[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"shoulder-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:shoulder-pain":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,76,0,25,[9,42,70,103,130,158,180,215,236,260,284,306,325,348,380,408,428,460,488,510,534,562,583,611,643],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100642100","dexmedetomidine-as-an-adjuvant-to-bupivacaine-in-ultrasound-guided-pericapsular-nerve-group-block-peng-100642100",false,"NCT07626346","Dexmedetomidine as an Adjuvant to Bupivacaine in Ultrasound-guided Pericapsular Nerve Group Block( PENG)","The Analgesic Efficacy of Dexmedetomidine as an Adjuvant to Bupivacaine in Ultrasound-guided Pericapsular Nerve Group Block( PENG) in Patients Undergoing Laparoscopic Shoulder Surgeries: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Male or female patients aged 18-65 years\n2. Patients Undergoing laparoscopic shoulder surgeries (shoulder arthroplasties and shoulder endoscopic surgeries )\n3. American Society of Anesthesiologists (ASA) physical status I-II\n\nExclusion Criteria:\n\n1. Patient refusal.\n2. hypersensitivity or contraindication to dexmedetomidine\n3. History of allergy or intolerance to study medications\n4. Chronic opioid use (\\>3 months)\n5. Pregnancy or breastfeeding\n6. Severe renal or hepatic impairment\n7. Patient's with coagulopathy disorders",true,"ALL","18 Years","65 Years",{"count":22,"type":23},84,"ESTIMATED","INTERVENTIONAL",[26],"NA","Patients are greatly concerned about pain that occurs shortly after shoulder surgeries. Most patients experience significant pain after shoulder surgery, with almost half reporting severe pain immediately after. Since shoulder surgeries are usually done as outpatient or one day procedures, good pain control after surgery is important for quick recovery and rehab for patient's overall recovery. Interscalene nerve blocks provide the best pain relief for shoulder surgery patients. They reduce pain for at least 8 hours and decrease the need for opioids for 8 to 12 hours after surgery. It anesthetizes most of the brachial plexus, except the ulnar nerve (C8-T1). It is useful for surgeries on the distal clavicle, shoulder, and proximal humorous .However, interscalene blocks also raise concerns about temporary and potential long-term problems with breathing, especially paralysis of the diaphragm and phrenic nerve. By targeting nerve roots in the neck rather than peripheral nerves, interscalene blocks also carry a higher risk of nerve damage.The pericapsular nerve group block has been effectively used in hip surgeries as in hip arthroplasty and it is one of the best regional anesthesia regarding many other hip operations. Recently PENG block has also shown to have strong analgesic effect on shoulder surgeries.\n\nDexmedetomidine (DEX) is a highly selective Alpha-2 adrenergic agonist. It has sedative and analgesic properties that thought to be due to binding to both presynaptic and postsynaptic alpha-2 adrenoreceptors and inhibiting the release of norepinephrine, as a result, it terminates the propagation of pain signals and inhibits the sympathetic activity decreasing heart rate and blood pressure.\n\nThe aim of our study is to compare the effect of adding dexmedetomidine to bupivacaine in ultrasound-guided Pericapsular nerve group block (PENG) with bupivacaine alone and determine its effect on duration of analgesia and post-operative opioid consumption.",[29],"Shoulder Pain","RECRUITING","2026-06-10",{"date":33,"type":34},"2026-06-12","ACTUAL",{"date":31,"type":34},{"date":37,"type":23},"2026-11",{"name":39,"class":40},"Kasr El Aini Hospital","OTHER",1,{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":24,"phases":52,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":41},"100643670","dry-needling-or-percutaneous-electrolysis-for-managing-myofascial-trigger-points-100643670","NCT07637760","Dry Needling or Percutaneous Electrolysis for Managing Myofascial Trigger Points?","Dry Needling or Percutaneous Electrolysis for Managing Myofascial Trigger Points? A Randomized Clinical Trial","PEDN","Inclusion Criteria:\n\n* Adults\n* Presence of shoulder pain for at least 3 months.\n* Shoulder pain intensity greater than 3 points on the visual analogue scale (VAS).\n* Shoulder-related disability greater than 20 points on the DASH questionnaire.\n* Presence of at least one active myofascial trigger point in the infraspinatus muscle.\n* Reproduction of the patient's familiar shoulder pain during palpation of the infraspinatus trigger point.\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Previous shoulder surgery or traumatic shoulder injury in the affected region.\n* Presence of severe structural or systemic pathology affecting the shoulder region, such as fracture, tumour, infection, inflammatory disease, or neurological disorder.\n* Clinical signs suggestive of cervical radiculopathy or other neurological conditions that could explain the shoulder symptoms.\n* Use of physiotherapy treatment, invasive therapy, or analgesic\u002Fanti-inflammatory medication during the week before participation.\n* Contraindications to dry needling or percutaneous electrolysis, including needle phobia, anticoagulant therapy, bleeding disorders, pregnancy, pacemaker or implanted electrical devices, local skin infection, or altered skin sensitivity in the treatment area.",{"count":51,"type":23},40,[26],"Dry needling (DN) and percutaneous electrolysis (PE) are minimally invasive physiotherapy techniques commonly used for the management of myofascial trigger points. DN consists of inserting a fine filiform needle into a hyperirritable area within a taut band of skeletal muscle, with the aim of eliciting local twitch responses and reducing myofascial pain. PE follows a similar needle-based approach but combines the mechanical stimulus of the needle with the application of a galvanic electrical current, producing an electrochemical reaction in the targeted tissue. Both techniques have been increasingly used in clinical practice for musculoskeletal pain conditions, including shoulder pain, although the evidence comparing their relative effectiveness remains limited.\n\nShoulder pain is one of the most prevalent musculoskeletal disorders and is frequently associated with the presence of active myofascial trigger points. Among the shoulder muscles, the infraspinatus has been identified as a clinically relevant structure because its trigger points may reproduce referred pain patterns commonly reported by patients with shoulder symptoms and may contribute to pain, reduced strength, altered mobility, and functional disability. Previous studies have suggested that invasive treatment of infraspinatus trigger points may produce short-term improvements in pain sensitivity and shoulder-related symptoms. However, most available research has examined dry needling or percutaneous electrolysis separately, and direct comparisons between both interventions in patients with shoulder pain remain scarce.\n\nThe physiological mechanisms underlying these techniques are not yet fully understood. Dry needling is thought to act through mechanical and neurophysiological mechanisms, including disruption of dysfunctional motor endplates, reduction of local nociceptive input, elicitation of local twitch responses, and activation of segmental and descending inhibitory pathways. Percutaneous electrolysis may share some of these needling-related effects, while also adding a galvanic current that may induce local biochemical changes and promote tissue recovery processes. Nevertheless, it remains unclear whether the addition of electrical current provides superior clinical effects compared with dry needling alone.\n\nSince limited research has directly compared dry needling and percutaneous electrolysis applied to active myofascial trigger points of the infraspinatus in patients with shoulder pain, the present study aimed to compare the effectiveness of both techniques as complementary interventions to manual therapy and therapeutic exercise. Specifically, this study sought to determine whether percutaneous electrolysis or dry needling produced greater short-term improvements in pain intensity and shoulder-related disability.",[29],[56,57,58,59,60],"Dry needling","Percutaneous electrolysis","Physiotherapy","Manual therapy","Exercise","NOT_YET_RECRUITING","2026-06-09",{"date":31,"type":34},{"date":65,"type":23},"2026-09-01",{"date":67,"type":23},"2027-02-01",{"name":69,"class":40},"Universidad Complutense de Madrid",{"id":71,"slug":72,"hasResults":12,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":12,"sex":18,"minAge":77,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":81,"conditions":82,"keywords":88,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":102},"100586828","zimmer-biomet-shoulder-arthroplasty-pmcf-study-100586828","NCT06920459","Zimmer Biomet Shoulder Arthroplasty PMCF Study","Zimmer Biomet Shoulder Arthroplasty Long-term Post Market Clinical Follow-up Study","Inclusion Criteria:\n\n* Patient must be 20 years of age or older.\n* Patient must be anatomically and structurally suited to receive shoulder arthroplasty implants.\n* Patient is a candidate for shoulder arthroplasty due to one or more of the following:\n\nNon-inflammatory degenerative joint disease including osteoarthritis and avascular necrosis.\n\nRheumatoid arthritis. Fractures of the proximal humerus, where other methods of treatment are deemed inadequate.\n\nDifficult clinical management problems, where other method of treatment may not be suitable or may be inadequate.\n\n* Patient must be able and willing to complete the protocol required follow-up.