[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"shortness-of-breath\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:shortness-of-breath":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,70,99,130,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100558686","cardiopulmonary-exercise-testing-and-oscillometry-for-the-evaluation-of-dyspnea-100558686",false,"NCT06554353","Cardiopulmonary Exercise Testing and Oscillometry for the Evaluation of Dyspnea","COED","Inclusion Criteria:\n\n* Willingness to perform breathing test\n* Must be able to speak and understand English\n* Referred for Cardiopulmonary Exercise Testing\n\nExclusion Criteria:\n\n* Unable to provide consent or perform oscillometry test","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","OBSERVATIONAL","This study will determine if airway resistance to airflow and pressure, measured by Oscillometry, is associated with abnormal findings on Cardiopulmonary Exercise Testing in subjects who are experiencing shortness of breath.",[24,25,26,27],"Breathing, Mouth","Lung Function Decreased","Dyspnea","Shortness of Breath","RECRUITING","2026-06-01",{"date":31,"type":32},"2026-06-03","ACTUAL",{"date":34,"type":32},"2024-10-29",{"date":36,"type":20},"2026-11-30",{"name":38,"class":39},"University of Rochester","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":40},"100627753","effectiveness-of-a-mastery-learning-education-program-for-parents-of-children-using-inhaler-therapy-in-an-emergency-unit-100627753","NCT07452731","Effectiveness of a Mastery Learning Education Program for Parents of Children Using Inhaler Therapy in an Emergency Unit","Evaluation of the Effectiveness of an Education Program Based on the Mastery Learning Theory for Parents of Children Receiving Inhaler Therapy: A Pediatric Emergency Department Example","Inclusion Criteria:\n\n* \\- Child is receiving inhaler medication.\n* Child has no intellectual or neurological disability.\n* Child has no facial anatomical defects affecting inhaler use.\n* Child has no life-threatening conditions.\n* Both mother and child can speak Turkish.\n* Mother has no communication barriers (e.g., mental capacity intact).\n* Mother is literate.\n* Voluntary participation in the study\n\nExclusion Criteria:\n\nRefusal to participate in the study.\n\n* Incomplete data provision.","1 Year","17 Years",{"count":51,"type":20},80,"INTERVENTIONAL",[54],"NA","Respiratory diseases account for a significant proportion of pediatric emergency department admissions, and effective management of respiratory conditions in children is crucial. Inhaler therapy is commonly used due to its rapid action, non-invasive nature, and ease of administration. However, the effectiveness of inhaler therapy largely depends on correct technique and adherence, particularly among children and their parents. Incorrect inhaler use may worsen clinical outcomes and increase respiratory complications. Educational interventions, including structured and technology-based training, have been shown to improve inhaler technique and treatment effectiveness.\n\nThe aim of this study is to evaluate the effectiveness of a mastery learning-based educational program provided to children receiving inhaler therapy and their parents in a pediatric emergency department.",[27],[58,59,60],"inhaler therapy","parent education","pediatric emergency","2026-03-01",{"date":63,"type":32},"2026-03-05",{"date":65,"type":32},"2025-11-05",{"date":67,"type":20},"2027-06-06",{"name":69,"class":39},"Emine ŞAHİN",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":52,"phases":80,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":40},"100607007","determinants-of-cardiorespiratory-fitness-and-effects-of-hiit-in-patients-with-anoca-obstructive-coronary-artery-diseaseanoca-100607007","NCT07182955","Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)","Determinants of Cardiorespiratory Fitness and Effects of High Intensity Interval Training (HIIT) in Patients With Angina and No Obstructive Coronary Artery Disease (ANOCA)","Inclusion Criteria:\n\n* Age 18-85\n* ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80)\n* Able to use the wearable and participate in a remote exercise program\n* Able to participate in intermittent high-intensity training.\n* Able to perform cardiopulmonary exercise testing (CPET)\n* Able to provide Health-related quality of life questionnaire (HRQOL)\n* Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English\n\nExclusion Criteria:\n\n* Systolic heart failure (LVEF \\\u003C50% or NYHA class III symptoms)\n* Prior myocardial infarction, coronary revascularization\n* Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment\n* Pregnancy (due to unknown effects on CPET exercise markers)\n* Inability to provide informed consent\n* Life expectancy \\\u003C1 year\n* Prisoners\n* Cognitively impaired\n* Non-English speaking","85 Years",{"count":79,"type":20},25,[54],"The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it.\n\nThis study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life.\n\nInvestigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.",[83,27,84],"MINOCA","Atherosclerotic Heart Disease of Native Coronary Artery",[86,87,88,89],"ANOCA\u002FMINOCA","High Intensity Interval Training","CPET Phenotype","Cardiorespiratory Fitness","2025-09-18",{"date":92,"type":32},"2025-09-19",{"date":94,"type":32},"2025-08-11",{"date":96,"type":20},"2026-04-14",{"name":98,"class":39},"University of Virginia",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":106,"sex":16,"minAge":17,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":52,"phases":110,"briefSummary":111,"conditions":112,"keywords":115,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":40},"100602822","training-strategies-to-maintain-performance-100602822","NCT07128511","Training Strategies to Maintain Performance","Compare Training Strategies to Maintain Cognitive Performance Under Respiratory Load","Inclusion Criteria:\n\n* Age 18-45\n* Healthy adult status confirmed by screening\n* FVC ≥ 75% predicted (based on ATS\u002FERS guidelines)\n\nExclusion Criteria:\n\n* History of neurological or respiratory disease\n* Respiratory illness or recent nicotine use (within 5 years)\n* Positive COVID-19 or pregnancy test",true,"45 Years",{"count":109,"type":20},15,[54],"• Statement of the Problem and Justification Cognitive performance under physiologically stressful conditions is critical in high-demand environments such as military operations, diving, and firefighting. One such stressor is restricted breathing, which can occur due to equipment (e.g., masks, regulators) or environmental pressures (e.g., underwater). Restricted breathing has been shown to increase physiological strain, which may in turn impact attention, reaction time, and task execution. Despite this, there is limited research examining how different breathing strategies can mitigate the cognitive effects of restricted respiration.