[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"severe-respiratory-distress-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:severe-respiratory-distress-syndrome":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100581802","phase-1-little-lungs-study-100581802",false,"NCT06855043","Little Lungs Study","Pilot Randomized Controlled Trial of Late Surfactant Therapy With Budesonide for Prevention of Bronchopulmonary Dysplasia","Neonate Inclusion Criteria:\n\n* Gestational age 22 0\u002F7 to 28 6\u002F7 weeks at birth\n* Age 7-14 days\n* Need invasive mechanical ventilatory support and a Fraction of Inspired Oxygen (FiO2) greater than or equal to 0.3\n\nBirthing Parent Inclusion Criteria:\n\n* Have a baby who meets neonate eligibility criteria and enrolls in the study.\n\nNeonate Exclusion Criteria:\n\n* Major congenital anomalies including congenital lung malformations and congenital diaphragmatic hernia and\u002For genetic disorders\n* Alternative, acute clinical etiology of respiratory deterioration or increased ventilatory requirements (e.g., sepsis, pneumonia, etc.)\n* History of pulmonary hemorrhage\n* Antibiotic use within 48 hours\n* Indomethacin or Ibuprofen use within 72 hours\n* Prior treatment with corticosteroids for prevention of lung disease\n* Not expected to survive for greater than 7 days at enrollment\n* Determined to be unstable by the clinical team\n* Enrolled in a conflicting clinical trial\n* Have a birth parent aged less than 18 years\n* Parent\u002Fguardian is unable to provide parental permission in English or Spanish","ALL","7 Days","14 Days",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","This clinical trial is being done to evaluate the safety and clinical response of late surfactant treatment with budesonide in extremely preterm infants requiring mechanical ventilation at 7-14 days of age.",[28,29],"Invasive Mechanical Ventilation","Severe Respiratory Distress Syndrome",[31],"premature birth","NOT_YET_RECRUITING","2026-01-23",{"date":35,"type":36},"2026-01-27","ACTUAL",{"date":38,"type":21},"2026-09",{"date":40,"type":21},"2029-03",{"name":42,"class":43},"University of Wisconsin, Madison","OTHER",2]