\n* Patient must be able and willing to sign the IRB\u002FEC approved informed consent.\n\nExclusion Criteria:\n\n* Patient is unwilling or unable to give consent or to comply with the follow-up program.\n* Patient has any condition which would in the judgement of the Investigator, place the patient at undue risk or interfere with the study.\n* Patient is known to be pregnant or breastfeeding.\n* Patient is a vulnerable subject (prisoner, mentally incompetent or unable to understand what participation to the study entails, a known alcohol or drug abuser, and\u002For anticipated to be non- compliant).\n* Patient is uncooperative or patient with neurologic disorders who is incapable or unwilling to follow directions.\n* Patient has any sign of infection affecting the shoulder joint or in its proximity which may spread to the implant site.\n* Patient has rapid joint destruction, marked bone loss, or bone resorption apparent on roentgenogram.\n* Patient has any neuromuscular disease compromising the affected limb that would render the procedure unjustifiable.\n* Patient presents with osteoporosis, which in the opinion of the Investigator, may limit the subject's ability to support total shoulder arthroplasty using the study device.\n* Patient has a metabolic disorder that may impair bone formation.\n* Patient has osteomalacia.","20 Years",{"count":79,"type":23},50,"OBSERVATIONAL","This is a multicenter, prospective, non-controlled post market surveillance study. The objectives of this study are to confirm the safety, performance, and clinical benefits of the Zimmer Biomet Shoulder Arthroplasty systems in primary anatomic shoulder arthroplasty and its instrumentation. Safety of the systems will be assessed by monitoring the frequency and incidence of adverse events. The performance and clinical benefits will be evaluated by assessment of the overall pain and functional performance, qualify of life, and radiographic parameters of all enrolled study subjects.",[83,84,85,29,86,87],"Shoulder Fractures","Shoulder Arthritis Osteoarthritis","Shoulder Injury","Degenerative Joint Disease","Arthritis Shoulder",[89,90,91],"medical device","PMCF","Anatomic Total Shoulder Arthroplasty","2026-06-05",{"date":94,"type":34},"2026-06-08",{"date":96,"type":34},"2025-04-29",{"date":98,"type":23},"2037-06",{"name":100,"class":101},"Zimmer Biomet","INDUSTRY",2,{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":17,"sex":18,"minAge":77,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":24,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":41},"100638670","effects-of-kinesio-taping-on-thoracolumbar-fascia-flexibility-in-patients-with-shoulder-injury-100638670","NCT07624136","Effects of Kinesio Taping on Thoracolumbar Fascia Flexibility in Patients With Shoulder Injury","Effects of Kinesio Taping on Thoracolumbar Fascia Flexibility in Patients With Subacromial Impingement Syndrome","Inclusion Criteria:\n\n* age between 20 and 40 years,\n* Body Mass Index (BMI) within the normal range (20-24.9 kg\u002Fm²),\n* a chronic (symptoms persisting for \\>3 months) SIS diagnosis\n\nExclusion Criteria:\n\n* any shoulder pathology other than SIS (e.g., rotator cuff tear, glenohumeral joint problems),\n* inability to perform 90° shoulder flexion due to joint limitation or pain ≥8 on the VAS,\n* overweight or obesity (BMI \\>25 kg\u002Fm²),\n* previous back surgery,\n* low back pain within the last six months, scoliosis, radiologically diagnosed kyphosis or thoracolumbar disc herniation, sacroiliac joint problems, restricted pelvic range of motion (anterior-posterior pelvic tilt), and scapular dyskinesia.","40 Years",{"count":112,"type":23},6,[26],"The aim of this randomized controlled trial is to investigate the acute effects of fascia correction Kinesio Taping applied to the thoracolumbar fascia (TLF) in individuals with Subacromial Impingement Syndrome (SIS). Participants will be randomly allocated into an intervention group and a sham taping control group. The intervention group will receive fascia correction Kinesio Taping applied to the thoracolumbar region, while the control group will receive sham taping without therapeutic effect. Clinical parameters including pain intensity, trunk range of motion, thoracolumbar fascia flexibility, lumbar mobility, and posterior shoulder capsule tightness will be assessed before the intervention and 45 minutes after the application. This study aims to provide evidence regarding the acute clinical effects of thoracolumbar fascia modulation in individuals with Subacromial Impingement Syndrome.",[116,29],"Subacromial Impingement Syndrome",[118,119,120],"shoulder pain","fascial chain","sobacromial impingment syndrome","2026-05-31",{"date":123,"type":34},"2026-06-03",{"date":125,"type":34},"2026-05-20",{"date":127,"type":23},"2026-09-20",{"name":129,"class":40},"Kübra Sarıoğlu",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":24,"phases":139,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":41},"100509732","comparing-mindfulness-based-breath-training-and-heart-rate-variability-biofeedback-for-shoulder-surgery-patients-in-the-postoperative-pain-100509732","NCT05917262","Comparing Mindfulness-based Breath Training and Heart Rate Variability Biofeedback for Shoulder Surgery Patients in the Postoperative Pain.","Comparing Preoperative Mindfulness-based Breath Training and Heart Rate Variability Biofeedback for Shoulder Surgery Patients in the Postoperative Pain, Shoulder Function, Emotion, Sleep, Quality of Life, Cognitive Function, and Electroencephalography","Inclusion Criteria:\n\nshoulder pain patients with\n\n* (1) pain ≥3months and ≥3 days per week\n* (2) pain intensity ≥ 40 (VAS scale from 0 no pain to 100 very painful)\n* (3) the surgical indication would be based on orthopedics opinions\n\nExclusion Criteria:\n\n* history of shoulder surgery in the prior 3 years\n* osteoporotic vertebral fractures or rheumatologic diseases\n* chronic widespread pain syndromes (fibromyalgia or chronic fatigue syndrome)\n* neurological disease (i.e., stroke, parkinson's disease, etc..)\n* psychiatric disease (i.e., dementia, depression, schizophrenia, etc)\n* cancer\n* patients who practiced yoga, meditation, chi-qong, mindfulness, or deep breathing exercises more than three times per week",{"count":138,"type":23},120,[26],"Although shoulder surgeries can effectively relieve pain intensity and restore shoulder function, some patients reported persistent post-operative pain at the 6-month post-surgery follow-up visit. This randomized study aims to determine the effectiveness of three different types of bio-psychosocial support to pre-operative shoulder surgery patients. This study will examine the differential effects of brief mindfulness-based breathing, heart rate variability biofeedback (HRV-BF), and cognitive behavioral pain psychoeducation for pre-operative patients.",[142,29],"Pain, Postoperative",[144,145,146,147,148],"Shoulder pain","Postoperative pain","mindfulness","HRV","biofeedback","2026-05-21",{"date":151,"type":34},"2026-05-22",{"date":153,"type":34},"2023-11-13",{"date":155,"type":23},"2026-12-31",{"name":157,"class":40},"Chang Gung Memorial Hospital",{"id":159,"slug":160,"hasResults":12,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":24,"phases":168,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":41},"100514428","value-of-capsular-repair-for-latarjet-100514428","NCT05978362","Value of Capsular Repair for Latarjet","Prospective, Multicenter, Randomized Single-blind Study on the Interest of Capsular Repair in the Latarjet Operation","CAP-LATARJET","Inclusion Criteria:\n\n* Patient, male or female, over the age of 18\n* Patient with shoulder instability with risk factors for recurrence (ISIS score \\> 3), requiring surgical stabilization by abutment\n* Affiliated patient or beneficiary of a social security scheme\n* Patient having been informed and having given his free, informed and written consent.\n\nExclusion Criteria:\n\n* Patient with history of surgery for instability of the same shoulder\n* Patient presenting contraindications to the realization of a postoperative scanner\n* Patient whose physical and\u002For psychological health is severely impaired, which according to the investigator may affect the compliance of the study participant\n* Patient participating in another clinical research or in a period of exclusion from another research still in progress at the time of inclusion\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision\n* Pregnant, breastfeeding or parturient woman\n* Patient hospitalized without consent.",{"count":167,"type":23},86,[26],"The purpose of the study is to evaluate the occurrence of osteoarthritis (YES\u002FNO) by radiography.",[29],"2026-05-12",{"date":173,"type":34},"2026-05-13",{"date":175,"type":34},"2023-10-11",{"date":177,"type":23},"2037-12",{"name":179,"class":40},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":181,"slug":182,"hasResults":12,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":187,"enrollmentInfo":188,"targetDuration":4,"studyType":24,"phases":190,"briefSummary":191,"conditions":192,"keywords":197,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":41},"100630864","usg-guided-shoulder-injections-in-frozen-shoulder-100630864","NCT07493213","USG-Guided Shoulder Injections in Frozen Shoulder","Effectiveness of USG-Guided Shoulder Injections as an Adjunct to a Home Exercise Program in the Conservative Management of Painful Frozen Shoulder and Its Association With Pain Phenotypes","Inclusion Criteria:\n\nAge between 18 and 75 years and willingness to participate in the study\n\nPresence of shoulder pain lasting at least 3 months and a diagnosis