[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"shock\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:shock":24},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,44,0,25,[9,40,68,101,130,160,191,217,237,257,284,312,337,373,403,430,459,487,515,535,571,600,619,638,658],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100644623","tissue-perfusion-pressure-for-predicting-fluid-responsiveness-in-patients-with-shock-100644623",false,"NCT07670390","Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With Shock","Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With Shock: A Prospective Observational Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Admitted to the Intensive Care Unit (ICU)\n* Diagnosed with shock and evidence of tissue hypoperfusion\n* Judged by the treating physician to require fluid resuscitation\n* Receiving invasive hemodynamic monitoring\n* Written informed consent obtained from the patient or legally authorized representative\n\nExclusion Criteria:\n\n* Pregnancy\n* Immediate requirement for extracorporeal life support, including: VV-ECMO, VA-ECMO, Ventricular assist devices\n* Expected survival less than 72 hours\n* Absence of invasive arterial pressure monitoring or arterial waveform availability \\\u003C25%\n* Any condition deemed unsuitable for study participation by the investigator.","ALL",{"count":19,"type":20},34,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate the ability of tissue perfusion pressure (TPP) to predict fluid responsiveness in critically ill patients with shock and tissue hypoperfusion. Eligible patients requiring fluid resuscitation will undergo a standardized fluid challenge test. Hemodynamic parameters, including cardiac output and TPP, will be recorded before and after fluid administration. Fluid responsiveness will be defined according to the change in cardiac output following fluid loading. The study will assess the correlation between changes in TPP and cardiac output and evaluate the diagnostic performance of TPP for predicting fluid responsiveness. The results may support the use of TPP as a practical and physiologically relevant parameter for individualized fluid management in patients with shock.",[24],"Shock",[26,27],"shock","tissue perfusion pressure","NOT_YET_RECRUITING","2026-06-25",{"date":31,"type":32},"2026-06-26","ACTUAL",{"date":34,"type":20},"2026-07-01",{"date":36,"type":20},"2028-06-01",{"name":38,"class":39},"Jingyuan,Xu","OTHER",{"id":41,"slug":42,"hasResults":12,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100599494","digital-out-of-hospital-management-on-clinical-outcomes-in-patients-with-early-cardiogenic-shock-100599494","NCT07085221","Digital Out-of-hospital Management on Clinical Outcomes in Patients With Early Cardiogenic Shock","Digital Out-of-hospital Management on Clinical Outcomes in Patients With Early Cardiogenic Shock: a Multi-center, Randomized Controlled Clinical Trial","DIGI-CS","Inclusion Criteria\n\n1. Age ≥ 18 years old;\n2. The patient meets the diagnosis of early-stage cardiogenic shock, with SCAI stage A, B, or C during hospitalization; (1) SCAI stage A:\n\nWithout signs of shock and meeting one of the following criteria:\n\n1. Combined with extensive myocardial infarction, diagnosed as widespread anterior wall myocardial infarction based on ST-segment elevation in ECG leads (V1-V5, aVL, I leads), inferior wall combined with right ventricular (II, III, aVF, V3R-V5R leads) and\u002For posterior wall myocardial infarction (V7-V9 leads), or recurrent myocardial infarction within 28 days.\n2. Concurrent acute heart failure or acute exacerbation of chronic heart failure. (2) SCAI stage B-C (meeting the following conditions)\n\n1\\) 60 \\\u003C SBP \\\u003C 90 mmHg or mean arterial blood pressure 50 \\\u003C MAP \\\u003C 60 mmHg or a decrease of \\> 30 mmHg from baseline lasting 30 minutes; or SBP ≥ 90 mmHg but heart rate \u002FSBP \\> 1 lasting \\> 30 minutes.\n\n2\\) The highest arterial blood lactate during hospitalization \\\u003C 5 mmol\u002FL. 3. Stable clinical symptoms at discharge, defined as:\n\n1. SBP ≥ 90 mmHg when vasoactive drugs are not used;\n2. No signs and symptoms of shock. 4. Understand and be willing to sign the informed consent, and be willing to follow the treatment and visit plan required by the protocol.\n\nExclusion Criteria\n\n1. Unable to use a smartphone for out-of-hospital management despite training\n2. The reasons for discharge were treatment withdrawal and transfer to another hospital for continued therapy\n3. Previous or current hospital admission due to cardiac arrest\n4. Refractory cardiogenic shock\n5. Refractory Heart Failure (ACC\u002FAHA guidelines Stage D heart Failure)\n6. Left ventricular ejection fraction \\\u003C 30%\n7. (Estimated) glomerular filtration rate \\\u003C 25 ml\u002Fmin or on dialysis\n8. Severe hepatic insufficiency (Child-Pugh class C)\n9. Severe chronic obstructive pulmonary disease (confirmed by pulmonary function tests, or requiring long-term home oxygen therapy or long-term use of corticosteroids)\n10. History of cardiac surgery\n11. Pregnant or lactating women\n12. Combined with malignant tumors and other serious diseases, the expected life span is less than 1 year\n13. Neuropsychiatric disorders, unable to cooperate with management;\n14. Participation in other clinical trials within the past year;\n15. Other circumstances considered to be inappropriate for this study by the investigator.","18 Years",{"count":50,"type":20},472,"INTERVENTIONAL",[53],"NA","This clinical study was a multi-center, open-label, randomized controlled clinical trial. A total of 472 patients with early-stage cardiogenic shock were recruited and randomly divided into the experimental group and the control group, with 236 cases in each group. The HeartMed-HF digital out-of-hospital management was used to manage the patients in the experimental group, while the patients in the control group were managed according to the discharge guidance. The primary endpoints were 1-year all-cause mortality and unplanned readmission after randomization (excluding emergency department visits). Secondary endpoints (at 3 months, 6 months, and 12 months post-randomization) were: all-cause mortality, rehospitalization for HF, recurrent MI, ischemia-driven repeat revascularization, stroke, BARC 3-5 grade major bleeding, unplanned formal rehospitalization, types of GDMT medications or GDMT target dose achievement rate.",[56,24],"Shock, Cardiogenic","RECRUITING","2026-06-15",{"date":60,"type":32},"2026-06-17",{"date":62,"type":32},"2025-07-26",{"date":64,"type":20},"2028-12-31",{"name":66,"class":39},"Renmin Hospital of Wuhan University",1,{"id":69,"slug":70,"hasResults":12,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":78,"conditions":79,"keywords":84,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100530991","icu-combined-assessment-of-cardio-respiratory-exercise-100530991","NCT06193980","ICU Combined Assessment of Cardio-Respiratory Exercise","Exercise Testing in ICU Survivors to Evaluate ICU-acquired Weakness","ICU-CARE","Inclusion Criteria:\n\n* Patients who have received mechanical ventilation for at least 7 days in the intensive care unit (ICU) and have subsequently been discharged from hospital.\n\nExclusion Criteria:\n\n* Unable to provide consent\n* Trajectory of health expected to be significantly limited in the upcoming 12 months\n* those who self-report that they cannot climb at least one flight of stairs due to limited exercise capacity\n* have significant orthopedic or musculoskeletal impairment affecting mobility\n* have a medical history of neuromuscular disease\n* ongoing respiratory limitations (i.e., supplemental oxygen)\n* significant heart disease (i.e. ejection fraction less than 30%, unstable ischemic heart disease, severe valvular heart disease)\n* a body mass index (BMI) of ≥ 40 kg\u002Fm2 (impacting NIRS signal due to adipose tissue thickness)\n* if participant's primary residence is a significant distance from the participating study site",{"count":77,"type":20},50,"This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness\u002Fdysfunction or ICU-Acquired Weakness (ICU-AW) and exercise limitations.",[80,81,24,82,83],"ICU Acquired Weakness","Sepsis","Critical Illness","Microcirculation",[85,86,83,87,88,89,90,91],"ICU Survivors","Oxygen Delivery","skeletal muscle","Exercise","near-infrared spectroscopy","cardiopulmonary exercise test","cardiovascular physiology","2026-06-11",{"date":58,"type":32},{"date":95,"type":32},"2023-12-15",{"date":97,"type":20},"2029-12",{"name":99,"class":39},"University of Manitoba",2,{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":111,"conditions":112,"keywords":115,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":67},"100634279","right-ventriculo-arterial-coupling-during-fluid-loading-in-icu-patients-100634279","NCT07537621","Right Ventriculo-Arterial Coupling During Fluid Loading in ICU Patients","Prospective Observational Study of Right Ventriculo-arterial Coupling Changes During Fluid Loading and Their Relationship With Congestion Parameters in Critically Ill