[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"severe-malnutrition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:severe-malnutrition":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100636693","prealbumin-and-igf-1-levels-in-pediatric-chronic-cholestasis-with-severe-malnutrition-after-nutrition-therapy-100636693",false,"NCT07569003","Prealbumin and IGF-1 Levels in Pediatric Chronic Cholestasis With Severe Malnutrition After Nutrition Therapy","Preliminary Study: Effect of Nutrition Therapy on Prealbumin and IGF-1 Level in Severe Malnutrition Under Five Years Old With Chronic Cholestasis","Inclusion Criteria:\n\n* Children under 5 years old\n* Diagnosed with chronic cholestasis and severe malnutrition\n* Parental\u002Fguardian informed consent\n* Willingness to use a nasogastric tube (NGT) if indicated\n* Covered by national health insurance or other insurance\n\nExclusion Criteria:\n\n* Comorbidities (heart failure, chronic kidney disease, HIV)\n* Severe acute infections (acute gastroenteritis, dengue fever, pneumonia)\n* Post-liver transplant\n* Post-Kasai portoenterostomy (jaundice-free)\n* Currently exclusively breastfeeding\n* Use of steroids or NSAIDs within two weeks prior to the study.\n* Receiving a transfusion of whole blood, fresh frozen plasma, or platelets within one week prior to the study","ALL","5 Years",{"count":19,"type":20},15,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn if a high-energy liquid diet improves the nutritional status of children with chronic cholestasis (a liver condition that blocks bile flow). Researchers want to see if this diet helps children who are malnourished.\n\nThe main questions the study aims to answer are:\n\n* Does the liquid diet raise the level of prealbumin (a marker of nutrition) in the blood?\n* Does the liquid diet raise the level of Insulin-like Growth Factor-1 (IGF-1) (a hormone that helps growth) in the blood?\n\nParticipants will:\n\n* Consume a high-energy liquid diet for 14 days.\n* Give blood samples at the start and at the end of the 2-week study.\n* Keep a daily record of what they eat and drink in a food diary. Researchers will compare the blood test results from the start and the end of the study to see if the liquid diet works to improve the children's prealbumin and IGF-1 levels. This study is important to help children with liver problems grow better and stay healthy.",[26,27,28],"Chronic Cholestasis","Severe Malnutrition","Pediatric Cholestasis",[26,30,31,32,33,34],"Severe malnutrition","Pediatric cholestasis","IGF-1","Prealbumin","Nutrition therapy","RECRUITING","2026-05-01",{"date":38,"type":39},"2026-05-06","ACTUAL",{"date":41,"type":39},"2026-04-06",{"date":43,"type":20},"2026-07",{"name":45,"class":46},"Indonesia University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":68,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":47},"100564942","enhancing-pediatric-acute-care-through-adaptive-e-learning-and-in-person-skills-practice-in-tanzania-100564942","NCT06635733","Enhancing Pediatric Acute Care Through Adaptive E-Learning and In-Person Skills Practice in Tanzania","A Cluster Randomized Controlled Trial of the Pediatric Acute Care Education (PACE) Program Combining Adaptive E-Learning with In-Person Skills Practice in Tanzania","PACE","Inclusion Criteria:\n\n* Healthcare providers actively involved in pediatric care at one of the selected healthcare centers.\n* Completion of core Pediatric Acute Care Education (PACE) adaptive learning modules prior to study participation.\n* Willingness to participate in In-Person Skills Practice (ISP) sessions.\n* Ability to engage with either the Rhapsode Capable™ platform (intervention group) or paper-based ISP methods (control group).\n* Minimum proficiency in written and spoken English.\n\nExclusion Criteria:\n\n* Healthcare providers not involved in pediatric or newborn clinical care at the time of recruitment.\n* Providers unable or unwilling to attend ISP sessions facilitated by clinical champions.\n* Individuals with no prior engagement in the PACE program.\n* Providers with significant technological barriers that prevent the use of the Rhapsode Capable™ platform (for the intervention group only).",{"count":57,"type":20},100,[23],"The goal of this clinical trial is to evaluate whether the integration of in-person skills practice (ISP) with an adaptive e-learning platform can improve refresher learning progress (RLP) among healthcare providers in pediatric care settings in Tanzania.\n\nThe main questions it aims to answer are:\n\nCan healthcare providers who participate in ISP sessions facilitated by clinical champions achieve greater improvements in refresher learning progress (RLP)? Will providers in the intervention group demonstrate improved metacognition and practical skill performance compared to those in the control group? Researchers will compare healthcare providers using the ISP digital platform (Rhapsode Capable™) to providers using paper-based ISP to see if the digital platform results in significantly higher RLP and fewer skill-based errors.\n\nParticipants will:\n\nComplete adaptive e-learning modules focused on pediatric care topics (e.g., newborn resuscitation, severe malnutrition).\n\nParticipate in ISP sessions where clinical champions provide feedback and assess performance.",[61,27,62,63,64,65,66,67],"Newborn Resuscitation","Severe Malaria","Severe Pneumonia","Severe Dehydration","In-Service Training","Computer-Assisted Instruction","Simulation Training",[69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87],"Pediatric acute care","Newborn resuscitation","Severe malnutrition in children","Severe malaria treatment","Severe dehydration management","Pediatric pneumonia care","In-person skills practice (ISP)","Adaptive e-learning for healthcare providers","Clinical skills training in low-resource settings","Health provider education","Clinical champions","Tanzania healthcare providers","Pediatric emergency training","Blended learning in pediatric care","Refresher learning progress (RLP)","Cluster randomized controlled trial (RCT)","Rhapsode Capable™ platform","Skills assessment in pediatric care","Continuous professional development (CPD) for healthcare providers","NOT_YET_RECRUITING","2024-10-08",{"date":91,"type":39},"2024-10-10",{"date":93,"type":20},"2025-01-06",{"date":95,"type":20},"2026-12-01",{"name":97,"class":46},"Stanford University"]