of primary frozen shoulder\n\nPain intensity ≥ 4\u002F10 on the Visual Analog Scale (VAS), resistant to medical treatment\u002Fanalgesics\n\nRestriction of ≥30 degrees in at least two planes of shoulder motion (flexion, abduction, or external rotation)\n\n\\-\n\nExclusion Criteria:\n\n* History of shoulder trauma\n\nPresence of neurological conditions such as stroke, brachial plexus injury, Parkinson's disease, or cervical spine pathology with or without radiculopathy\n\nHistory of shoulder surgery, shoulder malignancy or tumor, or prior shoulder manipulation\n\nPresence of shoulder arthritis, rotator cuff tear, other shoulder injuries, or thoracic outlet syndrome\n\nSystemic diseases affecting the shoulder, severe degeneration or trauma (e.g., osteoarthritis, rheumatoid arthritis, labral or articular cartilage injuries), or inflammatory rheumatic diseases\n\nSteroid injection to the affected extremity within the last 3 months, use of oral steroids or NSAIDs, or ongoing surgical\u002Finterventional treatment\n\nPregnancy or lactation\n\nUncontrolled diabetes, heart failure, or uncontrolled systemic diseases (e.g., liver failure, chronic kidney disease, significant endocrine disorders)\n\nCommunication problems or severe psychiatric disorders","75 Years",{"count":189,"type":23},68,[26],"Frozen shoulder (adhesive capsulitis) is characterized by pain and a progressive restriction of both active and passive shoulder range of motion, significantly impairing daily activities and quality of life. This study aims to evaluate the effectiveness of USG-guided shoulder injections, when added to a home-based exercise program, in the conservative management of patients with chronic, painful frozen shoulder.\n\nIn this prospective randomized study, patients diagnosed with painful frozen shoulder will be included. In addition to a standardized home-based exercise program, patients will receive either USG-guided suprascapular nerve block alone or a combination of suprascapular nerve block and subacromial injection. The effects of these approaches on clinical outcomes will be assessed over a 20-week follow-up period.\n\nPrimary outcome measures include pain intensity assessed by the Visual Analog Scale (VAS), functional status evaluated by the Shoulder Pain and Disability Index (SPADI), and shoulder range of motion. Secondary outcomes include depression level (Beck Depression Inventory), sleep quality, pain phenotype (nociplastic, neuropathic, or nociceptive), hand grip strength, ultrasonographic findings ( (coracohumeral ligament thickness, subacromial bursa thickness) , and patient satisfaction (subjective impression of improvement).\n\nThe results of this study are expected to provide evidence on the comparative effectiveness and additional benefits of different shoulder injection approaches when combined with home-based exercise therapy in patients with chronic frozen shoulder.",[193,194,29,195,196],"Frozen Shoulder","Adhesive Capsulitis","Nociplastic Pain","Neuropathic Pain",[193,194,198,199,29,200,201,202,203,204],"Shoulder Injection","Home Exercise Program","Range of Motion","SPADI","Ultrasound-Guided Injection","pain phenotypes","exercises","2026-05-11",{"date":207,"type":34},"2026-05-14",{"date":209,"type":34},"2026-04-01",{"date":211,"type":23},"2027-06-30",{"name":213,"class":214},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",{"id":216,"slug":217,"hasResults":12,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":187,"enrollmentInfo":222,"targetDuration":4,"studyType":24,"phases":223,"briefSummary":224,"conditions":225,"keywords":227,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":231,"startDateStruct":232,"completionDateStruct":233,"leadSponsor":235,"locationsCount":41},"100630865","efficacy-of-chemically-distinct-nonsteroidal-anti-inflammatory-drugs-nsaids-and-pain-phenotypes-in-adhesive-capsulitis-100630865","NCT07493226","Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis","Comparative Efficacy of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) With Distinct Chemical Structures in Shoulder Adhesive Capsulitis and the Role of Pain Phenotypes","Inclusion Criteria:\n\n1. Being between 18-75 years of age\n2. Having shoulder pain that has lasted for at least one month and being diagnosed with primary frozen shoulder\n3. Having a VAS pain level ≥ 4\u002F10\n4. Having ≥30 degrees of range of motion restriction in at least two planes (flexion, abduction, or external rotation)\n5. Not having any exclusion criteria and agreeing to participate in the study voluntarily\n\nExclusion Criteria:\n\n1. Patients with a history of shoulder trauma, those with musculoskeletal disorders characterized by pain and loss of function in the affected extremity (such as lateral epicondylitis, flexor tendon injury, de Quervein's tenosynovitis)\n2. Presence of neurological involvement such as stroke, brachial plexus injury, Parkinson's disease, and cervical spine injury with or without radiculopathy\n3. History of shoulder surgery, malignancy or tumor in the shoulder, those who have undergone shoulder manipulation\n4. Presence of shoulder arthritis, rotator cuff tear or other shoulder injuries, thoracic outlet syndrome\n5. Systemic disease affecting the shoulder region, severe degeneration or trauma (e.g., osteoarthritis, rheumatoid arthritis, history of labrum or articular cartilage injuries), inflammatory rheumatic diseases\n6. Those who have received steroid injections into the affected extremity within the last 3 months, those using oral steroids or NSAIDs, those receiving any surgical or interventional treatment, or Planned individuals:\n7. Those who are pregnant or lactating\n8. Those with uncontrolled diabetes, heart failure, uncontrolled systemic disease (liver disease, chronic kidney failure, significant endocrine disorders, etc.)\n9. Those with communication problems, severe psychiatric disorders\n10. Those allergic to NSAIDs or with any contraindications\n11. Those with bleeding, coagulation disorders, stomach ulcers, or symptomatic gastritis",{"count":138,"type":23},[26],"Patients aged 18-75 years who present to a tertiary rehabilitation hospital with shoulder pain and restricted range of motion, and who consent to participate, will be included in the study. Eligibility will be determined based on predefined inclusion and exclusion criteria.\n\nEligible patients will be randomly assigned to receive one of several nonsteroidal anti-inflammatory drugs (NSAIDs) with differing chemical properties (e.g., diclofenac, meloxicam, or indomethacin), in combination with a home-based exercise program for shoulder adhesive capsulitis. Patients' sociodemographic data, as well as detailed clinical and examination findings and baseline outcomes, will be recorded. Patients will be informed about their condition, and modifications to activities of daily living will be recommended.Patients' pain phenotypes (nociceptive, neuropathic, nociplastic) will be categorized based on clinical history and questionnaires, and it will be determined which pain types derive greater benefit from NSAIDs.\n\nFollow-up assessments will be conducted at the end of the first and second weeks. At the first-week follow-up, pain intensity will be evaluated using the Visual Analog Scale (VAS). If the treatment is deemed effective (defined as a ≥3-point reduction or ≥50% decrease in VAS), the same NSAID will be continued for an additional week; otherwise, it will be switched to an alternative NSAID with a different biochemical profile (group). The outcomes assessments will be performed by a blinded evaluator to minimize bias.",[193,194,29,226,195,196],"NSAID (Non-Steroidal Anti-Inflammatory Drug)",[228,229,118,203,204,230],"frozen shoulder","adhesive capsulitis","Nonsteroidal Anti-Inflammatory Drugs",{"date":207,"type":34},{"date":209,"type":34},{"date":234,"type":23},"2027-03-30",{"name":213,"class":214},{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":240,"acronym":241,"eligibilityCriteria":242,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":243,"targetDuration":4,"studyType":24,"phases":245,"briefSummary":246,"conditions":247,"keywords":248,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":102},"100613694","impact-of-different-electrical-frequencies-used-in-percutaneous-neuromodulation-on-muscle-strength-and-pressure-pain-thresholds-100613694","NCT07269925","Impact of Different Electrical Frequencies Used in Percutaneous Neuromodulation on Muscle Strength and Pressure Pain Thresholds","PENS-DOSE","Inclusion Criteria:\n\n* Presence of at least one latent myofascial trigger point (MTrP) in the infraspinatus muscle, identified according to the most recent Delphi consensus criteria.\n* Ability to read, understand, and sign the written informed consent form.\n\nExclusion Criteria:\n\n* Current pharmacological treatment that may affect muscle tone.\n* History of shoulder or spinal surgery.\n* Traumatic disorders such as whiplash-associated injuries, dislocations, or fractures.\n* Neuropathies, including radiculopathies or myelopathies.\n* Severe medical conditions (e.g., tumors, fractures, neurological or systemic diseases).\n* Clinically relevant asymmetries.