[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sexual-wellness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sexual-wellness":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,76,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100635796","assessment-of-sexual-well-being-in-patients-with-gynecologic-cancer-and-their-partners-the-oncosex-study-100635796",false,"NCT07557342","Assessment of Sexual Well-being in Patients With Gynecologic Cancer and Their Partners: the ONCOSEX Study","ONCOSEX","Inclusion Criteria:\n\n* Patients diagnosed with gynecological cancer: malignant ovarian tumor, ovarian tumor of uncertain behavior, cervical cancer, endometrial cancer, uterine sarcoma, vulvar cancer, vaginal cancer\n* Sexually active\n* Women who have a partner\n* Aged between 18 and 75\n* Women of any sexual orientation\n* Understanding and knowledge of the Italian language\n* Signing of the informed consent form\n* Signing of the informed consent form by the partner\n\nExclusion Criteria:\n\n* Benign gynecological conditions\n* Age \\\u003C 18 or \\> 75\n* Virgins or women who are no longer sexually active\n* Women with psychiatric or neurological disorders\n* Women or partners who have already undergone sexual counseling or sex therapy\n* Women who are unable to sign the informed consent form for the study","ALL","18 Years","75 Years",{"count":20,"type":21},200,"ESTIMATED","OBSERVATIONAL","Study type and design This is an observational, exploratory, prospective, longitudinal (cohort), multicenter, non-profit study. Its purpose is to observe changes in sexual function over time without modifying standard clinical care pathways.\n\nBackground and rationale Sexual dysfunctions and the psychological impact of gynecological cancers are often underestimated in clinical practice, despite the World Health Organization recognizing sexual health as a fundamental right. Cultural, personal, and educational barriers frequently hinder an open and systematic discussion of sexual health.\n\nAvailable literature highlights a significant deterioration in sexual quality of life and couple relationships among these patients; however, clear guidance on validated assessment tools and structured sexual counseling pathways is still lacking.\n\nStudy objectives\n\nPrimary objective: to evaluate whether and how sexual function questionnaire scores in patients and their partners change over time at different assessment time points.\n\nSecondary objective: to identify the proportion of patients and partners who would perceive sexual counseling as useful, as well as the preferred timing for such support.\n\nEndpoints\n\nPrimary endpoint: variation in Female Sexual Function Index (FSFI) scores in female patients and International Index of Erectile Function (IIEF-15) scores in male partners between assessment time points (T0-T1, T1-T2, T0-T2).\n\nSecondary endpoint: perceived usefulness of sexual counseling support and preferred timing, based on questionnaire responses.\n\nProcedures and assessment timeline Patients are enrolled at the time of diagnosis communication (T0). The same questionnaire is administered again six months after the start of treatment (T1) and twelve months after completion of therapy or surgery (T2). Participation requires written informed consent, and all data are collected in a pseudo-anonymized format. Partners are enrolled and assessed at the same time points.\n\nAssessment tools\n\nPatients: the validated Female Sexual Function Index (FSFI) questionnaire, plus an additional structured section exploring sexual experience, satisfaction, and difficulties.\n\nPartners: the IIEF-15 questionnaire for male partners; for female partners, the same instruments used for patients are administered.\n\nCollected variables Sociodemographic and clinical data, lifestyle habits, sleep quality, marital status, parity, ongoing or previous therapies, and FSFI and IIEF-15 questionnaire scores.\n\nSample size A total of 200 patients and 200 corresponding partners are expected to be enrolled.