\n\nUnderstanding whether specific breathing techniques can preserve cognitive function under stress has practical implications for operational readiness, safety, and task performance in extreme or demanding environments.\n\n• Synopsis of Relevant Research Previous human studies have shown that controlled breathing techniques, such as tactical or box breathing (inhale-hold-exhale-hold patterns), can reduce anxiety and improve focus in stressful situations. For example, tactical breathing has been adopted in military and law enforcement settings to enhance performance under pressure. Other research in sports psychology and respiratory therapy suggests that altering breathing frequency or depth can modulate autonomic nervous system activity, potentially affecting cognitive control and reaction time.\n\nAdditionally, psychomotor vigilance tasks (PVTs) have been widely used to assess the impact of physiological stressors - such as sleep deprivation, hypoxia, and fatigue - on sustained attention and reaction time. However, few studies have directly examined the interaction between structured breathing patterns and PVT performance during restrictive breathing loads.\n\n• Importance and Next Step This study represents a logical next step in understanding how breathing techniques can buffer against cognitive decline under conditions that simulate real-world respiratory restriction (e.g., underwater diving). By directly comparing the effects of two distinct breathing strategies during a controlled, restrictive breathing task, this research will help determine whether certain techniques are more effective in preserving attention and reaction time. The findings could inform training and operational protocols for individuals working in challenging environments, as well as guide future studies into breathing-cognition interactions under physical stress.",[27,113,114],"Shortness of Breath\u002FDyspnea","Respiratory Distress",[116,117,118,119],"dyspnea","shortness of breath","respiratory loading","breathing patterns","NOT_YET_RECRUITING","2025-08-13",{"date":123,"type":32},"2025-08-19",{"date":125,"type":20},"2025-08",{"date":127,"type":20},"2025-12",{"name":129,"class":39},"University of Florida",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":52,"phases":138,"briefSummary":139,"conditions":140,"keywords":141,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":155},"100515501","a-validation-study-to-evaluate-the-performance-of-caption-health-lung-guidance-and-interpretation-100515501","NCT05992324","A Validation Study to Evaluate the Performance of Caption Health Lung Guidance and Interpretation","Inclusion Criteria:\n\n* Patients over the age of 18\n* Patients presenting to the hospital or outpatient setting with shortness of breath and suspected B-lines.\n\nExclusion Criteria:\n\n* Patients in extremis\u002Fin whom a research lung ultrasound would not normally be performed due to other priorities",{"count":137,"type":20},220,[54],"The purpose of this study is to assess the efficacy of Caption LungAI.",[27],[142,143,144],"Lung Ultrasound","B-Lines","POCUS by non-expert user","2024-11-22",{"date":147,"type":32},"2024-11-26",{"date":149,"type":32},"2023-07-17",{"date":151,"type":20},"2025-03-01",{"name":153,"class":154},"Caption Health, Inc.","INDUSTRY",4,{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":16,"minAge":162,"maxAge":17,"enrollmentInfo":163,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":164,"conditions":165,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":181,"locationsCount":40},"100531568","prospective-multicentre-study-on-symptoms-in-first-onset-bronchial-asthma-in-children-and-adolescents-100531568","NCT06201494","Prospective Multicentre Study on Symptoms in First-onset Bronchial Asthma in Children and Adolescents","Inclusion Criteria:\n\n\\- Child 3 - 18 years old, first evaluation in pulmonary outpatient clinic for any of the following respiratory symptoms: cough, shortness of breath, chest tightness, wheezing, recurrent lower respiratory tract and lung infections, dyspnoea of any type, pathological listening findings.\n\nExclusion Criteria:\n\n* Other documented chronic respiratory, cardiovascular, neurological, genetic, infectious, metabolic disease, significant immaturity or other disease that may be accompanied by respiratory symptoms.","3 Years",{"count":51,"type":20},"Bronchial asthma may present with symptoms other than the commonly reported complaints (cough, chest tightness, shortness of breath and wheezing). Less common symptoms include chronic or recurrent productive cough, inspiratory dyspnoea or recurrent pneumonia. Children presenting with these symptoms are often diagnosed with asthma bronchiale and benefit from antiasthmatic management.",[166,167,26,168,169,170,27,171,172,173,174],"Asthma","Asthma in Children","Cough","Pneumonia","Wheezing","Chest Tightness","Lower Respiratory Tract and Lung Infections","Recurrent Respiratory Tract Infections","Mucus; Plug","2024-06-14",{"date":177,"type":32},"2024-06-18",{"date":179,"type":32},"2023-01-01",{"date":29,"type":20},{"name":182,"class":39},"Charles University, Czech Republic"]