Adults","RVPA-FLICU","Inclusion criteria:\n\n* Critically ill hospitalized patients\n* Age ≥ 18 years\n* Patients undergoing fluid loading at the discretion of the attending physician, following prediction of fluid responsiveness using any recommended maneuver or dynamic parameter, in the setting of acute circulatory failure requiring vasopressor support and\u002For mean arterial pressure \\\u003C 65 mmHg (or a decrease of ≥ 30 mmHg from baseline in patients with chronic hypertension), and\u002For other signs of hemodynamic instability (tachycardia, mottling, oliguria, hyperlactatemia)\n* Affiliated with a national health insurance system\n\nExclusion criteria :\n\n* Formal refusal from the patient or legally representative after information\n* Patients transferred from another intensive care unit\n* Pregnant or postpartum patients\n* Acute respiratory distress (defined as respiratory rate ≥ 35 breaths\u002Fmin and\u002For signs of increased work of breathing)\n* Ongoing acute coronary syndrome\n* Acute or pulmonale (defined by right ventricular dilation associated with paradoxical septal motion related to an abrupt increase in right ventricular afterload)\n* Primary pulmonary arterial hypertension\n* Intra-abdominal hypertension (intravesical pressure \\> 15 mmHg)\n* Poor echogenicity precluding adequate echocardiographic assessment of the right ventricle\n* Severe valvular heart disease or early postoperative period following valvular surgery",{"count":110,"type":20},100,"Preload responsiveness and venous congestion have largely been investigated independently in recent literature. However, recent data report a similar incidence of venous congestion regardless of fluid responsiveness status, challenging the concept of a linear continuum between preload independence and fluid intolerance. These findings support the need for a more individualized hemodynamic management strategy that takes venous congestion risk into account.\n\nThe right ventricle plays a central role in this framework. Its function is to maintain an adequate venous return pressure gradient to ensure cardiac output while limiting upstream venous congestion, under strong dependence on its afterload. In physiological conditions, the right ventricle adapts to changes in afterload by increasing contractility to preserve right ventriculo-arterial coupling and optimize its performance.\n\nIn chronic cardiopulmonary diseases, right ventriculo-arterial uncoupling is a well-established prognostic factor, including the presence of occult uncoupling revealed by fluid loading. In critically ill patients, right ventricular systolic dysfunction associated with venous congestion-defining right heart failure-is strongly associated with increased mortality, as is right ventriculo-arterial uncoupling itself.\n\nTo support the concept of fluid tolerance, the investigators hypothesize that impairment of right ventriculo-arterial coupling may exist or occur during fluid loading in critically ill patients, independently of preload responsiveness, and may be associated with worsening upstream venous congestion.",[24,113,114],"Right Ventricular Dysfunction","Venous Congestion",[116,117,118,119,120],"Right ventriculo-arterial coupling","Fluid loading","Venous congestion","VEXUS score","Critical care echocardiography","2026-06-09",{"date":123,"type":32},"2026-06-10",{"date":125,"type":32},"2026-06-03",{"date":127,"type":20},"2029-06-04",{"name":129,"class":39},"CHU de Reims",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":141,"conditions":142,"keywords":143,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":4},"100643770","cruise-system-in-flight-100643770","NCT07637240","CRUISE System in Flight","CRUISE Blinded STAT Helicopter Study","CRUISE","Inclusion Criteria:\n\n* All adult patients with signs of shock evaluated, treated, and\u002For transported by Emergency Medical Services under medical oversight of UPMC EMS Medical Directors and\u002For arriving at UPMC facilities with which the PI and Co-investigators routinely have access to the records.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Active atrial fibrillation or irregular rhythm\n* Open chest\n* Known right ventricular failure","100 Years",{"count":140,"type":20},60,"This is a prospective, observational, blinded clinical study with the purpose of assessing the safety of a non-invasive decision support system for the identification and management of shock (the CRUISE system). Researchers will compare the recommendations provided by the CRUISE system with those executed as part of the standard of care by transport paramedics and medics in acute ill adult critically ill patients in shock or requiring active resuscitation being transported by helicopter (STAT MedEvac) to Presbyterian Hospital.\n\nPlanned total enrollment is 60 patients.",[24],[144,24,145,146,147,148,149,150,151],"Helicopter","Transport","Resuscitation","Trauma","Medical","Device","STAT Medvec","Emergency","2026-06-05",{"date":121,"type":32},{"date":155,"type":20},"2026-07",{"date":157,"type":20},"2027-09",{"name":159,"class":39},"Hernando Gomez",{"id":161,"slug":162,"hasResults":12,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":170,"conditions":171,"keywords":175,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":67},"100640925","peripheral-pulse-assessment-and-arterial-pressure-pulsar-100640925","NCT07609095","Peripheral pULSe Assessment and Arterial pRessure (PULSAR)","Association Between Palpable Peripheral Pulses and Arterial Blood Pressure in Patients With Circulatory Shock: An International Prospective Multicenter Observational Cohort Study","PULSAR","Inclusion Criteria:\n\n* Clinical signs of circulatory shock or impending circulatory failure\n* Availability of non-invasive and\u002For invasive arterial blood pressure monitoring\n* Pulse palpation possible without interfering with emergency care\n\nExclusion Criteria:\n\n* Peripheral vascular conditions preventing reliable pulse palpation\n* Major extremity amputation affecting assessment sites\n* Clinical situations where study procedures interfere with life-saving treatment",{"count":169,"type":20},5000,"This prospective multicenter observational study aims to investigate the relationship between palpable peripheral pulses and simultaneously measured arterial blood pressure in adult patients with circulatory shock or impending circulatory failure. Peripheral pulse palpation is routinely used in emergency medicine, trauma care, critical care, and cardiopulmonary resuscitation as a rapid clinical assessment of circulation. However, the association between palpable pulses and actual arterial blood pressure remains poorly validated.\n\nPatients treated in emergency departments, intensive care units, operating rooms, and other acute care settings will undergo routine pulse palpation at predefined anatomical locations including carotid, femoral, and radial arteries. Simultaneously measured non-invasive and\u002For invasive arterial blood pressure values will be recorded from routine clinical monitoring systems. Additional clinical variables relevant to circulatory status will also be collected.\n\nThe study seeks to define blood pressure thresholds associated with pulse palpability and evaluate the agreement between invasive and non-invasive blood pressure measurements in patients with circulatory shock.",[172,173,174,24,82],"Circulatory Shock","Hemodynamic Instability","Hypotension",[172,176,177,178,179,174,180,147,146,173],"Hemodynamic Monitoring","Pulse Palpation","Peripheral Pulse","Arterial Blood Pressure","Critical Care","2026-05-19",{"date":183,"type":32},"2026-05-27",{"date":185,"type":20},"2026-06-01",{"date":187,"type":20},"2031-12-31",{"name":189,"class":190},"Region Stockholm","OTHER_GOV",{"id":192,"slug":193,"hasResults":12,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":198,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":199,"conditions":200,"keywords":203,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":67},"100634974","prediction-of-fluid-responsiveness-using-the-femoral-vein-to-artery-diameter-ratio-100634974","NCT07546656","Prediction of Fluid Responsiveness Using the Femoral Vein-to-Artery Diameter Ratio","Prediction of Fluid Responsiveness Using the Femoral Vein-to-Artery Diameter Ratio: A Prospective Observational Study","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Admission to the intensive care unit where the study is being conducted\n* Receiving invasive mechanical ventilation\n* Clinical indication for a fluid challenge due to acute circulatory failure or shock, as determined by the responsible intensive care physician\n* PiCCO monitoring already in place as part of routine clinical care\n* Clinical conditions allowing collection of pre- and post-fluid challenge cardiac index and ultrasonographic measurements\n* Technical feasibility of femoral vein and femoral artery diameter measurements by ultrasonography\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Failure to obtain written informed consent from the patient or legally authorized representative before enrollment\n* Absence of PiCCO monitoring as