\n\nStatistical analysis Data will be analyzed descriptively and longitudinally across the three time points. The primary analysis will use linear mixed-effects models for repeated measures, including random effects for subjects and fixed effects for time and relevant clinical covariates. Predefined subgroup analyses are planned. Statistical significance is set at p \\\u003C 0.05.",[25,26],"Sexual Wellness","Gynecologic Cancers",[28,29,30,31],"gynecologic cancers","sexuality","partner","cancer survivors","RECRUITING","2026-04-22",{"date":35,"type":36},"2026-04-29","ACTUAL",{"date":38,"type":21},"2026-04",{"date":40,"type":21},"2028-04",{"name":42,"class":43},"Casa di Cura Dott. Pederzoli","OTHER",6,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":70,"leadSponsor":72,"locationsCount":75},"100626857","efficacy-and-safety-of-shatavari-root-extract-in-womens-sexual-wellness-100626857","NCT07441083","Efficacy and Safety of Shatavari Root Extract in Women's Sexual Wellness","Efficacy and Safety of Shatavari (Asparagus Racemosus) Root Extract in Women's Sexual Wellness: A Prospective, Randomized, Double-Blind, Two-Arm, Parallel, Placebo-Controlled Study","Inclusion Criteria:\n\n1. Women between 20 to 50 years of age.\n2. Sexually active, attempting sexual activity, or experiencing concerns related to sexual desire or function, with a partner and have a FSFI total score ≤ 26.55.\n3. Have a PSS-10 score of ≥ 14 at screening.\n4. Women presenting with signs and symptoms suggestive of stress (e.g., difficulty, concentrating, physical exhaustion, anxiety, restlessness, insomnia, headache, fatigue, loss of appetite, worry, sweating, mental confusion, etc.).\n5. Participants who are reliable, honest, compliant, and agree to co operate with all trial evaluations as well as to be able to perform them as per investigator's opinion.\n6. Participants having sufficient understanding to communicate effectively with the investigator and are willing to discuss their sexual functioning with the investigative staff.\n7. Able to read and write in English or any other vernacular language.\n8. No plan to commence new treatments over the study period.\n9. Must have the ability and willingness to sign a written informed consent and to comply with all study procedures.\n\nExclusion Criteria:\n\n1. Participants taking any form of herbal extract in the last 3 months before study entry.\n2. Participants with hormonal imbalance including PCOS, and symptoms of perimenopause and menopause\n3. Participants who are on hormone replacement therapy (HRT) for more than 3 months.\n4. Participants with any active medical, surgical, or gynaecological problems.\n5. Participants with a history of alcohol, tobacco dependence, or any other substance abuse\n6. Participants with clinically relevant cardiovascular, gastrointestinal, hepatic, neurologic, endocrine, haematologic or other major systemic diseases making implementation of the protocol or other interpretation of the study result difficult.\n7. Participants with mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study.\n8. Participants with demonstrated inability to comply with the study procedures, including poor compliance.\n9. Participants with inability to attend follow-up visits.\n10. Patients with known hypersensitivity to Shatavari, or any of the ingredients of study interventions.\n11. Patients who had participated in other clinical trials during the previous 3 months.\n12. Patients who have any clinical condition, according to the investigator who does not allow safe fulfilment of clinical trial protocol.",true,"FEMALE","20 Years","50 Years",{"count":57,"type":21},60,"INTERVENTIONAL",[60],"NA","This randomized, double-blind, placebo-controlled clinical study is designed to evaluate the efficacy and safety of a standardized Shatavari (Asparagus racemosus) root extract (SRI-81) in improving women's sexual wellness. Sexual wellness is assessed as a multidimensional construct encompassing sexual function, sexual distress, sexual satisfaction, perceived stress, quality of life, and physiological stress markers. Participants will receive either Shatavari root extract or placebo for 12 weeks, with assessments conducted at baseline and follow-up visits.",[25,63],"Women Health",[65,66],"dietary supplement","shatavari",{"date":68,"type":36},"2026-04-27",{"date":35,"type":21},{"date":71,"type":21},"2026-08-15",{"name":73,"class":74},"SF Research Institute, Inc.","NETWORK",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":52,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":58,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":75},"100607952","the-effect-of-lemongrass-on-aerobic-performance-100607952","NCT07195240","The Effect of Lemongrass on Aerobic Performance","The Effect of Lemongrass on Aerobic Performance and Sexual Wellbeing Following High-Intensity Interval Training Training in Males","Inclusion Criteria:\n\n* Age ≥ 40 and ≤ 60 years.