[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sessile-serrated-lesion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sessile-serrated-lesion":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,38,72,100,117,140,168],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100645225","study-on-the-association-between-serrated-polyps-and-metachronous-advanced-colorectal-neoplastic-lesions-100645225",false,"NCT07678788","Study on the Association Between Serrated Polyps and Metachronous Advanced Colorectal Neoplastic Lesions","Risk Factors for Metachronous Advanced Colorectal Lesions After Endoscopic Resection of Serrated Lesions","Inclusion Criteria:\n\n* Adult patients aged \\> 18 years;At least one SP detected during the index colonoscopy and pathologically confirmed as TSA or SSL (according to the 2019 WHO classification criteria);Underwent complete polypectomy during the index colonoscopy;Received regular follow-up at Changhai Hospital, with an interval of ≥ 6 months between the index and follow-up colonoscopies;Complete clinical and pathological data.\n\nExclusion Criteria:\n\n* Incomplete colonoscopy or failed cecal intubation;Inadequate bowel preparation, defined as a Boston Bowel Preparation Scale (BBPS) score \\\u003C 6 or a score \\\u003C 2 in any bowel segment;Withdrawal time \\\u003C 6 minutes;Diagnosis of hereditary cancer syndromes, such as familial adenomatous polyposis (FAP) or Lynch syndrome;Concurrent inflammatory bowel disease (IBD) or indeterminate colitis;History of colorectal cancer or other malignancies;Incomplete clinical or pathological records.","ALL","18 Years",{"count":19,"type":20},750,"ESTIMATED","OBSERVATIONAL","This study aims to explore the risk factors associated with the development of ACN and same-site ACN in patients with SP, thereby informing the optimization of clinical surveillance strategies",[24,25],"Sessile Serrated Lesion","Serrated Polyp","NOT_YET_RECRUITING","2026-06-25",{"date":29,"type":30},"2026-07-01","ACTUAL",{"date":32,"type":20},"2026-06-01",{"date":34,"type":20},"2026-12-01",{"name":36,"class":37},"Changhai Hospital","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":71},"100642143","usage-of-aritificial-intelligence-in-aiding-with-colonic-sessile-serrated-lesions-detection-and-diagnosis-ai-ssl-100642143","NCT07650344","USAGE OF ARITIFICIAL INTELLIGENCE IN AIDING WITH COLONIC SESSILE SERRATED LESIONS DETECTION AND DIAGNOSIS (AI-SSL)","USAGE OF ARITIFICIAL INTELLIGENCE IN AIDING WITH COLONIC SESSILE SERRATED LESIONS DETECTION AND DIAGNOSIS (AI-SSLD)","AI-SSLD","Inclusion Criteria:\n\nAdult (40 - 80 years) Undergoing colonoscopy for screening, surveillance, or diagnostic indications. Complete colonoscopy with satisfactory Boston Bowel Prep Scale of 6 or higher. Provide informed consent to participate in the study\n\nExclusion Criteria:\n\nPersonal or family history of colorectal cancer Personal or family history of colonic polyposis syndromes Personal or family history of inflammatory bowel disease Prior colorectal surgery Contraindications to colonoscopy (intestinal obstruction, medical conditions that will make the risk of colonoscopy too high) Contraindications to polypectomy (ongoing anticoagulation \u002F double antiplatelet therapy that cannot be stopped for the colonoscopy) Inability to give consent Incomplete colonoscopy\u002F Unable to retrieve specimen for pathology Poor bowel preparation (Boston Bowel Prep Scale \\\u003C6) Pregnant Women",true,"40 Years","80 Years",{"count":50,"type":20},628,"INTERVENTIONAL",[53],"NA","The aim of this study is to is to evaluate if a real-time Computer Aided Detection (CADe) system can help improve the detection of SSL(sessile serrated lesions) versus a conventional colonoscopy (CC) using white light examination(WLE).",[24,56],"CADe",[58,59,56],"sessile serrated lesion","AI","RECRUITING","2026-06-10",{"date":63,"type":30},"2026-06-16",{"date":65,"type":30},"2026-05-21",{"date":67,"type":20},"2027-05-03",{"name":69,"class":70},"National Healthcare Group, Singapore","OTHER_GOV",3,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":51,"phases":84,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},"100637721","impact-of-acetic-acid-indigo-carmine-chromocolonoscopy-on-proximal-sessile-serrated-lesions-100637721","NCT07601217","Impact of Acetic Acid-Indigo Carmine Chromocolonoscopy on Proximal Sessile Serrated Lesions","Impact of Acetic Acid-Indigo Carmine Chromocolonoscopy on Proximal Sessile Serrated Lesions: a Multicenter Randomized Trial","ACID-SSL","Inclusion Criteria:\n\n* Patients whose age are between 45-85\n* Patients who have indications for screening\n* Patients who have signed inform consent form.