[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sinusitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sinusitis":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,74,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100517900","complicated-infections-in-otorhinolaryngology-100517900",false,"NCT06023550","Complicated Infections in Otorhinolaryngology","Analysis of Complicated Infections in Pediatric and Adult Populations Treated by Otorhinolaryngologist","ENT_infect","Inclusion Criteria:\n\n* Diagnoses: rhinitis AND\u002FOR sinusitis AND\u002FOR facial cellulitis AND\u002FOR facial abscess AND\u002FOR nasal furuncle AND\u002FOR infection of the outer AND\u002FOR middle AND\u002FOR inner ear AND\u002FOR temporal bone AND\u002FOR infection of the soft tissues of the neck with\u002Fwithout bone and cartilage involvement AND\u002FOR laryngitis AND\u002FOR epiglottitis (or supraglottitis) AND\u002FOR\n* complication of inflammation of the nose and paranasal cavities AND\u002FOR ear AND\u002FOR temporal bone AND\u002FOR:\n* treated at the Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Center Ljubljana.\n\nExclusion Criteria:\n\n* disagreement of the patient and\u002For parents (or legal guardians) with inclusion in the research,\n* failure to meet the inclusion criteria.","ALL",{"count":19,"type":20},2550,"ESTIMATED","1 Year","OBSERVATIONAL","This observational study aims to learn more about complicated infections treated by otorhinolaryngologists. The main questions to answer are:\n\n* What is the management of complicated sinonasal infections in Ljubljana, Slovenia,\n* What is the management of complicated ear and temporal bone infections in Ljubljana, Slovenia,\n* What is the management of complicated neck soft tissue infections in Ljubljana, Slovenia,\n* What is the management of complicated laryngeal infections in Ljubljana, Slovenia\n\nParticipants will receive standard treatment according to the established evidence-based clinical practice.",[25,26,27,28,29,30,31,32,33,34,35],"Sinusitis","Otitis","Laryngitis","Lymphadenitis","Quinsy","Peritonsillar Abscess","Parapharyngeal Abscess","Preseptal Cellulitis","Subperiosteal Abscess","Orbital Abscess","Epiglottitis","RECRUITING","2026-04-27",{"date":39,"type":40},"2026-04-29","ACTUAL",{"date":42,"type":40},"2024-09-01",{"date":44,"type":20},"2028-09",{"name":46,"class":47},"University Medical Centre Ljubljana","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":5},"100283878","in-clinic-endoscopic-polypectomy-for-chronic-sinusitis-with-nasal-polyps-100283878","NCT02975310","In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps","Endoscopic Polypectomy Performed In Clinic for Chronic Rhinosinusitis With Polyps: The EPIC Randomised Controlled Trial","Inclusion Criteria:\n\n1. Age 18 years or older\n2. Diagnosis of chronic rhinosinusitis with polyps requiring surgical treatment after having been treated with medical therapy as designated by the Canadian clinical practice guidelines for acute and chronic sinusitis. 15\n3. Bilateral nasal polyps present of Grade ≥ 2 on each side as determined by the Lildholdt scale score measured by nasal endoscopy at the screening visit.\n4. Must have nasal blockage score greater than or equal to 2 on the sinonasal outcome test SNOT-22 at the screening visit.\n5. Must have an American Society of Anesthesiologists physical status PS3 classification or less.\n6. Participants with comorbid asthma or chronic obstructive pulmonary disease (COPD) must have stable disease with no exacerbations (no emergency room visits, hospitalisations, or oral or parental steroid use for these lower respiratory conditions) within 3 months before the screening visit.\n7. Must be capable, in the opinion of the investigator, of providing informed consent to participate in the study. Participants must sign an informed consent document indicating that they understand the purpose of and procedures of the study and are willing to participate in the study.\n\nExclusion Criteria:\n\n1. Women who are pregnant or breast feeding as per patient's report\n2. Patients with hyperplastic polyps or polyps large enough that they result in external nasal deformity\n3. Facial pain\u002Fpressure score higher than 2 on the sinonasal outcome test SNOT-22 at the screening visit.