[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"serious-mental-illness-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:serious-mental-illness-symptoms":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100585351","mindfulness-based-neurofeedback-to-reduce-negative-thinking-in-charms-adolescents-100585351",false,"NCT06901232","Mindfulness-based Neurofeedback to Reduce Negative Thinking in CHARMS Adolescents","Effect of Network-based Real Time Neurofeedback Augmentation of Mindfulness Practice on Recurrent Negative Thinking in Adolescents at Risk for Serious Mental Illness","CHARMS","Inclusion Criteria:\n\n* Ages 14-21, inclusive\n* Recurrent negative thinking, defined as PTQ-C (\\\u003C18 years) or PTQ (18 years or older) total score \\>30 and at least two questions scored 3 or 4.\n* Able to understand study procedures, read, and write in English\n* If age is 18 years or older: Competent and willing to provide written informed consent\n* If age is less than 18 years: Competent and willing to provide written informed assent AND have a parent\u002Flegal guardian who is competent and willing to provide written informed consent\n* Access to a mobile device to complete daily survey assessments\n\nExclusion Criteria:\n\n* Any of the following lifetime mental health disorders by DSM-V criteria: psychotic disorders, anxiety disorder, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or eating disorder\n* Substance use disorder, moderate or severe in past six months.\n* Unstable medical or neurologic condition, epilepsy or seizure disorder, head injury, loss of consciousness \\>5 minutes\n* MRI contraindications (i.e. presence of ferromagnetic implants, cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, magnetic dental implants claustrophobia).\n* Visual, auditory, or cognitive impairment (IQ\\\u003C80 based on the Wechsler Abbreviated Intelligence Scale (WASI)) that may make it difficult to participate.\n* Any condition or situation that would, in the investigator's opinion, make it unlikely that the participant could adhere safely to the study protocol.\n* Pregnancy; a negative pregnancy test is required at enrollment\n* Individuals who are under the legal protection of the government or state (Wards of the State)\n* Inability to speak, read, or write English fluently","ALL","14 Years","21 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","The study will test the hypothesis that mindfulness-based neurofeedback (mbNF) will improve repetitive negative thinking and social and role functioning over sham neurofeedback in adolescents at risk for serious mental illness. To do so, 90 adolescents ages 14-21 with elevated repetitive negative thinking will be enrolled into a double-blind randomized clinical trial of sessions of mindfulness training with either active mindfulness-based neurofeedback or sham neurofeedback and three months of mindfulness practice and follow up.",[28,29],"Repetitive Negative Thinking","Serious Mental Illness Symptoms",[31,32,33],"Mindfulness","Repetitive negative thinking","Serious mental illness symptoms","NOT_YET_RECRUITING","2026-02-10",{"date":37,"type":38},"2026-02-12","ACTUAL",{"date":40,"type":22},"2027-09",{"date":42,"type":22},"2029-04",{"name":44,"class":45},"Massachusetts General Hospital","OTHER"]