part of routine clinical care or no clinical plan for fluid challenge\n* Inability to complete pre- and post-fluid challenge measurements (e.g., early death, urgent surgery, transfer)\n* Local conditions preventing reliable femoral ultrasonographic assessment, including open wound, infection, dressing, major anatomic obstacle, poor image quality, known femoral vein thrombosis, or severe vascular pathology on the relevant side\n* Conditions likely to significantly impair the reliability of thermodilution measurements (e.g., severe tricuspid regurgitation or significant intracardiac shunt)\n* Major treatment changes during the fluid challenge that preclude comparable measurements (e.g., major vasopressor dose change, major ventilator setting change, new arrhythmia)\n* Missing or inadequate data judged by the investigators to compromise data integrity, including absence of measurements required for the primary outcome",{"count":110,"type":20},"This prospective single-center observational study aims to evaluate whether the ultrasound-measured femoral vein-to-femoral artery diameter ratio can predict fluid responsiveness in mechanically ventilated adult intensive care patients with acute circulatory failure or shock. Only patients who already have PiCCO monitoring as part of routine clinical care and for whom a fluid challenge is clinically indicated will be included. No additional invasive procedure will be performed for study purposes. Cardiac index will be measured with PiCCO before and after administration of 500 mL balanced crystalloid over 10 minutes, and femoral vein and femoral artery diameters will be measured by bedside ultrasonography. Fluid responsiveness will be defined as an increase of more than 10% in cardiac index after fluid administration. The study will assess the diagnostic performance of the femoral vein-to-femoral artery diameter ratio as a practical bedside parameter to support hemodynamic decision-making in critically ill patients.",[201,202,24],"Fluid Responsiveness","Acute Circulatory Failure",[201,24,202,176,204,205,206,207],"Ultrasonography","Femoral Vein","Femoral Artery","PiCCO","2026-05-07",{"date":210,"type":32},"2026-05-11",{"date":212,"type":32},"2026-05-01",{"date":214,"type":20},"2027-03-01",{"name":216,"class":39},"Istanbul University - Cerrahpasa",{"id":218,"slug":219,"hasResults":12,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":225,"targetDuration":226,"studyType":21,"phases":4,"briefSummary":227,"conditions":228,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":232,"completionDateStruct":233,"leadSponsor":235,"locationsCount":67},"100635002","hemodynamic-profiles-and-macro-microcirculatory-coherence-in-liver-transplantation-an-integrative-approach-in-the-immediate-postoperative-period-100635002","NCT07547020","Hemodynamic Profiles and Macro-Microcirculatory Coherence in Liver Transplantation: an Integrative Approach in the Immediate Postoperative Period","Hemodynamic Profiles and Macro-Microcirculatory Coherence in Liver Transplantation: An Integrative Approach to the Immediate Postoperative Period","COHERENCE-LT","Inclusion Criteria: Consecutive adult patients (≥18 years) admitted to the intensive care unit in the immediate postoperative period following liver transplantation with hemodynamic instability.\n\n\\-\n\nExclusion Criteria: Primary graft failure.\n\n\\-",{"count":140,"type":20},"30 Days","Hemodynamic instability is a common and serious condition in patients undergoing liver transplantation and is associated with increased morbidity and mortality if not promptly recognized and treated. It results from multiple interacting factors, including blood loss, changes in vascular tone, cardiac dysfunction, and complications related to the surgical procedure.\n\nTraditional monitoring strategies focus on global hemodynamic variables such as blood pressure and cardiac output. However, these parameters may not accurately reflect tissue perfusion or oxygen delivery at the microcirculatory level. As a result, patients may appear hemodynamically stable while still experiencing inadequate tissue oxygenation.\n\nThis study aims to evaluate hemodynamic instability using an integrative physiological approach based on the interaction between different components of the cardiovascular system. Specifically, the study will assess four key interfaces: the relationship between the heart and the arterial system, the coherence between macrocirculation and microcirculation, the interaction between venous return and the right atrium, and the coupling between the right ventricle and the pulmonary circulation.\n\nThe main objective is to identify distinct hemodynamic profiles in patients during the immediate postoperative period following liver transplantation. In addition, the study will evaluate the incidence of tissue hypoxia within the first 24 hours and its association with clinical outcomes, including 30-day evolution.\n\nThis is a prospective observational study conducted in adult patients admitted to the intensive care unit after liver transplantation who develop hemodynamic instability requiring vasoactive support. During the first 24 hours, multimodal hemodynamic monitoring will be performed, including assessment of cardiac function, vascular tone, venous congestion, pulmonary circulation, and markers of tissue perfusion such as lactate levels and capillary refill time.\n\nBy integrating these variables, patients will be classified into different hemodynamic profiles according to the predominant underlying mechanism. This approach aims to improve the understanding of cardiovascular dysfunction in this setting and to support more individualized and physiologically guided management strategies.",[229,24,173],"Liver Transplantation","2026-04-27",{"date":212,"type":32},{"date":212,"type":20},{"date":234,"type":20},"2027-09-01",{"name":236,"class":39},"Hospital El Cruce",{"id":238,"slug":239,"hasResults":12,"nctId":240,"briefTitle":241,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":51,"phases":245,"briefSummary":246,"conditions":247,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":4},"100628911","a-proof-of-concept-study-of-ultrasound-stimulation-of-the-neck-to-enhance-anti-shock-efficacy-100628911","NCT07467798","A Proof-of-concept Study of Ultrasound Stimulation of the Neck to Enhance Anti-shock Efficacy","Inclusion Criteria:\n\n* Patients with shock who are ≥18 years of age and have a systolic blood pressure (SBP) between 60 mmHg and 90 mmHg;\n* Patients with arterial blood pressure monitoring or peripheral arterial pressure monitoring with intervals of single-digit minutes;\n* Patients with mild to moderate shock with a shock index (SI) of 1 ≤ SI ≤ 2;\n* Patients with complete medical records.\n\nExclusion Criteria:\n\n* Patients with unstable condition and estimated survival time \\\u003C24 hours;\n* Patients requiring emergency surgery to achieve control of their condition;\n* Perioperative patients requiring surgery due to conditions other than hypotension;\n* Pregnant or lactating patients;\n* Patients with neck wounds and\u002For carotid artery plaques who are unsuitable for ultrasound stimulation of the left carotid sinus;\n* Patients deemed unsuitable for inclusion by the investigator.",{"count":244,"type":20},30,[53],"The objective of this clinical study is to evaluate the initial efficacy and safety of LIPUS as an adjunct to standard therapy in patients with shock. The investigators will invite patients to participate in a proof-of-concept study investigating the efficacy of neck ultrasound stimulation to enhance anti-shock treatment, involving brief exposure to low-intensity pulsed ultrasound. This study examines whether LIPUS can enhance blood pressure in patients with shock, improve the efficacy of antihypotensive treatment, and reduce the dosage and duration of vasoactive drugs during active pharmacological therapy. By applying LIPUS as an adjunct to conventional treatment in clinical cases of shock, we aim to determine the clinical value of LIPUS and establish a theoretical foundation for developing innovative new therapies for shock.",[24],"2026-04-17",{"date":250,"type":32},"2026-04-22",{"date":252,"type":20},"2026-05",{"date":254,"type":20},"2027-11",{"name":256,"class":39},"Tao Liu",{"id":258,"slug":259,"hasResults":12,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":265,"enrollmentInfo":266,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":268,"conditions":269,"keywords":270,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":283},"100551471","the-prevalence-of-the-aortic-to-radial-pressure-gradient-in-states-of-shock-outside-the-context-of-cardiac-surgery-a-prospective-study-100551471","NCT06460519","The Prevalence of the Aortic to Radial Pressure Gradient in States of Shock, Outside the Context of Cardiac Surgery, a Prospective Study","Prevalence of the Aortic to Radial Pressure Gradient in States of Shock","PARECHOC","Inclusion Criteria:\n\n* age superior or equal 18 years\n* Vasopressors support superior or equal 0.5 µg\u002Fkg\u002Fmin of equivalent norepinephrine\n* Invasive monitoring of blood pressure with a radial arterial catheter and a femoral arterial catheter decided by de physician\n* Beginning of the shock less than 48 hours.