[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sham-tdcs\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sham-tdcs":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100544488","combination-of-neurostimulation-and-psychotherapy-to-stop-worrying-100544488",false,"NCT06369532","Combination of Neurostimulation and Psychotherapy to Stop Worrying","Stop Worrying, Learn to Let go Through a Combination of Neurostimulation and Psychotherapy","Inclusion Criteria:\n\n* Generalized anxiety disorder (GAD)\n* Depressive disorder\n\nExclusion Criteria:\n\n* other psychiatric pathology than GAD or depression screened by senior psychiatrist by means of the Mini-International Neuropsychiatric Interview (MINI) and psychiatric anamnesis\n* Abuse of alcohol, drugs or medication other than prescribed by general practitioner or psychiatrist\n* no consent to participate in measurement (questionnaire, fNIRS or EEG)\n* Insufficient knowledge of the current language (Dutch)\n* Acute or chronic suicidality\n* Acute psychosis or manic depressive disorder\n* Inability to commit to 8 sessions of Cognitive-Behavioral Therapy (CBT) or receive 4 weeks of transcranial Direct Current Stimulation (tDCS).","ALL","18 Years","70 Years",{"count":20,"type":21},85,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to investigate whether the combination of transcranial Direct Current Stimulation (tDCS) and cognitive-behavioral therapy (CBT) is more effective for treating repetitive negative thinking (RNT) in patients with the symptom of high rumination. High ruminators will be included (Group1, active tDCS-CBT group; Group2, sham tDCS-CBT group). All patients will receive active or sham tDCS.",[27,28],"Active tDCS","Sham tDCS",[30],"transcranial direct current stimulation","RECRUITING","2026-03-11",{"date":34,"type":35},"2026-03-12","ACTUAL",{"date":37,"type":35},"2024-03-06",{"date":39,"type":21},"2027-12-20",{"name":41,"class":42},"University Hospital, Ghent","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":5},"100591888","tdcs-combined-with-treadmill-training-in-patients-with-multiple-sclerosis-100591888","NCT06986278","tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis","Transcranial Direct Current Stimulation Combined With Treadmill Training With Partial Body Weight Support in Patients With Multiple Sclerosis","TDCS","Inclusion Criteria:\n\n* Ability to understand and follow instructions.\n* Diagnosis of Multiple Sclerosis according to McDonald criteria.\n* Expanded Disability Status Scale (EDSS) between 1 and 6.\n* Stable condition in the last three months.\n\nExclusion Criteria:\n\n* Peripheral neurological injury of lower limbs.\n* Metal objects in the head.\n* Uncontrolled epilepsy.\n* Diagnosis of psychiatric disorder.\n* Fractures or fissures in the skull.\n* Presence of any implanted electronic device (pacemaker, baclofen pump).\n* Presence of ulcers in the harness attachment area.\n* Osteoporotic fractures in the last 2 years.\n* Height \\> 190 cm.\n* Weight \\> 120 kg.",{"count":53,"type":21},78,[24],"This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.",[57,28],"tDCS",[59,60,61,62],"tdcs","gait","multiple sclerosis","gait training","2025-05-22",{"date":65,"type":35},"2025-05-29",{"date":67,"type":21},"2025-05-26",{"date":69,"type":21},"2025-12-31",{"name":71,"class":42},"University of Castilla-La Mancha"]