[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"severe-pneumonia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:severe-pneumonia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,39,64,90,112,138,187,206,228,258],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100640538","feasibility-and-preliminary-efficacy-of-a-child-life-based-breathing-exercise-program-for-children-recovering-from-severe-pneumonia-a-pilot-randomized-controlled-trial-100640538",false,"NCT07593989","Feasibility and Preliminary Efficacy of a Child Life-Based Breathing Exercise Program for Children Recovering From Severe Pneumonia: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n1. Children aged 6-18 years.\n2. Diagnosed with severe pneumonia and in the recovery phase.\n3. Written informed consent is obtained from caregivers, and assent is obtained from children when appropriate.\n\nExclusion Criteria:\n\n1. Contraindications to breathing exercise, including: (a) hemodynamic instability (e.g., bradycardia or tachycardia, arrhythmia, hypotension or hypertension); (b) open sternal incision; (c) extracorporeal membrane oxygenation (ECMO); (d) acute phase of severe wheezing or stridor; and (e) severe pulmonary hypertension.\n2. Communication disorders.","ALL","6 Years","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this pilot randomized controlled trial is to evaluate the feasibility and preliminary efficacy of a child life-based breathing exercise program for children recovering from severe pneumonia. The main questions it aims to answer are:\n\n* Is the child life-based breathing exercise program feasible for hospitalized children recovering from severe pneumonia?\n* Can the program improve caregiver satisfaction and promote recovery in children with severe pneumonia?\n\nResearchers will compare a child life-based breathing exercise program combined with routine health education with routine health education alone to determine whether the intervention improves rehabilitation outcomes.\n\nParticipants will:\n\n* Receive either routine health education alone or routine health education combined with the child life-based breathing exercise program\n* Participate in breathing exercise training during hospitalization\n* Complete assessments of caregiver satisfaction and clinical recovery outcomes, including improvement in chest imaging findings and time to resolution of symptoms such as cough, fever, and dyspnea.",[26],"Severe Pneumonia","NOT_YET_RECRUITING","2026-05-12",{"date":30,"type":31},"2026-05-18","ACTUAL",{"date":33,"type":20},"2026-06-01",{"date":35,"type":20},"2027-06-01",{"name":37,"class":38},"Children's Hospital of Fudan University","OTHER",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":4,"enrollmentInfo":45,"targetDuration":4,"studyType":47,"phases":4,"briefSummary":48,"conditions":49,"keywords":51,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":63},"100636609","a-prospective-observational-cohort-study-protocol-for-disease-severity-stratification-and-prognosis-assessment-in-patients-with-pneumonia-100636609","NCT07567911","A Prospective Observational Cohort Study Protocol for Disease Severity Stratification and Prognosis Assessment in Patients With Pneumonia","1. Inclusion and Exclusion Criteria for Pneumonia Patients 1.1 Inclusion Criteria 1) Age ≥ 18 years old; 2) Meeting the diagnostic criteria for pneumonia (acute onset + new infiltrates on imaging); 3) Time from onset to admission ≤ 72 hours; 4) Signed written informed consent. 1.1.1 Inclusion Criteria for Severe Pneumonia Patients A diagnosis of \"severe pneumonia\" can be made if one of the main criteria or ≥ 3 of the secondary criteria are met.\n\n   Main Criteria:\n\n   ① Requires mechanical ventilation with tracheal intubation\n\n   ② Requires vasopressor drugs after aggressive fluid resuscitation for septic shock\n\n   Secondary Criteria:\n   * Respiratory rate ≥ 30 breaths\u002Fmin\n\n     * PaO₂\u002FFiO₂ ≤ 250 mm Hg\n\n       * Multiple lobe infiltrates\n\n         * Confusion and\u002For disorientation\n\n           ⑤ Blood urea nitrogen ≥ 20 mg\u002FdL\n\n           ⑥ Leukopenia (WBC \\\u003C 4×10⁹\u002FL)\n\n           ⑦ Thrombocytopenia (PLT \\\u003C 100×10⁹\u002FL)\n\n           ⑧ Decreased body temperature (central body temperature \\\u003C 36 ℃)\n\n           ⑨ Hypotension requiring fluid resuscitation 1.2 Exclusion Criteria\n           1. End-stage diseases (such as expected survival \\\u003C 48 hours);\n           2. Long-term immunosuppressive therapy (prednisone \\> 20mg\u002Fd for more than 3 weeks, or neutropenia after chemotherapy);\n           3. Pregnant or lactating women. 