[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"silent-brain-infarction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:silent-brain-infarction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100596633","interventions-for-silent-brain-infarction-and-perioperative-neurocognitive-disorders-in-cardiovascular-surgery-100596633",false,"NCT07048002","Interventions for Silent Brain Infarction and Perioperative Neurocognitive Disorders in Cardiovascular Surgery","Interventions for Silent Brain Infarction and Perioperative Neurocognitive Disorders in Cardiovascular Surgery (the INSPIRE Study)","INSPIRE","Inclusion criteria:\n\n* Male or female adult patients aged 60 years or older\n* Receiving elective cardiovascular surgery with cardiopulmonary bypass\n* Written Informed consent provided\n\nExclusion criteria:\n\n* Contraindication to MRI scanning\n* Not suitable for receiving interventions to achieve NeuroFirst target bundle\n* Unable to receive neuro-cognitive evaluation due to language, vision, or hearing impairments\n* Breastfeeding or pregnancy\n* Terminal illness with a life expectancy of less than 3 months\n* Mental or legal disability\n* current enrollment in other interventional study","ALL","60 Years",{"count":20,"type":21},912,"ESTIMATED","INTERVENTIONAL",[24],"NA","the purpose of the study is to investigate whether a combined anesthetic targets bundle, known as the NeuroFirst strategy, focused on neurological protection, can reduce the incidence of silent brain infarction (SBI) and perioperative neurocognitive disorders (PND) in patients undergoing cardiac surgery. Additionally, the trial will assess the safety of this strategy.\n\nThe NeuroFirst target bundle incorporates multiple parameters, including mean arterial pressure (MAP), bispectral index (BIS), regional cerebral oxygen saturation (rSO2), and arterial inflow temperature during cardiopulmonary bypass.\n\nThe primary question this study seeks to answer is: Does the NeuroFirst strategy reduce the incidence of SBI and PND in cardiac surgery?\n\nTo address this, researchers will compare the NeuroFirst strategy with routine institutional practices based on published guidelines. Participants will be randomly assigned to either the NeuroFirst group or the routine care group. All participants will undergo magnetic resonance imaging (MRI), be assessed using the Confusion Assessment Method (CAM) and the Montreal Cognitive Assessment (MoCA), and be followed for up to one year postoperatively.",[27,28,29,30],"Silent Brain Infarction","Neurocognitive Disorders","Cardiac Surgery","Neuroprotective","RECRUITING","2025-11-19",{"date":34,"type":35},"2025-11-24","ACTUAL",{"date":37,"type":35},"2025-07-06",{"date":39,"type":21},"2028-10-31",{"name":41,"class":42},"Chinese Academy of Medical Sciences, Fuwai Hospital","OTHER",5,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":63,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":5},"100491894","prevalence-of-attributable-etiology-and-modifiable-stroke-risk-factors-in-patients-with-covert-brain-infarctions-100491894","NCT05685069","Prevalence of Attributable Etiology and Modifiable Stroke Risk Factors in Patients With Covert Brain Infarctions","Prevalence of Attributable Etiology and Modifiable Stroke Risk Factors in Patients With Covert Brain Infarctions (CBI-registry)","CBI-Registry","Inclusion Criteria:\n\n* Any clinically silent ischemic lesions of the brain parenchyma detected on neuroimaging defined according to established criteria as either:\n\n  * DWI positive lesions: Focus of restricted diffusion (high DWI signal and low ADC value) occurring in either white or gray matter, located in the cerebrum, cerebellum, or brain stem AND not satisfying the diagnostic criteria for MS OR\n  * Cavitatory Lesions: ≥ 3 mm in size that follow CSF on all sequences that are slit or wedge shaped with an irregular margin AND NOT longitudinally aligned with perforating vessels or with a multiple, bilateral symmetrical distribution OR\n  * T2W hyperintense\u002FT1W hypointense lesions: Focal lesion with high T2W signal and low T1W signal that have prior evidence of restricted diffusion; OR present within cortical gray matter or deep gray matter nuclei OR a lesion that is new, compared with an MRI performed within 3 months OR T2W hyper\u002FT1W hypointense lesions in the white matter, which are discontinuous but associated with the classic confluent periventricular T2 intense change of leukoaraiosis (Fazekas ≥2) AND NOT satisfying the diagnostic criteria for MS or with a significant patient history of severe trauma, radiation, drug toxicity, or carbon monoxide poisoning\n* Informed Consent as documented by signature by patient or legally authorized representative\n\nExclusion Criteria:\n\n* Projected life expectancy of less than 2 years,\n* Contraindication to MRI,\n* Patients with a history of symptoms compatible with an AIS\u002FTIA attributable to the lesion observed, covert neurological deficits are allowed,\n* Patient is already included in another clinical trial that will affect the objectives of this study,\n* Patient's lack of accountability, inability to appreciate the nature, meaning and consequences of the study and to formulate his\u002Fher own wishes correspondingly,\n* Women who are pregnant or breast feeding or intention to become pregnant during the course of the study,\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant,\n* Contraindications to any of the routine procedures, e.g. inability to obtain neurovascular ultrasound examination,\n* Known or suspected non-compliance, drug or alcohol abuse","16 Years",{"count":54,"type":21},230,"OBSERVATIONAL","The CBI registry is a prospective, interdisciplinary, multimodal observational registry of patients with covert brain infarction. Methods: A standardized workup in analogy to manifest ischemic stroke including cerebral MRI, long-term rhythm monitoring (3 x 7 days ECG), echocardiography, laboratory work-up and risk factor assessment as well as noninvasive angiography of the cervical and intracranial arteries will be performed.",[58,59,60,61,62,27],"Silent Stroke","Silent Cerebral Infarct","Covert Brain Infarct","Covert Brain Infarction","Lacune",[64,65,66],"Covert brain infarction","Covert cerebrovascular disease","Ischemic stroke","2024-11-12",{"date":69,"type":35},"2024-11-14",{"date":71,"type":35},"2019-03-01",{"date":73,"type":21},"2026-08-31",{"name":75,"class":42},"Insel Gruppe AG, University Hospital Bern"]