\n* Consent\n\nExclusion Criteria:\n\n* perioperative of cardiac surgery (between the beginning of the surgery and 7 days after)\n* pregnant woman or breast-feeding\n* Major person under protection\n* Person with privation of liberty by a justice decision, or an administrative decision","99 Years",{"count":267,"type":20},180,"First described in cardiac surgery, the aortic to radial pressure gradient (ATRAP) is the cause of an underestimation of the aortic pressure with a measure assumed with a radial catheter, and he can concert 1 of 3rd patients. The risks factor well known are small height, previous hypertension, long and difficult surgery, radial artery diameter less than 1.8mm.\n\nThe ATRAP definition is a pressure difference between radial and femoral (same of the aortic pressure) pressure of 25mmHg on the systolic pressure, or a pressure difference on the mean pressure of 10mmHg, both measures realised by arterial canulation, and with a duration superior than 5 minutes.\n\nIf this gradient appears in pathophysiological specifics situations, there is a risk of inappropriate administration of vasopressors, with more hospitalisation days, more side effect of vasopressors like an augmentation of myocardial work.\n\nThe ATRAP is documented in septic shock with a prevalence between 21% and 27%. The ATRAP can appear in shocks, moreover with doses of equivalent norepinephrine of 0.5 µg\u002Fkg\u002Fmin who is use for the definition of refractive shock, the difference between the two pressure is higher if the dose of equivalent norepinephrine is higher than 1µg\u002Fkg\u002Fmin. But the prevalence and risks factors are barely unknowns in this situation.\n\nMost of the time, a radial arterial catheter is used for hemodynamic monitoring for his simplicity of utilisation and the lows complications associated. Some medical teams in cardiac surgeries, or in intensive care unit (ICU) for the management of shocks used often radial and femoral arterial catheter. It seems there is no at risk for the utilisation of a radial and femoral arterial canulation.\n\nOut of the situation of cardiac surgery, there is a lack of information of the ATRAP, the objective of the study is to evaluate the prevalence of the ATRAP in shock, out of the situation of cardiac surgery.",[24],[271,272,273,274],"Radial artery","Femoral artery","Norepinephrine equivalent","Intensive care unit","2026-04-14",{"date":248,"type":32},{"date":278,"type":32},"2024-10-03",{"date":280,"type":20},"2027-11-03",{"name":282,"class":39},"Hospices Civils de Lyon",6,{"id":285,"slug":286,"hasResults":12,"nctId":287,"briefTitle":288,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":290,"enrollmentInfo":291,"targetDuration":292,"studyType":21,"phases":4,"briefSummary":293,"conditions":294,"keywords":295,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":67},"100594529","assessment-of-stroke-volume-in-shock-using-echocardiography-versus-bioreactive-impedance-100594529","NCT07020637","Assessment of Stroke Volume in Shock Using Echocardiography Versus Bioreactive Impedance","Inclusion Criteria\n\n* Age ≥ 18 years\n* Clinical diagnosis of shock as determined by the treating ICU physician (e.g., hypotension requiring vasopressors or evidence of end-organ hypoperfusion)\n* Able to obtain informed consent from the patient or a legally authorized representative\n* Enrollment within 24 hours of ICU admission\n\nExclusion Criteria:\n\n* Pregnancy\n* Known severe aortic valve disease or dynamic left ventricular outflow tract obstruction\n* Morbid obesity (BMI \\> 40) that precludes accurate echocardiographic imaging Presence of cardiac arrhythmias (e.g., atrial fibrillation with rapid ventricular response) affecting stroke volume measurements\n* Implanted cardiac assist devices (e.g., LVAD, pacemaker dependency)\n* Imminent death or decision for comfort care only","90 Years",{"count":244,"type":20},"1 Day","This study aims to evaluate the correlation between stroke volume measurements obtained by transthoracic echocardiography and bioreactance-based noninvasive cardiac output monitoring. The primary objective is to assess the level of agreement between these two modalities in critically ill patients.",[24,82],[296,297,298,299,300,301,302],"Cheeta NICOM","Bioreactance","Transthoracic Echocardiography","Passive Leg Raising","Stroke Volume","Shock Assssment","Noninvasive Cardiac Output Monitoring","2026-04-13",{"date":305,"type":32},"2026-04-15",{"date":307,"type":32},"2024-10-19",{"date":309,"type":20},"2026-04-30",{"name":311,"class":39},"University of Nevada, Las Vegas",{"id":313,"slug":314,"hasResults":12,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":318,"eligibilityCriteria":319,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":320,"targetDuration":4,"studyType":51,"phases":321,"briefSummary":322,"conditions":323,"keywords":324,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":100},"100489587","effects-of-increasing-mean-arterial-pressure-on-renal-function-in-patients-with-shock-and-with-elevated-central-venous-pressure-100489587","NCT05655065","Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure","Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure : a Pilot Study for the Individualization of Mean Arterial Pressure","MAPAKI","Inclusion Criteria:\n\n* Adult patients (≥ 18 years old )\n* Arterial hypotension requiring the etablishment of catecholamines\n* Norepinephrine dose ⩾ 0.1µg\u002Fkg\u002Fmin at the inclusion\n* High central venous pressure ≥ 12mmHg\n* Cardiac output monitoring (PICCO or Swan Ganz)\n\nExclusion Criteria:\n\n* Anuria\n* Patient with an emergency indication of renal replacement therapy (severe hyperkalemia, severe metabolical acidosis with pH \\\u003C7.15, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration \\> 40 mmol\u002Fl)\n* Pregnant, lactating or parturient woman\n* Patient deprived of liberty by judicial or administrative decision\n* Patient with psychiatric compulsory care\n* Patient subject to legal protection measures\n* Patients with do-no-reanimate order or withdrawal of life sustaining support",{"count":244,"type":20},[53],"The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure.",[24],[325,326,327],"mean arterial pressure","central venous pressure","Renal function","2026-03-31",{"date":330,"type":32},"2026-04-06",{"date":332,"type":32},"2023-01-02",{"date":334,"type":20},"2026-12-31",{"name":336,"class":190},"University Hospital, Angers",{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":17,"minAge":344,"maxAge":345,"enrollmentInfo":346,"targetDuration":345,"studyType":21,"phases":4,"briefSummary":347,"conditions":348,"keywords":356,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":371,"locationsCount":67},"100613980","characterization-of-extracellular-vesicles-from-the-cord-blood-of-extremely-preterm-new-borns-and-their-correlation-with-severe-morbidity-and-mortality-100613980","NCT07273643","Characterization of Extracellular Vesicles From the Cord Blood of Extremely Preterm New Borns and Their Correlation With Severe Morbidity and Mortality","VEEP","Inclusion Criteria:\n\n* Mother over 18 years old, able to speak and understand French\n* Newborn less than 28 weeks of gestation, born and hospitalized at Montpellier University Hospital\n* Umbilical cord venous blood collected immediately after birth (from the segment between the cord clamp and the placenta), with a volume of 10 ml (which can be reduced to 3 ml if collection is difficult) into an EDTA tube.\n* Parental non-opposition to the study obtained before sample collection\n\nExclusion Criteria:\n\n* Stillborn infant\n* Handling failure: failure to collect the sample or start the first centrifugation more than 3 hours after birth\n* General regulatory criteria: failure to obtain parental non-opposition, lack of social security coverage, individuals under legal guardianship, or participation in another ongoing research study with an active exclusion period","0 Days","3 Months",{"count":244,"type":20},"This study aims to understand the role of extracellular vesicles (EVs) in extremely premature infants, those born before 28 weeks of gestation. EVs are tiny particles released by cells that carry important information about the body's condition. In extremely premature infants, blood vessels may not function properly, leading to serious health problems such as bleeding in the brain, lung injury, or severe infections.\n\nResearchers believe that analyzing EVs in the umbilical cord blood of these infants may help predict which babies are at higher risk of developing these complications. By studying the size, number, and type of EVs, the team hopes to identify early markers that can guide doctors in providing better care.\n\nThe study will collect cord blood from 30 eligible infants born at the CHU of Montpellier. Blood samples will be processed to isolate platelet-poor plasma, which contains EVs. This plasma will be stored in a biobank, allowing future research on EVs and their role in extreme prematurity. EVs will then be analyzed in the laboratory to assess their characteristics and any links to severe health issues.