2. Inclusion and Exclusion Criteria for Patients with Suspected Infection but Negative Pathogen Testing 2.1 Inclusion Criteria\n\n           \u003C!-- -->\n\n           1. Age ≥ 18 years old;\n           2. Having infection-related symptoms or signs (such as fever, cough, sputum production, elevated white blood cells, etc.), clinically suspected of pneumonia;\n           3. All pathogen tests are negative within 3 days after admission;\n           4. Time from onset to admission ≤ 72 hours;\n           5. Signed written informed consent. 2.2 Exclusion Criteria\n\n           \u003C!-- -->\n\n           1. End-stage diseases (such as expected survival \\\u003C 48 hours);\n           2. Long-term immunosuppressive therapy;\n           3. Pregnant or lactating women;",{"count":46,"type":20},2700,"OBSERVATIONAL","This is a prospective, multicenter observational cohort study involving approximately 2,700 patients, designed to delineate the natural history of pneumonia by tracking the complete clinical course and dynamic multi-omics evolution from the acute phase to recovery; the study aims to quantify severe conversion rates and mortality by comparing baseline characteristics, pathogen distribution, and immune response trajectories between severe and non-severe groups, ultimately revealing the underlying molecular mechanisms of disease progression and optimizing clinical risk stratification strategies.",[26,50],"Pneumonia",[52,53],"pneumonia","severe pneumonia","2026-04-28",{"date":56,"type":31},"2026-05-05",{"date":58,"type":20},"2026-05-01",{"date":60,"type":20},"2028-05-28",{"name":62,"class":38},"Zhonghao Fang",1,{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":47,"phases":4,"briefSummary":75,"conditions":76,"keywords":77,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":86,"leadSponsor":88,"locationsCount":4},"100616648","rapid-identification-of-infectious-pathogens-in-severe-pneumonia-guided-by-bronchoscopic-imaging-and-lung-ct-100616648","NCT07308340","Rapid Identification of Infectious Pathogens in Severe Pneumonia Guided by Bronchoscopic Imaging and Lung CT","Clinical Study on Rapid Identification of Infectious Pathogens in Severe Pneumonia Patients Based on Bronchoscopic Imaging and Lung CT Guidance","IMG-GUIDE-IP","Inclusion Criteria:\n\n* Patients admitted to the study institution between January 2024 and December 2025, with a clinical diagnosis of severe pneumonia (consistent with the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Community-Acquired Pneumonia.\n* Patients who underwent both standalone lung CT examination and bronchoscopic imaging examination during hospitalization; complete imaging reports and bronchoscopy operation records are available.\n* Patients who completed at least one type of microbial standard test (as defined in Primary Outcome Measure: e.g., pathogen culture, nucleic acid detection, GM test); complete test reports are available.\n* Medical Records: Complete electronic medical records are available, including demographic information (age, gender), clinical symptoms, treatment regimens, and prognosis data (length of hospital stay, in-hospital mortality).\n\nExclusion Criteria:\n\n* Imaging\u002FMicrobial Data Deficiency: Patients with incomplete imaging data (e.g., missing lung CT images, unrecorded bronchoscopic mucosal changes) or unavailable microbial gold standard test results.\n* Bronchoscopy Contraindications: Patients who underwent bronchoscopic imaging for non-diagnostic purposes (e.g., foreign body removal, hemostasis) or had bronchoscopy-related complications (e.g., severe hemorrhage, pneumothorax) that affected examination completion.