[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sickle-cell-trait\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sickle-cell-trait":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,72,92],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":4,"leadSponsor":41,"locationsCount":44},"100098389","blood-sampling-for-research-related-to-sickle-cell-disease-100098389",false,"NCT00542230","Blood Sampling for Research Related to Sickle Cell Disease","High Sensitivity Screening of Compound Libraries to Discover a Drug for the Treatment of Sickle Cell Disease","* INCLUSION CRITERIA:\n* Patients with sickle cell trait\n* Patients with known hemoglobinopathies involving one or two genes for sickle hemoglobin\n* Healthy volunteers for control experiments\n* Age range: adults greater than or equal to 18 years of age\n\nEXCLUSION CRITERIA:\n\n* Subjects who are unable to comprehend the investigational nature of the laboratory research are ineligible to enroll in this protocol.\n* As a safety precaution in handling the blood samples, patients with HIV, Hepatitis B or Hepatitis C will be excluded from the study. HIV, Hepatitis B or Hepatitits C testing will not be done under this study. Participants must be co-enrolled under another NIH protocol where the screening evaluation has been performed.",true,"ALL","18 Years","100 Years",{"count":21,"type":22},250,"ESTIMATED","OBSERVATIONAL","This study will collect representative blood samples from healthy children and adults and from children and adults who have unique red blood cell features that are related to sickle cell disease. Sickle cell disease is a blood disease that limits the ability of red blood cells to carry oxygen throughout the body. The purpose of the study is to collect a variety of blood samples that may then be used to investigate advances and potential new drug treatments for sickle cell disease.\n\nVolunteers must be at least 18 years of old. Samples will be taken both from healthy volunteers and from volunteers who have unique red blood cell features that are related to sickle cell disease. Candidates will be screened with a medical history.\n\nDuring the study, participants will undergo a one- to two-hour outpatient procedure at the National Institutes of Health Clinical Center. Once researchers have explained the study and obtained the participant s consent, participants will donate 8 cc (approximately 2 teaspoons) of blood.\n\nBecause repeat testing helps researchers validate study findings, participants who have the unique red blood cell features mentioned above may also be asked if they are willing to return and donate another 2 cc to 8 cc of blood for additional studies. The amount of blood drawn will not exceed 50 ml with any eight-week period for adults or 7 cc within any six-week period for children.",[26,27,28],"Sickle Cell Trait","Sickle Cell Disease","Sickle Cell Anemia",[30,31,26,32,27,33],"Erythrocytes","Drug Screen","Sickle Hemoglobin","Natural History","RECRUITING","2026-06-05",{"date":37,"type":38},"2026-06-08","ACTUAL",{"date":40,"type":38},"2007-11-07",{"name":42,"class":43},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":56,"studyType":23,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":71},"100597875","sickle-cell-kidney-biorepository-100597875","NCT07064174","Sickle Cell Kidney Biorepository","Sickle Cell Kidney (SCeK) Biorepository","SCeK","Inclusion Criteria:\n\n1. Age over 18 years,\n2. Estimated glomerular filtration rate greater than or equal to 15 mL\u002Fmin,\n3. Presence of any hemoglobinopathy (will need to be confirmed by hemoglobin electrophoresis or genetic testing),\n4. Controls (absence of hemoglobinopathy) will be subject to review and only selected if demographics are identical to a currently enrolled participant with a hemoglobinopathy.\n\nExclusion Criteria:\n\n1. Age 66 years or older,\n2. Estimated glomerular filtration rate less than 15 mL\u002Fmin or on dialysis,\n3. Active pregnancy (may be enrolled 4 weeks or more after delivery),\n4. Active sickle cell pain episode requiring hospitalization or emergency room visit or pain infusion clinic visit (may be enrolled 2 weeks or more after resolution of severe pain),\n5. Active malignancy on induction or consolidation treatment. Maintenance chemotherapy in remission will be considered,\n6. Prisoners.","65 Years",{"count":55,"type":22},800,"10 Years","Kidney disease is a major cause of illness and death in people with sickle cell disease and sickle cell trait. Despite these concerning facts, we do not (1) have an in-depth understanding of how kidney disease starts in sickle cell disease and sickle cell trait, (2) have detailed insights into why kidney disease is worse in people with sickle cell disease and sickle cell trait, (3) have management options that are tailored to treating or preventing kidney disease in people with sickle cell disease or sickle cell trait.\n\nThe SCeK Biorepository is a specialized, secure repository designed for the collection of blood and urine samples from people with sickle cell disease and sickle cell trait. These samples are connected to detailed medical records, with the sole purpose of allowing researchers to better understand how kidney disease starts and progresses in people with the sickle cell gene. By studying these stored samples (using new tests) together with health information, researchers can find better early warning signs of kidney injury and develop better ways to protect kidney health in people with sickle cell disease and sickle cell trait.",[26,59,60],"Sickle Cell Disease (SCD)","Chronic Kidney Disease","2026-04-06",{"date":63,"type":38},"2026-04-13",{"date":65,"type":38},"2024-08-22",{"date":67,"type":22},"2049-12",{"name":69,"class":70},"University of Texas Southwestern Medical Center","OTHER",2,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100521575","achieving-understanding-of-the-natural-history-of-sickle-cell-trait-aunt-100521575","NCT06071377","Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)","Inclusion Criteria:\n\n1. Are willing to voluntarily participate and sign the study consent\n2. Know\u002Fsuspect they have SCT and are willing to get tested to confirm\u002Flearn about their SCT status\n3. Adults ages 18 and older\n\nExclusion Criteria:\n\n1. Unwilling to sign consent\n2. Known end-stage renal disease or dialysis\n3. Known SCD (including sickle cell-beta thalassemia)\n4. People who do not have SCT",{"count":79,"type":22},1000,"The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.",[26],"2025-11-04",{"date":84,"type":38},"2025-11-06",{"date":86,"type":38},"2023-04-01",{"date":88,"type":22},"2027-02",{"name":90,"class":70},"National Alliance for Sickle Cell Centers",10,{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":16,"sex":99,"minAge":100,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":103,"conditions":104,"keywords":105,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":44},"100599364","bone-loss-physical-function-and-frailty-in-older-women-with-sickle-cell-trait-sickle-cell-trait-100599364","NCT07083531","Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait","Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait","Inclusion Criteria:\n\n* Female of African Decent.\n* Age 50 years or older.\n* Lack of menstrual period for at least 12 consecutive months\n\nExclusion Criteria:\n\n* Taking medications known to influence bone metabolism (e.g., glucocorticoids, hormonal therapy, cancer or chemotherapy meds, anti-resorptive medications or anabolic therapies).\n* Known metabolic bone disorder (e.g., uncontrolled thyroid disease, hyperparathyroidism, Vitamin D deficiency)\n* Taking an investigational drug\n* Documented sickle cell disease","FEMALE","50 Years",{"count":102,"type":22},50,"This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the development of bone thinning in older women. The second purpose is to investigate whether women with SCT have reduced muscle function and increased frailty compared to women without SCT. The investigators estimate enrolling 50 female volunteers who are at least 50 years old and have not had a menstrual period for at least 12 consecutive months. Volunteers need not know whether they have SCT as this will be evaluated as part of the study.",[27,26],[59,106],"Sickle Cell Trait (SCT)","2025-07-16",{"date":109,"type":38},"2025-07-24",{"date":111,"type":38},"2022-08-23",{"date":113,"type":22},"2025-08-23",{"name":115,"class":70},"UConn Health"]