\n\nExclusion Criteria:\n\n* Patients undergoing surveillance colonoscopy after polypectomy or therapeutic colonoscopy for known polyps\n* Patients with a history of colonoscopy within the past 5 years\n* Patients with highly suspected or confirmed colorectal cancer\n* Patients with alarming signs or symptoms: hematochezia, melena, unexplained anemia, weight loss, abdominal mass, positive digital rectal examination\n* Pregnant or breastfeeding women\n* Patients with gastrointestinal obstruction\n* Patients with inflammatory bowel disease, colonic polyposis, or melanosis coli\n* Patients with coagulation disorders or who have taken antiplatelets or anticoagulants (e.g., aspirin, warfarin) within 7 days before colonoscopy\n* Patients currently participating in another clinical trial or who have participated in another clinical trial within the preceding 60 days\n* Patients with failed cecal intubation for any reason (e.g., obstructing lesion, intolerance of the procedure)\n* Patients with an Aronchick bowel preparation score \\>3 at colonoscope insertion, indicating inadequate preparation requiring a repeat bowel preparation\n* Patients who have used bowel preparation agents not recommended by guidelines, such as oral sodium phosphate or senna\n* Patients with known allergy to acetic acid-indigo carmine, brilliant blue dye, or medications related to colonoscopy\n* Patients with missing essential information in the case report form prior to enrollment","45 Years","85 Years",{"count":83,"type":20},2689,[53],"Chromocolonoscopy with acetic acid and indigo carmine has shown promise for improving the detection of sessile serrated lesions (SSLs), the precursor lesions responsible for a substantial proportion of interval colorectal cancers. Previous studies have demonstrated its potential to enhance visualization of both adenomatous and non-adenomatous polyps, particularly the subtle SSLs that are frequently missed during conventional white-light colonoscopy. However, high-quality randomized controlled trials comparing chromocolonoscopy with standard white-light imaging to provide definitive evidence on its efficacy for SSL detection are lacking. We therefore conducted a multicenter, prospective, randomized controlled trial to evaluate the diagnostic yield of acetic acid-indigo carmine chromocolonoscopy versus standard colonoscopy for SSL detection.",[24],[24,88,89,90],"Sessile Serrated Lesion Detection Rate","Chromocolonoscopy","Acetic Acid and Indigo Carmine","2026-05-17",{"date":93,"type":30},"2026-05-22",{"date":95,"type":20},"2026-06-15",{"date":97,"type":20},"2028-11-15",{"name":36,"class":37},1,{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":46,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":51,"phases":109,"briefSummary":110,"conditions":111,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":112,"startDateStruct":113,"completionDateStruct":114,"leadSponsor":116,"locationsCount":4},"100638679","polyp-pretreatment-device-for-ssl-diagnosis-100638679","NCT07601230","Polyp Pretreatment Device for SSL Diagnosis","Efficacy of a Polyp Pretreatment Device in Improving Diagnosis of Sessile Serrated Lesions in Colorectal Polyps","Inclusion Criteria:\n\n1. Patients undergoing colonoscopic polypectomy (≤3 lesions if multiple).\n2. Sessile\u002Fflat polyps (Paris 0-Is,0-IIa, 0-IIb, 0-IIc) resected by snare or EMR with intact specimens.\n3. Signed informed consent.\n\nExclusion Criteria:\n\n1. Refusal or lack of informed consent.\n2. Polyp size ≥25 mm or fragmented resection.