\n* Generalized musculoskeletal conditions such as fibromyalgia.",{"count":244,"type":23},30,[26],"Percutaneous electrical nerve stimulation (PENS) involves delivering electrical currents through fine filiform needles inserted near tissues such as muscles, ligaments, or nerves. It has been explored for various chronic pain conditions affecting the cervical and lumbar spine, as well as the upper and lower limbs. Despite its growing clinical use, the overall quality of evidence supporting PENS for chronic musculoskeletal pain remains limited. Most studies have applied the technique directly over nerve structures, and while some reviews have shown greater pain reduction compared to transcutaneous electrical nerve stimulation (TENS), the superiority of PENS has not been conclusively demonstrated. Research specifically examining its application on nerve tissues, particularly in the upper limbs, remains scarce. Some preliminary and single-case studies have reported improvements in pain and disability following PENS directed at the radial nerve, but these findings are limited by small sample sizes and the absence of control groups. The physiological mechanisms underlying PENS are still not fully understood, though both peripheral and central processes are believed to be involved. Evidence suggests that PENS can reduce local sensitivity to pressure pain through peripheral mechanisms and may also enhance descending inhibitory control by activating conditioned pain modulation at the central level. However, further studies are necessary to clarify these effects.\n\nSince to date, limited research has specifically examined the optimal PENS dosage, the present study aimed to compare two PENS dosage for improving muscle strength and pain pressure thresholds.",[29],[249,250,251],"Percutaneous electrical nerve stimulation","Strength","Pain pressure thresholds","2026-05-05",{"date":254,"type":34},"2026-05-08",{"date":256,"type":34},"2026-02-15",{"date":258,"type":23},"2026-07-30",{"name":69,"class":40},{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":267,"enrollmentInfo":268,"targetDuration":4,"studyType":24,"phases":269,"briefSummary":270,"conditions":271,"keywords":272,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":41},"100546717","effects-of-dry-needling-on-the-behavior-of-the-shoulder-muscles-100546717","NCT06398574","Effects of Dry Needling on the Behavior of the Shoulder Muscles","Effect of Dry Needling Technique on Shoulder Muscle Functionality in Subjects With and Without Shoulder Pain.","Inclusion Criteria:\n\n* Subjects of legal age\n* Subjects without shoulder pain or with unilateral shoulder pain of \\> 3 months duration.\n* Have shoulder mobility of 90º of abduction and at least 30º of glenohumeral external rotation.\n\nExclusion Criteria:\n\n* Have neck pain.\n* Whiplash\n* Having had trauma to the shoulder.\n* Having fibromyalgia.\n* Be pregnant.\n* Being afraid of needles.","70 Years",{"count":51,"type":23},[26],"The main objective of this study will be to evaluate the effects of the application of the dry needling technique on the activity of the rotator cuff muscles in the shoulder.\n\nThe evaluation of the effects of the application of the dry needling technique will be carried out in subjects with and without shoulder pain.To do this, muscle strength, possible thickness changes in the muscle and electromyographic activity will be measured before and immediately after the application of a dry needling technique.\n\nLikewise, other variables will be measured such as the pressure pain threshold (PPT), pain with a Numeric Verbal Scale, kinesiophobia and catastrophism, the shoulder pain and disability index (SPADI) and the influence of expectations about dry needling.",[29],[56,273,274],"Shoulder muscle strength","Surface electromyography","2026-04-27",{"date":277,"type":34},"2026-05-01",{"date":279,"type":34},"2024-05-06",{"date":281,"type":23},"2026-12-20",{"name":283,"class":40},"University of Alcala",{"id":285,"slug":286,"hasResults":12,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":12,"sex":18,"minAge":77,"maxAge":4,"enrollmentInfo":291,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":293,"conditions":294,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":41},"100625331","osseofit-stemless-shoulder-system-anatomic-100625331","NCT07421245","OsseoFit Stemless Shoulder System (Anatomic)","OsseoFit Stemless Shoulder System (Anatomic) Post-Market Clinical Follow-up Study","Inclusion Criteria:\n\n* Patient must be 20 years of age or older.\n* The patient must be anatomically and structurally suited, as evident by scapula and proximal humerus closure, to receive the implants.\n* Patient planned to receive OsseoFit™ anchor with uncemented fixation.\n* Patient planned to receive a Modular Alliance Glenoid with bone cement. The porous posts must be coated with Porous Plasma Spray (PPS) and may be inserted without bone cement.\n* Patient planned to receive shoulder arthroplasty due to osteoarthritis.\n* Patient must be able and willing to complete the protocol required follow-up schedule.\n* Patient must be able and willing to sign the IRB approved consent.\n\nExclusion Criteria:\n\n* Patient is unwilling or unable to give consent or to comply with the follow-up program.\n* Patient has any condition which would in the judgement of the Investigator, place the patient at undue risk or interfere with the study.\n* Patient is known to be pregnant or breastfeeding.\n* Patient is a vulnerable participant (prisoner, mentally incompetent or unable to understand what participation to the study entails, a known alcohol or drug abuser, and\u002For anticipated to be non-compliant).\n* Patient is uncooperative or patient with neurologic disorders who is incapable or unwilling to follow directions.\n* Patient has any neuromuscular disease compromising the affected limb.\n* Patient has any sign of infection affecting the shoulder joint or in its proximity which may spread to the implant site. This may include:\n\n  * Local\u002Fsystemic infection\n  * Sepsis\n  * Osteomyelitis\n* Patient presents with Osteomalacia.\n* Patient presents with a humeral bone fracture.\n* Patient presents with malunion or non-union of the tuberosities of the proximal humerus.\n* Patient has had a previous operative shoulder prosthesis (stem or stemless).\n* Patient has irreparable cuff tear.\n* Patient presents with inadequate humeral bone, which in the opinion of the Investigator, may lead to poor implant fixation. This may include but is not limited to:\n\n  * Osteoporosis\n  * Extensive Avascular Necrosis\n  * Rheumatoid Arthritis\n  * Metaphyseal bony defects (including large cysts)",{"count":292,"type":23},136,"The purpose of this clinical research protocol is to evaluate the safety, efficacy, and long-term outcomes of the OsseoFit Stemless Shoulder System (Anatomic) in patients with a primary diagnosis of osteoarthritis. The study aims to assess the intraoperative characteristics, postoperative complications, functional outcomes, and radiographic findings associated with the use of the stemless implant system. Ultimately, this research aims to improve patient outcomes, enhance surgical techniques, and inform clinical decision-making in the treatment of shoulder pathology.",[295,29,83,296,297],"Shoulder Injuries","Shoulder Arthritis","Shoulder Disease","2026-04-22",{"date":300,"type":34},"2026-04-23",{"date":302,"type":23},"2026-04",{"date":304,"type":23},"2036-01",{"name":100,"class":101},{"id":307,"slug":308,"hasResults":12,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":4,"eligibilityCriteria":312,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":313,"enrollmentInfo":314,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":316,"conditions":317,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":102},"100576701","mdr---comprehensive-primary-revision-stems-pmcf-100576701","NCT06788717","MDR - Comprehensive Primary Revision Stems PMCF","Post-market Clinical Follow-up Study to Provide Safety, Performance and Clinical Benefits Data of the Comprehensive® Primary Revision Stems (Implants and Instrumentation) - A Retrospective and Prospective Consecutive Series Study","Inclusion Criteria\n\n* Patient must be 18 years of age or older.\n* Patient must be willing and able to follow directions.\n* Study devices must have been implanted following the surgical technique and IFU for the Comprehensive Revision Stem\n\nExclusion Criteria\n\n* Off-label use.\n* Patient is a prisoner.\n* Patient is a current alcohol or drug abuser.\n* Patient has a psychiatric illness or cognitive deficit that will not allow for proper informed consent.\n* Patient is unwilling to sign informed consent.\n* Uncooperative patient or patient with neurologic disorders who are incapable of following directions.","100 Years",{"count":315,"type":23},59,"The objective of this retrospective and prospective consecutive series PMCF (Post Market Clinical Follow Up) study is to collect long-term data confirming safety, performance and clinical benefits of the Comprehensive Primary Revision Stems (implants and instrumentation) when used for shoulder arthroplasty at 1, 3, 5, 7 and 10 years.",[29,295,83,297,296],{"date":319,"type":34},"2026-04-28",{"date":321,"type":34},"2025-06-19",{"date":323,"type":23},"2040-12",{"name":100,"class":101},{"id":326,"slug":327,"hasResults":12,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":332,"enrollmentInfo":333,"targetDuration":335,"studyType":80,"phases":4,"briefSummary":336,"conditions":337,"keywords":338,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":341,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":41},"100571287","development-of-the-photographic-shoulder-scale-100571287","NCT06718296","Development of the Photographic Shoulder Scale","Development of a Photographic Shoulder Scale to Assess Shoulder Movements in Daily Activities","Inclusion Criteria:\n\n* Individuals with traumatic or non-traumatic shoulder pain lasting for more than 3 months\n\nExclusion Criteria:\n\n* Individuals with neurological and\u002For rheumatological diseases\n* Active local or systemic infections\n* A history of cancer\n* Severe visual impairments\n* Patients with traumatic conditions awaiting surgery","64 Years",{"count":334,"type":23},100,"7 Days","Shoulder pain is a common cause of musculoskeletal complaints that affects home and work activities, as well as quality of life. It is the third most common musculoskeletal issue after spinal and knee pathologies. The prognosis for individuals with shoulder pain can vary, with approximately 50% still reporting symptoms six months after seeking primary care. In addition to pain, functional limitations can occur, interfering with work, hobbies, and social or sports activities. A large group of patients report persistent shoulder pain with a high rate of sick leave. As a result, the total economic cost associated with shoulder pain also becomes a significant concern.