[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skin-dullness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skin-dullness":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":4},"100637469","efficacy-and-safety-of-overnight-occlusive-ha35-gel-for-facial-aesthetic-improvement-100637469",false,"NCT07584811","Efficacy and Safety of Overnight Occlusive HA35 Gel for Facial Aesthetic Improvement","A Prospective, Single-Arm, Open-Label Pilot Clinical Study to Evaluate Efficacy and Safety of Overnight Occlusive Topical 10% 35 kDa Hyaluronan (HA35) Gel for Facial Subcutaneous Fat Appearance, Erythema, Skin Radiance, and Pore Condition","HA35-FACIAL","Inclusion Criteria:\n\n* Age 18-60 years, male or female\n* Seeking non-invasive improvement of facial appearance\n* Presenting with at least one of: facial subcutaneous fat accumulation, facial erythema, skin dullness, nasal alar pore enlargement\n* Baseline NRS score ≥2 for at least one target parameter\n* Ability to complete self-assessments\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Facial aesthetic treatments (injection, laser, fat reduction, peeling) within 2 weeks\n* Active facial dermatitis, infection, or open wounds\n* Known hypersensitivity to hyaluronan or gel components\n* Pregnant or lactating women\n* Severe systemic disease or uncontrolled medical condition","ALL","18 Years","60 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of overnight occlusive topical application of 10% high-concentration 35 kDa hyaluronan (HA35) gel for facial aesthetic improvement. Eligible participants will receive overnight occlusive application once every 2 days for a total of 5 treatments over 10 days. The primary objectives are to assess changes in facial subcutaneous fat appearance, inflammatory erythema, skin radiance, and nasal alar pore enlargement after 1 and 5 applications. Safety and local tolerability will be evaluated throughout the study period. This is a minimal-risk, non-pharmacological, non-invasive aesthetic intervention.",[28,29,30,31,32],"Facial Subcutaneous Fat","Facial Erythema","Skin Dullness","Nasal Alar Pore Enlargement","Facial Aesthetic Improvement",[34,35,36,37,38,39,29,40,41,42,43],"Hyaluronan","35 kDa Hyaluronan","HA35","Overnight Occlusive","Topical Gel","Facial Fat","Skin Radiance","Pore Improvement","Non-invasive Aesthetic","Pilot Clinical Study","NOT_YET_RECRUITING","2026-05-07",{"date":47,"type":48},"2026-05-13","ACTUAL",{"date":50,"type":22},"2026-05-01",{"date":52,"type":22},"2026-07-20",{"name":54,"class":55},"Nakhia Impex LLC","INDUSTRY"]