\n* Duplicate Enrollment: Patients who were admitted multiple times for severe pneumonia during the study period; only the first admission is included to avoid duplicate data.","80 Years",{"count":74,"type":20},400,"Severe pneumonia requires rapid and accurate diagnosis for targeted treatment, but single lung CT has limitations in identifying pathogens and distinguishing infectious\u002Fnon-infectious etiologies. This is a retrospective self-controlled study enrolling patients diagnosed with severe pneumonia at the institution between 2024 and 2025 (recruitment will be extended 6-12 months if fewer than 400 patients are enrolled), all of whom underwent both single lung CT and bronchoscopy-combined CT examinations.\n\nClinical data will be collected retrospectively, including demographic information, bronchoscopic mucosal findings (e.g., congestion, exudation), lung CT lesion characteristics (e.g., consolidation, ground-glass opacity), and gold standard diagnostic results (pathogenic detection or clinical comprehensive diagnosis). The core objective is to compare the diagnostic precision between single lung CT and bronchoscopy-combined CT, focusing on accuracy, sensitivity, and specificity across three etiological subtypes (bacterial\u002Ffungal, viral, non-infectious).\n\nBronchoscopy complements CT by directly visualizing airway mucosal changes, while CT provides panoramic views of pulmonary lesions. Their combination is hypothesized to improve diagnostic accuracy. The findings aim to optimize diagnostic strategies for severe pneumonia, guiding clinicians to select more effective imaging approaches.",[26],[26,78,79,80,81],"Infectious Pathogen Identification","Bronchoscopic Imaging","Lung CT","Retrospective Cohort Study","2026-02-05",{"date":84,"type":31},"2026-02-09",{"date":58,"type":20},{"date":87,"type":20},"2026-12-31",{"name":89,"class":38},"The First Hospital of Jilin University",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":47,"phases":4,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":109,"locationsCount":111},"100524903","microbiome-and-host-susceptibility-in-severe-pneumonia-a-prospective-multicenter-cohort-study-100524903","NCT06114784","Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter, Cohort Study","Identification of Lung and Intestinal Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter Cohort Study","MASS","Inclusion Criteria:\n\n1\\. New lung infection that meets one of the following definitions: the patient receives mechanical ventilation (invasive or non-invasive) due to acute respiratory failure, with a PEEP level of 5cm or above; Patients receiving high flow oxygen therapy with a FiO2 of 50% or more and a PaO2: FiO2 ratio below 300\n\nExclusion Criteria:\n\n1. Expected length of stay in ICU is less than 1 day\n2. Pregnant",{"count":99,"type":20},2000,"This study was a prospective multicenter cohort of severe pneumonia. And by collecting clinical samples to clarify the correlation between lung microbiome, intestinal microbiome, host susceptibility, and prognosis of severe pneumonia patients.",[26],"RECRUITING","2025-08-04",{"date":105,"type":31},"2025-08-07",{"date":107,"type":31},"2023-09-25",{"date":87,"type":20},{"name":110,"class":38},"First Affiliated Hospital of Zhejiang University",15,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":47,"phases":4,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":4},"100588076","herpes-simplex-virus-type-1-infectionreactivation-of-patients-with-severe-pneumoniathe-hsv-sp-study-100588076","NCT06936683","Herpes Simplex Virus Type 1 Infection\u002FReactivation of Patients With Severe Pneumonia（the HSV-SP Study）","Prognostic Effect of Herpes Simplex Virus Type 1 Infection\u002FReactivation in the Lower Respiratory Tract of Critical Care Patients With Severe Pneumonia（the HSV-SP Study）: a Study Protocol for a Multicenter, Prospective Cohort Study","Inclusion Criteria:\n\n* 1: Age\\>18 years old. 2: Clinical diagnosis for severe pneumonia. 3: ICU stay time \\>72 hours. 4: A written informed consent form was obtained from the members of the patients' family.