[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"seroma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:seroma":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,51,80,101,131,157],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100642717","prophylactic-use-of-cinpwt-in-gynecologic-laparotomy-100642717",false,"NCT07645547","Prophylactic Use of ciNPWT in Gynecologic Laparotomy","Implementation of Prophylactic Negative Pressure Wound Therapy (ciNPWT) in High-Risk Patients in Gynecologic Oncology: A Prospective Feasibility Study and Nested Qualitative Analysis","Inclusion Criteria:\n\n* Adult female patients scheduled for planned abdominal surgery for gynecologic or gynecologic-oncologic indications.\n\nIdentification as \"high-risk\" for wound healing complications based on a clinical risk screening at admission.\n\nSigned informed consent.\n\nExclusion Criteria:\n\n* Failure to provide informed consent.","FEMALE","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a prospective, open-label, non-randomized interventional feasibility study with a nested qualitative analysis. The study exploratively verifies the feasibility of targeted prophylactic closed incision negative pressure wound therapy (ciNPWT) in clinical practice for patients with a high predicted risk of wound healing complications and compares the 30-day incidence of postoperative complications with standard dressing.\n\nParticipants will:\n\n* Get ciNPWT or standard dressing after planned laparotomy\n* Answer the questionairs about qualite of life\n* Will visit the clinic 30 days after surgery to see the final result",[26,27,28,29,30],"Surgical Site Infection (SSI)","Wound Healing Complication","Seroma","Hematoma","Dehiscence",[32,33,34,35,36,37,38],"ciNPWT","laparotomy","surgical site infection","SSI","feasibility","PROMs","ASEPSIS","NOT_YET_RECRUITING","2026-06-11",{"date":42,"type":43},"2026-06-12","ACTUAL",{"date":45,"type":20},"2026-07",{"date":47,"type":20},"2028-12",{"name":49,"class":50},"University Hospital Hradec Kralove","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":58,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100631233","phase-2-doxycycline-use-in-post-operative-seromas-100631233","NCT07498010","Doxycycline Use in Post-Operative Seromas","The Role of Doxycycline in the Management of Postoperative Seromas: A Pilot Study","Inclusion Criteria:\n\n* Patient with seroma formation following orthopedic procedure\n* \\>18 years old\n* Willing and able to provide informed consent\n* Pre-operative imaging (US, CT) demonstrating seroma formation\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Age \\\u003C18 years\n* Known allergy to tetracyclines\n* Significant hepatic or renal dysfunction (Alanine Aminotransferase (ALT)\u002FAspartate Aminotransferase (AST) \\>3× Upper Limit of Normal (ULN), Creatinine Clearance (CrCl \\\u003C30 mL\u002Fmin)\n* History of photosensitivity or photodermatosis\n* Concurrent isotretinoin or retinoid therapy\n* Current use of anticoagulants or immunosuppressants\n* Active GI ulceration or esophageal disease\n* Any condition likely to impair adherence or drug absorption (e.g., malabsorption syndromes)","ALL",{"count":60,"type":20},10,[62],"PHASE2","Seromas are collections of serous fluid that can develop following surgical procedures and may persist as fibrous-lined pseudocysts if not adequately treated. In orthopedic surgery, particularly after arthroplasty, seromas can impair wound healing, increase pain, and limit postoperative rehabilitation, potentially compromising patient recovery. Current treatment strategies including compression, percutaneous aspiration, and repeat surgical intervention have variable success, and aspiration carries the risk of introducing bacteria into an otherwise sterile fluid collection. Sclerotherapy has been proposed as an alternative strategy to induce fibrosis within the cavity and eliminate the potential space. Doxycycline, a tetracycline antibiotic commonly used for pleurodesis, has demonstrated sclerosing properties through mechanisms including mesothelial cell destruction, inhibition of fibrinolysis, and stimulation of fibroblast activity. While doxycycline sclerotherapy has shown success in treating conditions such as Morel-Lavallée lesions and has been described in isolated orthopedic case reports, its role in managing postoperative seromas after arthroplasty remains poorly studied. Further investigation