\n* Body Mass Index (BMI) ≥ 19 and ≤ 35 kg\u002Fm2.\n* Willingness and ability to comply with the protocol in the opinion of the Investigator.\n* Judged by the Investigator to be in good health as assessed by a health screening questionnaire.\n* Currently identifies as the same biological sex as at birth.\n* Currently deemed to be between a physical activity status of sedentaryy to moderately trained (Meet World Health Organization minimum activity guidelines: Adults aged 18-64 years old completing at least 150 to 300 min moderate-intensity activity or 75-150 min of vigorous-intensity activity a week, plus muscle-strengthening activities 2 or more days a week).\n* Have a blood pressure \\\u003C 140\u002F90 mmHg.\n\nExclusion Criteria:\n\n* A history of heart disease.\n* Any disease that might interfere with the absorption of nutrients (e.g. Chron's disease, celiac disease).\n* Recent musculoskeletal or soft tissue injury (within the last 3 months).\n* The habitual use of medication that is antihypertensive or antidiabetic medication or might inhibit the ability to complete the study participation.\n* Alcohol Intake of greater than 21 units per week.\n* A change in bodyweight of more than 3kg within the month preceding the study.\n* Currently following a weight-loss or weight-gain programme.\n* Any known bleeding disorder or reaction to withdrawal of blood samples","MALE","25 Years","60 Years",{"count":87,"type":21},40,[60],"The goal of this experimental study is to examine the influence of Lemongrass extract on aerobic training parameters following a 6-week training programme in males. A secondary aim will be to explore the influence on sexual wellness. Participants will attend 23 visits to the laboratory involving:\n\n* fitness testing (some to exhaustion).\n* blood sampling (capillary and venous samples).\n* a supervised 6 week high-intensity interval training (HIIT) programme.\n* consuming either the lemongrass extract or placebo in the form of tablets, once a day during the 6 week training.",[25,91,92],"Aerobic Capacity","Exercise Efficiency","2026-04-08",{"date":95,"type":36},"2026-04-13",{"date":97,"type":36},"2025-10-24",{"date":99,"type":21},"2026-06",{"name":101,"class":43},"Northumbria University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":52,"sex":53,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":58,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":123},"100610967","sexual-well-being-of-women-undergoing-mastectomy-and-reconstruction-100610967","NCT07234461","Sexual Well-being of Women Undergoing Mastectomy and Reconstruction","Sexual Well-being of Women Undergoing Mastectomy and Reconstruction: a National Survey.","Inclusion Criteria:\n\n* Patients undergoing mastectomy for primary breast cancer;\n* High-risk healthy patients undergoing risk reducing mastectomies;\n* Unilateral and\u002For bilateral mastectomies;\n* If unilateral mastectomy, both patients requiring or not contralateral mammaplasty of the healthy breast;\n* All reconstructive procedures included (autologous and heterologous reconstructions).\n\nExclusion Criteria:\n\n* Patients undergoing breast conservation;\n* Patients who previously underwent breast cancer treatment, requiring further surgery for local relapse or secondary breast cancers;\n* Delayed post-mastectomy reconstructions;\n* Patients not available for e-correspondence.",{"count":20,"type":21},[60],"The study plans to collect data from patients on sexual well-being after mastectomy and immediate reconstruction by surveys.\n\nThis data can support preoperative patient counselling and the prevention and care of adverse effects of cancer treatments.\n\nSpecific subpopulations of mastectomy women showing severe sexual impairment can be outlined; they may benefit from lifestyle changes and intervention strategies (intravaginal use of diazepam, local hyaluronic acid, intravaginal use of spermidine, pelvic floor gymnastic and physiotherapy).\n\nOur goal is to improve quality of life of breast cancer patients.",[113,25],"Mastectomy and Breast Reconstruction","2026-02-02",{"date":116,"type":36},"2026-02-04",{"date":118,"type":36},"2026-01-21",{"date":120,"type":21},"2026-10",{"name":122,"class":43},"European Institute of Oncology",19]