[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sickle-cell-crisis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sickle-cell-crisis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100627576","phase-3-optimal-timing-of-ketamine-initiation-for-scd-pain-100627576",false,"NCT07450430","Optimal Timing of Ketamine Initiation for SCD Pain","Double-blind, Randomized, Placebo Controlled Study to Evaluate Optimal Timing of Ketamine Initiation","Inclusion Criteria:\n\n* sickle cell disease diagnosis\n* presenting with pain to ED or infusion clinic\n* patient at study site\n* 6 to 24 years old\n\nExclusion Criteria:\n\n* allergy to ketamine\n* severe side effects associated with ketamine\n* unable to consent","ALL","6 Years","24 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","The goal of this clinical trial is to learn if the use of early ketamine decreases the chance of admission to the hospital in patients with sickle cell disease presenting with pain.\n\nThe main questions this study aims to answer are:\n\n* Does ketamine given within 1 hour of acute care presentation decrease the chance of hospital admission?\n* If admitted, does continuing ketamine in the first few hours of admission decrease opioid use or length of stay compared to those who start it later in the admission?\n\nResearchers will compare the study arm to patients with sickle cell disease who receive placebo within 1 hour of presentation for the first aim.\n\nParticipants will be given ketamine\u002Fplacebo by mouth without 1 hour of presentation.\n\nIf admitted, all participants will be able to start open label IV ketamine upon admission to the floor based on their clinical needs. Participants who end up starting ketamine will be reviewed to determine if early start to ketamine is helpful in reducing opioid use and length of stay.",[27,28],"Sickle Cell Disease","Sickle Cell Crisis",[30,31,32],"sickle cell disease","ketamine","pain","NOT_YET_RECRUITING","2026-03-05",{"date":36,"type":37},"2026-03-09","ACTUAL",{"date":39,"type":21},"2026-02",{"date":41,"type":21},"2030-02",{"name":43,"class":44},"Boston Children's Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100560634","phase-4-ketorolac-for-acute-vaso-occlusive-crisis-in-pediatric-sickle-cell-disease-100560634","NCT06579703","Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease","Ketorolac Dosing for Acute Vaso-Occlusive Crisis in Pediatric Patients With Sickle Cell Disease","Inclusion Criteria:\n\n* Pediatric patients with sickle cell disease (any genotype) who present to DCMC Emergency department or outpatient hematology clinic with acute pain.\n\nExclusion Criteria:\n\n* Patients receiving NSAID medication \\\u003C6 hours from presentation\n* known kidney injury\n* sickle nephropathy\n* bleeding concerns\n* allergy to NSAID medication\n* chronic pain patient\n* hemodynamic instability as defined by the treating provider","1 Day","21 Years",{"count":56,"type":21},102,[58],"PHASE4","Pediatric patients who present with acute vaso-occlusive pain crisis may have equivalent pain reduction scores at lower dosing of intravenous Ketorolac compared to standard dosing of 0.5 mg\u002Fkg\u002Fdose IV (\\\u003C16yo max 15mg, \\>16yo max 30mg) x 1 dose.",[27,28,61],"Veno-occlusive Disease","2024-08-28",{"date":64,"type":37},"2024-08-30",{"date":66,"type":21},"2024-09-30",{"date":68,"type":21},"2028-02-15",{"name":70,"class":44},"Children's Blood and Cancer Center at Dell Children's Medical Center",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":45},"100467976","sickle-cell-improvement-enhancing-care-in-the-emergency-department-100467976","NCT05373771","Sickle Cell Improvement: Enhancing Care in the Emergency Department","SCIENCE","Inclusion Criteria:\n\n* ED visit for uncomplicated pain crisis\n* Sickle cell disease\n* Receipt of at least one opioid\n\nExclusion Criteria:\n\n* Acute chest syndrome\n* Fever \\> 38.5 in the ED\n* priapism\n* sickle cell trait","18 Years",{"count":80,"type":21},5328,[82],"NA","Sickle cell disease (SCD) is an inherited blood disorder affecting approximately 36,000 children in the United States, approximately 90% of whom are Black. The disease is characterized by recurrent, severe pain crises which result in high rates of emergency department visits and hospitalizations, and decreased quality of life. The National Heart, Lung and Blood Institute, as well as the American Society of Hematology, have endorsed pain management guidelines regarding the timeliness of care for children presenting with these acute pain crises. These evidence-based guidelines are infrequently followed, resulting in increased pain and hospitalizations. In additional to other barriers to following the guideline, structural racism has been proposed as a significant contributor and the New England Journal of Medicine recently called for the institution of SCD-specific pain management protocols to combat structural racism and reduce time to opioid administration. The investigators' long-term goal is to improve the care and health outcomes of children with acute painful vaso-occlusive crisis treated in the emergency department. The overall aim of the investigators is to test a care pathway using multifaceted implementation strategies to increase guideline adherent care for children in the emergency department with acute painful vaso-occlusive crisis.",[28],"RECRUITING","2023-08-08",{"date":88,"type":37},"2023-08-14",{"date":90,"type":37},"2021-09-01",{"date":92,"type":21},"2027-08-31",{"name":94,"class":44},"Medical College of Wisconsin"]