[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"short-chain-fatty-acids-concentration-in-stools\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:short-chain-fatty-acids-concentration-in-stools":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,59],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100635233","effects-of-dietary-fats-on-gut-microbiota-composition-and-metabolic-activity-in-healthy-adults-100635233",false,"NCT07550023","Effects Of Dietary Fats on Gut Microbiota Composition and Metabolic Activity in Healthy Adults","Inclusion Criteria:\n\n* Adults aged 20-50 years\n* Body mass index (BMI) between 20 and 30 kg\u002Fm²\n* Generally healthy\n* Stable body weight (±2 kg) over the past 2 months\n* Living in the Glasgow area\n* Non-smoker\n\nExclusion Criteria:\n\n* Use of antibiotics within the past 3 months\n* Current use of medications affecting gut microbiota or cardiometabolic health\n* Regular use of dietary supplements that may influence study outcomes (e.g. probiotics, prebiotics, vitamins, minerals, fish oil), unless willing to discontinue prior to study start\n* Presence of chronic gastrointestinal, metabolic, cardiovascular, hepatobiliary, or pancreatic disease\n* History of major gastrointestinal surgery\n* Diagnosed diabetes or use of lipid-lowering therapy\n* Known fat malabsorption disorders\n* Pregnant or lactating women\n* Post-menopausal women\n* Following a restrictive or specific diet (e.g. vegan, ketogenic diet)\n* Food allergies or intolerances relevant to study interventions (e.g. dairy, coconut)\n* Recent significant weight change (±2 kg in the past month)\n* High reliance on ready meals or takeaway foods (\\>7 main meals per week)\n* Participation in another research study that may interfere with this study",true,"ALL","20 Years","50 Years",{"count":20,"type":21},64,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will investigate how adding a specific type of dietary fat to daily meals for two weeks affects the gut bacteria and their activity. Participants will be randomly assigned to consume one of four types of fat: butter, coconut oil, olive oil, or sunflower oil (60 mL each day for 2 weeks). Stool and blood samples (after an overnight fast) will be collected at 3 time points during the study (Days 1, 7, and 22). These samples will be used to measure metabolites produced by gut bacteria, the types of bacteria present in the gut, blood lipids, and inflammatory markers. The study, based on previous in vitro findings, aims to understand whether different types of fats (based on their structure and level of saturation) have different effects on gut bacteria and their activity in healthy subjects.",[27,28,29,30],"Short Chain Fatty Acids Concentration in Stools","Gut Microbiota Diversity and Composition","Blood Lipid Profiles","Inflammation Biomarkers",[32,33,34,35,36,37,38,39,40,41,42,43,44,45],"Gut microbiome","Gut microbiota","Dietary fat","Short-chain fatty acids","SCFA","Saturated fat","Monounsaturated fat","Polyunsaturated fat","Butter","Olive oil","Coconut oil","Sunflower oil","MUFA","PUFA","RECRUITING","2026-04-17",{"date":49,"type":50},"2026-04-24","ACTUAL",{"date":52,"type":50},"2026-03-23",{"date":54,"type":21},"2028-03-31",{"name":56,"class":57},"University of Glasgow","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":15,"sex":16,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":4,"studyType":22,"phases":71,"briefSummary":72,"conditions":73,"keywords":74,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":58},"100622784","the-effect-of-vitamin-c-supplementation-on-gut-microbiota-composition-and-function-in-healthy-adults-100622784","NCT07388121","The Effect of Vitamin C Supplementation on Gut Microbiota Composition and Function in Healthy Adults","The Effect of Vitamin C Supplementation on Gut Microbiota Composition and Metabolic Activity in Healthy Adults","VitaGut","Inclusion Criteria:\n\n* Healthy individuals aged 18-65 years with a BMI between 18.5-35 Kg\u002Fm2\n* Self-reported good health with no chronic conditions requiring regular medical care\n* Willing to provide blood, urine, and stool samples at multiple time points\n\nExclusion Criteria:\n\n* Aged \\\u003C18 or \\>65 years\n* Smoking\n* Chronic illness requiring regular medication or GP visits\n* Current or recent medication affecting gut transit or digestion\n* Major gastrointestinal surgery\n* Pregnant or breastfeeding\n* Regular use of pre\u002Fprobiotics, vitamins, or minerals (unless willing to discontinue 2-4 weeks prior)\n* Antibiotics in past 3 months\n* Weight change \\>±2 kg in past month\n* Participation in other research likely to interfere with this study","18 Years","65 Years",{"count":70,"type":21},23,[24],"The aim of this dietary intervention study is to explore how vitamin C affects the bacteria that live in our gut. Vitamins are essential nutrients found in fruits and vegetables. Our bodies cannot make them on their own, but we need them to function correctly. Vitamins play various roles, including supporting the immune system and assisting with energy production. Some vitamins in our diet can reach the large intestine, where they may be used by gut bacteria to promote their growth. In this study, we aim to investigate how our gut bacteria interact with vitamin C and how this interaction affects their growth and activity.\n\nFor this study, participants will follow their habitual diet for one-week (run-in period), followed by two consecutive two-week supplementation periods in which they will first take a moderate dose (200 mg\u002Fday) and then a high-dose (1000 mg\u002Fday) of vitamin C. A final one-week period follow up period will involve a return to their habitual diet. Faecal, blood and urine samples will be collected at the start and end of each supplementation period to explore changes in gut microbiota composition, activity and markers of inflammation.",[27,28],[75,76,36],"vitamin C","gut microbiota","2026-01-30",{"date":79,"type":50},"2026-02-04",{"date":81,"type":50},"2025-11-01",{"date":83,"type":21},"2026-07-01",{"name":56,"class":57}]