is needed to determine whether doxycycline injection may serve as a safe and effective treatment to reduce persistent seromas and the need for additional interventions in orthopedic patients.",[28],[66,67,68,69,70],"seroma","doxycycline","post operative complications","sclerotherapy","fibrosis induction","2026-05-11",{"date":73,"type":43},"2026-05-12",{"date":45,"type":20},{"date":76,"type":20},"2027-10-01",{"name":78,"class":50},"University of Miami",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":58,"minAge":17,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":4,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":99,"locationsCount":79},"100597614","management-of-seroma-after-posterior-lumbar-spine-decompression-100597614","NCT07060781","Management of Seroma After Posterior Lumbar Spine Decompression","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* Patients undergoing elective posterior lumbar spine decompression.\n\nExclusion Criteria:\n\n* History of previous lumbar spine surgery.\n* Active spinal infection, trauma, or malignancy.\n* Severe medical comorbidities that contraindicate surgery or influence wound healing (e.g., uncontrolled diabetes, immunosuppression, severe cardiovascular disease).\n* Patients unfit for general anesthesia.",{"count":87,"type":20},50,"OBSERVATIONAL","The aim of this study is to evaluate the clinical presentation and management strategies of seroma formation following posterior lumbar spine decompression.",[28,91],"Lumbar Spine Decompression","RECRUITING","2025-07-19",{"date":95,"type":43},"2025-07-22",{"date":93,"type":43},{"date":98,"type":20},"2025-12-30",{"name":100,"class":50},"Kafrelsheikh University",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":58,"minAge":17,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":111,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":79},"100515275","phase-2-outcomes-of-high-volume-saline-irrigation-vs-povidone-iodine-solution-cleaning-of-iowi-in-preventing-ssis-in-emergency-laparotomies-100515275","NCT05989386","Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies","Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of Intraoperative Incision Wound in Preventing Surgical Site Infections in Emergency Laparotomies: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • Patients undergoing emergency laparotomy under the care of surgical-6 unit of Dr. Ruth K. M. Pfau Civil Hospital Karachi\n\n  * The age of patients should be between 18-60 years old.\n\nExclusion Criteria:\n\n* Diabetic patients\n* Immune-suppressed patients\n* Patients taking steroids\n* Patients undergoing chemo-radiotherapy.\n* Pregnant females\n* Previous abdominal surgery within the last 30 days.\n* Presence of concurrent abdominal wall infections.\n* Trauma Laparotomies\n* Large Bowel perforations","60 Years",{"count":110,"type":20},200,[62,112],"PHASE3","The goal of this clinical trial is to compare the outcomes of High-volume saline irrigation vs Povidone-iodine solution cleaning of the intraoperative incision wound in preventing superficial surgical site infections in patients undergoing emergency laparotomies. The main question it aims to answer are:\n\n* Incidence of SSI after intervention\n* Length of hospital stay\n\nParticipants will be randomly assigned to two groups receiving either of the two groups:\n\nGroup A: 1000ml of IOWI with saline solution prior to incision closure Group B: The incisional wound will be closed conventionally without irrigation.\n\nResearchers will compare groups A( experimental group) and B (control group) to compare the incidence of superficial surgical site infections after intervention.",[115,116,117,118,119,120,121,28],"Surgical Site Infection","Surgical Wound","Surgical Incision","Emergency Laparotomies","Laparotomies","Post Operative Wound Infection","Wound Infection","2025-06-14",{"date":124,"type":43},"2025-06-18",{"date":126,"type":43},"2023-04-29",{"date":128,"type":20},"2025-12-29",{"name":130,"class":50},"Dow University of Health Sciences",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":139,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":21,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":79},"100508359","seroma-of-the-mammary-gland-100508359","NCT05899387","Seroma of the Mammary Gland","Prospective, International, Multicenter Minimal Interventional Study to Detect Possible Markers for Prediction of Seroma Development and Risk Assessment