-disorders-in-youth-100588517","NCT06942429","Stepped Versus Stratified Care for Anxiety Disorders in Youth","Stepped Versus Stratified Care for Anxiety Disorders in Youth: A Pragmatic Non-Inferiority Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged 8.0 to 17.5 years. Confirmed by the child and\u002For caregiver.\n2. Principal DSM-5-TR anxiety disorder of social anxiety disorder, generalized anxiety disorder, panic disorder, separation anxiety disorder, specific phobia, or agoraphobia. Confirmed by the structured diagnostic interview (DIAMOND-KID). \"Principal\" indicates that the anxiety disorder is judged by the clinician to be in most urgent need of treatment (among potential co-occurring disorders).\n3. Available caregiver who can support the child in treatment. Confirmed by the caregiver.\n4. Child and at least one caregiver can read, write, and communicate in Swedish. Confirmed by the child and\u002For caregiver.\n5. Child (≥13 years) and caregiver have access to a Swedish electronic identification (BankID or Freja eID).\n6. Access to the internet. Confirmed by the child and\u002For caregiver.\n7. Ability to attend in-person CBT sessions at the clinic. Confirmed by the child and\u002For caregiver.\n\nExclusion Criteria:\n\n1. Principal DSM-5-TR anxiety disorder of specific phobia concerning the domain of blood-injection-injury (due to the ICBT program not including relevant information on applied-tension techniques to avoid fainting during exposure exercises). Confirmed by a specific phobia of this sort being classified as the most functionally impairing anxiety disorder during the structured diagnostic interview (DIAMOND-KID).\n2. Ongoing psychological treatment for an anxiety disorder. Confirmed by the child and\u002For caregiver.\n3. Social\u002Ffamilial\u002Feducational difficulties in more immediate need of management than an anxiety disorder. Confirmed by the assessor through information from the child and\u002For caregiver and\u002For other available sources.\n4. Immediate risk to self or others that require urgent attention, such as suicidality. Confirmed by the assessor through information from the child and\u002For caregiver and other available sources.\n5. The potential participant has a relative (e.g., sibling, cousin) included in the study. Confirmed by the assessor through information from the caregiver and other available sources.","8 Years",{"count":91,"type":21},556,[58],"The goal of this clinical trial is to compare stepped care to stratified care as overall healthcare models for children and adolescents aged 8-17 with anxiety disorders. It addresses one main question:\n\n• Is stepped care non-inferior to stratified care in supporting participants to achieve a treatment response?\n\nResearchers will compare two care models:\n\n* Stepped care, where all participants begin with 14 weeks of internet-delivered cognitive behavioral therapy (ICBT) and receive an additional 14 weeks of personalized in-person CBT if needed.\n* Stratified care, where participants are assigned to either 14 weeks of ICBT or 14 weeks of in-person CBT based on clinical complexity, and may also receive additional 14 weeks of in-person CBT if necessary.\n\nParticipants will:\n\n* Be randomly assigned to one of the two care models.\n* Complete a wide range of assessments at baseline, during treatment, and at 4, 8, 12, and 24 months, with the 8-month point as the primary endpoint.\n* Receive either ICBT, in-person CBT, or both, depending on their care model and response to treatment.\n* Participate in ancillary studies involving DNA sampling, cognitive testing, and national registry linkages to help predict treatment response and long-term outcomes.",[29,28,62,95,96,97],"Panic Disorder","Generalized Anxiety Disorder","Agoraphobia",[99,100,101,102,103,104,70,105],"anxiety disorders","children","adolescents","cognitive behavioral therapy","non-inferiority","care models","stratified care","2026-02-24",{"date":72,"type":35},{"date":109,"type":35},"2025-06-19",{"date":111,"type":21},"2031-03-05",{"name":113,"class":81},"Region Skane",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":16,"minAge":89,"maxAge":53,"enrollmentInfo":121,"targetDuration":4,"studyType":56,"phases":123,"briefSummary":124,"conditions":125,"keywords":127,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":43},"100566921","internet-delivered-cognitive-behavioral-intervention-for-youths-with-anxiety-disorders-100566921","NCT06661460","Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders","Development and Preliminary Evaluation of a New Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders","Inclusion Criteria:\n\n1\\) 8 to \\\u003C18 years of age.