\n\nThe most frequently reported clinical pathologies associated with chronic shoulder pain are rotator cuff disorders, adhesive capsulitis, and glenohumeral osteoarthritis, which collectively constitute the largest portion of all shoulder pain pathologies. Patient-reported outcome measures (PROMs) are often used to assess functional loss and disability in patients. These outcome measures provide evidence about patients' perceptions of treatment and offer data on the long-term effectiveness of interventions. For this purpose, many shoulder-specific questionnaires have been developed.\n\nDeveloping a tool that uses photographs representing activities to measure how much patients struggle with daily life activities could be an important alternative for shoulder patients. An example of such a scale is the Photograph Series of Daily Activities-Short Electronic Version (PHODA-SeV), which was developed for low back pain. A different photographic scale has also been developed to assess avoidance behavior in patients with shoulder pain. Similarly, developing a specific photographic scale to assess daily life activities in patients with shoulder pain could be useful in clinical practice, as it would help patients better understand the scope of the questions.",[29],[29,339,340],"Photographic Assessment","Shoulder Pain Assessment Scale",{"date":275,"type":34},{"date":343,"type":34},"2024-12-15",{"date":345,"type":23},"2027-12-01",{"name":347,"class":40},"Istanbul University - Cerrahpasa",{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":75,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":12,"sex":18,"minAge":77,"maxAge":4,"enrollmentInfo":354,"targetDuration":4,"studyType":24,"phases":356,"briefSummary":357,"conditions":358,"keywords":361,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":373,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":379},"100438054","zimmer-biomet-shoulder-arthroplasty-pmcf-100438054","NCT04984291","Zimmer Biomet Shoulder Arthroplasty PMCF","Inclusion Criteria:\n\n* Patient must be 20 years of age or older.\n* Patient must be anatomically and structurally suited to receive shoulder arthroplasty implants.\n* Patient is a candidate for shoulder arthroplasty due to one or more of the following:\n\n  * Non-inflammatory degenerative joint disease including osteoarthritis and avascular necrosis.\n  * Rheumatoid arthritis.\n  * Correction of functional deformity.\n  * Fractures of the proximal humerus, where other methods of treatment are deemed inadequate.\n  * Difficult clinical management problems, where other methods of treatment may not be suitable or may be inadequate.\n* Patient must be able and willing to complete the protocol required follow-up.\n* Patient must be able and willing to sign the IRB\u002FEC approved informed consent.\n* Patient has grossly deficient rotator, (for reverse application)\n\n  * With severe arthropathy and\u002For\n  * Previously failed shoulder joint replacement\n* Patient must have functional deltoid muscle (for reverse application)\n\nExclusion Criteria:\n\n* Patient is unwilling or unable to give consent or to comply with the follow-up program.\n* Patient has any condition which would in the judgement of the Investigator, place the patient at undue risk or interfere with the study.\n* Patient is known to be pregnant or breastfeeding.\n* Patient is a vulnerable subject (prisoner, mentally incompetent or unable to understand what participation to the study entails, a known alcohol or drug abuser, and\u002For anticipated to be non-compliant).\n* Patient is uncooperative or patient with neurologic disorders who is incapable or unwilling to follow directions.\n* Patient has any sign of infection affecting the shoulder joint or in its proximity which may spread to the implant site.\n* Patient has rapid joint destruction, marked bone loss, or bone resorption apparent on roentgenogram.\n* Patient has any neuromuscular disease compromising the affected limb that would render the procedure unjustifiable.\n* Patient presents with osteoporosis, which in the opinion of the Investigator, may limit the subject's ability to support total shoulder arthroplasty using the study device.\n* Patient has osteomalacia.\n* Patient has a metabolic disorder that may impair bone formation.\n* Patient has deficient rotator cuff.\n* Patient presents with significant injury to the upper brachial plexus.\n* Patient has paralysis of the axillary nerve.\n* Patient has non-functional deltoid or external rotator muscles.",{"count":355,"type":23},584,[26],"The objectives of this study are to confirm the safety, performance, and clinical benefits of Zimmer Biomet Shoulder Arthroplasty Systems and its instrumentation in primary or revision shoulder arthroplasty. These objectives will be assessed using standard scoring systems, radiographic evidence, and adverse event records. Safety of the system will be assessed by monitoring the frequency an incidence of adverse events.",[83,296,359,360,295,29],"Shoulder Osteoarthritis","Shoulder Deformity",[362,363,364,365,366,367,368,369,370,371,372],"Total Shoulder Arthroplasty","Glenoid","Humeral Stem","Stem Adapter","Humeral Head","Humeral Bearing","Humeral Trays","Head Adapter","Reverse","Anatomic","Hemi",{"date":319,"type":34},{"date":375,"type":34},"2021-07-28",{"date":377,"type":23},"2033-08-15",{"name":100,"class":101},17,{"id":381,"slug":382,"hasResults":12,"nctId":383,"briefTitle":384,"officialTitle":384,"acronym":4,"eligibilityCriteria":385,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":386,"enrollmentInfo":387,"targetDuration":4,"studyType":24,"phases":389,"briefSummary":390,"conditions":391,"keywords":393,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":406,"locationsCount":41},"100630612","supraspinatus-tendon-acute-effects-after-two-exercise-exposures-a-crossover-randomized-trial-100630612","NCT07489937","Supraspinatus Tendon Acute Effects After Two Exercise Exposures: a Crossover Randomized Trial.","General inclusion criteria\n\n1. Between 18 and 45 years of age\n2. Able to perform physical activity with their shoulder (moderate arm exercise for 15 min, such as tennis or housework)\n\nGeneral exclusion criteria\n\n1. Shoulder fracture\n2. Frozen shoulder (\\>50% restriction in shoulder range of motion)\n3. Shoulder surgery\n4. Full rotator-cuff tears\n5. Bilateral shoulder pain\n6. Shoulder instability (history or positive apprehension test)\n7. Corticosteroid injection in the last 6 weeks\n8. Neurological diseases\n9. Cardiological diseases\n10. Systemic diseases (rheumatic diseases, autoimmune diseases)\n11. Uncontrolled diabetes\n12. Pregnancy\n\nGroup-specific inclusion criteria\n\n1. Shoulder pain group: report unilateral shoulder pain with an average shoulder pain score of≥ 3 in the last week.\n2. Control group: report no shoulder pain within 6 months.","45 Years",{"count":388,"type":23},24,[26],"The purpose of this study is to understand acute tendon changes after two exercise programs. We will invite individuals with and without shoulder pain to participate in this study. Every individual will participate in both exercise programs separated by up to 15 days. The researcher will evaluate the shoulder tendon using ultrasound before each exercise program and at 1 hour, 6 hours and 24 hours after each exercise program. The researcher will also evaluate self reported pain, pain sensitivity testing, and self reported questionnaires. We will compare the tendon changes after each exercise program, as well as between participants with and without shoulder pain.",[29,392],"Healthy Adult",[394,395,118,396,397,398,399],"rotator cuff related shoulder pain","rotator cuff tendinopathy","tendon thickness","exercise","subacromial pain","ultrasound","2026-04-21",{"date":298,"type":34},{"date":403,"type":34},"2026-04-20",{"date":405,"type":23},"2027-04-01",{"name":407,"class":40},"University of Florida",{"id":409,"slug":410,"hasResults":12,"nctId":411,"briefTitle":412,"officialTitle":412,"acronym":4,"eligibilityCriteria":413,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":110,"enrollmentInfo":414,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":416,"conditions":417,"keywords":418,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":422,"completionDateStruct":424,"leadSponsor":426,"locationsCount":41},"100634730","kinematics-and-muscle-activity-during-the-tennis-serve-and-musculoskeletal-characteristics-in-tennis-players-with-subacromial-pain-syndrome-or-history-of-shoulder-pain-100634730","NCT07543484","Kinematics and Muscle Activity During the Tennis Serve and Musculoskeletal Characteristics in Tennis Players With Subacromial Pain Syndrome or History of Shoulder Pain","Inclusion Criteria:\n\n* Amateur tennis players\n* National Tennis Rating Program (NTRP) should level ≥ 3.5\n* Training experience: ≥ 3 years, current or former school team players\n* Training