\n\nExclusion Criteria:\n\n* 1: severe ventilation dysfunction, and effective respiratory support has not been used; 2: Aortic aneurysm and esophageal varices at risk of rupture; 3: Recent acute coronary syndrome, uncontrolled severe hypertension, and malignant arrhythmia; 4: Irreversible bleeding tendencies, such as severe coagulation dysfunction, massive hemoptysis, or gastrointestinal bleeding; 5: Multiple pulmonary bullae at risk of rupture. 6: Estimated survival time\\\u003C24 hours. 7: Included in another interventional clinical study.","100 Years",{"count":121,"type":20},323,"Severe pneumonia(SP) is a one of the main causes of death for critically ill patients.Samples of bronchoalveolar lavage fluid (BALF) from SP patients often report positive for herpes simplex virus type 1 (HSV-1) DNA. However, to date, it is unclear the impact and significance of this positive result on SP patients. This study will evaluate the prognostic impact of lower respiratory tract HSV-1 infection\u002Freactivation on ICU severe pneumonia patients.At the same time, by analyzing the risk factors that affect prognosis, we will identify populations with the potential for intervention benefits and provide a basis for further intervention treatment.",[26],[125,126,127,128],"Severe pneumonia","Herpes simplex virus type 1","infection\u002Freactivation","Prognostic effect","2025-04-22",{"date":131,"type":31},"2025-04-25",{"date":133,"type":20},"2025-06-01",{"date":135,"type":20},"2027-10-01",{"name":137,"class":38},"Second Affiliated Hospital of Guangzhou Medical University",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":21,"phases":148,"briefSummary":149,"conditions":150,"keywords":158,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":63},"100564942","enhancing-pediatric-acute-care-through-adaptive-e-learning-and-in-person-skills-practice-in-tanzania-100564942","NCT06635733","Enhancing Pediatric Acute Care Through Adaptive E-Learning and In-Person Skills Practice in Tanzania","A Cluster Randomized Controlled Trial of the Pediatric Acute Care Education (PACE) Program Combining Adaptive E-Learning with In-Person Skills Practice in Tanzania","PACE","Inclusion Criteria:\n\n* Healthcare providers actively involved in pediatric care at one of the selected healthcare centers.\n* Completion of core Pediatric Acute Care Education (PACE) adaptive learning modules prior to study participation.\n* Willingness to participate in In-Person Skills Practice (ISP) sessions.\n* Ability to engage with either the Rhapsode Capable™ platform (intervention group) or paper-based ISP methods (control group).\n* Minimum proficiency in written and spoken English.\n\nExclusion Criteria:\n\n* Healthcare providers not involved in pediatric or newborn clinical care at the time of recruitment.\n* Providers unable or unwilling to attend ISP sessions facilitated by clinical champions.\n* Individuals with no prior engagement in the PACE program.\n* Providers with significant technological barriers that prevent the use of the Rhapsode Capable™ platform (for the intervention group only).",{"count":147,"type":20},100,[23],"The goal of this clinical trial is to evaluate whether the integration of in-person skills practice (ISP) with an adaptive e-learning platform can improve refresher learning progress (RLP) among healthcare providers in pediatric care settings in Tanzania.\n\nThe main questions it aims to answer are:\n\nCan healthcare providers who participate in ISP sessions facilitated by clinical champions achieve greater improvements in refresher learning progress (RLP)? Will providers in the intervention group demonstrate improved metacognition and practical skill performance compared to those in the control group? Researchers will compare healthcare providers using the ISP digital platform (Rhapsode Capable™) to providers using paper-based ISP to see if the digital platform results in significantly higher RLP and fewer skill-based errors.\n\nParticipants will:\n\nComplete adaptive e-learning modules focused on pediatric care topics (e.g., newborn resuscitation, severe malnutrition).