[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sevoflurane\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sevoflurane":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,72,100,123,150,171],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100604699","impact-of-isoflurane-and-sevoflurane-on-oxidative-stress-in-patients-undergoing-laparoscopic-cholecystectomy-100604699",false,"NCT07152912","Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy","A Comparative Study Between the Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Age from 20 to 60 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) Physical Status I-II.\n* Undergoing elective laparoscopic cholecystectomy under general anesthesia.\n\nExclusion Criteria:\n\n* Refusal of participation in the study by patients.\n* Diabetes (type I or II), endocrine system, and immune system diseases.\n* Chronic infection and sepsis.\n* Cardiac condition as classified bythe New York Heart Association (NYHA) \\> class II.\n* Hepatic disease: INR \\> 1.5, and\u002For albumin \\\u003C 2.5 g\u002FdL.\n* Renal disease: glomerular filtration rate (GFR) \\\u003C 85 ml\u002Fmin.\n* Mental and neurological disorders.","ALL","20 Years","60 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","The primary aim of this work is to assess the impact of exposure to isoflurane or sevoflurane as an inhalation anesthetic on the oxidative stress and inflammatory conditions in patients undergoing elective moderate invasive surgery (laparoscopic cholecystectomy).",[27,28,29,30],"Isoflurane","Sevoflurane","Oxidative Stress","Laparoscopic Cholecystectomy","RECRUITING","2025-09-04",{"date":34,"type":35},"2025-09-05","ACTUAL",{"date":32,"type":35},{"date":38,"type":21},"2026-03-01",{"name":40,"class":41},"Ain Shams University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100597736","sevoflurane-with-or-without-intravenous-lidocaine-infusion-versus-propofol-anesthesia-on-intracranial-pressure-and-cerebral-oxygenation-during-laparoscopic-hysterectomy-100597736","NCT07062367","Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy","Effect of Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* American Society of Anesthesiologists (ASA) physical status I and Ⅱ.\n* Body mass index (BMI) ≤35.\n* Females scheduled for laparoscopic hysterectomy.\n\nExclusion Criteria:\n\n* Patients' refusal to participate in the study.\n* Hypersensitivity and allergy to drugs of the study.\n* Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery\n* Any central nervous system or cardiovascular disease, severe hepatic or renal impairment\n* Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery\n* If peak inspiratory pressure (PIP) exceeds 35.","FEMALE","18 Years","65 Years",{"count":54,"type":21},90,[24],"This study will be conducted to evaluate the effects of different anesthetic modalities \\[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).",[28,58,59,60,61,62],"Lidocaine","Propofol","Intracranial Pressure","Cerebral Oxygenation","Laparoscopic Hysterectomy","2025-07-02",{"date":65,"type":35},"2025-07-14",{"date":67,"type":35},"2025-02-01",{"date":69,"type":21},"2027-02-01",{"name":71,"class":41},"Tanta University",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":4,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":42},"100595694","effect-of-sevoflurane-on-sweat-threshold-in-children-of-different-ages-100595694","NCT07035782","Effect of Sevoflurane on Sweat Threshold in Children of Different Ages","Inclusion Criteria:\n\n1. Age: 0-12 years old;\n2. American Society of Anesthesiologists physical status I or II;\n3. Weight within the normal range and body-mass index (BMI) for age between the 25th and 85th percentiles;\n4. scheduled elective lower-body surgery under general anesthesia, expected to last at least 1 hour.\n\nExclusion Criteria:\n\n1. The guardian of the child refused to participate in the study;\n2. Operations involving extensive incisions, such as massive debridement or other operations requiring removal of large amounts of tissue;\n3. Contraindications to esophageal temperature probe insertion (e.g., esophageal varices, congenital anomalies);\n4. Thyroid dysfunction or autonomic dysfunction;\n5. Premature infants (≤1 year old).",true,"12 Years",{"count":81,"type":21},100,[24],"Hypothermia is a common complication in pediatric anesthesia. Hypothermia will prolong the recovery time of anesthesia, and may also lead to increased oxygen consumption, prolonged blood coagulation time, and affect the metabolism of anesthetic drugs and postoperative immune function. Sevoflurane is the most commonly