[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"severe-pneumonia-caused-by-multidrug-resistant-gram-negative-bacterial-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:severe-pneumonia-caused-by-multidrug-resistant-gram-negative-bacterial-infection":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100608837","a-study-on-integrated-chinese-and-western-medicine-for-severe-pneumonia-caused-by-multidrug-resistant-gram-negative-bacterial-infections-100608837",false,"NCT07206745","A Study on Integrated Chinese and Western Medicine for Severe Pneumonia Caused by Multidrug-Resistant Gram-Negative Bacterial Infections","Efficacy Evaluation of Integrated Traditional Chinese and Western Medicine in the Treatment of Severe Pneumonia Caused by Multidrug-Resistant Gram-Negative Bacterial Infections: A Randomized, Double-Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Meeting the diagnostic criteria for severe pneumonia, aged ≥18 years and \\\u003C80 years;\n* Microbiological culture confirming Gram-negative bacterial infection resistant to three or more classes of antibiotics, such as extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae, carbapenem-resistant Acinetobacter baumannii (CRAB), and multidrug-resistant Pseudomonas aeruginosa (MDR-PA);\n* Written informed consent obtained from the patient or their legal representative.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women;\n* Patients with impaired consciousness, dementia, psychiatric disorders, or other conditions that preclude effective communication and cooperation;\n* Patients with aspiration pneumonia, fungal pneumonia, viral pneumonia, pulmonary tuberculosis, or HIV-associated Pneumocystis jirovecii pneumonia;\n* Patients with severe hepatic or renal insufficiency, such as liver cirrhosis with Child-Pugh score of 10-15, or estimated glomerular filtration rate (eGFR) \\\u003C30 mL\u002Fmin\u002F1.73 m²;\n* Patients with hematologic malignancies, solid organ transplantation, or congenital\u002Facquired diseases leading to immunodeficiency;\n* Patients with multidrug-resistant bacterial infections outside the lung (e.g., urinary tract, abdominal cavity, bloodstream);\n* Patients with severe cardiac dysfunction (NYHA class IV), malignant arrhythmias, or other hemodynamically unstable conditions;\n* Patients who have already received antimicrobial therapy for more than one week;\n* Patients who have participated in another drug clinical trial within one month prior to enrollment;\n* Patients with known allergy to the investigational drug.","ALL","18 Years","80 Years",{"count":20,"type":21},152,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate the clinical efficacy of a traditional Chinese medicine formula granule (Feireqing Granules) in the treatment of severe pneumonia caused by multidrug-resistant Gram-negative bacterial infections (MDR-GNB severe pneumonia), to establish a therapeutic regimen, and to generate high-quality clinical evidence.",[27],"Severe Pneumonia Caused by Multidrug-resistant Gram-negative Bacterial Infection",[29,30,31,32,33],"Severe pneumonia","multidrug-resistant Gram-negative bacterial infection","traditional Chinese medicine","randomized controlled trial","Fei Re Qing Granules","NOT_YET_RECRUITING","2025-09-26",{"date":37,"type":38},"2025-10-03","ACTUAL",{"date":40,"type":21},"2025-10-01",{"date":42,"type":21},"2027-12-31",{"name":44,"class":45},"Henan University of Traditional Chinese Medicine","OTHER"]