\n\nParticipate in ISP sessions where clinical champions provide feedback and assess performance.",[151,152,153,26,154,155,156,157],"Newborn Resuscitation","Severe Malnutrition","Severe Malaria","Severe Dehydration","In-Service Training","Computer-Assisted Instruction","Simulation Training",[159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177],"Pediatric acute care","Newborn resuscitation","Severe malnutrition in children","Severe malaria treatment","Severe dehydration management","Pediatric pneumonia care","In-person skills practice (ISP)","Adaptive e-learning for healthcare providers","Clinical skills training in low-resource settings","Health provider education","Clinical champions","Tanzania healthcare providers","Pediatric emergency training","Blended learning in pediatric care","Refresher learning progress (RLP)","Cluster randomized controlled trial (RCT)","Rhapsode Capable™ platform","Skills assessment in pediatric care","Continuous professional development (CPD) for healthcare providers","2024-10-08",{"date":180,"type":31},"2024-10-10",{"date":182,"type":20},"2025-01-06",{"date":184,"type":20},"2026-12-01",{"name":186,"class":38},"Stanford University",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":72,"enrollmentInfo":193,"targetDuration":4,"studyType":47,"phases":4,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":4},"100557084","rapid-diagnosis-of-severe-respiratory-tract-infectious-diseases-and-screening-of-biomarkers-for-stratified-diagnosis-100557084","NCT06533514","Rapid Diagnosis of Severe Respiratory Tract Infectious Diseases and Screening of Biomarkers for Stratified Diagnosis","Inclusion Criteria:\n\n* Meets the diagnostic criteria for severe pneumonia；\n* Age≥18 years old and \\\u003C 80 years old；\n* Willing to sign informed consent for the course of the study；\n\nExclusion Criteria:\n\n* Patients with intracranial hypertension, acute coronary syndrome, pleural fistula, pneumothorax, or subcutaneous emphysema;\n* Pregnant and lactating patients;\n* Severely hemodynamically unstable (an increase in vasopressors by more than 30% in the first 6 hours, or norepinephrine \\>0.5mg\u002Fkg\u002Fmin);\n* Those who do not consent to participate in this study；",{"count":147,"type":20},"The purpose of this study is to clarify the biomarkers for rapid diagnosis and stratified diagnosis of severe respiratory tract infectious diseases through clinical experiments.",[26,196],"Biomarkers","2024-07-30",{"date":199,"type":31},"2024-08-01",{"date":201,"type":20},"2024-09-01",{"date":203,"type":20},"2025-12-01",{"name":205,"class":38},"Chinese PLA General Hospital",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":47,"phases":4,"briefSummary":215,"conditions":216,"keywords":217,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":63},"100555645","the-application-of-different-sedation-protocols-in-icu-patients-with-severe-pneumonia-100555645","NCT06514781","The Application of Different Sedation Protocols in ICU Patients With Severe Pneumonia","ICU","Inclusion Criteria:\n\n(1)From February 1, 2023, to March 30, 2024, diagnosed with severe pneumonia in the Respiratory Intensive Care Unit of Xiangya Hospital, Central South University. The diagnosis of severe pneumonia is based on meeting at least one major criterion or three or more minor criteria:\n\n1. Major criteria:\n\n   ①Infectious shock requiring vasopressor therapy despite adequate fluid resuscitation;②Respiratory failure requiring tracheal intubation or mechanical ventilation.\n2. Minor criteria:\n\n   * Respiratory rate ≥ 30 breaths\u002Fmin; ②Oxygenation index (PaO2\u002FFiO2) ≤ 250;\n\n     * Involvement of multiple lobes; ④Altered mental status and\u002For disorientation; ⑤Blood urea nitrogen ≥ 20 mg\u002Fdl (7.14 mmol\u002FL); ⑥Systolic blood pressure \\\u003C 90 mmHg requiring aggressive fluid resuscitation. (2)Patients receiving mechanical ventilation who require sedation treatment. (3)Age ≥ 18 years.\n\nExclusion Criteria:\n\n1. Allergic to routine sedative or analgesic medications.\n2. Patients who have not undergone pain and sedation assessment.\n3. Patients transferred to another hospital during treatment.