used inhaled anesthetic in children. This study explored the effect of sevoflurane on the sweat threshold of pediatric patients and analyzed the characteristics of body temperature regulation in children of different ages under anesthesia, which will help to understand the mechanism of body temperature regulation in children under anesthesia, and also provide a scientific basis for clinical anesthesia temperature management.",[85,86,87,28],"Child, Only","Temperature Regulation; Disorder","Low Body Temperatures",[89,87,28],"Pediatric Anesthesia","NOT_YET_RECRUITING","2025-06-16",{"date":93,"type":35},"2025-06-25",{"date":95,"type":21},"2025-06",{"date":97,"type":21},"2026-06",{"name":99,"class":41},"Second Affiliated Hospital of Wenzhou Medical University",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":107,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":4},"100585857","comparison-of-sevoflurane-and-propofol-on-ani-100585857","NCT06907823","Comparison of Sevoflurane and Propofol on ANI","Comparison of Sevoflurane and Propofol on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* American society of anesthesiologists physical status class I or II\n\nExclusion Criteria:\n\n* history of drugs that can affect the central nervous system and autonomic nervous system, such as anticholinergics, betablockers, antidepressants..etc.\n* history of allergic reaction to sevoflurane and\u002For propofol\n* history of and\u002For family history of malignant hyperthermia\n* neurodegenerative disorder\n* psychiatric disorder\n* arrhythmia\n* diabetes mellitus\n* drug abuse history","19 Years",{"count":109,"type":21},30,[24],"The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia. The main question it aims to answer is whether propofol anesthesia results in lesser ANI change to a nociceptive stimulation compared to sevoflurane.",[59,28,113],"Analgesia Nociception Index","2025-06-08",{"date":116,"type":35},"2025-06-10",{"date":118,"type":21},"2025-06-30",{"date":120,"type":21},"2025-12-31",{"name":122,"class":41},"Pusan National University Yangsan Hospital",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":78,"sex":16,"minAge":130,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":134,"phases":4,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":42},"100560659","the-eeg-study-under-sevoflurane-anesthesia-in-children-100560659","NCT06580028","The EEG Study Under Sevoflurane Anesthesia in Children","Electroencephalogram Study in Children Under Sevoflurane Anesthesia - a Prospective,Observational Study","Inclusion Criteria:\n\n1. aged 1 days#6 years#;\n2. with American Society of Anesthesiologists (ASA) physical status I or II#;\n3. children requiring general anesthesia under sevoflurane;\n4. parents or legal guardians of children who volunteered to participate in the trial; And signed the informed consent form.\n\nExclusion Criteria:\n\n1. Congenital malformation or other genetic conditions that are thought to affect brain development ;\n2. History of severe heart, brain, liver, kidney and metabolic diseases ;\n3. Premature infants (≤32 weeks);\n4. Upper respiratory tract infection in the last two weeks.","1 Day","6 Years",{"count":133,"type":21},280,"OBSERVATIONAL","Sevoflurane is one of the most commonly used volatile anesthetics in children because of its rapid induction, recovery and recovery properties. Clinical studies using noninvasive brain monitoring have shown that general anesthetics and hypnotics generate electroencephalogram (EEG) oscillations in specific spatial tissues that are fundamentally related to the structure and function of neural circuits. Slow-wave-delta (0.1-4 Hz) oscillations were present in children of all ages, and the advantage of frontal α-wave oscillations appeared at approximately 6 months, began to be consistent at 10 months, and persisted at older ages. Another study, which analyzed EEG under sevoflurane general anesthesia in children aged 0-6 months, found that Theta and alpha wave power decreased with a decrease in sevoflurane concentrations in infants between 4 and 6 months of recovery. However, these studies lack detailed characterization of the neural circuit activity associated with anesthesia, especially at specific developmental ages that are highly correlated with brain plasticity. The aim of this study was to explore electroencephalogram (EEG) of children of different ages under sevoflurane general anesthesia (including anesthesia induction, maintenance and recovery) . By analyzing these EEG data in detail, we hope to be able to better understand the EEG characteristics of children of different