[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"severe-sepsis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:severe-sepsis":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100435821","a-multi-center-data-system-and-collaborative-network-in-china-for-severe-infection-and-sepsis-children-100435821",false,"NCT04955210","A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children","Establishment of a Multi-Center Big Data System for Severe Infection and a Collaborative Network on Sepsis in Chinese Children","Inclusion Criteria:\n\n1. Children between 0 and 18 years old.\n2. Severe pneumonia and\u002For sepsis.\n\nExclusion Criteria:\n\n1. notifiable infectious diseases.\n2. The researcher believes that he is not suitable to participate in other situations in this study.\n3. Participants in other clinical trials in the same period.","ALL","29 Days","18 Years",{"count":20,"type":21},5000,"ESTIMATED","OBSERVATIONAL","1\\. To research the current situation of severe infection in children in China, and to investigate the incidence, prognosis and disease burden of severe infection in children in different regions of China. 2. Establish the risk prediction model and diagnosi model of severe infection in children, and verify the accuracy of the model in multi-center; 3. To study the effectiveness and safety of different treatments in real diagnosis and treatment, and to evaluate the efficacy of subgroups under different ages and high risk factors.",[25,26],"Critical Illness","Severe Sepsis",[28,25,29],"Sepsis","severe infection","RECRUITING","2026-03-13",{"date":33,"type":34},"2026-03-16","ACTUAL",{"date":36,"type":34},"2022-04-30",{"date":38,"type":21},"2026-12-31",{"name":40,"class":41},"Children's Hospital of Fudan University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":68,"locationsCount":42},"100156990","alveolar-dead-space-as-predictor-of-organ-failure-in-severe-sepsis-100156990","NCT01315782","Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis","Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation","Inclusion Criteria:\n\n* Adults with severe sepsis or septic shock on mechanical ventilation\n* Enrolled in the initial six hours of ICU admission\n\nExclusion Criteria:\n\n* Patients with withdrawal or hospice order.\n* Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.\n* Patients with COPD.\n* Patients transferred from outside ICU with ongoing sepsis management for more than six hours.",{"count":51,"type":21},30,"This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure.\n\nThe measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.",[28,26,54,55],"Septic Shock","Multi-organ Failure",[28,57,58,59,60],"Severe sepsis","Septic shock","Alveolar dead space","Multi-organ failure","NOT_YET_RECRUITING","2025-06-10",{"date":64,"type":34},"2025-06-11",{"date":66,"type":21},"2026-12",{"date":66,"type":21},{"name":69,"class":41},"The University of Texas Health Science Center, Houston",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":92},"100527082","recovery-from-acute-immune-failure-in-septic-shock-by-immune-cell-extracorporeal-therapy---observational-long-term-outcome-follow-up-100527082","NCT06143137","Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy - Observational Long-term Outcome Follow up","ReActIF- LTO","Inclusion Criteria:\n\n1. Subject or legal surrogate is willing and able to provide written informed consent and comply with all protocol requirements or the implementation of other established procedures according to the local regulations of the contributing center to include subjects who are unable to provide informed consent.\n2. Subject was enrolled in the ReActIF-ICE study and successfully passed the Day 2 re-evaluation of that trial.\n\nExclusion Criteria:\n\n* none","80 Years",{"count":79,"type":21},142,"Subjects previously enrolled \u002F randomized in the ReActIF-ICE (Recovery from acute immune failure in septic shock by immune cell extracorporeal terapy - immune competence enhancement) study received either standard sepsis treatment (control group) or standard sepsis treatment and additionally the ARTICE treatment (treatment group) during their index hospitalization. All subjects are followed up for 90 days after enrollment.\n\nIn this long term follow up study, the enrolled subjects shall be followed up beyond 90 days for up to 5 years.",[26],"2024-08-01",{"date":84,"type":34},"2024-08-02",{"date":86,"type":34},"2024-01-01",{"date":88,"type":21},"2030-02-28",{"name":90,"class":91},"Artcline GmbH","INDUSTRY",2]