\n\nThe findings from this study could improve understanding of circulatory problems in extremely premature infants, help identify early predictors of severe complications, and inform better monitoring and treatment strategies. The creation of a plasma biobank also provides a valuable resource for future research to enhance care and outcomes for this vulnerable population.",[349,350,351,352,353,24,354,355],"Intraventricular Hemorrhage","Pulmonary Hemorrhage","Death","ELGAN (22-28SA)","Bronchopulmonary Dysplasia (BPD)","Extracellular Vesicles","Enterocolitis, Necrotizing",[357,358,359,360,361,362,363],"ELGAN","Extremely Low Gestational Age Newborn (ELGAN)","Extracellular vesicles","EVs","Intraventricular hemorrage","Pulmonary hemorrhage","Bronchopulmonary Dysplasia","2026-02-19",{"date":366,"type":32},"2026-02-23",{"date":368,"type":32},"2026-01-13",{"date":370,"type":20},"2027-10-13",{"name":372,"class":39},"University Hospital, Montpellier",{"id":374,"slug":375,"hasResults":12,"nctId":376,"briefTitle":377,"officialTitle":378,"acronym":4,"eligibilityCriteria":379,"healthyVolunteers":12,"sex":17,"minAge":380,"maxAge":4,"enrollmentInfo":381,"targetDuration":4,"studyType":51,"phases":383,"briefSummary":384,"conditions":385,"keywords":388,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":67},"100624544","enteral-versus-parenteral-nutrition-during-recovery-after-shock-100624544","NCT07411014","Enteral Versus Parenteral Nutrition During Recovery After Shock","Enteral Versus Parenteral Nutrition During Early Recovery in the Critically Ill After Shock: A Prospective, Multicenter, Open-label, Randomized Controlled Study","Screening Criteria:\n\n* Subjects must be at least 19 years of age at the time of screening.\n* Subjects must be admitted to the intensive care unit (ICU).\n* Subjects must be receiving vasopressor therapy for shock.\n* Subjects must have a documented history of maximum vasopressor requirement with a vasopressor-inotropic score (VIS) of 12 or greater, calculated as follows:\n\nVIS = dopamine dose (µg\u002Fkg\u002Fmin) + dobutamine dose (µg\u002Fkg\u002Fmin) + 10 × milrinone dose (µg\u002Fkg\u002Fmin) + 100 × epinephrine dose (µg\u002Fkg\u002Fmin) + 100 × norepinephrine dose (µg\u002Fkg\u002Fmin) + 10,000 × vasopressin dose (U\u002Fkg\u002Fmin)\n\nInclusion Criteria:\n\n* Subjects must meet all screening criteria.\n* Subjects must have central venous access suitable for the administration of parenteral nutrition (PN).\n* Subjects must demonstrate a decreasing vasopressor requirement, defined as a current VIS of 12 or less at the time of enrollment.\n\nExclusion Criteria:\n\n* Subjects with contraindications to enteral nutrition (EN) or parenteral nutrition (PN) at the time of enrollment will be excluded.\n* Subjects requiring specific nutritional management, including but not limited to long-term home enteral nutrition, long-term parenteral nutrition, or a diagnosis of refeeding syndrome, will be excluded.\n* Subjects who are pregnant or breastfeeding will be excluded.\n* Subjects with severe comorbid conditions associated with an estimated life expectancy of less than three months will be excluded.\n* Subjects with a documented do-not-resuscitate (DNR) order will be excluded.\n* Subjects with active gastrointestinal bleeding will be excluded.\n* Subjects who have undergone gastrointestinal surgery within one month prior to enrollment will be excluded.\n* Subjects currently participating in another randomized controlled trial comparing enteral nutrition and parenteral nutrition will be excluded.","19 Years",{"count":382,"type":20},1150,[53],"This study compares enteral nutrition and parenteral nutrition in critically ill adult patients recovering from shock while receiving decreasing doses of vasopressors in the intensive care unit.\n\nEligible patients will be randomly assigned to receive either enteral or parenteral nutrition during the early recovery phase of shock.\n\nThe study aims to determine whether enteral nutrition improves clinical outcomes, including ICU mortality and ICU-acquired infections, compared with parenteral nutrition.",[24,82,386,387],"Nutritional Support","Vasopressor Therapy",[389,390,391,392,393,24],"Enteral Nutrition","Parenteral Nutrition","Critically Ill Patients","Shock Recovery","Vasopressor Weaning","2026-02-13",{"date":396,"type":32},"2026-02-18",{"date":398,"type":20},"2026-02-01",{"date":400,"type":20},"2029-12-31",{"name":402,"class":39},"Samsung Medical Center",{"id":404,"slug":405,"hasResults":12,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":409,"eligibilityCriteria":410,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":411,"enrollmentInfo":412,"targetDuration":414,"studyType":21,"phases":4,"briefSummary":415,"conditions":416,"keywords":418,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":67},"100622618","correlation-between-eit-based-pulse-wave-method-for-pulmonary-perfusion-monitoring-and-pulmonary-artery-catheter-based-stroke-volume-measurement-100622618","NCT07385963","Correlation Between EIT-based Pulse Wave Method for Pulmonary Perfusion Monitoring and Pulmonary Artery Catheter-based Stroke Volume Measurement","EIT-Based Pulmonary Perfusion Pulse Wave Versus Swan-Ganz Catheter in Stroke Volume Correlation","EIT-Cath Corre","Inclusion Criteria:\n\n* Critically ill patients requiring mechanical ventilation support.\n* Patients meeting the 2023 global ARDS definition and\u002For shock patients receiving vasoactive medication therapy.\n* Patients who have already had a pulmonary artery catheter inserted due to clinical needs.\n\nExclusion Criteria:\n\n* Age under 18 years or over 80 years.\n* Patients with severe obesity (BMI ≥ 35 kg\u002Fm²).\n* Pregnant or lactating women.\n* Pulmonary embolism.\n* Patients undergoing ECMO therapy.\n* Arrhythmia.\n* Contraindications to EIT monitoring.\n* Contraindications to pulmonary artery catheter use.\n* Failure to provide signed informed consent.","80 Years",{"count":413,"type":20},19,"2 Days","The goal of this clinical study is to learn if a new, non-invasive monitoring method called EIT Pulse Wave can accurately measure blood flow to the lungs (pulmonary perfusion) and predict heart stroke volume (SV) in critically ill patients. It will also learn about the safety of this monitoring approach. The main questions it aims to answer are:\n\nHow well does the EIT Pulse Wave measurement of lung blood flow correlate with the SV measured by the standard method (Swan-Ganz catheter)? Can we build a reliable model to predict SV non-invasively using the EIT Pulse Wave signal? Researchers will compare the EIT Pulse Wave measurements directly with the Swan-Ganz catheter measurements to see if the new method is accurate.\n\nParticipants will:\n\nBe critically ill adults in the ICU who are already receiving mechanical ventilation and have a Swan-Ganz catheter in place for medical reasons.\n\nUndergo simultaneous monitoring using both the EIT device and the Swan-Ganz catheter every 30 minutes for up to 48 hours.\n\nHave their ventilator settings adjusted to different levels as part of the study protocol while both measurements are recorded.",[24,417],"Acute Respiratory Distress Syndrome",[82,417,24,176,419,420],"Electric Impedance","Pulmonary Circulation","2026-01-26",{"date":423,"type":32},"2026-02-04",{"date":425,"type":20},"2026-02-02",{"date":427,"type":20},"2027-03-15",{"name":429,"class":39},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology",{"id":431,"slug":432,"hasResults":12,"nctId":433,"briefTitle":434,"officialTitle":435,"acronym":436,"eligibilityCriteria":437,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":438,"targetDuration":440,"studyType":21,"phases":4,"briefSummary":441,"conditions":442,"keywords":446,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":67},"100437150","resuscitative-tee-collaborative-registry-100437150","NCT04972526","Resuscitative TEE Collaborative Registry","Evaluation of the Clinical Impact and Safety of Focused Transesophageal Echocardiography During Resuscitation of Critically Ill Patients in the Emergency Department and Intensive Care Settings","rTEECoRe","Inclusion Criteria:\n\n* Adult critically-ill patients who as part of their routine clinical care receive focused TEE in the emergency department of intensive care setting.\n\nExclusion Criteria:\n\n* Children (age under 18 years)\n* Vulnerable populations",{"count":439,"type":20},1000,"1 Month","The general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and intensive care settings. The target population for this study are critically-ill patients over the age of 18 who as part of their routine clinical care are receiving a focused TEE.\n\nThe primary objective of this study is to determine the clinical impact and safety of TEE performed during the evaluation of critically-ill patients in the emergency department and intensive care settings.