volume: ≥ 4 hours\u002Fweek\n\nExclusion Criteria:\n\n* Any current musculoskeletal injuries preventing maximum skill execution at the time of testing\n* Previously had any form of surgery or trauma\n* Patient-reported pain that will inhibit participation in this study",{"count":415,"type":23},60,"Tennis players often suffer from shoulder pain due to the repetitive high-loaded overhead movements during serving, and subacromial pain syndrome is one of the main types of shoulder pain. Previous shoulder injury has been identified as one of the risk factors for shoulder overuse injuries in overhead sports. No research has explored differences in trunk kinematics and shoulder muscle activities among tennis players with and without subacromial pain syndrome or a history of shoulder pain. Furthermore, limited studies have examined shoulder kinematics during tennis serve and musculoskeletal characteristics in tennis players with subacromial pain syndrome or a history of shoulder pain. Therefore, this study aims to investigate shoulder and trunk kinematics and shoulder muscle activity during the tennis serve and musculoskeletal characteristics in tennis players with subacromial pain syndrome or a history of shoulder pain. This study will recruit sixty tennis players with subacromial pain syndrome, a history of shoulder pain, and healthy players. The electromagnetic tracking system will be applied to collect shoulder and trunk kinematics during the tennis serve, and surface electromyography will be simultaneously used for recording shoulder muscle activities. Moreover, we will collect shoulder and trunk rotational joint range of motion, isometric strength and rate of force development of shoulder internal and external rotation, scapulothoracic and glenohumeral joint control capability, upper quarter Y-balance test performance, and posterior shoulder endurance. This study will compare the difference of these measures in tennis players with subacromial pain syndrome or a history of shoulder pain to healthy players.",[29],[419],"shoulder pain, tennis, kinematics, electromyography","2026-04-15",{"date":298,"type":34},{"date":423,"type":34},"2026-01-29",{"date":425,"type":23},"2027-01-29",{"name":427,"class":40},"National Yang Ming Chiao Tung University",{"id":429,"slug":430,"hasResults":12,"nctId":431,"briefTitle":432,"officialTitle":433,"acronym":434,"eligibilityCriteria":435,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":187,"enrollmentInfo":436,"targetDuration":4,"studyType":24,"phases":438,"briefSummary":439,"conditions":440,"keywords":443,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":451,"lastUpdatePostDateStruct":452,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":458,"locationsCount":41},"100625856","contextually-enriched-individualized-exercise-versus-contextually-fixed-exercise-for-rotator-cuff-related-shoulder-pain-100625856","NCT07428070","Contextually Enriched Individualized Exercise Versus Contextually Fixed Exercise for Rotator Cuff-Related Shoulder Pain","Comparison of the Effectiveness of Contextually Enriched Exercise Programs in Rotator Cuff-related Shoulder Pain","CONTEXT-RCRSP","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* Clinical diagnosis of rotator cuff-related shoulder pain\n* Shoulder pain duration longer than 3 months\n* Painful arc during shoulder flexion or abduction\n* Positive Neer or Hawkins-Kennedy test\n* Pain during resisted external rotation or abduction, or positive Jobe test\n* Ability to understand and speak Turkish\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Clinical signs of a large rotator cuff tear characterized by marked weakness without pain\n* Other shoulder conditions (e.g., frozen shoulder defined as at least 30 percent passive glenohumeral restriction in two or more directions, advanced osteoarthritis, fracture, dislocation, or severe acromioclavicular joint pathology)\n* Previous shoulder surgery\n* Neurological disorders or significant systemic diseases such as rheumatoid arthritis\n* Current or past history of malignancy\n* Physical or cognitive impairments preventing participation in assessments or intervention sessions\n* Reproduction of shoulder symptoms with active cervical spine movements indicating symptomatic cervical pathology\n* Corticosteroid injection within the previous 6 weeks\n* Participation in other concurrent shoulder treatments during the study",{"count":437,"type":23},72,[26],"The goal of this clinical trial is to learn whether adding personalized contextual factors to an exercise program can improve pain and function in people with rotator cuff-related shoulder pain. This condition is a common cause of shoulder pain and can limit daily activities.\n\nThe main questions this study aims to answer are:\n\n1. Does a contextually enriched and individualized exercise program lead to greater improvement in upper-limb disability (measured by the QuickDASH questionnaire) compared with a contextually fixed program?\n2. Does it lead to greater reductions in pain intensity (measured by the Numeric Pain Rating Scale) and greater improvements in autonomic nervous system regulation (measured by heart rate variability)?\n3. Does it result in more favorable changes in psychosocial outcomes, exercise adherence, and therapeutic alliance?\n\nResearchers will compare two exercise programs to determine whether adding personalized contextual features enhances treatment effectiveness.\n\nOne group will receive a standardized, evidence-based exercise program delivered in a fixed and neutral manner.\n\nThe other group will receive the same exercise program with added personalized contextual elements, such as:\n\n* Preferred music and lighting\n* Choice between equivalent exercises (without changing exercise type or dosage)\n* Motivational feedback and supportive communication\n* Personalized progress tracking\n\nBoth groups will:\n\n* Attend supervised exercise sessions twice per week for 12 weeks\n* Follow a structured home exercise program\n* Complete questionnaires assessing pain, function, and psychological factors\n* Undergo heart rate variability assessment to evaluate autonomic regulation\n* Be followed for 12 months after treatment\n\nThe researchers expect that integrating personalized contextual elements into exercise therapy may enhance recovery, increase motivation, and improve long-term outcomes.",[441,29,442],"Rotator Cuff Related Shoulder Pain","Rotator Cuff Injuries",[442,29,444,445,446,447,448,449,450],"Contextual Healing","Placebo Effect","Exercise Therapy","Therapeutic Alliance","Treatment Adherence","Pain Catastrophizing","Kinesiophobia","2026-04-06",{"date":453,"type":34},"2026-04-09",{"date":455,"type":23},"2026-05-06",{"date":457,"type":23},"2028-05-06",{"name":459,"class":40},"Istanbul Nisantasi University",{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":466,"eligibilityCriteria":467,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":468,"targetDuration":4,"studyType":24,"phases":470,"briefSummary":471,"conditions":472,"keywords":475,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":41},"100623287","ultrasound-guided-serratus-posterior-superior-intercostal-plane-block-for-analgesia-in-arthroscopic-shoulder-surgery-100623287","NCT07394673","Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Analgesia in Arthroscopic Shoulder Surgery","Postoperative Analgesic Efficacy of Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block in Arthroscopic Shoulder Surgery","SPSIP","Inclusion Criteria:\n\n* Classified as American Society of Anesthesiologists (ASA) physical status I-II-III\n* Scheduled for elective shoulder arthroscopy surgery\n* Surgery performed under general anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Use of anticoagulant or antiplatelet medications\n* Presence of bleeding diathesis or coagulation disorders\n* Known allergy or hypersensitivity to local anesthetics or opioid medications\n* Infection or history of previous surgery at the planned block site\n* Alcohol or drug dependence\n* Cognitive impairment preventing reliable pain assessment using the NRS\n* Pregnancy or lactation\n* Diabetes mellitus\n* Renal or hepatic impairment",{"count":469,"type":23},80,[26],"This study aimed to evaluate the effectiveness of serratus posterior superior intercostal plane (SPSIP) block in managing postoperative pain in patients undergoing arthroscopic shoulder surgery.",[473,29,474],"Postoperative Pain, Acute","Serratus Posterior Superior Intercostal Plane Block",[476,477,478],"postoperative analgesia","shoulder arthroscopy","serratus posterior superior intercostal plane block","2026-03-26",{"date":481,"type":34},"2026-03-27",{"date":483,"type":34},"2026-02-20",{"date":485,"type":23},"2026-07-20",{"name":487,"class":214},"Bursa City Hospital",{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":4,"eligibilityCriteria":494,"healthyVolunteers":12,"sex":18,"minAge":495,"maxAge":20,"enrollmentInfo":496,"targetDuration":4,"studyType":24,"phases":498,"briefSummary":499,"conditions":500,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":504,"completionDateStruct":506,"leadSponsor":508,"locationsCount":4},"100629991","the-effect-of-early-phase-graded-motor-imagery-following-massive-rotator-cuff-repair-100629991","NCT07481864","The Effect of Early-Phase Graded Motor Imagery Following Massive Rotator Cuff Repair.","The Effect of Early-Phase Graded Motor Imagery Following Massive Rotator Cuff Repair","Inclusion Criteria:\n\n* Age between 30 and 65 years\n* Presence of an arthroscopically repaired anterior-superior rotator cuff tear, involving the supraspinatus and subscapularis tendons\n\nExclusion Criteria:\n\n* Age