\n3. Severe specimen damage\u002Fcautery artifact or time from resection to fixation \\>30 min.\n4. Suspected\u002Fconfirmed CRC, IBD, or polyposis syndromes.\n5. Anticoagulants (aspirin\u002Fwarfarin) within 7 days or coagulation disorders.",{"count":108,"type":20},1156,[53],"Colorectal cancer (CRC) is the third most common malignancy globally. Sessile serrated lesions (SSLs) account for 15-30% of CRC via the serrated pathway. Accurate SSL diagnosis relies on basal crypt features, which are often obscured by specimen curling during standard formalin fixation, leading to underdiagnosis. A novel polyp pretreatment device mechanically maintains mucosal flatness, ensuring vertical sectioning relative to the muscularis mucosae. This randomized, double-blind, parallel-controlled trial evaluates whether the device improves SSL diagnostic rate and section orientation in sessile colorectal polyps.",[24],{"date":93,"type":30},{"date":95,"type":20},{"date":115,"type":20},"2028-05-01",{"name":36,"class":37},{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":46,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":124,"targetDuration":126,"studyType":21,"phases":4,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":4},"100624508","quantitative-fecal-immunochemical-test-for-detection-of-colorectal-cancer-and-precancerous-lesions-in-sohag-100624508","NCT07410546","Quantitative Fecal Immunochemical Test for Detection of Colorectal Cancer and Precancerous Lesions in Sohag","Role of Quantitative Fecal Immunochemical Test as a Diagnostic Tool in Evaluation of Site and Type of Colorectal Cancer and Precancerous Lesions in Sohag Government","Inclusion Criteria:\n\n* Adults aged 40 to 75 years\n* Individuals undergoing screening or diagnostic colonoscopy\n* Participants able to provide informed consent\n\nExclusion Criteria:\n\n* Age below 40 years or above 75 years\n* History of colorectal surgery\n* Inflammatory bowel disease\n* Inadequate bowel preparation\n* Refusal to participate",{"count":125,"type":20},150,"1 Day","Colorectal cancer is a major cause of cancer-related morbidity and mortality worldwide, and early detection significantly improves patient outcomes. The fecal immunochemical test (FIT) is a non-invasive stool-based test used for detection of colorectal cancer; however, its diagnostic performance varies according to lesion type and anatomical location.\n\nThis prospective observational cohort study aims to evaluate the diagnostic accuracy of quantitative fecal immunochemical testing (qFIT) in detecting colorectal cancer and precancerous lesions, including advanced adenomas and sessile serrated lesions, in adults undergoing colonoscopy in Sohag Government. The study will assess the sensitivity, specificity, and optimal cutoff values of qFIT according to lesion type, location, and histopathological characteristics.",[129,130,24],"Colorectal Cancer","Colorectal Adenoma","2026-02-07",{"date":133,"type":30},"2026-02-13",{"date":135,"type":20},"2026-02",{"date":137,"type":20},"2026-08",{"name":139,"class":37},"Sohag University",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":46,"sex":16,"minAge":47,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":51,"phases":150,"briefSummary":151,"conditions":152,"keywords":155,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":99},"100616679","impact-of-computer-aided-detection-system-on-the-proximal-adenoma-miss-rate-100616679","NCT07308743","Impact of Computer-aided Detection System on the Proximal Adenoma Miss Rate","Impact of Computer-aided Detection System on the Proximal Adenoma Miss Rate: a Multicenter Tandem Rondomized Controlled Trial","Inclusion Criteria:\n\n1. Patients age 40-75 years old, regardless of gender\n2. Patients presenting for physical examination, colorectal cancer screening or diagnosis\n3. Patients voluntarily signs an informed consent form\n\nExclusion Criteria:\n\n1. Unable to cooperate ot tolerate colonoscopy\n2. History of inflammatory bowel disease\n3. History of colorectal cancer\n4. Previous colorectal surgery\n5. History of recurrent constipation\n6. Taking anticoagulant