\n\nThe secondary objective(s) of this study are to characterize the use of this imaging modality in the subsets of critically-ill patients in shock and cardiac arrest; including but not limited to; description of the frequency of studies, clinical indications, clinician characteristics, echocardiography findings, timing of studies, procedure-related complications and patient outcomes.",[443,444,445,24,173],"Cardiac Arrest","Cardiac Arrest Circulatory","Cardiac Arrest, Out-Of-Hospital",[447,146,443,448,449],"Transesophageal Echocardiography","Point-of-care Ultrasound","Focused Cardiac Ultrasound","2026-01-12",{"date":452,"type":32},"2026-01-14",{"date":454,"type":32},"2020-12-01",{"date":456,"type":20},"2027-12-15",{"name":458,"class":39},"University of Pennsylvania",{"id":460,"slug":461,"hasResults":12,"nctId":462,"briefTitle":463,"officialTitle":464,"acronym":4,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":466,"targetDuration":4,"studyType":51,"phases":468,"briefSummary":470,"conditions":471,"keywords":472,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":480,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":67},"100218248","phase-4-vasoactive-drugs-in-intensive-care-unit-100218248","NCT02118467","Vasoactive Drugs in Intensive Care Unit","A Randomized Double Blind Trial of Vasoactive Drugs for the Management of Shock in the ICU","Inclusion Criteria:\n\n1. Age greater than or equal to 18 years old\n2. Requirement for vasoactive drugs via a central venous catheter for the treatment of shock. Shock will be defined as mean arterial pressure less than 70 mmHg or systolic blood pressure less than 100 mmHg despite administration of at least 1000 mL of crystalloid or 500 mL of colloid, unless there is an elevation in the central venous pressure to \\> 12 mmHg or in the pulmonary artery occlusion pressure to \\> 14 mmHg coupled with signs of tissue hypoperfusion (e.g. altered mental state, mottled skin, urine output \\\u003C 0.5 mL\u002Fkg body weight for one hour, or a serum lactate level of \\> 2 mmol per liter).\n\nExclusion Criteria:\n\n1. Cardiopulmonary arrest\n2. Pregnancy\n3. Severe right heart failure",{"count":467,"type":20},836,[469],"PHASE4","The investigators hypothesis is that for ICU patients with shock, the use of the vasoactive drugs phenylephrine and vasopressin will reduce tachydysrhythmias when compared to norepinephrine and epinephrine. To investigate this hypothesis, the investigators are conducting a randomized double blind controlled trial comparing phenylephrine and vasopressin vs. norepinephrine and epinephrine in ICU patients with shock that is not responsive to IV fluids. All patients admitted to the adult intensive care units at the University of Chicago will be screened for eligibility.",[24],[24,473,474,475,476,477,478,479],"Vasopressor agents","Norepinephrine","Epinephrine","Phenylephrine","Vasopressin","Atrial fibrillation","Tachyarrhythmia",{"date":368,"type":32},{"date":482,"type":32},"2014-05-15",{"date":484,"type":20},"2026-12-01",{"name":486,"class":39},"University of Chicago",{"id":488,"slug":489,"hasResults":12,"nctId":490,"briefTitle":491,"officialTitle":491,"acronym":492,"eligibilityCriteria":493,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":494,"targetDuration":4,"studyType":51,"phases":496,"briefSummary":497,"conditions":498,"keywords":503,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":506,"lastUpdatePostDateStruct":507,"startDateStruct":509,"completionDateStruct":511,"leadSponsor":513,"locationsCount":67},"100608613","diagnostic-and-prognostic-evaluation-of-vasorin-during-septic-shock-100608613","NCT07203833","Diagnostic and Prognostic Evaluation of Vasorin During Septic Shock","VASO-DIAG","Inclusion Criteria:\n\n* Adults over 18 years.\n* Patients admitted for less than 24 hours in intensive care unit of the CHU Amiens Picardie.\n* Group 1: patients with septic shock defined by sepsis with 2 mmol\u002Fl Lactates, requiring vasopressors to maintain mean blood pressure at 65 mmHg (despite adequate vascular filling) in the presence of fever (T°\\>38.3) with a documented or suspected infection\n* Group 2: patients with a shock defined by arterial hypotension requiring the use of vasopressors with 2 mmol\u002Fl Lactates but without suspected infection and apyrexie (T°\\\u003C38°). For example: vasoplegia post cardiac surgery with CBP or cardiogenic shock or hemorrhagic shock\n\nExclusion Criteria:\n\n* Pregnant women\n* Group 1 : No evidence of suspected or documented infection\n* Group 2 : Presence of fever and\u002For suspected infection",{"count":495,"type":20},144,[53],"Septic shock is the most severe form of infection. Currently, an early specific biomarker for septic shock is needed. Remember that shock situations are numerous, not only septic (eg hemorrhagic, cardiogenic...), and also accompanied by a severe pro-inflammatory state that it is sometimes difficult to distinguish from a septic state. Procalcitonin (PCT) is the most studied biomarker but still lacks sensitivity (77%) and specificity (79%). The investigators hypothesize that the Vasn could become this potential new biomarker and would allow a better diagnosis and thus the need or not to treat patients with antibiotics. The laboratory studies suggest a link between Vasn and septic shock. The goal of this project is to measure and compare plasma Vasn concentrations in 2 groups of patients = group 1: septic shock versus group 2: non-septic shock. Briefly, shock is defined as low blood pressure requiring vasopressor agents with confirmed infection (group 1) or without suspected infection such as patients admitted in intensive care unit post cardiac surgery with CBP (group 2). The investigators will also assess patient 28-day mortality to identify Vasn as a potential prognostic biomarker.",[499,500,24,501,502],"Vasorin","Septic Shock","Biomarker","Infection",[504,505,24,501,502],"Septic shock","vasorin","2026-01-06",{"date":508,"type":32},"2026-01-07",{"date":510,"type":32},"2025-10-19",{"date":512,"type":20},"2027-05",{"name":514,"class":39},"Centre Hospitalier Universitaire, Amiens",{"id":516,"slug":517,"hasResults":12,"nctId":518,"briefTitle":519,"officialTitle":520,"acronym":4,"eligibilityCriteria":521,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":522,"targetDuration":4,"studyType":51,"phases":524,"briefSummary":525,"conditions":526,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":528,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":533,"locationsCount":67},"100480360","phase-4-central-line-study-100480360","NCT05534971","Central Line Study","A Randomized Study Comparing Two Techniques for Central Venous Catheter Insertion","Inclusion Criteria:\n\nAdult patients in the emergency department who require ultrasound guided central line placement are eligible for participation and will be referred for participation in the study by the clinical team.\n\nExclusion Criteria:\n\n* Inherited, acquired, or medication related coagulopathy or thrombocytopenia (platelets \\\u003C 100,000). Patients will not be excluded for use of aspirin or other anti-platelet medication.\n* Previous central venous access at the same anatomical site.\n* Any indwelling catheter or wire that could potentially interfere with central line placement\n* Anterior border of the target vein deeper than 3.5cm\n\nOr for any clinical feature that would interfere with obtaining informed consent including dementia, delirium, or encephalopathy, as determined by the clinical attending physician.",{"count":523,"type":20},160,[469],"Two different techniques for placing a central venous catheter will be compared. The studyu team hypothesizes that clinicians randomized to the peripheral catheter technique will have higher first attempt success rates, fewer procedural complications, and a shorter mean time to procedure completion than physicians assigned to wire through hollow bore needle.",[24],"2026-01-03",{"date":506,"type":32},{"date":530,"type":32},"2022-11-16",{"date":532,"type":20},"2027-12",{"name":534,"class":39},"Montefiore Medical Center",{"id":536,"slug":537,"hasResults":12,"nctId":538,"briefTitle":539,"officialTitle":540,"acronym":541,"eligibilityCriteria":542,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":543,"targetDuration":4,"studyType":51,"phases":544,"briefSummary":547,"conditions":548,"keywords":553,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":67},"100615474","phase-1-point-of-care-ai-assistance-and-critical-care-outcomes-a-randomized-trial-100615474","NCT07293078","Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial","Prospective Evaluation of a Point-of-Care Artificial Intelligence Model in Critical Care Outcomes","POC-AI-ICU","Inclusion Criteria:\n\n1. Adult patients (≥ 18 years) admitted to the medical intensive care unit (MICU) at participating hospitals.\n2. Direct admissions from the emergency department or transfers from medical wards to the MICU.\n3. Critically ill patients meeting local ICU admission criteria.\n\nExclusion Criteria:\n\n1. Transfers to the MICU from outside hospitals, operating room, or post-anesthesia care unit.\n2. Age \\\u003C 18 years.\n3. Incomplete or missing essential clinical information at admission (e.g., key labs or documentation not yet available).