younger than 30 years or older than 65 years\n\n  * Presence of severe malignant, hematological, endocrine, metabolic, rheumatologic, or gastrointestinal diseases\n  * Diagnosis of glenohumeral osteoarthritis (Kellgren-Lawrence grade III or higher, with radiographic evidence of osteophytes)\n  * Current treatment with cytotoxic agents or systemic corticosteroids\n  * Alcohol dependence, history of substance abuse, or psychological\u002Femotional disorders that may compromise the validity of informed consent\n  * Previous surgery on the ipsilateral shoulder\n  * Multiple tendon tears, such as combined tears involving the supraspinatus together with the infraspinatus or subscapularis tendons","30 Years",{"count":497,"type":23},38,[26],"Massive rotator cuff tears are associated with significant pain, functional limitations, and prolonged rehabilitation following surgical repair. In the early postoperative phase, rehabilitation protocols are often limited due to surgical protection requirements, which may delay the restoration of motor control and shoulder function. Graded motor imagery (GMI), a movement representation technique that includes laterality recognition, motor imagery, and mirror therapy, has been shown to modulate cortical processing and improve pain and motor function in various musculoskeletal and neurological conditions. However, its potential role in early postoperative shoulder rehabilitation has not been adequately investigated.",[29],"2026-03-16",{"date":503,"type":34},"2026-03-19",{"date":505,"type":23},"2026-08-15",{"date":507,"type":23},"2026-10-30",{"name":509,"class":40},"Acibadem University",{"id":511,"slug":512,"hasResults":12,"nctId":513,"briefTitle":514,"officialTitle":515,"acronym":4,"eligibilityCriteria":516,"healthyVolunteers":12,"sex":18,"minAge":517,"maxAge":267,"enrollmentInfo":518,"targetDuration":4,"studyType":24,"phases":520,"briefSummary":521,"conditions":522,"keywords":523,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":526,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":532,"locationsCount":41},"100607344","the-efficacy-and-safety-of-shoulder-motion-style-acupuncture-treatment-msat-on-in-patients-with-shoulder-pain-caused-by-traffic-accidents-100607344","NCT07187336","The Efficacy and Safety of Shoulder Motion Style Acupuncture Treatment (MSAT) on in Patients With Shoulder Pain Caused by Traffic Accidents","The Efficacy and Safety of Shoulder Motion Style Acupuncture Treatment (MSAT) on in Patients With Shoulder Pain Caused by Traffic Accidents: A Pragmatic Randomized Controlled Trial","Inclusion Criteria:\n\nAdults aged 19 to 70 years\n\nHospitalized with shoulder pain within 5 days after a traffic accident\n\nShoulder pain intensity ≥ 5 on the Numeric Rating Scale (NRS) with observed limitation of movement\n\nAble and willing to provide written informed consent\n\nExclusion Criteria:\n\nSerious conditions causing shoulder pain (e.g., malignant tumor, infection)\n\nProgressive or severe neurological deficits\n\nRecent shoulder surgery or procedure within 3 weeks\n\nShoulder pain mainly due to non-shoulder disorders (e.g., fibromyalgia, rheumatoid arthritis, gout)\n\nContraindications to MSAT (e.g., fracture, dislocation, ligament rupture or instability, severe inflammation)\n\nChronic diseases interfering with assessment (e.g., cardiovascular disease, renal disease, diabetic neuropathy, dementia, epilepsy)\n\nCurrent use of steroids, immunosuppressants, psychiatric drugs, or other medications that may affect results\n\nContraindications to acupuncture (e.g., bleeding disorders, anticoagulant use, severe diabetes, severe cardiovascular disease)\n\nPregnant or planning pregnancy\n\nSevere psychiatric illness\n\nParticipation in another interventional clinical trial\n\nUnable to provide informed consent\n\nAny other condition deemed inappropriate by the investigator","19 Years",{"count":519,"type":23},98,[26],"This study will test the effectiveness and safety of Motion Style Acupuncture Treatment (MSAT) for shoulder pain caused by traffic accidents. About 98 hospitalized patients with acute shoulder pain after a traffic accident will take part.\n\nParticipants will be randomly assigned to one of two groups:\n\nMSAT + integrative Korean medicine group (acupuncture, herbal medicine, pharmacopuncture, Chuna therapy, plus MSAT), or\n\nIntegrative Korean medicine only group (acupuncture, herbal medicine, pharmacopuncture, Chuna therapy).\n\nMSAT involves inserting needles into the shoulder area and gently moving the joint to improve pain relief and mobility. All treatments used in this study are standard care in Korean medicine.\n\nThe main outcomes are pain reduction, shoulder movement, daily function, quality of life, and patient satisfaction. Safety will also be monitored by recording any side effects such as temporary soreness, bruising, or discomfort.\n\nTreatment will be provided during hospitalization (up to 5 days), and patients will be followed up by phone at 2 weeks and 1 month after enrollment.\n\nThe results of this trial will help determine whether adding MSAT to standard integrative Korean medicine treatment provides greater benefit for patients with acute shoulder pain after traffic accidents.",[29],[524],"motion style acupuncture treatment","2026-03-05",{"date":527,"type":34},"2026-03-09",{"date":529,"type":34},"2025-11-02",{"date":531,"type":23},"2026-09-30",{"name":533,"class":40},"Jaseng Medical Foundation",{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":539,"acronym":540,"eligibilityCriteria":541,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":187,"enrollmentInfo":542,"targetDuration":4,"studyType":24,"phases":543,"briefSummary":544,"conditions":545,"keywords":548,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":4},"100627168","comparison-of-the-effectiveness-of-usg-guided-interscalene-block-versus-combined-interscalen-suprascapular-block-for-arthroscopic-shoulder-surgery-100627168","NCT07445126","Comparison of the Effectiveness of USG-Guided Interscalene Block Versus Combined Interscalen-Suprascapular Block for Arthroscopic Shoulder Surgery","Comparison of the Effectiveness of Ultrasound-Guided Interscalene Block Versus Combined Interscalene and Suprascapular Nerve Blocks in Arthroscopic Shoulder Surgery","ISB vs SSB","Inclusion Criteria:\n\nPlanned arthroscopic shoulder surgery ASA physical status I-III Age between 18 and 75 years Ability to provide informed consent Suitable for regional anesthesia with ultrasound guidance\n\nExclusion Criteria:\n\nAllergy or contraindication to local anesthetics Coagulopathy or current anticoagulant therapy Infection at the block injection site Severe pulmonary disease (e.g., severe COPD) Pre-existing neurological deficit in the operative upper limb Body mass index \\> 40 kg\u002Fm² Pregnancy or breastfeeding History of phrenic nerve palsy Inability to cooperate with block procedure or follow-up",{"count":415,"type":23},[26],"This study aims to compare two commonly used regional anesthesia techniques for shoulder arthroscopy: the ultrasound-guided interscalene block and the combined interscalene-suprascapular nerve block. Both techniques are routinely performed to reduce pain during and after shoulder surgery. The purpose of this study is to determine which method provides better postoperative pain control, reduces the need for pain medication, and causes fewer side effects such as diaphragmatic dysfunction. Participants will receive one of the two nerve block techniques before surgery, and their pain scores, opioid consumption, and respiratory effects will be monitored during the first 24 hours after the operation.",[29,546,547],"Artroscopic Surgery","Postoperative Pain",[549,550,551,552,547],"Interscalene Block","Suprascapular Nerve Block","Regional Anesthesia","Artroscopic Shoulder Surgery","2026-02-25",{"date":555,"type":34},"2026-03-03",{"date":557,"type":23},"2026-03-01",{"date":559,"type":23},"2026-12-30",{"name":561,"class":40},"Asuman Ocaklar",{"id":563,"slug":564,"hasResults":12,"nctId":565,"briefTitle":566,"officialTitle":567,"acronym":4,"eligibilityCriteria":568,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":569,"targetDuration":4,"studyType":24,"phases":571,"briefSummary":572,"conditions":573,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":576,"lastUpdatePostDateStruct":577,"startDateStruct":579,"completionDateStruct":580,"leadSponsor":581,"locationsCount":41},"100625592","interscalene-block-versus-anterior-suprascapular-block-for-post-thoracotomy-shoulder-pain-100625592","NCT07424638","Interscalene Block Versus Anterior Suprascapular Block for Post-Thoracotomy Shoulder Pain","Interscalene Block Versus Anterior Suprascapular Block for Post-Thoracotomy Shoulder Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\> 18 years and ≤ 65 years old.\n* American Society of Anesthesiologists (ASA) physical status II-III.\n* Body mass index 18-35 kg\u002Fm2.\n* Patients who have a confirmed diagnosis of lung cancer and are scheduled for elective open-lung surgery.\n\nExclusion Criteria:\n\n* Allergy to local anesthetics.\n* Known psychiatric or neurologic disorders.\n* Alcohol or narcotics abuse.\n* Contraindications to thoracic epidural or suprascapular block, or interscalene block, e.g., coagulopathy or local infection.\n* Pre-existing shoulder symptoms.\n* History of previous thoracotomy.\n* Severe restrictive or obstructive pulmonary disease.