\n4. Patients who abandon treatment and are discharged within less than 72 hours of treatment.",{"count":214,"type":20},600,"This study collected data from 600 patients with severe pneumonia to compare the duration of mechanical ventilation under different sedation regimens in real-world settings. It also evaluated and compared the sedation success rates, hemodynamic changes, and clinical outcomes of patients with severe pneumonia.",[26],[125,218],"Sedative","2024-07-17",{"date":221,"type":31},"2024-07-23",{"date":223,"type":31},"2024-01-01",{"date":225,"type":20},"2024-12-31",{"name":227,"class":38},"Xiangya Hospital of Central South University",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":47,"phases":4,"briefSummary":238,"conditions":239,"keywords":243,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":257},"100555785","fulminant-severe-cap---an-observational-study-100555785","NCT06516601","Fulminant Severe CAP - an Observational Study","Fulminant Cases Among Severe Community-acquired Pneumonia - an Observational Retrospective Study","FULMISCAP","Inclusion Criteria: severe community acquired pneumonia according to ATS\u002FIDSA -\n\nExclusion Criteria: incomplete outcome data\n\n\\-",{"count":237,"type":20},1460,"Severe community-acquired pneumonia (CAP) represents a major cause of hospital mortality. Among severe CAP cases, some exhibit a rapidly progressive evolution, leading to severe ARDS\u002Facute respiratory failure and septic shock within hours to a few days. This type of pneumonia, known as \"fulminant pneumonia,\" is characterized by its rapid onset and deterioration, often necessitating immediate medical intervention. Despite its severity, the true incidence and optimal treatment for fulminant pneumonia are not well understood. This knowledge gap is due to the lack of attention towards pneumonia as a potential time-dependent illness and the separation of overlapping clinical topics: severe pneumonia, ARDS, and sepsis.\n\nIn clinical practice, pneumonia is the most frequent cause of both ARDS and sepsis. However, these conditions are often considered separately, combining ARDS and sepsis from various extra-pulmonary causes with those originating from pneumonia. The COVID-19 pandemic, with its vast number of severe CAP cases in a short period, has highlighted the existence of fulminant pneumonias, underscoring the need for further investigation. Recent randomized clinical trials (RCTs) and experiences from COVID-19 have suggested that early and prolonged corticosteroid administration can reduce mortality in patients with severe SARS-CoV-2 infection and severe CAP\u002FARDS of bacterial origin.\n\nThe aim of this observational study is to analyze the rate of fulminant pneumonia and assess the impact of early corticosteroid treatment in a multicentric population of hospitalized patients with severe pneumonia.",[240,26,241,242],"Community-acquired Pneumonia","ARDS, Human","Sepsis",[244,245,246,247,248],"fulminant pneumonia","community acquired pneumonia","ARDS","sepsis","corticosteroids",{"date":250,"type":31},"2024-07-24",{"date":252,"type":31},"2018-01-02",{"date":254,"type":20},"2024-10-01",{"name":256,"class":38},"University of Trieste",2,{"id":259,"slug":260,"hasResults":11,"nctId":261,"briefTitle":262,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":15,"minAge":264,"maxAge":4,"enrollmentInfo":265,"targetDuration":4,"studyType":47,"phases":4,"briefSummary":267,"conditions":268,"keywords":269,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":63},"100138157","detection-and-characterization-of-lower-respiratory-infections-in-critically-ill-patients-100138157","NCT01068990","Detection and Characterization of Lower Respiratory Infections in Critically Ill Patients","Inclusion Criteria:\n\n* Patients admitting medical ICU with pneumonia\n* Medical ICU admitted patients who is developed new pneumonia\n\nExclusion Criteria:\n\n* Patients already treated more than 48 hours for pneumonia in transferring hospital and no causative organism is isolated","16 Years",{"count":266,"type":20},300,"This study is a prospective observation study for lower respiratory tract infections in medical intensive care unit. Microbiologic and clinical characteristics and outcomes of patients with severe pneumonia in medical intensive care unit will be monitored and analyzed.",[26],[52],"2024-04-17",{"date":272,"type":31},"2024-04-18",{"date":274,"type":4},"2010-03",{"date":276,"type":20},"2028-02-28",{"name":278,"class":38},"Asan Medical Center"]