[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"severe-brain-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:severe-brain-injury":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,52,76,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100623564","the-rebro-severe-traumatic-brain-injury-registry-100623564",false,"NCT07398274","The Örebro Severe Traumatic Brain Injury Registry","The Örebro Severe Traumatic Brain Injury Registry (ÖrSBID): A Prospective Observational Cohort Study","ÖrSBID","Inclusion Criteria:\n\n* Age \\> 16 years\n* Severe traumatic brain injury or other severe brain injury requiring neurointensive or neurointermediate care\n* Admission to Örebro University Hospital\n\nExclusion Criteria:\n\n* Age \\\u003C 16 years \\\u003C 90 years\n* Non-survivable brain injury\n* Patients not requiring neurointensive or neurointermediate care\n* Declinced consent by patient or legal representative","ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","12 Months","OBSERVATIONAL","Traumatic brain injury and other severe brain injuries requiring neurointensive care are associated with high mortality, long-term disability and substantial societal burden. Despite advances in critical care, outcomes after severe brain injury remain difficult to predict and secondary brain injury plays a major role in determining prognosis.\n\nThe Örebro Severe Brain Injury Database (ÖrSBID) is a prospective observational registry that aims to systematically collect detailed clinical, physiological, imaging and biological data from adult patients with severe brain injury requiring care at the neurointesive care unit or neurointermediate care unit at Örebro University Hospital.\n\nThe purpose of the registry is to enable deep phenotyping of severe brain injury, improve understanding of secondary injury mechanisms, support outcome prediction and provide a platform for longitudinal follow-up and future research. No experimental interventions are performed as part of the study.",[26,27,28,29],"Severe Traumatic Brain Injury","Severe Brain Injury","Ischemic Stroke","Intracerebral Hemorrhage",[31,32,33,34,35,36,37,38],"severe traumatic brain injury","severe brain injury","neurointensive care","neurocritical care","multimodal monitoring","biomarkers","longitudinal follow-up","multiomics","NOT_YET_RECRUITING","2026-02-04",{"date":42,"type":43},"2026-02-09","ACTUAL",{"date":45,"type":21},"2026-02-08",{"date":47,"type":21},"2028-02-15",{"name":49,"class":50},"András Zoltán Buki","OTHER_GOV",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":51},"100577396","effect-of-the-stellate-ganglion-block-on-the-retinal-microcirculation-100577396","NCT06797752","Effect of the Stellate Ganglion Block on the Retinal Microcirculation","Effect of the Stellate Ganglion Block on the Retinal Microcirculation: A Pilot Study","Inclusion Criteria:\n\n* Age 18 years or older\n* Patients receiving the stellate ganglion nerve block for an approved indication, e.g. complex regional pain syndrome\n\nExclusion Criteria:\n\n* Pregnancy\n* Non-English speaking\n* Temporary or permanent physical limitation that renders the patient unable to sit up and look inside OCTA device",{"count":60,"type":21},50,"Surges in the sympathetic nervous system occur at the ictus of a variety of neurological critical illnesses including intracranial hemorrhage and ischemic stroke. It is hypothesized that these exaggerated increases in sympathetic nervous activity produce maladaptations that promote secondary brain injury. One of these possible mechanisms include diffuse vasospasm that cause cerebral ischemia. Hence, methods to abrogate the sympathetic nervous system in this context are under active investigation. One possible method is the regional anesthesia technique of the stellate ganglion nerve block, which is ordinarily used for complex regional pain syndrome, but has been shown to reduce cerebral sympathetic activity and reduces vasospasm in patients with subarachnoid hemorrhage. However, its effect on the microcirculation is not clear. Hence, we propose to study patients receiving the stellate ganglion nerve block as part of their standard medical care and to image their retinal microcirculation before and after the procedure using Optical Coherence Tomography Angiography (OCTA).",[63,27,64,29],"OCTA","Subarachnoid Hemorrhage","RECRUITING","2025-11-15",{"date":68,"type":43},"2025-11-19",{"date":70,"type":43},"2024-10-07",{"date":72,"type":21},"2026-10-07",{"name":74,"class":75},"University of Texas Southwestern Medical Center","OTHER",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100581503","transcranial-temporal-interference-stimulation-in-severely-brain-injured-patients-with-disorders-of-consciousness-100581503","NCT06851156","Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness","An Exploratory Trial Evaluating Temporal Interference Stimulation of CM-pf In Patients With Disorders of Consciousness","Inclusion Criteria:\n\n* traumatic and nontraumatic etiology of VS\u002FUWS or MCS according to published diagnostic criteria.\n\nExclusion Criteria:\n\n* patients in coma, with less than 1 week after acute brain insult, with fluctuating diagnosis on baseline assessment, and with a metallic cerebral implant or pacemaker, and with epilepsy.","65 Years",{"count":85,"type":21},10,"INTERVENTIONAL",[88],"NA","The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.",[91,27,92,93],"Disorders of Consciousness","Unresponsive Wakefulness Syndrome","Minimally Conscious State","2025-04-06",{"date":96,"type":43},"2025-04-09",{"date":98,"type":43},"2025-04-07",{"date":100,"type":21},"2025-12-31",{"name":102,"class":75},"Xijing Hospital",2,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":4},"100529904","chinese-severe-brain-injury-trial-100529904","NCT06179836","Chinese Severe Brain Injury Trial","CSBIT","Inclusion Criteria:\n\n* a clear cause of brain injury\n* disorders of consciousness, GCS≤12\n* within six months of onset\n\nExclusion Criteria:\n\n* not applicable",{"count":112,"type":21},3000,"Building a Large Chinese Cohort(Chinese Severe brain injury Trial）",[27],"2023-12-20",{"date":117,"type":43},"2023-12-22",{"date":119,"type":21},"2024-01-01",{"date":121,"type":21},"2027-12-31",{"name":123,"class":75},"Xuanwu Hospital, Beijing"]