[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sepsis-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sepsis-syndrome":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,65],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100378163","sepsis-from-syndrome-to-personalized-care-100378163",false,"NCT04203979","Sepsis: From Syndrome to Personalized Care","Inclusion Criteria:\n\n* admitted to emergency department OUH, Ullevål.\n* managed by the medical rapid response team or the sepsis rapid response team\n\nExclusion Criteria:\n\n* Not given informed consent by patient or next of kin (if patient is not able to)","ALL","18 Years",{"count":18,"type":19},1950,"ESTIMATED","1 Year","OBSERVATIONAL","This is a prospective, observational study designed to examine the performance of biomarkers, molecular biological methods and other analysis in blood from patient with suspected sepsis in the Emergency department, as well as identidying novel sepsis endotypes. Around 1500 patients will be enrolled.",[24,25,26,27],"Sepsis Syndrome","Sepsis","Sepsis, Severe","Septic Shock","RECRUITING","2026-03-17",{"date":31,"type":32},"2026-03-19","ACTUAL",{"date":34,"type":32},"2020-01-06",{"date":36,"type":19},"2027-09-30",{"name":38,"class":39},"Oslo University Hospital","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":40},"100550428","identification-of-markers-of-poor-clinical-prognosis-in-sepsis-by-epigenetic-analysis-100550428","NCT06446947","Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis","Identification de Marqueurs de Mauvais Pronostic Clinique du Sepsis Par Analyse épigénétique.","EPISEPSIS","Inclusion Criteria:\n\n* Male patients,\n* Patients between 45 and 75 years of age,\n* Patients undergoing major esophageal or digestive carcinological surgery,\n* Patients with post-operative gram-negative bacterial sepsis (proven or suspected in the context of organ failure).\n\nExclusion Criteria:\n\n* patients under 45 and aged 76 and over,\n* female patients,\n* non-carcinological or minor surgery,\n* non-esophageal or non-digestive surgery,\n* Gram-positive bacterial or fungal infections in the absence of associated BGN,\n* patients with hematological cancer,\n* immunocompromised patients,\n* septic surgery (surgical site infection),\n* patients expressing opposition to data collection and analysis (clinical and\u002For biological) within the regulatory framework of the study,\n* patients under guardianship or curatorship,\n* patients not affiliated to a social security system or equivalent in France,\n* patients deprived of their liberty.","MALE","45 Years","75 Years",{"count":53,"type":19},25,"Sepsis is a multifactorial syndrome characterized by a dynamic course and a clinical outcome dependent on several factors, and responsible for one in five deaths worldwide. The aim of this trial is to identify new prognostic markers for the progression of sepsis to septic shock, by comparing epigenetic markers between patients who have or have not developed severe forms of sepsis.\n\nThe main objective of this preliminary study is to identify prognostic markers for the progression of sepsis to septic shock, i.e. to compare targeted markers between subjects with sepsis who progress to septic shock versus subjects with sepsis who do not progress to septic shock.",[24,27,25],"2026-02-10",{"date":58,"type":32},"2026-02-12",{"date":60,"type":32},"2025-03-20",{"date":62,"type":19},"2026-09-30",{"name":64,"class":39},"Assistance Publique Hopitaux De Marseille",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":74,"conditions":75,"keywords":82,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":40},"100459360","analysis-of-the-evolution-of-mortality-in-an-intensive-care-unit-100459360","NCT05261607","Analysis of the Evolution of Mortality in an Intensive Care Unit","Epidemiological Analysis of the Evolution of the Case-mix and Mortality in the Intensive Care Unit of Hospital Universitario De Getafe (1991-2026)","Inclusion Criteria:\n\n• Patients admitted to intensive care unit\n\nExclusion Criteria:\n\n• None",{"count":73,"type":19},25000,"The intensive care units is of the main components of modern healthcare systems. Formally, its aim is to offer the critically ill health care fit to their needs; ensuring that this health care is appropriate, sustainable, ethical and respectful of their autonomy. Intensive medicine is a cross-sectional specialty that encompasses a broad spectrum of pathologies in their most severe condition, and specifically has as its foundation the practice of comprehensive care of the patient with organ dysfunction and susceptible to recovery. Although critically ill patients are a heterogeneous population, they have in common the need for a high level of care, often requiring the use of high technology, specific procedures for the support of organ dysfunction and the collaboration of other medical and surgical specialties for their management and treatment.\n\nSince their origins in the late 1950s, intensive care units have been adapting to the changes arising from the best scientific evidence. In the late 1990s and early 2000s, there were some successful clinical trials published that had tested alternative management strategies in the ICU.\n\nMechanical ventilation is an intervention that defines the critical care specialty. Between 1970 and the 1990s, the management focused on normalizing arterial blood gas with aggressive mechanical ventilation. Over the ensuing decades, it became apparent that performing positive pressure ventilation worsened lung injury. The pivotal moment in the mechanical ventilation story would be the low versus high tidal volume trial. This trial shifted the focus away from normalizing gas exchange to reducing harm with mechanical ventilation. Further, it paved way for further trials testing ventilation interventions (PEEP strategy, prone position ventilation) and nonventilation interventions (neuromuscular blockade, corticosteroids, inhaled nitric oxide, extracorporeal gas exchange) in critically ill patients.\n\nThat evidence-based intensive care medicine has undoubtedly had an influence on the outcome of critically ill patients, in general, and, particularly, of patients requiring mechanical ventilation. Temporal changes in mortality over the time have been scarcely reported for patients admitted to intensive care unit.\n\nObjective of this study is to estimate the changes over the time in several outcomes in the patients admitted to an 18-beds medical-surgical intensive care unit from 1991 (year of start of activity) to 2026",[76,77,78,79,24,80,81],"Intensive Care Unit","Mortality","Epidemiology","Respiration, Artificial","Respiratory Failure","Neurologic Disorder",[83,84,77],"Intensive care units","Outcome","2025-03-11",{"date":87,"type":32},"2025-03-13",{"date":89,"type":32},"1991-07-01",{"date":91,"type":19},"2026-10-31",{"name":93,"class":39},"Hospital Universitario Getafe"]