\n\n* Confirmed by the child\u002Fcaregiver and subsequently by the medical record system. 2) A principal DSM-5-TR anxiety disorder of specific phobia, separation anxiety disorder, social anxiety disorder, generalized anxiety disorder, panic disorder or agoraphobia.\n* Confirmed by the Diagnostic Interview for Anxiety, Mood, and OCD and related Neuropsychiatric Disorders - Child and Adolescent Version (DIAMOND-KID).\n\n  3\\) Child and caregiver able to read, write and communicate in Swedish.\n* Confirmed by the child\u002Fcaregiver. 4) An available caregiver who can support the child in treatment.\n* Confirmed by the caregiver. 5) Access to a smartphone, tablet, or laptop\u002Fdesktop device, and the internet.\n* Confirmed by the child\u002Fcaregiver.\n\nExclusion Criteria:\n\n1\\) Principal DSM-5-TR anxiety disorder of specific phobia concerning the domain of blood-injection-injury (due to the ICBT program not including relevant information on applied-tension techniques to avoid fainting during exposure exercises).\n\n* Confirmed by a blood-injection-injury phobia being classified as the principal anxiety disorder as assessed by the DIAMOND-KID.\n\n  2\\) Established or suspected intellectual disability.\n* Confirmed by the caregiver (through previous diagnosis) and\u002For by attending a special needs school for learning difficulties.\n\n  3\\) Another mental disorder in more immediate need of management than an anxiety disorder (e.g., schizophrenia spectrum and other psychotic disorders, bipolar disorder, anorexia nervosa, substance use disorders).\n* According to the DIAMOND-KID and\u002For other available sources. 4) Social\u002Ffamilial\u002Feducational difficulties in more immediate need of management than an anxiety disorder.\n* Confirmed by the assessor through information from the child\u002Fcaregiver and\u002For other available sources.\n\n  5\\) Immediate risk to self or others that require urgent attention, such as acute suicidality.\n* Confirmed by the assessor through information from the child\u002Fcaregiver and other available sources.\n\n  6\\) Previous CBT for an anxiety disorder, defined as five or more sessions with a certified CBT therapist within the 12 months prior to assessment.\n* Confirmed by the child\u002Fcaregiver or the medical record system. 7) Ongoing psychological treatment for an anxiety disorder.\n* Confirmed by the child\u002Fcaregiver or the medical record system. 8) Initiation or adjustment of any psychotropic medication for anxiety (i.e., selective serotonin reuptake inhibitors, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitor or antipsychotics) within 8 weeks prior to assessment.\n* Confirmed by the child\u002Fcaregiver or the medical record system. 9) Participation in user involvement sessions in the present study.\n* Confirmed by the researcher.",{"count":122,"type":21},48,[58],"The goal of this study is to develop a new internet-delivered cognitive behavioral therapy (ICBT) intervention for youths with anxiety disorders based on the best current knowledge about effective cognitive behavioral therapy for the target group, refine the intervention in collaboration with patient and public representatives, and conduct a preliminary evaluation of the treatment effects in an open clinical trial.\n\nThe primary objective of the study is:\n\n1\\. To evaluate the preliminary efficacy of a newly developed ICBT intervention for children and adolescents with anxiety disorders in reducing anxiety severity, as measured by the Pediatric Anxiety Rating Scale (PARS).\n\nSecondary objectives of the study are:\n\n1. To examine the preliminary efficacy (PARS) of the ICBT intervention at 3 months post-treatment.\n2. To examine how youths with anxiety disorders, their caregivers, therapists, and healthcare leadership experience the ICBT intervention.\n3. To examine factors (e.g., age, type of anxiety disorder, presence of depressive symptoms, experiences of ICBT) that predict treatment outcome.\n4. To examine how the ICBT intervention can be improved (e.g., treatment content and technical delivery) for future use.