[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sexually-transmitted-infection-sti\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sexually-transmitted-infection-sti":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,92],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100589353","assessing-the-effects-of-a-multisectoral-agricultural-intervention-on-the-reproductive-and-sexual-health-of-adolescent-girls-and-young-women-100589353",false,"NCT06953310","Assessing the Effects of a Multisectoral Agricultural Intervention on the Reproductive and Sexual Health of Adolescent Girls and Young Women","Vijana Shamba","Inclusion Criteria:\n\nAdolescent Girls and Young women (AGYW):\n\n* AGYW assigned female at birth\n* Between 15-19 years of age at enrollment\n* Attending the selected schools with at least 18 months remaining of schooling\n* STI-uninfected and not pregnant at baseline\n* Has an adult caregiver willing to participate\n* Demonstrates moderate to severe FI based on the Household Food Insecurity Access Scale (HFIAS), and\u002For malnutrition (BMI less than two standard deviations below the mean for age-specific BMI\n\nCaregiver:\n\n* At least 18 years old.\n* At least 1 AGYW aged 15-19 years old attending the selected schools\n* household has access to farming land\n* household has available surface water in the form of lakes, rivers, ponds, or shallow wells (home is 200m from permanent water source)\n\nExclusion Criteria:\n\n* AGYW or adult caregivers who have inadequate cognitive and\u002For hearing capacity to complete planned study procedures\n* AGYW or adult caregivers who do not speak Dholuo, Kiswahili, or English\n* Married AGYW and those who serve as heads of households\n* AGYW who are pregnant at screening\n\nAdolescent girls who test positive for gonorrhea or chlamydia at screening will be invited to re-screen at least 14 days after receiving treatment and will be eligible to enroll if they have a confirmatory negative STI test.",true,"ALL","15 Years",{"count":20,"type":21},900,"ESTIMATED","INTERVENTIONAL",[24],"NA","In Kenya, HIV incidence among adolescent girls and young women (AGYW) ages 15-24 years is 1-2 per 100 person-years and approximately 30% of AGYW have had at least one sexually transmitted infection (STI). Kisumu and Migori counties in Western Kenya have some of the highest HIV\u002FSTI incidence in the country. Food insecurity (FI) and poverty are also highly prevalent in Western Kenya. FI and poverty are important drivers of vulnerability to HIV and STIs among AGYW. Poverty alleviation interventions have the potential to reduce STIs and HIV risk among AGYW but, to date, these interventions have reported mixed findings on HIV\u002FSTI outcomes, have been primarily targeted at the individual level, and none have focused on agriculture or FI. Therefore, there remains a critical need to develop sustainable, multi-level, economic and FI interventions that improve AGYW STI\u002FHIV prevention outcomes. Our team has successfully developed a household-level agricultural intervention in Western Kenya called Shamba Maisha (\"farm life\" in Kiswahili; SM) to reduce household FI. In our prior pilot study with AGYW, the investigators found that SM was feasible, acceptable, and associated with less FI and improved mental health. In this proposal, the investigators will build upon our promising SM work by examining the effectiveness and implementation of our SM intervention, including provision of a water pump and agricultural implements for use at home, training in agriculture delivered at school-based demonstration farms, and adolescent-caregiver relationship strengthening training. The investigators plan to conduct this school- and home-based cluster randomized trial with 800 AGYW and their primary caregivers recruited from schools in Kisumu and Migori counties. The investigators will randomize 20 schools in Kisumu and Migori in a 1:1 ratio to intervention or control conditions and follow AGYW-caregiver dyads for 18 months with surveys and STI\u002Fpregnancy testing to assess intervention impacts. The study has the following aims: Aim 1. Determine the impact of SM on adolescent HIV prevention and sexual and reproductive health outcomes (primary outcome is gonorrhea and\u002For chlamydia incidence). Aim 2. Assess the effect of SM on intermediate outcomes theorized from our published conceptual framework to be on the causal pathway, including household food security and wealth, and adolescent and caregiver factors including mental health and aspects of the caregiver-AGYW relationship dyad (e.g., communication). Aim 3. Identify critical implementation facilitators and barriers influencing SM effectiveness and delivery and conduct a programmatic cost assessment. The investigators will also evaluate the extent to which SM can have \"spillover\" nutritional benefits for a larger population of adolescents who had access to demonstration farms at intervention schools but did not receive other aspects of the intervention. The ultimate goal is to provide an innovative household-level intervention to halt the cycle of FI, and poor HIV-related outcomes among vulnerable populations including AGYW, consistent with the \"Ending the HIV Epidemic\".",[27,28,29,30],"Sexually Transmitted Infection (STI)","HIV","Food Insecurity","Mental Health",[32,33,34,35,28,36,37],"multisectoral agriculture intervention","sexual and reproductive health","Kenya","adolescent girls and young women","food