ages under sevoflurane anesthesia, and thus develop a neurophysiology pediatric anesthesia status monitoring strategy.",[137,28,138],"Electroencephalography","Child Neglect",[28,140,141],"Children","Electroencephalogram","2025-02-04",{"date":144,"type":35},"2025-02-07",{"date":146,"type":35},"2024-09-04",{"date":148,"type":21},"2026-09",{"name":99,"class":41},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":169,"leadSponsor":170,"locationsCount":42},"100562274","sevoflurane-sedation-as-an-alternative-for-awake-fiberoptic-intubation-in-difficult-airway-patients-100562274","NCT06601036","Sevoflurane Sedation as an Alternative for Awake Fiberoptic Intubation in Difficult Airway Patients","Inclusion Criteria:\n\n* Age from 18 to 50 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-II.\n* Patients with difficult airway (Mallampati grade 3 and 4 with mouth opening less than 5 cm).\n\nExclusion Criteria:\n\n* Patient refusal.\n* Patients with bleeding disorders and nasal mass.\n* Allergy or intolerance to one of the study medications.\n* Patients with uncontrolled systemic diseases.\n* patients with gastro-esophageal reflex.\n* history of nasopharyngeal surgery or drug abuse.","50 Years",{"count":158,"type":21},70,[24],"The aim of this study is to compare patient satisfaction and intubating conditions with fiber optic intubation under sevoflurane sedation versus airway blocks in difficult airway patients",[28,162,163,164],"Sedation","Awake Fiberoptic Intubation","Difficult Airway","2024-09-17",{"date":167,"type":35},"2024-09-19",{"date":165,"type":35},{"date":67,"type":21},{"name":71,"class":41},{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":16,"minAge":179,"maxAge":180,"enrollmentInfo":181,"targetDuration":4,"studyType":22,"phases":183,"briefSummary":185,"conditions":186,"keywords":190,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":4},"100559141","phase-4-low-flow-anesthesia-in-children-undergoing-strabismus-surgery-100559141","NCT06560268","Low Flow Anesthesia in Children Undergoing Strabismus Surgery","Effects of Different Fresh Gas Flows on Emergence Agitation and Anesthetic Agent Consumption in Children Undergoing Strabismus Surgery","LFA in child","Inclusion Criteria:\n\n* 3-10 years old children with strabismus\n\nExclusion Criteria:\n\n* Mental retardation\n* Cardiovascular disease\n* Serebrovasculay disease\n* Renal disease\n* Hepatic disease\n* Pulmonary disease","3 Years","10 Years",{"count":182,"type":21},150,[184],"PHASE4","Emergence agitation (EA) involves restlessness, disorientation, excitation, non-purposeful movement, inconsolability, thrashing, and incoherence during early recovery from general anesthesia. Sevoflurane and desflurane have increased the incidence of EA in children. A proposed explanation for this is that sevoflurane and desflurane cause differential recovery rates in brain function, due to differences in clearance of inhalational anesthetics from the central nervous system; whereas audition and locomotion recover first, cognitive function recovers later, resulting in EA. Low-flow anaesthesia (LFA) occurs when the fresh gas flow (FGF) is significantly lower than the patient's minute volume. In a low-flow system, the recirculated fraction should amount to at least 50% after carbon dioxide (CO2) absorption.In LFA using minimal FGF (250-500 mL\u002Fmin), if the vaporizer is turned off 10-15 minutes before the end of the operation and the FGF is not changed, the inhaled anesthetic agent concentration gradually and slowly decreases to zero and the inhaled agent consumption decreases even more. In a study conducted on infants undergoing cleft lip-palate surgery, it was shown that the incidence of postoperative agitation were statistically lower in infants who administered 0.5 L\u002Fmin FGF.\n\nStrabismus surgery is one of the most frequently performed ophthalmologic operations in children and is associated with moderate postoperative pain and a high incidence of EA (40-86%). The incidence of EA after strabismus surgery is high, especially due to visual disturbances; however, the pathogenesis of this condition remains unclear. In our study, the effects of different FGFs administered in children undergoing strabismus surgery on EA and anesthetic agent consumption will be investigated.",[187,28,188,189],"Low Flow Anesthesia","Strabismus","Emergence Delirium",[191,192,193,194],"emergence agitation","strabismus","children","low flow anesthesia","2024-08-23",{"date":197,"type":35},"2024-08-26",{"date":199,"type":21},"2024-11-04",{"date":201,"type":21},"2025-07-04",{"name":203,"class":41},"Cukurova University"]