[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"severely-burned-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:severely-burned-patients":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100618282","monitoring-the-clinical-and-immunological-effects-of-microbiome-changes-following-severe-burn-injury-100618282",false,"NCT07329595","Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury","microbiome","Inclusion Criteria:\n\n* Adult patients (age between 18 and 65 years) meeting the diagnostic criteria for severe burn injury, burns involving more than 20% of the total body surface area (TBSA) and\u002For inhalation injury.\n* Burn injury caused by scalding, flame, electrical, contact, or chemical exposure\n* Hospital admission within 24 hours following injury\n\nExclusion Criteria:\n\n* Patients with inflammatory bowel diseases or malignant neoplasms.\n* Patients with a history of major gastric and\u002For intestinal resections\n* Patients in a pre-injury ECOG performance status of 4.","ALL","18 Years","65 Years",{"count":20,"type":21},30,"ESTIMATED","OBSERVATIONAL","The aim of this study is to longitudinally monitor dynamic changes in the gut microbiome following severe burn injury using fecal samples. Under standard nutritional protocols and intensive care management, serial fecal sampling is performed to assess alterations in microbiome diversity and composition, as well as the indirect effects of these changes on measurable inflammatory biomarkers, endocrine, hematological, immunological, and other organ-specific parameters, the clinical course, and patient outcomes.",[25,26,27],"Severely Burned Patients","Gut Microbiota Diversity and Composition","Inflammatory Responses",[29,30],"severe burn injury","gut microbiome","RECRUITING","2026-01-06",{"date":34,"type":35},"2026-01-09","ACTUAL",{"date":37,"type":35},"2023-12-01",{"date":39,"type":21},"2026-12-31",{"name":41,"class":42},"Tamas Vegh, MD","OTHER"]