\n4. Primary surgical or cardiac (e.g., STEMI) patients.\n5. Pregnant or postpartum women.\n6. Prisoners.",{"count":439,"type":20},[545,546],"PHASE1","PHASE2","This is a prospective, unmasked, randomized, multicenter clinical trial evaluating the impact of point-of-care large language model (LLM)-based decision support on diagnostic accuracy and clinical outcomes in adult medical intensive care unit (MICU) patients.\n\nConsecutive adult ICU admissions at participating community hospitals (initially MetroWest Medical Center and St. Vincent Hospital) will be screened for eligibility. Eligible patients will be randomized 1:1 to standard care or an AI-assisted group. In both arms, initial evaluation and management will follow usual practice. For patients randomized to AI assistance, de-identified admission data (history and physical, labs, imaging reports, and other relevant documentation) will be formatted and submitted to a state-of-the-art LLM (ChatGPT-5) at the time of admission. The AI-generated differential diagnosis and therapeutic recommendations will be provided to the admitting team for consideration. For the standard care arm, LLM output will be generated but not shared with clinicians.\n\nAfter discharge, a masked chart review will determine the \"ground truth\" primary diagnosis and extract outcomes including: Primary Outcome - a composite of medical errors (from time of ICU admission through day 7 of ICU stay, or ICU discharge, whichever comes first); Secondary Outcomes - 90-day mortality, ICU and hospital length of stay, and ventilator-free days.",[82,81,549,550,551,552,24],"Acute Respiratory Failure (ARF)","Multi-organ Failure","Acute Kidney Injury","Delirium Confusional State",[180,554,555,556,557,558,559,81,24,560,561],"Intensive Care Unit","Large Language Model","Artificial Intelligence","Diagnostic Accuracy","Clinical Decision Support","Critical Care Outcomes","Acute Respiratory Failure","Multiorgan Failure","2025-12-15",{"date":564,"type":32},"2025-12-18",{"date":566,"type":20},"2026-01-01",{"date":568,"type":20},"2029-06-30",{"name":570,"class":39},"MetroWest Artificial Intelligence Research Workgroup",{"id":572,"slug":573,"hasResults":12,"nctId":574,"briefTitle":575,"officialTitle":575,"acronym":576,"eligibilityCriteria":577,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":578,"targetDuration":4,"studyType":51,"phases":580,"briefSummary":581,"conditions":582,"keywords":586,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":592,"lastUpdatePostDateStruct":593,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":598,"locationsCount":67},"100593686","fluid-management-and-individualized-resuscitation-in-sepsis-100593686","NCT07009665","Fluid Management and Individualized Resuscitation in Sepsis","FLUIDS","Inclusion Criteria:\n\n* Adult patients (≥ 18 years of age);\n* Referred to internal medicine, nephrology, geriatric medicine, oncology, hematology, lung medicine, rheumatology, gastrointestinal \u002F liver medicine, urology, or emergency medicine (non-trauma);\n* Confirmed or suspected infection according to the physician's judgement upon arrival to the ED, based the presence of an acute phase response not due to an alternative non-infectious cause (i.e., body temperature \\\u003C 36°C or \\>38°C, leukocyte count \\> 12 x109\u002FL or C-reactive protein \\> 50 mg\u002FL), and\u002For on symptoms suggestive for an infection (e.g. productive cough, dyspnea, dysuria, pollakisuria, abdominal pain, erythema)\n* Need for hemodynamic resuscitation, based on any of the following (first measurement at ED arrival \\[triage\\]):\n* Mean arterial pressure (MAP) \\\u003C 70 mmHg\n* Systolic blood pressure (SBP) \\\u003C 90 mmHg or a SBP decrease \\>40 mmHg\n* Lactate \\> 4.0 mmol\u002FL\n* Shock index\\* \\> 0.9\n* Enrolled in study within one hour after ED arrival\n\nExclusion Criteria:\n\n* Primary diagnosis of: acute cerebral vascular event, acute coronary syndrome, acute pulmonary edema, status asthmaticus, major cardiac arrhythmia, drug overdose, or injury from burn or trauma, diabetic ketoacidosis, hyper-osmolarity syndrome, pancreatitis\n* Known aortic insufficiency, aortic abnormalities, or intraventricular heart defect, such as ventral septal defect or atrial septal defect\n* Known advanced heart failure - meaning NYHA IV functional class HF, on waiting list for heart transplant, LVAD recipient or chronic inotrope use.\n* Known end-stage kidney disease (dialysis-dependent CKD stage 5 or eGFR \\\u003C15 mL\u002Fmin\u002F1.73 m²)\n* Decompensated liver cirrhosis at ED admission (e.g., ascites, hepatic encephalopathy, or variceal bleeding)\n* Hemodynamic instability due to active bleeding\n* Patient has received \\>1 liter of IV fluid prior to study randomization\n* Requires immediate surgery\n* Transfer from another hospital after initiation of therapy (a.o. referred by another hospital ICU) or another in-hospital setting\n* Pregnant women\n* Trauma patients\n* Suspected intra-abdominal hypertension, based on the presence of portal hypertension (i.e. presence of ascites due to liver cirrhosis, esophageal varices or as measured by Doppler ultrasound)\n* Inability to obtain IV access\n* Patient uncouples from treatment algorithm\n* Patient should be excluded based on the opinion of the Clinician\u002FInvestigator\n* Not able to commence treatment protocol within 1 hour after randomization\n* Potential ICU-admission unwanted by advanced care directive (e.g., limited life expectancy)",{"count":579,"type":20},188,[53],"The goal of this clinical trial is to find out if a personalized treatment approach can improve care for people with sepsis in the emergency department (ED).\n\nSepsis is a life-threatening condition that happens when the body has an uncontrolled response to an infection. This can lead to low blood pressure, organ failure, and death if not treated quickly. Right now, most people with sepsis receive a standard amount of fluids to raise their blood pressure. But this one-size-fits-all approach can lead to fluid overload and other complications. Because each person responds differently, this study will test whether a more personalized treatment-based on how the heart responds to fluids-can lead to safer and more effective care.\n\nThe study will include 188 adults who come to the ED at the University Medical Centre Groningen (UMCG) with suspected sepsis in need of hemodynamic resuscitation. Everyone in the study will receive fluids to support their blood pressure.\n\nParticipants will be randomly assigned to one of two groups:\n\n* Personalized treatment group: Fluids and vasopressors (medications that raise blood pressure) will be given based on how the heart responds to each fluid dose. This response is measured using a non-invasive monitor that tracks stroke volume index (ΔSVI)-a measure of how much blood the heart pumps.\n* Standard care group: Fluids will be given based on current guidelines (30 milliliters per kilogram of body weight), as decided by the treating doctor.\n\nResearchers will compare how much fluid is given during the first 3 hours of care. They will also look at:\n\n* When and how much vasopressor medicine is used\n* How well blood pressure and circulation respond\n* Signs of organ recovery or damage\n* How long participants stay in the hospital\n* Any problems or side effects during treatment\n\nThe researchers hope that this personalized approach will lead to using less fluid, starting vasopressors earlier, and helping people with sepsis recover more safely and quickly.",[81,24,583,584,585,201],"Personalized Medicine","Emergency Medicine","Critical Care, Fluid Resuscitation",[81,24,587,588,589,590,591],"Personalized medicine","emergency medicine","critical care","fluid resuscitation","fluid responsiveness","2025-12-14",{"date":594,"type":32},"2025-12-19",{"date":596,"type":32},"2025-09-01",{"date":484,"type":20},{"name":599,"class":39},"University Medical Center Groningen",{"id":601,"slug":602,"hasResults":12,"nctId":603,"briefTitle":604,"officialTitle":604,"acronym":605,"eligibilityCriteria":606,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":607,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":609,"conditions":610,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":611,"lastUpdatePostDateStruct":612,"startDateStruct":614,"completionDateStruct":616,"leadSponsor":617,"locationsCount":67},"100507560","diagnostic-performance-of-the-mitral-annulus-velocity-variation-measured-by-tissue-doppler-to-evaluate-the-fluid-responsiveness-during-the-initial-management-of-shock-in-patients-admitted-to-the-emergency-department-100507560","NCT05888974","Diagnostic Performance of the Mitral Annulus Velocity Variation Measured by Tissue Doppler to Evaluate the Fluid Responsiveness During the Initial Management of Shock in Patients Admitted to the Emergency Department","EVO-E'","Inclusion Criteria:\n\n* Patient has been informed of the study and does not refuse to participate.\n* Patient is at least ≥ 18 years of age.\n* The patient must be beneficiary of a health insurance plan.