[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sepsis-at-intensive-care-unit\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sepsis-at-intensive-care-unit":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,79,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100627688","phase-2-adjunctive-fludrocortisone-in-septic-shock-100627688",false,"NCT07451886","Adjunctive Fludrocortisone in Septic Shock","Adjunctive Fludrocortisone in Septic Shock: a Multicenter, Double-blind, Randomized, Placebo-controlled Pilot Trial (AFLUDROS-1)","AFLUDROS-1","Inclusion Criteria:\n\n1. suspected or confirmed adult sepsis as defined by ≥ 2 increase in Sequential Organ Failure Assessment (SOFA) score due to infection\n2. ≥0.25 μg\u002Fkg\u002Fmin of noradrenaline infusion or vasoactive-inotropic score (VIS) ≥25 to maintain mean arterial pressure (MAP) ≥65 mmHg for at least 1 hour\n3. onset of septic shock within 24 hours\n4. shock due to infection with no other proven or apparent cause\n5. hypoperfusion defined as arterial or venous lactate concentration \\>2.0 mmol\u002FL\n6. mechanical ventilation\n\nExclusion Criteria:\n\n1. fludrocortisone cannot be administered within 24 hours of onset of septic shock\n2. death is deemed imminent or inevitable by treating clinicians\n3. limitation of therapy\n4. an underlying disease process with a life expectancy of less than 90 days\n5. pregnancy (confirmed or suspected)\n6. receiving immunomodulatory agents including hydrocortisone \\> 300mg\u002Fday\n7. enteral medication cannot be administered\n8. prescribed fludrocortisone for other medical condition\n9. contraindication to hydrocortisone or fludrocortisone","ALL","18 Years",{"count":20,"type":21},32,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Sepsis is a life-threatening condition caused by the body's dysregulated response to an infection. While corticosteroids are known to help stabilize blood pressure in septic shock, their ability to reduce mortality is still debated. Recent analyses suggest that combining fludrocortisone with hydrocortisone may be more effective at saving lives than hydrocortisone alone.\n\nTo test this hypothesis, a large, definitive international trial is needed. However, this research proposal is for a smaller pilot study (Phase II) involving 32 critically ill patients. The primary goal of this pilot is to determine the feasibility of conducting the subsequent large-scale trial that would compare hydrocortisone alone against the combination therapy and potentially change medical practice.",[27,28,29,30,31],"Sepsis","Septic Shock","Sepsis - to Reduce Mortality in the Intensive Care Unit","Sepsis and Septic Shock","Sepsis at Intensive Care Unit",[33,34,27,35,36,37],"Fludrocortisone","Septic shock","hydrocortisone","intensive care unit","pilot","RECRUITING","2026-06-01",{"date":41,"type":42},"2026-06-02","ACTUAL",{"date":44,"type":42},"2026-04-01",{"date":46,"type":21},"2028-07-31",{"name":48,"class":49},"Chinese University of Hong Kong","OTHER",5,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100624858","written-sepsis-education-for-patients-100624858","NCT07415096","Written Sepsis Education for Patients","Setting Up For Success: A Pilot Feasibility Randomized Controlled Trial of Written Education for Sepsis Survivors","Inclusion Criteria:\n\n* Confirmed diagnosis of sepsis based on the sepsis-3 definition (infection + Sequential Organ Failure Assessment \\[SOFA\\] increase \\>2)\n* Admitted to an ICU\n* At least 18 years old at study commencement\n\nExclusion Criteria:\n\n* Unable to read basic English\n* Despite available accommodations, they lack the cognitive, mental, or physical capacity to complete study assessments by ICU discharge\n* Readmitted to ICU during their index hospital stay\n* Hospital length of stay surpasses 30 days.",{"count":59,"type":21},30,[61],"NA","This pilot feasibility randomized controlled trial (RCT) aims to determine if it feasible to recruit, deliver, and evaluate a written discharge educational material (a brochure) to adult Intensive Care Unit (ICU) patients diagnosed with sepsis.\n\nThe main questions it aims to answer are:\n\n1. Feasibility to identify and enroll \\>80% of eligible participants\n2. Feasibility to recruit 30 participants over a 6-month period\n3. Fidelity of intervention, assessed as \\>75% of participants receiving assigned intervention Researchers will assess the feasibility of comparing two groups: (1) Control - usual ICU discharge care, and (2) Intervention - usual ICU discharge care plus the receipt of an educational sepsis brochure and an explicit opportunity to ask questions about sepsis, answered by a trained intensive care unit (ICU) Registered Nurse.