insecurity","Shamba Maisha","RECRUITING","2026-04-06",{"date":41,"type":42},"2026-04-13","ACTUAL",{"date":44,"type":42},"2025-05-20",{"date":46,"type":21},"2028-05-30",{"name":48,"class":49},"University of California, San Francisco","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":16,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":70,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":91},"100599849","this-study-evaluates-the-alpco-syphilis-t-and-syphilis-nt-clia-kits-for-detecting-syphilis-antibodies-in-serum-and-plasma-samples-from-at-risk-hiv-positive-pregnant-and-healthy-individuals-will-assess-assay-performance-versus-established-comparator-tests-100599849","NCT07089836","This Study Evaluates the ALPCO Syphilis-T and Syphilis-NT CLIA Kits for Detecting Syphilis Antibodies in Serum and Plasma. Samples From At-risk, HIV-positive, Pregnant, and Healthy Individuals Will Assess Assay Performance Versus Established Comparator Tests.","ALPCO Syphilis-T and Syphilis-NT CLIA Kits: Detection of Antibodies to Treponema Pallidum and Against Lipoidal Antigens in Human Serum and Plasma","Inclusion Criteria:\n\n* Male, Female, or Other(s)\n* Patients undergoing routine syphilis testing (asymptomatic at risk, suspected with symptoms, prior history of syphilis, high risk for syphilis) or previously diagnosed with syphilis through a test performed in an accredited laboratory.\n* Participants must be willing to provide the required blood samples for the clinical study, in addition to any samples requested by their physician.\n* Pregnant individuals and children (under 22): 1 clinical study tube of blood.\n* All other participants (excluding pregnant individuals and children): 2 clinical study tubes of blood.\n* Participants must be able and willing to sign the informed consent form (ICF).\n* Participants aged 13 to 17 will be asked to sign an assent form. Written parental or guardian consent will also be required prior to enrollment. The assent form will use age-appropriate language and be reviewed with the participant before any procedures.\n\nExclusion Criteria:\n\n* Patients currently being treated with antibiotics or completed a course of antibiotics within the past 30 days\n* Patients with pre-existing conditions that would make blood collection difficult or harmful\n* If the samples are not collected in strict accordance with the established sampling protocol, as determined by the study team.\n* Any medical, psychological, or social condition that, in the judgment of the investigator, could interfere with the participant's ability to comply with study requirements, or pose a risk to their safety, or compromise the integrity of the study.","13 Years",{"count":60,"type":21},1000,"OBSERVATIONAL","This study will evaluate the clinical performance of two investigational diagnostic kits developed by ALPCO: the Syphilis-T CLIA Kit and the Syphilis-NT CLIA Kit. These kits are designed to detect antibodies to Treponema pallidum and non-treponemal lipoidal antigens, respectively, in human serum and plasma using the automated KleeYa platform. The study will collect and analyze blood samples from individuals suspected of having syphilis, those at high risk, HIV-positive patients, pregnant individuals, and healthy controls. The aim is to determine the kits' Positive Percent Agreement (PPA) and Negative Percent Agreement (NPA) compared to established reference assays.",[64,65,66,67,68,69,27],"Treponema Pallidum","Treponema Pallidum Infection","Syphilis Infection","Serum","Plasma","Blooddraw",[71,72,73,74,75,76,77,78,79,80],"Non Treponema","Treponema","Syphilis","Sample Collection","Treponema pallidum","Non-treponemal test","Chemiluminescent immunoassay","HIV-positive","Pregnant women","Blood sample collection","2026-02-09",{"date":83,"type":42},"2026-02-11",{"date":85,"type":42},"2025-12-10",{"date":87,"type":21},"2026-07",{"name":89,"class":90},"American Laboratory Products Company","INDUSTRY",6,{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":16,"sex":99,"minAge":100,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":50},"100577077","community-burden-of-mg-infection-100577077","NCT06793605","Community Burden of MG Infection","Community Burden of Mycoplasma Genitalium Infection and Its Implications for Test-and-treat Strategies","Inclusion Criteria:\n\n* men who have sex with men aged 18 or above, normally living in Hong Kong, and could communicate in written and spoken English or Chinese\n\nExclusion Criteria:\n\n* cannot provide consent","MALE","18 Years",{"count":102,"type":21},920,"Objective: To assess the burden and the transmission dynamics of Mycoplasma genitalium (MG) infection in men who have sex with men in Hong Kong.\n\nDesign and setting: involving a) a cross-sectional study (completion of an online self-administered survey, followed by self-sampling for testing in the laboratory, and performance of HIV self-test); b) a mathematical modelling study to simulate the transmission dynamics of MG infection and resistant MG infection and compare the impacts of test-and-treat strategies.\n\nParticipants: Around 920 men who have sex with men would be recruited",[27,105],"Mycoplasma Genitalium Infection",[107,108,109,110],"Mycoplasma genitalium","Chlamydia trachomatis","Neisseria gonorrhoeae","men who have sex with men","2025-03-14",{"date":113,"type":42},"2025-03-18",{"date":115,"type":42},"2025-02-18",{"date":117,"type":21},"2027-12-31",{"name":119,"class":49},"Chinese University of Hong Kong"]