\n* Patient has shock with a mean blood pressure less than 65 mmHg (\\\u003C)\n* The patient does not have acute intracranial pathology\n* The referring physician has decided on a vascular filling with 500mL of crystalloids (NaCl 0.9% or Ringer lactate)\n\nExclusion Criteria:\n\n* The patient has already received 2 vascular fillings since the beginning of his management\n* The patient is in shock and has a contraindication to vascular filling : shock of a cardiogenic or obstructive nature\n* The patient has an intracranial pathology requiring maintain a MAP ≥ 80 mmHg\n* The patient is intubated or on Non-Invasive Ventilation before the vascular filling\n* The patient is under court protection\n* The patient is pregnant, parturient or nursing",{"count":608,"type":20},187,"Assessing the response to vascular filling in shock is a challenge in emergency medicine.\n\nThe mitral annulus velocity measured by tissue Doppler (E') has recently been characterized as sensitive to the preload conditions of a patient.\n\nThe investigators hypothesize that the E' variation (∆E') before and after fluid filling allows us to assess the response to vascular filling. The investigators hypothesize that the ∆E' has a good diagnostic performance to establish whether a patient is responsive to fluid filling, defined by an area under the ROC curve greater than 0.75.",[24],"2025-12-03",{"date":613,"type":32},"2025-12-04",{"date":615,"type":32},"2023-08-01",{"date":334,"type":20},{"name":618,"class":39},"Centre Hospitalier Universitaire de Nīmes",{"id":620,"slug":621,"hasResults":12,"nctId":622,"briefTitle":623,"officialTitle":624,"acronym":4,"eligibilityCriteria":625,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":626,"enrollmentInfo":627,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":628,"conditions":629,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":631,"lastUpdatePostDateStruct":632,"startDateStruct":633,"completionDateStruct":634,"leadSponsor":636,"locationsCount":67},"100613268","femoral-vein-internal-jugular-vein-and-inferior-vein-cava-collapsibility-indices-in-polytrauma-patients-by-sonographic-evaluation-before-and-after-resuscitation-100613268","NCT07264374","Femoral Vein, Internal Jugular Vein and Inferior Vein Cava Collapsibility Indices in Polytrauma Patients by Sonographic Evaluation Before and After Resuscitation.","Comparative Study of Femoral Vein, Internal Jugular Vein and Inferior Vein Cava Collapsibility Indices in Polytrauma Patients Presenting to the Emergency Department by Sonographic Evaluation Before and After Resuscitation.","Inclusion Criteria:\n\n* Adult patients aged ≥ 18years. ( Patients presented by hypovolemic shock\n\nExclusion Criteria:\n\n* Patient refusal Body Mass Index \\> 40 kg\u002Fm2. Cardiac patients or cardiac tamponade Aortic injury or for cardio-thoracic emergent operation Patients with abdominal mass or other pathology as abdominal collection. Any patient needs emergent surgical intervention History of pulmonary artery hypertension. Femoral vein occlusion. Pregnancy. Pulmonary oedema. Patients will need mechanical ventilation.","65 Years",{"count":77,"type":20},"The aim of this study is to evaluate correlation between the collapsibility indices of the FV or IJV to IVC-CI among polytrauma patients presenting to the ED by sonographic evaluation before and after resuscitation.",[24,630],"Hyopvolemia","2025-12-02",{"date":613,"type":32},{"date":562,"type":20},{"date":635,"type":20},"2026-12-15",{"name":637,"class":39},"Assiut University",{"id":639,"slug":640,"hasResults":12,"nctId":641,"briefTitle":642,"officialTitle":643,"acronym":4,"eligibilityCriteria":644,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":645,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":646,"conditions":647,"keywords":648,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":649,"lastUpdatePostDateStruct":650,"startDateStruct":652,"completionDateStruct":654,"leadSponsor":656,"locationsCount":4},"100612692","validation-of-the-icvs-model-in-patients-admitted-to-the-intensive-care-unit-100612692","NCT07256886","Validation of the iCVS Model in Patients Admitted to the Intensive Care Unit","Validation of the iCVS Model in Patients Admitted to the Intensive Care Unit: a Retrospective Study","Inclusion Criteria: The relevant experiment population are all patients over age 18 admitted to the ICU in Meir -\n\nExclusion Criteria: Missing data\n\n\\-",{"count":382,"type":20},"One of the significant challenges in the care of critically ill patients in the intensive care unit is the assessment of hemodynamically unstable patients (shock states). The treating team uses data such as heart rate, arterial blood pressure, physical examination findings, etc. to assess the patient's cardiac output, peripheral vascular resistance, filling pressures and volumes, and vascular tone. These assessments are essential to assess the cause of shock (cardiac cause, hypovolemia, sepsis, etc.), but in many situations they are not easy to perform and require extensive knowledge and experience. Assessing the hemodynamic status of a critically ill patient based on dynamic mechanical models may be a good option for more accurate assessment of complex patients. Such a model is, for example, the iCVS model: it is a relatively simple, mechanical-dynamic model that can be used to understand complex cardiovascular conditions. This model requires only age and weight as initial data, and as dynamic data the model requires only an arterial blood pressure (AR) curve and a central venous pressure (CVP) curve. The model is based on the shape of the above curves for the purpose of analyzing the cardiovascular status of the patient. The model is suitable for both adults and children, although most of the work to date has been among pediatric intensive care patients.",[24],[26],"2025-11-20",{"date":651,"type":32},"2025-12-01",{"date":653,"type":20},"2026-04-01",{"date":655,"type":20},"2030-04-30",{"name":657,"class":39},"Meir Medical Center",{"id":659,"slug":660,"hasResults":12,"nctId":661,"briefTitle":662,"officialTitle":663,"acronym":4,"eligibilityCriteria":664,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":626,"enrollmentInfo":665,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":667,"conditions":668,"keywords":671,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":676,"lastUpdatePostDateStruct":677,"startDateStruct":679,"completionDateStruct":680,"leadSponsor":681,"locationsCount":67},"100608836","ivc-ultrasound-versus-central-venous-pressure-for-early-detection-of-hypovolemia-in-shock-patients-100608836","NCT07206732","IVC Ultrasound Versus Central Venous Pressure for Early Detection of Hypovolemia in Shock Patients","Ultrasound-Guided Inferior Vena Cava Assessment Versus Central Venous Pressure Monitoring in Early and Post-Resuscitation Detection of Hypovolemia Among Shocked Patients in the Emergency Department","Inclusion Criteria:\n\n1- Adult patients aged ≥18 years. 2.Both male and female patients will be included in the study. 3. Presentation to the Emergency Department with clinical evidence of shock, defined by: Hypotension (systolic blood pressure \\\u003C90 mmHg or mean arterial pressure \\\u003C65 mmHg).\n\nEvidence of tissue hypoperfusion (e.g., altered mental status, cold extremities, or oliguria).\n\nElevated serum lactate (\\>2 mmol\u002FL). 4. Shock attributed to hypovolemic, septic, or hemorrhagic etiologies. 5. Patients requiring fluid resuscitation and hemodynamic monitoring.\n\nExclusion Criteria:\n\n1 - Patients younger than 18 years. 2. Pregnancy. 3.Cardiogenic or obstructive shock (e.g., cardiac tamponade, massive pulmonary embolism, or tension pneumothorax).\n\n4.Known inferior vena cava (IVC) anomalies (e.g., congenital absence, thrombosis).\n\n5\\. Increased intra-abdominal pressure or severe ascites. 6. Morbid obesity (BMI ≥40 kg\u002Fm²) or any condition interfering with adequate IVC ultrasound visualization.\n\n7\\. Prior central venous catheterization performed before Emergency Department arrival.\n\n8\\. Congestive heart failure (CHF) with left ventricular ejection fraction (LVEF \\\u003C40%) or pulmonary hypertension.\n\n9\\. Refusal of the patient or legal guardian to participate in the study.",{"count":666,"type":20},80,"This study aims to compare ultrasound-guided inferior vena cava (IVC) assessment with central venous pressure (CVP) monitoring for the detection of hypovolemia in shock patients in the emergency department. The primary objective is to evaluate the diagnostic accuracy and clinical utility of IVC collapsibility index compared to CVP values in both early and post-resuscitation phases. The study will prospectively enroll shock patients, collect demographic and clinical data, and analyze the correlation between IVC and CVP measurements to determine their role in guiding fluid resuscitation and hemodynamic management.",[24,669,670],"Hypovolemia","Circulatory Failure",[24,669,672,673,674,675],"Emergency department","Central venous pressure","Fliud resuscitation","Ultrasound guided IVC","2025-11-16",{"date":678,"type":32},"2025-11-19",{"date":562,"type":20},{"date":635,"type":20},{"name":637,"class":39}]