\n4. History of any surgical procedure that prevents the ability to accurately grade the nasal polyps\n5. Participants who will not be able to complete the follow-up appointments\u002Fevaluations\n6. Have significant oral structural abnormalities, e.g. unrepaired cleft palate\n7. Septal deviation requiring correction in order to perform either EPIC or ESS procedures\n8. Diagnosis of an immunodeficiency or immunocompromised state\n9. Diagnosis of cystic fibrosis\n10. Diagnosis of allergic fungal sinusitis\n11. Contraindication to the use of oral corticosteroids (e.g. uncontrolled diabetes, congestive heart failure, uncontrolled hypertension, known renal insufficiency, known peptic ulcer disease, known glaucoma, pregnancy)\n12. History of either Churg-Strauss syndrome, primary ciliary dyskinesia, or vasculitis (e.g. granulomatosis with polyangiitis(GPA))\n13. Allergy, hypersensitivity, or contraindication to the use of local or topical lidocaine anesthetics, nasal topical 1:1000 adrenaline, nasal decongestants, nasal steroid spray\n14. Any serious or unstable concurrent disease, psychiatric disorder, or any significant condition that, in the opinion of the investigator, could confound the results of the study or could interfere with the participant's participation or compliance with the study\n15. A recent (within 1 year of the screening visit) clinically significant history of drug or alcohol abuse, or dependence that, in the opinion of the investigator could interfere with the participant's participation or compliance with the study\n16. Inability to read and understand English\n17. Any medical condition that in the opinion of the investigator would interfere with the treatment\n18. Any participant who is unfit to undergo surgery under general anesthesia\n19. Current participation in another clinical trial at the time of the screening visit.\n20. Participant is unable to undergo an awake procedure\n21. Diagnosis or Aspirin Exacerbated Respiratory Disease (AERD)","18 Years",{"count":58,"type":20},140,"INTERVENTIONAL",[61],"NA","Chronic rhinosinusitis, also called chronic sinusitis, is a very common life-long disease affecting over 5% of the Canadian population. Its symptoms, including daily facial pain and headache, an inability to breath through the nose and complete smell loss, regularly impair one's ability to work and to enjoy and participate in daily activities. The annual cost of chronic sinusitis to Canada is estimated at $1.3 billion while the government pays an estimated $860 million yearly for chronic sinusitis treatment. Chronic sinusitis with polyps, the most common type of chronic sinusitis, is usually treated with a combination of medications and surgery. Until now, surgical treatment has only been performed in the operating room, at a cost of about $3500 per procedure. But, recent studies have shown that a new procedure, \"in-clinic polyp removal\", can provide an improvement in patient symptoms to levels equal to those for sinus surgery performed in a hospital operating room. Moreover, in clinic polyp removal has additional advantages including a shorter procedure recovery time, a significantly lower cost to the health care system (about one-tenth the cost or $450), and a shorter wait time for treatment. With the proposed pragmatic trial, the investigators will determine whether the in clinic polyp removal procedure is as good as sinus surgery in the operating room at controlling patient symptoms of chronic sinusitis. The investigators will also determine the cost and health-benefits for a patient, the healthcare system and for society of in clinic polyp removal in comparison to sinus surgery done in a hospital operating room. The investigators will then know if this new treatment, in clinic polyp removal, can replace sinus surgery as the standard of care for these patients.",[25,64],"Nasal Polyps","2025-12-23",{"date":67,"type":40},"2025-12-30",{"date":69,"type":40},"2017-04-11",{"date":71,"type":20},"2026-12",{"name":73,"class":47},"Ottawa Hospital Research Institute",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":59,"phases":85,"briefSummary":86,"conditions":87,"keywords":92,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":48},"100554125","how-omt-benefits-newly-diagnosed-patients-with-respiratory-illness-when-given-alongside-other-standard-care-100554125","NCT06495021","How OMT Benefits Newly Diagnosed Patients With Respiratory Illness When Given Alongside Other Standard Care.","OMT and Respiratory Illness","Inclusion Criteria:\n\n* Patients being seen for respiratory illness symptoms at Geisinger 65-Forward Buckhorn, PA clinic for care.