[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"severe-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:severe-periodontitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100366051","impact-of-treating-severe-periodontitis-on-inflammatory-activity-of-atheromatous-plaques-in-patients-with-acute-myocardial-infarction-ami-100366051",false,"NCT04046237","Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)","PAROCARD","Inclusion Criteria:\n\n* Patients hospitalized for an acute myocardial infarction and included in the Frenchie registry\n* Score ≥ 5 on the screening questionnaire for periodontitis\n* Six teeth at least (excluding wisdom teeth)\n* Consent signature\n* Affiliation to a French medical insurance (Sécurité Sociale)\n\nExclusion Criteria:\n\n* Patients with diseases,other than cardiovascular and diabetes, known to change the periodontal state such as AIDS, rheumatoid arthritis, Chediak-Higashi syndrome, Papillon-Lefèvre\n* Systemic antibiotic therapy\\> 48 hours in the 3 months prior to inclusion\n* Acute heart failure\n* Uncontrolled ventricular rhythm disorders\n* Impossibility for the patient to attend follow-up visits\n* Impossibility to maintain the extended position for 20 minutes\n* Immunosuppressive therapy\\> 1 month in the 6 months prior to inclusion\n* Pregnancy, breastfeeding\n* Known hypersensitivity to chlorhexidine, povidone, 18-fluoro-deoxyglucose","ALL","30 Years","70 Years",{"count":20,"type":21},210,"ESTIMATED","INTERVENTIONAL",[24],"NA","Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group versus treatment by dental surgeons as part of their usual practice in the control group.\n\nFor the intervention group, periodontal management will be carried out for a maximum of 6 months after randomisation, prolonged by a follow-up of 6 months including a maintenance visit at M9.\n\nAll patients will have an FDG-PET at M0 and M12 for evaluation of inflammation on carotid atherosclerotic plaques.",[27,28,29],"Acute Myocardial Infarction","Severe Periodontitis","Carotid Atherosclerosis",[27,28,31,29],"FDG-PET","RECRUITING","2025-09-01",{"date":35,"type":36},"2025-09-08","ACTUAL",{"date":38,"type":36},"2019-08-02",{"date":40,"type":21},"2028-08",{"name":42,"class":43},"Assistance Publique - Hôpitaux de Paris","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100553280","effectiveness-of-periodontitis-treatment-on-the-metabolic-activity-of-symptomatic-carotid-atherosclerotic-plaque-responsible-for-ischemic-stroke-100553280","NCT06484036","Effectiveness of Periodontitis Treatment on the Metabolic Activity of Symptomatic Carotid Atherosclerotic Plaque Responsible for Ischemic Stroke","Effectiveness of Periodontitis Treatment on the Metabolic Activity of Symptomatic Carotid Atherosclerotic Plaque Responsible for Ischemic Stroke: a Multicenter Randomized Controlled Trial: a Multicenter Randomized Controlled Trial","PerioStroke","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Minor ischemic stroke of the anterior circulation (NIHSS ≤ 5) of atherothrombotic origin according to the TOAST scale \\\u003C30 days\n* Atheroma plaque of the ipsilateral carotid bulb \\>30% not eligible for intervention (endarterectomy or angioplasty-stenting)\n* Severe periodontitis (stage 3 or 4)\n* Signed informed consent\n* Affiliation to a social security scheme\n\nExclusion Criteria:\n\n* \\\u003C 6 teeth\n* Without independent oral hygiene\n* Contraindications to PET scan\n* Known allergy to fluoro-deoxyglucose and its excipient\n* Immunosuppressive treatment\n* Uncontrolled diabetes\n* High risk of infective endocarditis\n* Organ transplant pending\n* Progressive infectious diseases\n* Active smoking not stopped\n* Patient deprived of liberty by judicial or administrative decision\n* Patient under legal protection (guardianship, curatorship)\n* Participation in another interventional research involving humans or being in the exclusion period following previous research involving humans\n* Pregnant or breastfeeding woman Patient under AME (state medical aid)","18 Years",{"count":55,"type":21},157,[24],"Cardiovascular disease is the world's leading cause of death. Atherothrombosis is a common cause of ischemic stroke.\n\nA strong epidemiological link has been established between periodontitis and the risk of stroke. It shares common risk factors with atherothrombosis, and its severe form is associated with low-grade systemic inflammation and daily low-intensity bacteremia. Atherothrombosis is a frequent cause of ischemic stroke.\n\nPeriodontal bacteria have been found within atheromatous plaques, correlated with a greater risk of rupture.\n\nThus, periodontitis could be a modifiable risk factor for atherothrombosis and future vascular events: its early diagnosis and treatment could have a major impact on cardiovascular prevention.\n\nHypothesis: In patients with periodontitis who have had an ischemic stroke, periodontal treatment may reduce atherosclerotic plaque activity.",[28,59],"Ischemic Stroke",[61,28,59],"PET scan","NOT_YET_RECRUITING","2024-06-28",{"date":65,"type":36},"2024-07-03",{"date":67,"type":21},"2024-09-01",{"date":69,"type":21},"2028-09-01",{"name":42,"class":43}]