[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skin-barrier-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skin-barrier-function":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100635110","study-of-a-peptide-creams-effect-on-the-facial-skin-barrier-using-a-side-by-side-comparison-100635110",false,"NCT07548424","Study of a Peptide Cream's Effect on the Facial Skin Barrier Using a Side-by-Side Comparison","Evaluation of the Effect of a Topical Formulation Containing Acetyl Hexapeptide-37 on Objective Skin Barrier Parameters of the Face in a Randomized Controlled Split-Face Design","Inclusion Criteria:\n\n* healthy volunteers who gave written informed consent\n\nExclusion Criteria:\n\n* presence of active skin diseases or dermatological conditions\n* known allergy or hypersensitivity to any ingredient of the study products\n* pregnancy or breastfeeding\n* use of topical or systemic corticosteroids, immunosuppressive drugs, or antihistamines prior to or during the study",true,"ALL","18 Years","50 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to evaluate whether a topical face cream containing the peptide Acetyl Hexapeptide-37 improves skin hydration and strengthens the skin barrier compared to a placebo cream in healthy adult participants. The study uses a split-face design, in which one side of the face is treated with the peptide cream and the other side with a placebo (a cream without the active ingredient).\n\nThe main questions it aims to answer are:\n\n* Does the peptide cream improve skin hydration and reduce transepidermal water loss compared to placebo?\n* Does the peptide cream affect skin erythema or cause irritation?\n* How do participants rate the comfort and tolerability of the peptide cream?\n\nResearchers will compare the treated and placebo sides of the face to assess differences in skin barrier function and tolerability.\n\nParticipants will:\n\n* Attend a baseline visit for assessment of facial skin parameters, including hydration, transepidermal water loss, and erythema\n* Apply the peptide cream to one side of the face and the placebo cream to the other side once daily for 4 weeks\n* Attend weekly follow-up visits for non-invasive skin measurements\n* Record any skin sensations (e.g., stinging, tightness) or adverse effects throughout the study",[28,29,30],"Skin Barrier Function","Skin Hydration","Topical Peptide Effects on Facial Skin Barrier Function","RECRUITING","2026-06-15",{"date":34,"type":35},"2026-06-17","ACTUAL",{"date":37,"type":35},"2026-05-04",{"date":39,"type":22},"2027-01",{"name":41,"class":42},"University of Split, School of Medicine","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":16,"sex":50,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":43},"100636096","clinical-observational-study-on-changes-in-skin-physiological-parameters-following-ablative-and-non-ablative-fractional-laser-treatment-at-different-doses-100636096","NCT07561242","Clinical Observational Study on Changes in Skin Physiological Parameters Following Ablative and Non-Ablative Fractional Laser Treatment at Different Doses","Inclusion Criteria:\n\n* Female Chinese study participants aged 18 to 60 years (inclusive).\n* Fitzpatrick skin phototypes III, IV, or V.\n* Willing to receive non-ablative fractional laser (M22) and ablative fractional laser (CO2) irradiation on the test sites during the study.\n* No primary or secondary lesions (such as scars, ulcers, vesicles, tattoos) on the test sites.\n* Has not participated in any other studies involving the test area (forearms) in the past 2 months.\n* Agrees not to use skin-whitening products on the test area during the study period.\n* In good general health at the time of the study.\n* Volunteers to participate and signs the informed consent form and photo release authorization.\n* Willing to comply with all requirements of the study.\n\nExclusion Criteria:\n\n* Study participants with skin diseases or skin allergies in the test area.\n* Presence of moderate to severe inflammatory skin diseases (e.g., active eczema, acute photosensitive dermatitis, etc.) on the test sites within the past 4 weeks, or those who require treatment with oral or topical corticosteroids or immunosuppressants for skin conditions.\n* On the day of the visit, the investigator judges the presence of significant diffuse erythema, desquamation, or exudation in the test area that may significantly affect skin color measurement.\n* The investigator assesses that the participant is currently suffering from a stable or progressively worsening disease.\n* Participant is planning for pregnancy, is pregnant, or is breastfeeding (applicable to female participants only).\n* Participant with immunodeficiency.\n* Participant has a history of photosensitivity or photoallergy.\n* Participant has a history of skin cancer or malignant melanoma.\n* Presence of significant scars, tattoos, surgical incisions, or pigmented lesions (e.g., prominent birthmarks) in the test area that may affect assessment, and in the investigator's judgment, would impede normal imaging or scoring.\n* Has used high-potency active products containing high concentrations of retinoic acid\u002Fretinol, alpha hydroxy acids, salicylic acid, etc., on the test area frequently (≥3 times per week) for an extended period (≥4 weeks) within the past 3 months, which, in the investigator's judgment, may significantly affect skin texture or barrier status.\n* History of moderate to severe sun exposure (e.g., prolonged outdoor work, travel to seaside\u002Fhigh altitude) within the past 4 weeks, resulting in significant tanning or sunburn in the test area that, in the investigator's judgment, may interfere with study-related readings.\n* Participation in other clinical or consumer testing projects involving the skin condition of the test area within the past 4 weeks.\n* Presence of significant mental or cognitive impairment affecting compliance, and the investigator considers the participant unable to understand the study procedures or complete the tests as required.","FEMALE","60 Years",{"count":53,"type":22},20,"OBSERVATIONAL","This clinical observational study investigates the dose-response relationship between laser energy intensity and skin damage\u002Frepair by applying different parameter sets of fractional ablative (CO2) and non-ablative (M22) lasers to the inner forearms of approximately 20 healthy Chinese female volunteers (aged 18-60, Fitzpatrick skin types III-V) in a single-center, self-controlled design. Each participant receives both laser types on contralateral arms, with four distinct energy\u002Fdensity combinations per laser applied to separate test areas, and the dynamic skin responses are evaluated at baseline, immediately post-treatment, and at 30 minutes, 1, 2, 3, 4 hours, 7 days, and 10 days thereafter through clinical assessments (edema, erythema, etc.), standardized photography, high-frequency ultrasound (Dermascan), and objective instrumental measurements of skin color (Chromameter CM26dG), melanin\u002Fhemoglobin (Mexameter MX18), and barrier function (TEWL via Vapometer). The collected data will be analyzed using descriptive and comparative statistical methods to characterize the acute injury and recovery profiles, aiming to establish a foundational model for future post-procedure cosmetic intervention research.",[28,57],"Wound Healing","2026-04-24",{"date":60,"type":35},"2026-05-01",{"date":62,"type":35},"2026-03-21",{"date":64,"type":22},"2026-04-30",{"name":66,"class":67},"ChinaNorm","INDUSTRY"]