\n\nParticipants will:\n\n* Undergo ICBT treatment for anxiety disorders during 12 weeks\n* Complete questionnaires at multiple time points throughout the study\n* Participate in follow-ups post-treatment and 3 months post-treatment\n* A selection of participants will also be invited to focus group interviews with the aim to generate ideas on how the intervention may be improved for future use",[126,62,29,28,96,95,97],"ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)",[128,129,68,130,131,132,133],"Anxiety disorders","Children","Cognitive Behavioral Therapy","Remote delivery","Internet","Internet-delivered cognitive behavioral therapy","2026-02-19",{"date":136,"type":35},"2026-02-20",{"date":138,"type":35},"2025-12-12",{"date":140,"type":21},"2027-06-01",{"name":142,"class":81},"Lund University",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":150,"targetDuration":4,"studyType":56,"phases":152,"briefSummary":153,"conditions":154,"keywords":159,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":43},"100594846","comparative-effectiveness-of-internet-based-versus-parent-coached-cognitive-behavioral-therapy-for-children-and-adolescents-with-anxiety-and-ocd-100594846","NCT07024758","Comparative Effectiveness of Internet-based Versus Parent-Coached Cognitive-Behavioral Therapy For Children and Adolescents With Anxiety and OCD","ASTRO","Inclusion Criteria:\n\n* The child is between the ages of 7 to 17 years inclusive at enrollment.\n* The child has clinically significant symptoms of anxiety and\u002For OCD, as indicated by a score of 12 or higher on the Pediatric Anxiety Rating Scale (PARS).\n* The child is appropriate for anxiety-focused treatment (e.g., anxiety or OCD is the primary or co-primary problem as diagnosed using the DIAMOND-KID).\n* One parent\u002Fguardian is able and willing to participate in assessment and treatment (e.g., has sufficient English fluency, the decisional capacity to participate, and can commit to treatment duration).\n* The participating parent\u002Fguardian lives with their child at least 50% of the time per self-report.\n* Both parent and child can read and understand English.\n* The participant has an IQ above 69, based on the KBIT-2, another valid test or clinician judgement (e.g., a previous assessment conducted, and report shared with study team).\n* Participants must be in the state of Texas for treatment sessions\u002Fassessments.\n\nExclusion Criteria:\n\n* The child has a diagnosis of a lifetime psychotic disorder and\u002For conduct disorder.\n* The child has significant, current and active suicidality\u002Fhomicidality and\u002For self-injury requiring medical intervention.\n* The child has limited verbal communication abilities (e.g., no independent verbal communication).\n* The child is receiving concurrent psychotherapy with anxiety and\u002For OCD as the primary focus. They can pause ongoing therapy to enroll.\n* The child has initiated new antidepressant medication within 12-weeks of assessment (4-weeks for stimulants\u002Fbenzodiazepines\u002Fantipsychotics) or during therapy.\n* The child has changed psychotropic medication dosage within 4-weeks of assessment (2-weeks for stimulants\u002Fbenzodiazepines\u002Fantipsychotics) or during therapy.\n* The child requires a higher level of care than can be provided through the study (e.g., significant, current suicidal ideation).",{"count":151,"type":21},174,[58],"Anxiety disorders in children and adolescents are common and confer significant disability. Cognitive behavioral therapy (CBT) is the recommended treatment for youth with anxiety, yet many families cannot access CBT due to cost, practicalities of attending in-person treatment sessions, and a shortage of trained providers, especially in rural areas. To combat these barriers, other treatment methods have been developed.\n\nPrevious research has shown that family-based, internet-delivered CBT (iCBT) for anxiety and OCD in youth has shown a significant reduction in anxiety symptoms. Parent-coached exposure therapy (PCET) focuses entirely on teaching parents and youth together how to address anxiety through the completion of in-session parent-coached exposures and assigning parent-coached exposure as homework in between sessions.\n\nAlthough both iCBT and PCET show positive results in treating pediatric anxiety in comparison to standard-care CBT, little is known about the comparative efficacy of iCBT and PCET.\n\nThis research is being done to understand the comparative effectiveness of two different types of cognitive-behavioral therapy (CBT) for treating anxiety or OCD in youth.",[63,155,156,30,28,95,157,64,158],"Anxiety Disorder of Childhood or Adolescence","Social Anxiety Disorder of Childhood","Panic Attacks","Phobia, Specific",[160,161,162,100,101],"Obsessive-compulsive disorder","anxiety","cognitive-behavioral therapy","2025-07-18",{"date":165,"type":35},"2025-07-20",{"date":167,"type":35},"2025-07-01",{"date":169,"type":21},"2028-06-30",{"name":171,"class":81},"Baylor College of Medicine"]