[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"serratus-anterior-plane-block\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:serratus-anterior-plane-block":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100641523","timing-of-serratus-anterior-plane-block-in-mastectomy-surgery-100641523",false,"NCT07661212","Timing of Serratus Anterior Plane Block in Mastectomy Surgery","The Effect of Serratus Anterior Plane Block Timing on Postoperative Quality of Recovery, Postoperative Pain, and Inflammatory Response in Elective Unilateral Mastectomy Surgery: A Prospective Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Female patients aged 18 years or older\n* Scheduled for elective unilateral mastectomy surgery\n* Planned to undergo surgery under general anesthesia\n* American Society of Anesthesiologists physical status I-III\n* Willing and able to participate in the study\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Known allergy to local anesthetics planned for use in the study\n* Chronic opioid use\n* Current steroid or immunosuppressive therapy\n* Presence of chronic inflammatory disease\n* Surgical duration shorter than 30 minutes\n* Active infection\n* Coagulopathy\n* Infection at the planned block site\n* Pregnancy or lactation\n* Advanced hepatic failure or advanced renal failure\n* Reoperation due to recurrent disease\n* Inability to communicate adequately or to provide reliable pain scores\n* Psychiatric or neurological condition limiting reliable completion of the QoR-15 questionnaire or Numeric Rating Scale assessments","FEMALE","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","Postoperative pain following mastectomy may adversely affect early mobilization, patient comfort, and overall quality of recovery. Serratus anterior plane block is an ultrasound-guided regional anesthesia technique that provides analgesia to the anterolateral thoracic wall and is increasingly used as part of multimodal analgesia for breast surgery. Although the analgesic efficacy of serratus anterior plane block has been investigated in breast surgery, the clinical impact of the timing of block administration remains insufficiently defined.\n\nThis prospective, randomized, controlled, patient and assessor blinded clinical trial will compare two different timings of ultrasound-guided serratus anterior plane block in adult female patients undergoing elective unilateral mastectomy under general anesthesia. Participants will be randomized to receive serratus anterior plane block either after induction of general anesthesia and before surgical incision, or after completion of surgery and before extubation. In both groups, the block will be performed under ultrasound guidance using 25 mL of 0.25% bupivacaine.\n\nThe primary outcome is postoperative quality of recovery at 24 hours, assessed using the Quality of Recovery-15 questionnaire. Secondary outcomes include postoperative pain scores at predefined time points during the first 24 postoperative hours, intraoperative remifentanil consumption, postoperative opioid and non-opioid analgesic requirements, time to first analgesic requirement, postoperative nausea and vomiting, length of hospital stay, complications, inflammatory response markers including CRP and neutrophil-to-lymphocyte ratio, and intraoperative hemodynamic variables.\n\nThe study is planned to enroll 80 participants at a single tertiary training and research hospital. The findings are expected to clarify whether preincisional administration of serratus anterior plane block provides superior postoperative recovery, analgesic efficacy, and modulation of inflammatory response compared with administration at the end of surgery.",[26,27,28,29],"Quality of Recovery After Mastectomy","Serratus Anterior Plane Block","Postoperative Pain","Mastectomy",[27,28,29,31,32,33,34,35,36,37,38],"Regional Anesthesia","Pain Management","Bupivacaine","Quality of Recovery","CRP","Neutrophil-Lymphocyte Ratio","Inflammation","Breast Surgery","NOT_YET_RECRUITING","2026-06-18",{"date":42,"type":43},"2026-06-22","ACTUAL",{"date":45,"type":20},"2026-09-01",{"date":47,"type":20},"2027-10-01",{"name":49,"class":50},"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","OTHER_GOV",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":59,"minAge":17,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":51},"100595462","assessment-of-morbidity-and-mortality-following-serratus-anterior-plane-block-sapb-for-unilateral-rib-fractures-100595462","NCT07032766","Assessment of Morbidity and Mortality Following Serratus Anterior Plane Block (SAPB) for Unilateral Rib Fractures","SAPB","Inclusion Criteria:\n\n* Patients over 18 years of age being treated in the Emergency Department at Jacobi Medical Center\n* Presenting within 24 hours of injury\n* Patient with 2 or more unilateral, anterior or lateral rib fractures\n* Able to provide consent (patient or health care proxy)\n* Clinical team believes the patient will require inpatient admission at the time of enrollment\n\nExclusion Criteria:\n\n* Patients in traumatic arrest or hemodynamic instability\n* Patient expected to be discharged from the hospital within 24 hours\n* Prisoner\n* Pregnancy\n* Children less than 18 years of age\n* The patient is known or is suspected to be allergic to anesthetic\n* Significant pain from another traumatic and distracting injury\n* Patients without the ability to consent (or no health care proxy to consent)\n* Patients with bilateral or posterior rib fractures","ALL",{"count":61,"type":20},220,"OBSERVATIONAL","The goal of this observational study is to learn about the long-term effects of the serratus anterior plane block (SAPB) in adult patients who suffered multiple unilateral anterolateral rib fractures within 24 hours of patient presentation to the emergency department. The main question it aims to answer is:\n\nDoes the SAPB for multiple anterolateral rib fractures demonstrate reduction in patient morbidity and mortality, including incidence of pneumonia, length of hospital stay, discharge disposition, and death, as compared to standard analgesic regimens.\n\nThe SAPB will be performed if a physician trained in the SAPB is available within 24 hours of injury. If a trained physician is not available and the patient meets inclusion criteria, they will receive parental analgesia with opioid therapy. They will be followed until date of hospital discharge, up until 60 days.",[32,65,27],"Rib Fracture Multiple",[67,68,69,70],"serratus anterior plane block","rib fractures","mortality","morbidity","RECRUITING","2025-08-11",{"date":74,"type":43},"2025-08-13",{"date":76,"type":43},"2025-08-10",{"date":78,"type":20},"2026-08",{"name":80,"class":81},"Albert Einstein College of Medicine","OTHER",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":21,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":51},"100588917","ultrasound-guided-pectoral-nerve-blocks-thoracic-erector-spinae-plane-block-and-serratus-anterior-plane-block-for-breast-surgery-100588917","NCT06947642","Ultrasound-guided Pectoral Nerve Blocks, Thoracic Erector Spinae Plane Block and Serratus Anterior Plane Block for Breast Surgery","Comparison Between Ultrasound-guided Pectoral Nerve Blocks, Thoracic Erector Spinae Plane Block and Serratus Anterior Plane Block for Breast Surgery: A Prospective Randomized Study","Inclusion Criteria:\n\n• Age from 21 to 65 years old female, American Society of Anesthesiologists (ASA) physical status I or II, who will undergo breast surgeries under general anesthesia.\n\nExclusion Criteria:\n\n* Patient refusal to participate in research.\n* Body Mass Index (BMI) ≥35 kg\u002Fm2.\n* Sensitivity to the intervention drugs.\n* Coagulation abnormalities.\n* Psychiatric disorder and communication difficulties.\n* Chronic neurological disease.\n* Any skin infection at the needle puncture site.\n* Chest wall deformity","21 Years","65 Years",{"count":92,"type":20},60,[23],"The study will compare ultrasound-guided Pectoral nerve block, Erector Spinae Plane block, and Serratus anterior plane block for pain management following elective breast surgeries",[96,97,98,27,38],"Ultrasound","Pectoral Nerve Blocks","Thoracic Erector Spinae Plane Block","2025-05-19",{"date":101,"type":43},"2025-05-20",{"date":103,"type":43},"2025-04-30",{"date":105,"type":20},"2026-09-30",{"name":107,"class":81},"Tanta University"]