and antiplatelet drugs berfore procedure\n7. High risk conditions such as severe cardiovascular and cerebrovascular diseases, severe anemia, or uncorrected infections\n8. Pregnant or lactating women Researchers concluded that patient was not suitable to participate in this trial.","75 Years",{"count":149,"type":20},686,[53],"This is a prospective, multicenter randomized controlled trial designed to determine whether the use of computer-aided detection system could reduce the miss rates of adenomas, SSLs, and polyps in the proximal colon during tandem colonoscopy.",[153,154,24],"Colon Adenomas","Colon Polyps",[156,157,158],"computer-aided detection","proximal adenoma miss rate","Randomized Tandem Colonoscopy Study","2025-12-17",{"date":161,"type":30},"2025-12-30",{"date":163,"type":20},"2025-12",{"date":165,"type":20},"2027-07",{"name":167,"class":37},"Nanfang Hospital, Southern Medical University",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":46,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":175,"targetDuration":4,"studyType":51,"phases":177,"briefSummary":178,"conditions":179,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":186,"leadSponsor":188,"locationsCount":190},"100602742","computer-aided-water-exchange-colonoscopy-with-and-without-linked-color-imaging-for-detection-of-clinically-significant-serrated-lesions-100602742","NCT07127471","Computer-Aided Water Exchange Colonoscopy With and Without Linked-Color Imaging for Detection of Clinically Significant Serrated Lesions","A Multicenter Prospective Randomized Controlled Trial of Linked-Color Imaging for Detection of Clinically Significant Serrated Lesions in Computer-Aided Water Exchange Colonoscopy","Inclusion Criteria:\n\n* Male and female patients aged 40-80 years scheduled for average-risk screening colonoscopy, post-polypectomy surveillance, diagnosis for gastrointestinal symptoms (including unexplained iron deficiency anemia and clinically significant diarrhea of unexplained origin), or referred for colonoscopy owing to a positive fecal immunochemical test (FIT) or guaiac fecal occult blood test (gFOBT) result.\n\nExclusion Criteria:\n\n* familial adenomatous polyposis and hereditary non-polyposis CRC syndrome\n* personal history of serrated polyposis syndrome\n* personal history of CRC\n* history of inflammatory bowel disease\n* previous colonic resection\n* overt gastrointestinal bleeding\n* emergency colonoscopy or inpatients\n* planned EMR or ESD of large polyps\n* colon stricture or obstruction\n* contraindications to colonoscopy (eg, acute diverticulitis or toxic megacolon)\n* antithrombotic therapy precluding complete polyp resection\n* American Society of Anesthesiology classification of physical status \\>3\n* pregnant women or women planning pregnancy\n* refusal to provide a written informed consent",{"count":176,"type":20},1090,[53],"The goal of this clinical trial is to compare the detection rate of clinically significant serrated lesions (CSSL) in participants undergoing water exchange (WE) colonoscopy with artificial intelligence (AI)-based computer-aided detection (CADe) for screening, surveillance, diagnosis for symptoms, or referred owing to a positive fecal immunochemical test (FIT) or guaiac fecal occult blood test (gFOBT) result. There will be two arms in this study: WE with AI-assisted CADe (WEAID) control and WEAID plus linked-color imaging (LCI). The main question it aims to answer is whether the addition of LCI into WEAID colonoscopy increases CSSL detection rate. Both groups use water instead of air to insert the colonoscope into the cecum. The control method uses CADe to help detect colonic lesions. The study method uses a combination of CADe and LCI to detect lesions. Researchers will compare CSSL detection rate to see if the addition of LCI increases the detection of CSSL during CADe-assisted WE colonoscopy.",[180,181,24,153],"Sessile Colonic Polyp","Serrated Lesion","2025-11-17",{"date":184,"type":30},"2025-11-20",{"date":182,"type":30},{"date":187,"type":20},"2027-07-31",{"name":189,"class":37},"Evergreen General Hospital, Taiwan",4]