of a Breast Seroma After Mastectomy with or Without Implant-based Breast Reconstruction","SerMa","Inclusion criteria study group and control group 1:\n\n* Written informed consent\n* Age ≥ 18 years\n* all stages of DCIS or primary breast cancer (T1-T4, N0 or N+, M0) including all histopathological subtypes (ER\u002FPR positive, ER positive\u002FPR negative, Her-2\u002Fneu positive and triple negative)\n* Surgical procedure planned including ablatio or subcutaneous mastectomy with implant or expander insertion\n\nInclusion criteria control group 2 and 3:\n\n* Written informed consent\n* Age ≥ 18 years\n* Surgical procedure planned with implant or expander insertion with or without subcutaneous mastectomy\n\nExclusion criteria:\n\n* Age \\\u003C18 years\n* Male sex\n* Breast cancer patients planned for breast conserving therapy\n* Recurrent breast cancer disease\n* History of breast surgery\n* Diagnosis of LCIS only\n* Pregnancy at time of diagnosis\n* Patients with a known immunodeficiency",true,{"count":141,"type":20},2000,[23],"The study is designed as international, prospective, minimal interventional study in cooperation with EUBREAST e.V. (European Breast Cancer Research Association of Surgical Trialists). Furthermore, it is planned to initiate a registry for postoperative breast seromas.",[28,145,146,147],"Breast Cancer","Mastectomy","Breast Implant; Complications","2025-02-25",{"date":150,"type":43},"2025-02-28",{"date":152,"type":43},"2024-04-01",{"date":154,"type":20},"2027-07-01",{"name":156,"class":50},"University Hospital Augsburg",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":21,"phases":166,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":79},"100511585","fixation-of-skin-flaps-after-mastectomy-using-running-or-interrupted-sutures-for-combatting-seroma-100511585","NCT05941351","fixAtion of skiN Flaps After Mastectomy Using ruNning or Interrupted suturEs for Combatting Seroma","ANNIE","Inclusion Criteria:\n\n* Female sex.\n* 18 years or older.\n* Indication for mastectomy.\n\nExclusion Criteria:\n\n* Patients undergoing breast conserving therapy\n* Patients undergoing direct breast reconstruction\n* Patients undergoing modified radical mastectomy\n* Unable to comprehend implications and extent of study and sign for informed consent",{"count":165,"type":20},361,[23],"Rationale: Flap fixation significantly reduces the incidence of seroma formation after mastectomy. Therefore, research should focus on finding the most optimal way to secure the skin flaps to the pectoral muscle. Previous studies have compared running sutures, interrupted sutures and tissue glue application to conventional wound closure. A recent systematic review with network meta-analysis indicated running sutures as the most optimal technique, however direct comparisons and high quality articles were lacking.\n\nObjective: This prospective trial aims to directly compare running sutures with interrupted sutures in order to prevent complications in patients undergoing a mastectomy.\n\nStudy design: This trial will combine a retrospective cohort from the previous SARA-trial in Zuyderland MC with a randomised prospective trial. This study design was chosen to acquire a sample size with sufficient power and the ability to conduct this study in an acceptable time frame.\n\nStudy population: A retrospective cohort of patients participating in the SARA trial (RCT) and a prospective cohort of patients undergoing a mastectomy for breast cancer.\n\nIntervention: Group 1: Flap fixation after mastectomy with running sutures. Group 2: Flap fixation after mastectomy with interrupted sutures.\n\nMain study parameters\u002Fendpoints: The primary endpoint is the incidence of complications requiring interventions in both groups, including clinically significant seroma, infections and bleeding complications. Secondarily, the length of the procedure and cosmetic results will be compared.\n\nNature and extent of the burden and risks associated with participation, benefit and group relatedness: When participating, patients will undergo 3 additional outpatient clinic visits. Study visits will be combined with regular visits where possible, including the first postoperative visit after 7-10 days and either the 6 week or 3 month visit.",[28],"2023-07-03",{"date":171,"type":43},"2023-07-12",{"date":173,"type":20},"2025-01-01",{"date":175,"type":20},"2027-03-01",{"name":177,"class":50},"Zuyderland Medisch Centrum"]