\n* Patients age of 65-100\n* New diagnosis of upper respiratory illness, sinusitis, bronchitis, or pneumonia during outpatient visit.\n\nExclusion Criteria:\n\n* Patients that have a healing fracture, including the spine, pelvis, shoulder, ribs, vertebrae, or extremities.\n* Patients actively receiving any type of cancer treatment\n* Patients with active or previously diagnosed liver disease.","65 Years","100 Years",{"count":84,"type":20},68,[61],"This study is to see Osteopathic Manipulative Therapy, or OMT, can aid in treating patients being seen for respiratory illness and associated symptoms. The hypothesis is that the addition of OMT therapy, alongside other standard care (such as a medication), can help lessen patient symptoms sooner than just other treatment alone, and the duration of the condition will shorten as well.",[88,25,89,90,91],"Pneumonia","Bronchitis","Respiratory Disease","Respiratory Tract Infections",[93,94,95],"Osteopathic Manual Therapy","Respiratory Illness","OMT","2025-07-07",{"date":98,"type":40},"2025-07-08",{"date":100,"type":40},"2024-12-31",{"date":102,"type":20},"2026-06",{"name":104,"class":47},"Geisinger Clinic",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":59,"phases":115,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":4},"100554419","efficacy-of-two-nasal-products-based-on-diluted-seawater-in-the-treatment-of-upper-respiratory-infectionsconditions-100554419","NCT06498843","Efficacy of Two Nasal Products Based on Diluted Seawater in the Treatment of Upper Respiratory Infections\u002FConditions","Clinical Evaluation of the Effectiveness of Nasal Pump Spray Medical Devices DM004 and DM020 Based on Diluted Seawater in the Treatment of Colds, Rhinitis, Sinusitis, and Other Upper Respiratory Infections\u002FConditions","Inclusion Criteria:\n\n* Autonomous adult, or minor with the consent of their legal representative\n* Adults and children from 3 months old\n* Ability of the patient (for adults) or their legal representative (for children) to follow the instructions for product use\n* Having signed a free and informed consent to participate in the study expressed by the patient (for adults) or by their legal representative (for children) after being informed by the doctor.\n* Person with an upper respiratory tract infection (cold, rhinitis, rhinopharyngitis…) with symptoms of nasal congestion and nasal discharge of moderate to severe intensity (Jackson derived score (nasal congestion + nasal discharge) ≥ 4 on Day 0).\n* Persons with symptoms that started no more than 48 hours before the first visit\n\nExclusion Criteria:\n\n* Person not showing cold symptoms, particularly no nasal congestion (chronic dry rhinitis, or Jackson derived score (nasal congestion + nasal discharge) \\< 4 on Day 0).\n* Person undergoing treatment with a cortisone derivative, mucolytic, or medication containing pseudoephedrine or a similar product acting on nasal congestion or having used such a product within the 3 days preceding inclusion.\n* Person having used a nasal wash product within the 3 days preceding inclusion.\n* Person whose ability to use the product daily and complete the daily follow-up diary is in doubt.\n* Person refusing to sign the informed consent form prior to the study.\n* Person participating or having participated in any other clinical study within the 30 days preceding the study.\n* Person participating in any other clinical study.","3 Months",{"count":114,"type":20},91,[61],"The goal of this interventional clinical trial is to test the safety and efficacy of two medical devices in subjects aged from 3 months old for the treatment of colds, rhinitis, sinusitis, and other upper respiratory infections\u002Fconditions for 7 days.",[118,25,119,120],"Rhinitis","Upper Respiratory Infections","Colds","NOT_YET_RECRUITING","2024-07-31",{"date":124,"type":40},"2024-08-02",{"date":126,"type":20},"2025-01",{"date":128,"type":20},"2025-06",{"name":130,"class":131},"YSLab","INDUSTRY"]