\n\nParticipants will receive intervention or control just prior to their discharge from ICU. They will complete online or phone survey assessments 24-48 hours post ICU discharge and 15-days post hospital discharge. Mortality and readmission data will additionally be assessed at 30-days post-discharge.",[27,30,31],[27,65,66,67,68],"Post-Sepsis Syndrome","Patient Education","Sepsis Rehabilitation","Care Transitions","NOT_YET_RECRUITING","2026-03-01",{"date":72,"type":42},"2026-03-03",{"date":74,"type":21},"2026-02",{"date":76,"type":21},"2026-09",{"name":78,"class":49},"McMaster University",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100624216","hemodynamic-venous-congestion-ultrasound-vexus-by-icu-nurses-in-sepsis-patients-100624216","NCT07406750","Hemodynamic Venous Congestion Ultrasound (VExUS) by ICU Nurses in Sepsis Patients.","Hemodynamic Diagnostic Ultrasound of Venous Congestion (VExUS) Performed by Intensive Care Nurses on Patients With Sepsis.","VEXIVAN","Inclusion Criteria:\n\nIntensive Care Nurses a) Intensive care nurse, specialist degree in intensive care. b) ≥1,5 years of experience in intensive care. c) ≥75% clinical employment rate at the ICU. d) Continued employment until 2026 at the ICU at Örebro University Hospital. e) Written informed consent Intensive Care Patients\n\n1. Patients with suspected or verified sepsis according to the Sepsis 3 criteria (suspected or confirmed infection), ≥qSOFA (systolic blood pressure \\\u003C 90 mmHg, GCS ≤ 13, respiratory rate ≥ 22 per minute) or rise in SOFA score ≥ 2 points and admitted to the ICU.\n2. ≥18 years of age.\n\nExclusion Criteria:\n\nIntensive Care Nurses\n\na) Personnel with primarily an administration position or less clinical duty at the ICU.\n\nIntensive Care Patients\n\n1. Patients with preexisting liver cirrhosis.\n2. Pregnancy.",true,{"count":89,"type":21},46,"OBSERVATIONAL","Sepsis is a serious condition where the body's immune response to infection overreacts, leading to organ damage and death. Venous congestion, a buildup of blood in the veins, can occur in sepsis and contribute to organ injury. VExUS (Venous Excess Ultrasound Score) is an ultrasound method that can detect congestion early. This study examines whether ICU nurses, after training, can perform VExUS reliably, explores their experiences, and investigates links between VExUS findings and clinical outcomes.",[27,30,31,93],"Intensive Care Nurses",[95,96,97,98,99,100],"sepsis","intensive care","ultrasound","venous congestion","VExUS","intensive care nurse","2026-02-13",{"date":103,"type":42},"2026-02-18",{"date":44,"type":21},{"date":106,"type":21},"2027-05-31",{"name":108,"class":49},"Region Örebro County",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":87,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":116,"targetDuration":118,"studyType":90,"phases":4,"briefSummary":119,"conditions":120,"keywords":126,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":141},"100578328","role-of-transposable-elements-in-septic-immune-aging-100578328","NCT06809868","Role of Transposable Elements in Septic Immune Aging","SITE","Inclusion Criteria:\n\n* Age 18 or older\n* Admitted to ICU with sepsis (Sepsis 3 Criteria)\n* SOFA score of at least 2 at time of enrollment\n\nExclusion Criteria:\n\n* Patients on organ transplantation immunosuppression\n* Patients with preexisting leukopenia\n* Cancer patients receiving CAR-T therapy\n* Patients who are under 18 years of age or otherwise deemed pediatric\n* Patients with an ongoing bleeding diathesis (ie: DIC, hemorrhagic shock)\n* Patients with a chronic hemoglobin below 7.0\n* Patients who, prior to their ICU admission, are blood transfusion dependent",{"count":117,"type":21},116,"6 Weeks","The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is:\n\n1. Do transposable elements prematurely age the immune systems of patients with sepsis?\n2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU?\n3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU?\n\nParticipants will have blood drawn from them but will not be subjected to additional interventions.",[27,30,121,122,123,31,124,125],"Sepsis With Multiple Organ Dysfunction (MOD)","Sepsis With Acute Organ Dysfunction","Sepsis, Severe","Sepsis, Severe Sepsis and Septic Shock","Sepsis, Septic Shock",[27,127,128,129,130,131],"Transposable Elements","Immune Aging","Mortality","Secondary Infections","Critical Care Medicine (ICU)","2026-01-28",{"date":134,"type":42},"2026-01-30",{"date":136,"type":42},"2025-02-14",{"date":138,"type":21},"2028-08-14",{"name":140,"class":49},"University of California, San Francisco",1]