\n* Pre-existing contralateral diaphragmatic paralysis.",{"count":570,"type":23},75,[26],"This study aims to compare the frequency of occurrence of ipsilateral shoulder pain in patients undergoing thoracotomy with ultrasound-guided interscalene block, anterior suprascapular block as adjunct to epidural and epidural block only.",[549,574,575,29],"Anterior Suprascapular Block","Thoracotomy","2026-02-21",{"date":578,"type":34},"2026-02-24",{"date":576,"type":34},{"date":258,"type":23},{"name":582,"class":40},"National Cancer Institute, Egypt",{"id":584,"slug":585,"hasResults":12,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":4,"eligibilityCriteria":589,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":590,"targetDuration":4,"studyType":24,"phases":591,"briefSummary":592,"conditions":593,"keywords":596,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":602,"lastUpdatePostDateStruct":603,"startDateStruct":605,"completionDateStruct":607,"leadSponsor":609,"locationsCount":41},"100614097","hiit-for-inflammatory-driven-shoulder-pain-100614097","NCT07275164","HIIT for Inflammatory-driven Shoulder Pain.","Revolutionizing Musculoskeletal Shoulder Pain Management: High-intensity Interval Training as a Systemic Intervention. A Feasibility Study.","Inclusion Criteria:\n\nShoulder pain group\n\n* Shoulder pain \\> 3 months\n* Diagnosis of rotator cuff related shoulder pain or frozen shoulder\n* Understanding Dutch in speaking and writing.\n\nControl group\n\no Understanding Dutch in speaking and writing\n\nExclusion Criteria:\n\nShoulder pain group\n\n* \\\u003C18 years\n* Shoulder surgery or trauma in past year\n* Neurological, cancer, or neuromuscular disease\n* Osteoarthritis, cervical or AC joint pathology\n* Heavy physical exertion \\\u003C48h before testing\n\nControl group\n\n* \\\u003C18 years\n* recent or recurrent neck\u002Fshoulder pain\n* systemic or neurological disease\n* psychiatric disorders\n* pregnancy\u002Fbreastfeeding\n* pain medication \\\u003C48h before test",{"count":244,"type":23},[26],"This feasibility study investigates whether high-intensity interval training (HIIT) is feasible and acceptable for individuals with long-term shoulder pain where low-grade inflammation is suspected. Many patients do not recover fully with current local treatments, and systemic factors such as inflammation, and metabolic changes, additionally disturbances in the functioning of the nervous system often seem to play a role. HIIT is a time-efficient form of exercise that has been shown to improve inflammation and metabolic values and positively influence the balance of the nervous system. In this feasibility study, the investigators are enrolling 15 individuals with persistent shoulder pain (diagnosed with rotator cuff-related shoulder pain or frozen shoulder) with \\>3 months of symptoms, and 15 individuals without shoulder complaints. All participants will undergo measurements of inflammatory levels, glycosylated hemoglobin (HbA1c), blood pressure, body composition, pain sensitivity tests, and complete questionnaires about autonomic complaints and quality of life. Participants with shoulder pain will also perform one personalized HIIT session on a cycle ergometer. The investigators will assess whether participants accept a systemic intervention for their shoulder pain, if they are cooperative, and how they feel about the session; additionally, any side effects will be recorded. The aim is to determine whether HIIT is practically feasible and safe for this group and whether there are indications that systemic factors such as inflammation and nervous system function are associated with persistent shoulder pain. The outcome will determine whether follow-up research with a larger study is worthwhile.",[594,441,193,595,29],"Chronic Shoulder Pain","Shoulder Adhesive Capsulitis",[597,598,599,600,228,394,601],"low-grade inflammation","chronic shoulder pain","autonomic dysfunction","metabolic syndrome","high intensity interval training","2026-02-10",{"date":604,"type":34},"2026-02-13",{"date":606,"type":34},"2025-12-10",{"date":608,"type":23},"2026-10",{"name":610,"class":40},"Universiteit Antwerpen",{"id":612,"slug":613,"hasResults":12,"nctId":614,"briefTitle":615,"officialTitle":616,"acronym":617,"eligibilityCriteria":618,"healthyVolunteers":12,"sex":18,"minAge":619,"maxAge":620,"enrollmentInfo":621,"targetDuration":4,"studyType":24,"phases":623,"briefSummary":624,"conditions":625,"keywords":631,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":634,"lastUpdatePostDateStruct":635,"startDateStruct":637,"completionDateStruct":639,"leadSponsor":641,"locationsCount":41},"100523389","embolization-treatment-of-chronic-refractory-shoulder-tendinopathy-100523389","NCT06095050","Embolization Treatment of Chronic Refractory Shoulder Tendinopathy","Efficacy of Lipiodol Embolization for Chronic Tendinopathy of the Rotator Cuff","ELECTRC","Inclusion Criteria:\n\n1. Male, female, transgender female, transgender male, non-binary\n2. Moderate to severe shoulder pain (VAS \\> 40)\n3. Pain refractory to at least 6 months of physician-directed conservative therapy (analgesics or injections or PT), including a minimum of 6 weeks of PT\n4. Willing, able, and mentally competent to provide informed consent and to tolerate angiography and physical therapy\n\nExclusion Criteria:\n\n1. History of peripheral arterial disease or peripheral artery disease symptoms including claudication, diminished or absent upper\u002Flower extremity pulses, or known upper extremity arterial atherosclerosis or occlusion that would limit selective angiography\n2. Known history of anaphylaxis to iodinated contrast agents or gadolinium based contrast\n3. Acute kidney injury\n4. Allergy to poppy seeds or lipiodol\n5. Renal dysfunction as defined by serum creatinine \\>1.6 dl\u002Fmg or eGFR \\\u003C60 obtained within 30 days of procedure.\n6. Uncorrectable coagulopathy (platelet count \\\u003C 50,000, international normalized ratio \\>1.8 within 30 days of procedure\n7. Active systemic or local upper extremity infection\n8. Patient pregnant, intending to become pregnant during the study.\n9. Prior shoulder replacement surgery\n10. Prior rotator cuff repair surgery\n11. Previous history of complete full-thickness tear of the rotator cuff\n12. Presence of non-MRI compatible devices (e.g., non-compatible cardiac pacemaker).","21 Years","80 Years",{"count":622,"type":23},41,[26],"This is a randomized controlled trial in which patients with moderate to severe shoulder pain (Visual Analog Scale (VAS) \\> 40), in the setting of rotator cuff tendinopathy refractory to conservative treatment, will be enrolled.\n\nThe primary aim of the study is to estimate the effect of transcatheter arterial embolization (TAE) with physical therapy (PT) vs PT alone on the change in shoulder pain at 12-month follow up. Scientific objectives also include an assessment of safety of the intervention, assessment of changes in Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity score, Shoulder Pain and Disability Index (SPADI) scores, MRI Tendinopathy Score between the TAE + PT and PT groups.",[29,626,627,628,629,630],"Tendinopathy","Rotator Cuff Tendinitis","Rotator Cuff Tendinosis","Embolization","Arterial Occlusion",[632,118,633],"pain","tendinopathy","2026-02-04",{"date":636,"type":34},"2026-02-06",{"date":638,"type":34},"2025-01-16",{"date":640,"type":23},"2028-04-21",{"name":642,"class":40},"Brigham and Women's Hospital",{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":4,"eligibilityCriteria":649,"healthyVolunteers":17,"sex":650,"minAge":19,"maxAge":4,"enrollmentInfo":651,"targetDuration":4,"studyType":24,"phases":652,"briefSummary":654,"conditions":655,"keywords":656,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":660,"lastUpdatePostDateStruct":661,"startDateStruct":662,"completionDateStruct":664,"leadSponsor":666,"locationsCount":41},"100623708","phase-4-bupivacaine-with-epinephrine-over-diaphragm-in-laparoscopy-100623708","NCT07400146","Bupivacaine With Epinephrine Over Diaphragm in Laparoscopy","Instillation of Bupivacaine With Epinephrine Over Diaphragm to Reduce Postoperative Shoulder Pain Following Benign Gynecologic Laparoscopic Surgery: A Randomized Control Trial","Inclusion Criteria:\n\n* Provide a signed and dated informed consent form\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* 8 years of age or older\n* Undergoing laparoscopic surgery at Cedars-Sinai Medical Center with a surgeon in the Minimally Invasive Gynecologic Surgery division.\n\nExclusion Criteria:\n\n* Pregnancy\n* Urgent\u002Fnon-scheduled surgery\n* Scheduled for planned or possible concomitant non-gynecologic surgery (e.g., urologic or colorectal procedure)\n* Baseline shoulder pain\n* Baseline opioid use\n* Baseline of chronic pain syndrome\n* Conversion to open surgery\n* Allergy or intolerance to bupivacaine, lidocaine (or amide class of anesthetics), oxycodone, acetaminophen, or ibuprofen\n* Planned post-operative admission","FEMALE",{"count":334,"type":23},[653],"PHASE4","Postoperative shoulder pain is often reported to be particularly bothersome after laparoscopy. The benefits of local anesthetic, such as bupivacaine, applied to subcutaneous tissue for general postoperative pain management after surgery is well established. However, there have been no studies on sprayed bupivacaine over the diaphragm to reduce shoulder pain in laparoscopic surgery. The purpose of the study is to evaluate if sprayed infra-diaphragmatic bupivacaine compared to placebo (saline) will improve postoperative shoulder pain in patients undergoing benign laparoscopic gynecologic surgery. The entire study will be conducted at Cedar Sinai Medical Center.",[547,29],[657,658,659],"Laparoscopy","Gynecologic surgery","Bupivacaine","2026-02-03",{"date":602,"type":34},{"date":663,"type":23},"2026-02",{"date":665,"type":23},"2026-08",{"name":667,"class":40},"Cedars-Sinai Medical Center"]